-
1
-
-
41349099104
-
Cancer statistics 2008
-
Jemal, A. et al. Cancer statistics, 2008. CA Cancer J. Clin. 58, 71-96 (2008).
-
(2008)
CA Cancer J. Clin.
, vol.58
, pp. 71-96
-
-
Jemal, A.1
-
2
-
-
79953158399
-
Exploring the genomes of cancer cells: Progress and promise
-
Stratton, M. R. Exploring the genomes of cancer cells: progress and promise. Science 331, 1553-1558 (2011).
-
(2011)
Science
, vol.331
, pp. 1553-1558
-
-
Stratton, M.R.1
-
3
-
-
0017167185
-
The clonal evolution of tumor cell populations
-
Nowell, P. C. The clonal evolution of tumor cell populations. Science 194, 23-28 (1976).
-
(1976)
Science
, vol.194
, pp. 23-28
-
-
Nowell, P.C.1
-
4
-
-
33845243362
-
Cancer as an evolutionary and ecological process
-
DOI 10.1038/nrc2013, PII NRC2013
-
Merlo, L. M., Pepper, J. W., Reid, B. J. & Maley, C. C. Cancer as an evolutionary and ecological process. Nature Rev. Cancer 6, 924-935 (2006). (Pubitemid 44862677)
-
(2006)
Nature Reviews Cancer
, vol.6
, Issue.12
, pp. 924-935
-
-
Merlo, L.M.F.1
Pepper, J.W.2
Reid, B.J.3
Maley, C.C.4
-
5
-
-
70350336005
-
Cancer research meets evolutionary biology
-
Pepper, J., Scott Findlay, C., Kassen, R., Spencer, S. & Maley, C. Cancer research meets evolutionary biology. Evol. Appl. 2, 62-70 (2009).
-
(2009)
Evol. Appl.
, vol.2
, pp. 62-70
-
-
Pepper, J.1
Scott Findlay, C.2
Kassen, R.3
Spencer, S.4
Maley, C.5
-
7
-
-
0027244510
-
The frequency of carcinoma and intraepithelial neoplasia of the prostate in young male patients
-
Sakr, W. A., Haas, G. P., Cassin, B. F., Pontes, J. E. & Crissman, J. D. The frequency of carcinoma and intraepithelial neoplasia of the prostate in young male patients. J. Urol. 150, 379-385 (1993). (Pubitemid 23215874)
-
(1993)
Journal of Urology
, vol.150
, Issue.2
, pp. 379-385
-
-
Sakr, W.A.1
Haas, G.P.2
Cassin, B.F.3
Pontes, J.E.4
Crissman, J.D.5
-
8
-
-
0037062496
-
Chromosome translocations and covert leukemic clones are generated during normal fetal development
-
DOI 10.1073/pnas.112218799
-
Mori, H. et al. Chromosome translocations and covert leukemic clones are generated during normal fetal development. Proc. Natl Acad. Sci. USA 99, 8242-8247 (2002). (Pubitemid 34651037)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.12
, pp. 8242-8247
-
-
Mori, H.1
Colman, S.M.2
Xiao, Z.3
Ford, A.M.4
Healy, L.E.5
Donaldson, C.6
Hows, J.M.7
Navarrete, C.8
Greaves, M.9
-
9
-
-
75149134769
-
Barrett's oesophagus and oesophageal adenocarcinoma: Time for a new synthesis
-
Reid, B. J., Li, X., Galipeau, P. C. & Vaughan, T. L. Barrett's oesophagus and oesophageal adenocarcinoma: time for a new synthesis. Nature Rev. Cancer 10, 87-101 (2010).
-
(2010)
Nature Rev. Cancer
, vol.10
, pp. 87-101
-
-
Reid, B.J.1
Li, X.2
Galipeau, P.C.3
Vaughan, T.L.4
-
10
-
-
63049102497
-
Parallel progression of primary tumours and metastases
-
Klein, C. A. Parallel progression of primary tumours and metastases. Nature Rev. Cancer 9, 302-312 (2009).
-
(2009)
Nature Rev. Cancer
, vol.9
, pp. 302-312
-
-
Klein, C.A.1
-
11
-
-
0015854554
-
The relationship between growth rate, labelling index and histological type of human solid tumours
-
Malaise, E. P., Chavaudra, N. & Tubiana, M. The relationship between growth rate, labelling index and histological type of human solid tumours. Eur. J. Cancer 9, 305-312 (1973).
-
(1973)
Eur. J. Cancer
, vol.9
, pp. 305-312
-
-
Malaise, E.P.1
Chavaudra, N.2
Tubiana, M.3
-
12
-
-
57349185631
-
Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity
-
Tsai, A. G. et al. Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity. Cell 135, 1130-1142 (2008).
-
(2008)
Cell
, vol.135
, pp. 1130-1142
-
-
Tsai, A.G.1
-
13
-
-
0035826823
-
Carcinogen-specific induction of genetic instability
-
DOI 10.1073/pnas.081082898
-
Bardelli, A. et al. Carcinogen-specific induction of genetic instability. Proc. Natl Acad. Sci. USA 98, 5770-5775 (2001). (Pubitemid 32435717)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.10
, pp. 5770-5775
-
-
Bardelli, A.1
Cahill, D.P.2
Lederer, G.3
Speicher, M.R.4
Kinzler, K.W.5
Vogelstein, B.6
Lengauer, C.7
-
14
-
-
0033388315
-
Genetic instability and Darwinian selection in tumors
-
Cahill, D. P., Kinzler, K. W., Vogelstein, B. & Lengauer, C. Genetic instability and Darwinian selection in tumors. Trends Cell Biol. 9, M57-M60 (1999).
-
(1999)
Trends Cell Biol.
, vol.9
-
-
Cahill, D.P.1
Kinzler, K.W.2
Vogelstein, B.3
Lengauer, C.4
-
15
-
-
28544438548
-
Radiation and the microenvironment-tumorigenesis and therapy
-
Barcellos-Hoff, M. H., Park, C. & Wright, E. G. Radiation and the microenvironment-tumorigenesis and therapy. Nature Rev. Cancer 5, 867-875 (2005).
-
(2005)
Nature Rev. Cancer
, vol.5
, pp. 867-875
-
-
Barcellos-Hoff, M.H.1
Park, C.2
Wright, E.G.3
-
16
-
-
2442649306
-
Selectively advantageous mutations and hitchhikers in neoplasms: P16 lesions are selected in Barrett's esophagus
-
DOI 10.1158/0008-5472.CAN-03-3249
-
Maley, C. C. et al. Selectively advantageous mutations and hitchhikers in neoplasms: p16 lesions are selected in Barrett's esophagus. Cancer Res. 64, 3414-3427 (2004). (Pubitemid 38657913)
-
(2004)
Cancer Research
, vol.64
, Issue.10
, pp. 3414-3427
-
-
Maley, C.C.1
Galipeau, P.C.2
Li, X.3
Sanchez, C.A.4
Paulson, T.G.5
Reid, B.J.6
-
17
-
-
84983720414
-
Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data
-
Tao, Y. et al. Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. Proc. Natl Acad. Sci. USA 108, 12042-12047 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 12042-12047
-
-
Tao, Y.1
-
18
-
-
77249123407
-
Signatures of mutation and selection in the cancer genome
-
Bignell, G. R. et al. Signatures of mutation and selection in the cancer genome. Nature 463, 893-898 (2010).
-
(2010)
Nature
, vol.463
, pp. 893-898
-
-
Bignell, G.R.1
-
19
-
-
78651439545
-
Identifying cancer driver genes in tumor genome sequencing studies
-
Youn, A. & Simon, R. Identifying cancer driver genes in tumor genome sequencing studies. Bioinformatics 27, 175-181 (2011).
-
(2011)
Bioinformatics
, vol.27
, pp. 175-181
-
-
Youn, A.1
Simon, R.2
-
20
-
-
33747869580
-
Statistical analysis of pathogenicity of somatic mutations in cancer
-
DOI 10.1534/genetics.105.044677
-
Greenman, C., Wooster, R., Futreal, P. A., Stratton, M. R. & Easton, D. F. Statistical analysis of pathogenicity of somatic mutations in cancer. Genetics 173, 2187-2198 (2006). (Pubitemid 44285695)
-
(2006)
Genetics
, vol.173
, Issue.4
, pp. 2187-2198
-
-
Greenman, C.1
Wooster, R.2
Futreal, P.A.3
Stratton, M.R.4
Easton, D.F.5
-
21
-
-
78249261016
-
Accumulation of driver and passenger mutations during tumor progression
-
Bozic, I. et al. Accumulation of driver and passenger mutations during tumor progression. Proc. Natl Acad. Sci. USA 107, 18545-18550 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 18545-18550
-
-
Bozic, I.1
-
22
-
-
30344444783
-
The molecular basis of common and rare fragile sites
-
DOI 10.1016/j.canlet.2005.07.039, PII S0304383505008268
-
Schwartz, M., Zlotorynski, E. & Kerem, B. The molecular basis of common and rare fragile sites. Cancer Lett. 232, 13-26 (2006). (Pubitemid 43054977)
-
(2006)
Cancer Letters
, vol.232
, Issue.1
, pp. 13-26
-
-
Schwartz, M.1
Zlotorynski, E.2
Kerem, B.3
-
23
-
-
79957501125
-
Human cancers express mutator phenotypes: Origin, consequences and targeting
-
Loeb, L. A. Human cancers express mutator phenotypes: origin, consequences and targeting. Nature Rev. Cancer 11, 450-457 (2011).
-
(2011)
Nature Rev. Cancer
, vol.11
, pp. 450-457
-
-
Loeb, L.A.1
-
24
-
-
33745541234
-
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
-
DOI 10.1038/ng1834, PII N1834
-
Weisenberger, D. J. et al. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nature Genet 38, 787-793 (2006). (Pubitemid 43980599)
-
(2006)
Nature Genetics
, vol.38
, Issue.7
, pp. 787-793
-
-
Weisenberger, D.J.1
Siegmund, K.D.2
Campan, M.3
Young, J.4
Long, T.I.5
Faasse, M.A.6
Kang, G.H.7
Widschwendter, M.8
Weener, D.9
Buchanan, D.10
Koh, H.11
Simms, L.12
Barker, M.13
Leggett, B.14
Levine, J.15
Kim, M.16
French, A.J.17
Thibodeau, S.N.18
Jass, J.19
Haile, R.20
Laird, P.W.21
more..
-
25
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646-674 (2011).
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
26
-
-
63849149890
-
Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers
-
Siegmund, K. D., Marjoram, P., Woo, Y. J., Tavare, S. & Shibata, D. Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers. Proc. Natl Acad. Sci. USA 106, 4828-4833 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 4828-4833
-
-
Siegmund, K.D.1
Marjoram, P.2
Woo, Y.J.3
Tavare, S.4
Shibata, D.5
-
27
-
-
69049103181
-
Intra-tumor heterogeneity of MLH1 promoter methylation revealed by deep single molecule bisulfite sequencing
-
Varley, K. E., Mutch, D. G., Edmonston, T. B., Goodfellow, P. J. & Mitra, R. D. Intra-tumor heterogeneity of MLH1 promoter methylation revealed by deep single molecule bisulfite sequencing. Nucleic Acids Res. 37, 4603-4612 (2009).
-
(2009)
Nucleic Acids Res.
, vol.37
, pp. 4603-4612
-
-
Varley, K.E.1
Mutch, D.G.2
Edmonston, T.B.3
Goodfellow, P.J.4
Mitra, R.D.5
-
28
-
-
84859247862
-
Overlooking evolution: A systematic analysis of cancer relapse and therapeutic resistance research
-
Aktipis, C. A., Kwan, V. S. Y., Johnson, K. A., Neuberg, S. L. & Maley, C. C. Overlooking evolution: a systematic analysis of cancer relapse and therapeutic resistance research. PLoS ONE 6, e261000 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Aktipis, C.A.1
Kwan, V.S.Y.2
Johnson, K.A.3
Neuberg, S.L.4
Maley, C.C.5
-
29
-
-
36949025507
-
Genetic progression and the waiting time to cancer
-
Beerenwinkel, N. et al. Genetic progression and the waiting time to cancer. PLoS Comput. Biol. 3, e225 (2007).
-
(2007)
PLoS Comput. Biol.
, vol.3
-
-
Beerenwinkel, N.1
-
30
-
-
33646204788
-
Clonal interference and the periodic selection of new beneficial mutations in Escherichia coli
-
de Visser, J. A. & Rozen, D. E. Clonal interference and the periodic selection of new beneficial mutations in Escherichia coli. Genetics 172, 2093-2100 (2006).
-
(2006)
Genetics
, vol.172
, pp. 2093-2100
-
-
De Visser, J.A.1
Rozen, D.E.2
-
31
-
-
48249128273
-
Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett's oesophagus
-
Leedham, S. J. et al. Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett's oesophagus. Gut 57, 1041-1048 (2008).
-
(2008)
Gut
, vol.57
, pp. 1041-1048
-
-
Leedham, S.J.1
-
32
-
-
79953766940
-
Tumour evolution inferred by single-cell sequencing
-
Navin, N. et al. Tumour evolution inferred by single-cell sequencing. Nature 472, 90-94 (2011).
-
(2011)
Nature
, vol.472
, pp. 90-94
-
-
Navin, N.1
-
33
-
-
78751644099
-
Genetic variegation of clonal architecture and propagating cells in leukaemia
-
Anderson, K. et al. Genetic variegation of clonal architecture and propagating cells in leukaemia. Nature 469, 356-361 (2011).
-
(2011)
Nature
, vol.469
, pp. 356-361
-
-
Anderson, K.1
-
34
-
-
0032983538
-
Colorectal adenoma and cancer divergence. Evidence of multilineage progression
-
Tsao, J. L. et al. Colorectal adenoma and cancer divergence. Evidence of multilineage progression. Am. J. Pathol. 154, 1815-1824 (1999).
-
(1999)
Am. J. Pathol.
, vol.154
, pp. 1815-1824
-
-
Tsao, J.L.1
-
35
-
-
33645396945
-
Genetic clonal diversity predicts progression to esophageal adenocarcinoma
-
Maley, C. C. et al. Genetic clonal diversity predicts progression to esophageal adenocarcinoma. Nature Genet. 38, 468-473 (2006).
-
(2006)
Nature Genet.
, vol.38
, pp. 468-473
-
-
Maley, C.C.1
-
36
-
-
0026569818
-
Clonal expansion of p53 mutant cells is associated with brain tumour progression
-
Sidransky, D. et al. Clonal expansion of p53 mutant cells is associated with brain tumour progression. Nature 355, 846-847 (1992).
-
(1992)
Nature
, vol.355
, pp. 846-847
-
-
Sidransky, D.1
-
37
-
-
78049398107
-
Distant metastasis occurs late during the genetic evolution of pancreatic cancer
-
Yachida, S. et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 467, 1114-1117 (2010).
-
(2010)
Nature
, vol.467
, pp. 1114-1117
-
-
Yachida, S.1
-
38
-
-
0027790582
-
Punctuated equilibrium comes of age
-
DOI 10.1038/366223a0
-
Gould, S. J. & Eldredge, N. Punctuated equilibrium comes of age. Nature 366, 223-227 (1993). (Pubitemid 24410249)
-
(1993)
Nature
, vol.366
, Issue.6452
, pp. 223-227
-
-
Gould, S.J.1
Eldredge, N.2
-
39
-
-
78650959663
-
Massive genomic rearrangement acquired in a single catastrophic event during cancer development
-
Stephens, P. J. et al. Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell 144, 27-40 (2011).
-
(2011)
Cell
, vol.144
, pp. 27-40
-
-
Stephens, P.J.1
-
40
-
-
51349126920
-
Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing
-
Campbell, P. J. et al. Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing. Proc. Natl Acad. Sci. USA 105, 13081-13086 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 13081-13086
-
-
Campbell, P.J.1
-
41
-
-
35548936833
-
Models, mechanisms and clinical evidence for cancer dormancy
-
DOI 10.1038/nrc2256, PII NRC2256
-
Aguirre-Ghiso, J. A. Models, mechanisms and clinical evidence for cancer dormancy. Nature Rev. Cancer 7, 834-846 (2007). (Pubitemid 350006258)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.11
, pp. 834-846
-
-
Aguirre-Ghiso, J.A.1
-
42
-
-
70449552851
-
Immunologically silent cancer clone transmission from mother to offspring
-
Isoda, T. et al. Immunologically silent cancer clone transmission from mother to offspring. Proc. Natl Acad. Sci. USA 106, 17882-17885 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 17882-17885
-
-
Isoda, T.1
-
43
-
-
79952593287
-
Contagious cancer
-
Welsh, J. S. Contagious cancer. Oncologist 16, 1-4 (2011).
-
(2011)
Oncologist
, vol.16
, pp. 1-4
-
-
Welsh, J.S.1
-
44
-
-
37549013776
-
A microenvironmental model of carcinogenesis
-
Gatenby, R. A. & Gillies, R. J. A microenvironmental model of carcinogenesis. Nature Rev. Cancer 8, 56-61 (2008).
-
(2008)
Nature Rev. Cancer
, vol.8
, pp. 56-61
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
45
-
-
33745515023
-
Tumour microenvironment - TGF: The molecular Jekyll and Hyde of cancer
-
DOI 10.1038/nrc1926, PII N1926
-
Bierie, B. & Moses, H. L. Tumour microenvironment: TGFb: the molecular Jekyll and Hyde of cancer. Nature Rev. Cancer 6, 506-520 (2006). (Pubitemid 43980540)
-
(2006)
Nature Reviews Cancer
, vol.6
, Issue.7
, pp. 506-520
-
-
Bierie, B.1
Moses, H.L.2
-
46
-
-
79955702339
-
Deadly teamwork: Neural cancer stem cells and the tumor microenvironment
-
Lathia, J. D., Heddleston, J. M., Venere, M. & Rich, J. N. Deadly teamwork: neural cancer stem cells and the tumor microenvironment. Cell Stem Cell 8, 482-485 (2011).
-
(2011)
Cell Stem Cell
, vol.8
, pp. 482-485
-
-
Lathia, J.D.1
Heddleston, J.M.2
Venere, M.3
Rich, J.N.4
-
47
-
-
0016692602
-
Mutation selection and the natural history of cancer
-
Cairns, J. Mutation selection and the natural history of cancer. Nature 255, 197-200 (1975).
-
(1975)
Nature
, vol.255
, pp. 197-200
-
-
Cairns, J.1
-
48
-
-
33751217466
-
Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment
-
DOI 10.1016/j.cell.2006.09.042, PII S0092867406013481
-
Anderson, A. R., Weaver, A. M., Cummings, P. T. & Quaranta, V. Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment. Cell 127, 905-915 (2006). (Pubitemid 44792251)
-
(2006)
Cell
, vol.127
, Issue.5
, pp. 905-915
-
-
Anderson, A.R.A.1
Weaver, A.M.2
Cummings, P.T.3
Quaranta, V.4
-
49
-
-
79955700272
-
Solving the puzzle of metastasis: The evolution of cell migration in neoplasms
-
Chen, J., Sprouffske, K., Huang, Q. & Maley, C. C. Solving the puzzle of metastasis: the evolution of cell migration in neoplasms. PLoS ONE 6, e17933 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Chen, J.1
Sprouffske, K.2
Huang, Q.3
Maley, C.C.4
-
50
-
-
59649117924
-
Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
-
Mazzone, M. et al. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell 136, 839-851 (2009).
-
(2009)
Cell
, vol.136
, pp. 839-851
-
-
Mazzone, M.1
-
51
-
-
77958501473
-
DNA damage-mediated induction of a chemoresistant niche
-
Gilbert, L. A. & Hemann, M. T. DNA damage-mediated induction of a chemoresistant niche. Cell 143, 355-366 (2010).
-
(2010)
Cell
, vol.143
, pp. 355-366
-
-
Gilbert, L.A.1
Hemann, M.T.2
-
52
-
-
41949139438
-
Comparative lesion sequencing provides insights into tumor evolution
-
DOI 10.1073/pnas.0712345105
-
Jones, S. et al. Comparative lesion sequencing provides insights into tumor evolution. Proc. Natl Acad. Sci. USA 105, 4283-4288 (2008). (Pubitemid 351754372)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.11
, pp. 4283-4288
-
-
Jones, S.1
Chen, W.-D.2
Parmigiani, G.3
Diehl, F.4
Beerenwinkel, N.5
Antal, T.6
Traulsen, A.7
Nowak, M.A.8
Siegel, C.9
Velculescu, V.E.10
Kinzler, K.W.11
Vogelstein, B.12
Willis, J.13
Markowitz, S.D.14
-
53
-
-
77951139631
-
Genome remodelling in a basal-like breast cancer metastasis and xenograft
-
Ding, L. et al. Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature 464, 999-1005 (2010).
-
(2010)
Nature
, vol.464
, pp. 999-1005
-
-
Ding, L.1
-
54
-
-
79960093087
-
Accurate reconstruction of the temporal order of mutations in neoplastic progression
-
Sprouffske, K., Pepper, J. W. & Maley, C. C. Accurate reconstruction of the temporal order of mutations in neoplastic progression. Cancer Prev. Res. 4, 1135-1144 (2011).
-
(2011)
Cancer Prev. Res.
, vol.4
, pp. 1135-1144
-
-
Sprouffske, K.1
Pepper, J.W.2
Maley, C.C.3
-
55
-
-
0141482011
-
Leukemia in twins: Lessons in natural history
-
DOI 10.1182/blood-2002-12-3817
-
Greaves, M. F., Maia, A. T., Wiemels, J. L. & Ford, A. M. Leukemia in twins: lessons in natural history. Blood 102, 2321-2333 (2003). (Pubitemid 37193565)
-
(2003)
Blood
, vol.102
, Issue.7
, pp. 2321-2333
-
-
Greaves, M.F.1
Maia, A.T.2
Wiemels, J.L.3
Ford, A.M.4
-
56
-
-
77951751194
-
Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia
-
Bateman, C. M. et al. Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia. Blood 115, 3553-3558 (2010).
-
(2010)
Blood
, vol.115
, pp. 3553-3558
-
-
Bateman, C.M.1
-
57
-
-
14644396631
-
Testicular germ-cell tumours in a broader perspective
-
DOI 10.1038/nrc1568
-
Oosterhuis, J. W. & Looijenga, L. H. Testicular germ-cell tumours in a broader perspective. Nature Rev. Cancer 5, 210-222 (2005). (Pubitemid 40314952)
-
(2005)
Nature Reviews Cancer
, vol.5
, Issue.3
, pp. 210-222
-
-
Oosterhuis, J.W.1
Looijenga, L.H.J.2
-
59
-
-
80055101101
-
Temporal dissection of tumorigenesis in primary cancers
-
Durinck, S. et al. Temporal dissection of tumorigenesis in primary cancers. Cancer Discov. 1, 137-143 (2011).
-
(2011)
Cancer Discov.
, vol.1
, pp. 137-143
-
-
Durinck, S.1
-
60
-
-
0036792092
-
Metapopulation dynamics and spatial heterogeneity in cancer
-
Gonzalez-Garcia, I., Sole, R. V. & Costa, J. Metapopulation dynamics and spatial heterogeneity in cancer. Proc. Natl Acad. Sci. USA 99, 13085-13089 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 13085-13089
-
-
Gonzalez-Garcia, I.1
Sole, R.V.2
Costa, J.3
-
61
-
-
41149121704
-
Complex patterns of ETS gene alteration arise during cancer development in the human prostate
-
DOI 10.1038/sj.onc.1210843, PII 1210843
-
Clark, J. et al. Complex patterns of ETS gene alteration arise during cancer development in the human prostate. Oncogene 27, 1993-2003 (2008). (Pubitemid 351442741)
-
(2008)
Oncogene
, vol.27
, Issue.14
, pp. 1993-2003
-
-
Clark, J.1
Attard, G.2
Jhavar, S.3
Flohr, P.4
Reid, A.5
De-Bono, J.6
Eeles, R.7
Scardino, P.8
Cuzick, J.9
Fisher, G.10
Parker, M.D.11
Foster, C.S.12
Berney, D.13
Kovacs, G.14
Cooper, C.S.15
-
62
-
-
74949101897
-
Inferring tumor progression from genomic heterogeneity
-
Navin, N. et al. Inferring tumor progression from genomic heterogeneity. Genome Res. 20, 68-80 (2010).
-
(2010)
Genome Res.
, vol.20
, pp. 68-80
-
-
Navin, N.1
-
63
-
-
38949105905
-
Ductal carcinoma in situ and the emergence of diversity during breast cancer evolution
-
DOI 10.1158/1078-0432.CCR-07-1127
-
Allred, D. C. et al. Ductal carcinoma in situ and the emergence of diversity during breast cancer evolution. Clin. Cancer Res. 14, 370-378 (2008). (Pubitemid 351226103)
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.2
, pp. 370-378
-
-
Allred, D.C.1
Wu, Y.2
Mao, S.3
Nagtegaal, I.D.4
Lee, S.5
Perou, C.M.6
Mohsin, S.K.7
O'Connell, P.8
Tsimelzon, A.9
Medina, D.10
-
64
-
-
76649128993
-
Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype
-
Park, S. Y., Gonen, M., Kim, H. J., Michor, F. & Polyak, K. Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype. J. Clin. Invest. 120, 636-644 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 636-644
-
-
Park, S.Y.1
Gonen, M.2
Kim, H.J.3
Michor, F.4
Polyak, K.5
-
65
-
-
78649248733
-
A comprehensive survey of clonal diversity measures in Barrett's esophagus as biomarkers of progression to esophageal adenocarcinoma
-
Merlo, L. M. et al. A comprehensive survey of clonal diversity measures in Barrett's esophagus as biomarkers of progression to esophageal adenocarcinoma. Cancer Prev. Res. 3, 1388-1397 (2010).
-
(2010)
Cancer Prev. Res.
, vol.3
, pp. 1388-1397
-
-
Merlo, L.M.1
-
66
-
-
58149380742
-
Stem cell concepts renew cancer research
-
Dick, J. E. Stem cell concepts renew cancer research. Blood 112, 4793-4807 (2008).
-
(2008)
Blood
, vol.112
, pp. 4793-4807
-
-
Dick, J.E.1
-
67
-
-
0035499267
-
Stem cells, cancer, and cancer stem cells
-
DOI 10.1038/35102167
-
Reya, T., Morrison, S. J., Clarke, M. F. & Weissman, I. L. Stem cells, cancer, and cancer stem cells. Nature 414, 105-111 (2001). (Pubitemid 33041634)
-
(2001)
Nature
, vol.414
, Issue.6859
, pp. 105-111
-
-
Reya, T.1
Morrison, S.J.2
Clarke, M.F.3
Weissman, I.L.4
-
68
-
-
80052503103
-
Cancer stem cells renew their impact
-
Greaves, M. Cancer stem cells renew their impact. Nature Med. 17, 1046-1048 (2011).
-
(2011)
Nature Med.
, vol.17
, pp. 1046-1048
-
-
Greaves, M.1
-
69
-
-
67649939163
-
The increasing complexity of the cancer stem cell paradigm
-
Rosen, J. M. & Jordan, C. T. The increasing complexity of the cancer stem cell paradigm. Science 324, 1670-1673 (2009).
-
(2009)
Science
, vol.324
, pp. 1670-1673
-
-
Rosen, J.M.1
Jordan, C.T.2
-
70
-
-
77953811725
-
Cancer stem cells: Back to Darwin? Semin
-
Greaves, M. Cancer stem cells: back to Darwin? Semin. Cancer Biol. 20, 65-70 (2010).
-
(2010)
Cancer Biol.
, vol.20
, pp. 65-70
-
-
Greaves, M.1
-
71
-
-
68749099671
-
Identification of selective inhibitors of cancer stem cells by high-throughput screening
-
Gupta, P. B. et al. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 138, 645-659 (2009).
-
(2009)
Cell
, vol.138
, pp. 645-659
-
-
Gupta, P.B.1
-
72
-
-
3943088431
-
Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
-
DOI 10.1056/NEJMoa040258
-
Jamieson, C. H. et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N. Engl. J. Med. 351, 657-667 (2004). (Pubitemid 39063268)
-
(2004)
New England Journal of Medicine
, vol.351
, Issue.7
, pp. 657-667
-
-
Jamieson, C.H.M.1
Ailles, L.E.2
Dylla, S.J.3
Muijtjens, M.4
Jones, C.5
Zehnder, J.L.6
Gotlib, J.7
Li, K.8
Manz, M.G.9
Keating, A.10
Sawyers, C.L.11
Weissman, I.L.12
-
73
-
-
43449084346
-
Arf-/- multipotent progenitors
-
DOI 10.1038/nature06869, PII NATURE06869
-
Akala, O. O. et al. Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/-multipotent progenitors. Nature 453, 228-232 (2008). (Pubitemid 351667977)
-
(2008)
Nature
, vol.453
, Issue.7192
, pp. 228-232
-
-
Akala, O.O.1
Park, I.-K.2
Qian, D.3
Pihalja, M.4
Becker, M.W.5
Clarke, M.F.6
-
74
-
-
33746498580
-
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9
-
DOI 10.1038/nature04980, PII NATURE04980
-
Krivtsov, A. V. et al. Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature 442, 818-822 (2006). (Pubitemid 44258912)
-
(2006)
Nature
, vol.442
, Issue.7104
, pp. 818-822
-
-
Krivtsov, A.V.1
Twomey, D.2
Feng, Z.3
Stubbs, M.C.4
Wang, Y.5
Faber, J.6
Levine, J.E.7
Wang, J.8
Hahn, W.C.9
Gilliland, D.G.10
Golub, T.R.11
Armstrong, S.A.12
-
75
-
-
79851510907
-
Somatic mutations in cancer prognosis and prediction: Lessons from TP53 and EGFR genes
-
Olivier, M. & Taniere, P. Somatic mutations in cancer prognosis and prediction: lessons from TP53 and EGFR genes. Curr. Opin. Oncol. 23, 88-92 (2011).
-
(2011)
Curr. Opin. Oncol.
, vol.23
, pp. 88-92
-
-
Olivier, M.1
Taniere, P.2
-
76
-
-
78651100119
-
Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures
-
Mizuno, H., Spike, B. T., Wahl, G. M. & Levine, A. J. Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures. Proc. Natl Acad. Sci. USA 107, 22745-22750 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 22745-22750
-
-
Mizuno, H.1
Spike, B.T.2
Wahl, G.M.3
Levine, A.J.4
-
77
-
-
70349123829
-
The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells
-
Cicalese, A. et al. The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. Cell 138, 1083-1095 (2009).
-
(2009)
Cell
, vol.138
, pp. 1083-1095
-
-
Cicalese, A.1
-
78
-
-
57349143739
-
Efficient tumour formation by single human melanoma cells
-
Quintana, E. et al. Efficient tumour formation by single human melanoma cells. Nature 456, 593-598 (2008).
-
(2008)
Nature
, vol.456
, pp. 593-598
-
-
Quintana, E.1
-
79
-
-
73149110562
-
Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content
-
Pece, S. et al. Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell 140, 62-73 (2010).
-
(2010)
Cell
, vol.140
, pp. 62-73
-
-
Pece, S.1
-
80
-
-
78751661556
-
Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells
-
Notta, F. et al. Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells. Nature 469, 362-367 (2011).
-
(2011)
Nature
, vol.469
, pp. 362-367
-
-
Notta, F.1
-
81
-
-
79955711142
-
Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse
-
Clappier, E. et al. Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse. J. Exp. Med. 208, 653-661 (2011).
-
(2011)
J. Exp. Med.
, vol.208
, pp. 653-661
-
-
Clappier, E.1
-
82
-
-
74949090309
-
The therapeutic promise of the cancer stem cell concept
-
Frank, N. Y., Schatton, T. & Frank, M. H. The therapeutic promise of the cancer stem cell concept. J. Clin. Invest. 120, 41-50 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 41-50
-
-
Frank, N.Y.1
Schatton, T.2
Frank, M.H.3
-
83
-
-
35948984135
-
Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region
-
DOI 10.1038/nbt1350, PII NBT1350
-
Ishikawa, F. et al. Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nature Biotechnol. 25, 1315-1321 (2007). (Pubitemid 350076512)
-
(2007)
Nature Biotechnology
, vol.25
, Issue.11
, pp. 1315-1321
-
-
Ishikawa, F.1
Yoshida, S.2
Saito, Y.3
Hijikata, A.4
Kitamura, H.5
Tanaka, S.6
Nakamura, R.7
Tanaka, T.8
Tomiyama, H.9
Saito, N.10
Fukata, M.11
Miyamoto, T.12
Lyons, B.13
Ohshima, K.14
Uchida, N.15
Taniguchi, S.16
Ohara, O.17
Akashi, K.18
Harada, M.19
Shultz, L.D.20
more..
-
84
-
-
75549083303
-
Tumor heterogeneity: Causes and consequences
-
Marusyk, A. & Polyak, K. Tumor heterogeneity: causes and consequences. Biochim. Biophys. Acta 1805, 105-117 (2010).
-
(2010)
Biochim. Biophys. Acta
, pp. 105-117
-
-
Marusyk, A.1
Polyak, K.2
-
85
-
-
65049084510
-
Distinct pools of cancer stem-like cells coexist within human glioblastomas and display different tumorigenicity and independent genomic evolution
-
Piccirillo, S. G. M. et al. Distinct pools of cancer stem-like cells coexist within human glioblastomas and display different tumorigenicity and independent genomic evolution. Oncogene 28, 1807-1811 (2009).
-
(2009)
Oncogene
, vol.28
, pp. 1807-1811
-
-
Piccirillo, S.G.M.1
-
86
-
-
78650373172
-
How melanomas bypass new therapy
-
Solit, D. & Sawyers, C. L. How melanomas bypass new therapy. Nature 468, 902-903 (2010).
-
(2010)
Nature
, vol.468
, pp. 902-903
-
-
Solit, D.1
Sawyers, C.L.2
-
87
-
-
77949884311
-
Cycling toward elimination of leukemic stem cells
-
Goff, D. & Jamieson, C. Cycling toward elimination of leukemic stem cells. Cell Stem Cell 6, 296-297 (2010).
-
(2010)
Cell Stem Cell
, vol.6
, pp. 296-297
-
-
Goff, D.1
Jamieson, C.2
-
88
-
-
77950809059
-
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
-
Sharma, S. V. et al. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell 141, 69-80 (2010).
-
(2010)
Cell
, vol.141
, pp. 69-80
-
-
Sharma, S.V.1
-
89
-
-
79952395270
-
Cancer genomics: From discovery science to personalized medicine
-
Chin, L., Andersen, J. N. & Futreal, P. A. Cancer genomics: from discovery science to personalized medicine. Nature Med. 17, 297-303 (2011).
-
(2011)
Nature Med.
, vol.17
, pp. 297-303
-
-
Chin, L.1
Andersen, J.N.2
Futreal, P.A.3
-
90
-
-
70350435633
-
Shifting paradigms: The seeds of oncogene addiction
-
Sawyers, C. L. Shifting paradigms: the seeds of oncogene addiction. Nature Med. 15, 1158-1161 (2009).
-
(2009)
Nature Med.
, vol.15
, pp. 1158-1161
-
-
Sawyers, C.L.1
-
91
-
-
0036090222
-
Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
-
Graham, S. M. et al. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood 99, 319-325 (2002).
-
(2002)
Blood
, vol.99
, pp. 319-325
-
-
Graham, S.M.1
-
92
-
-
73649102105
-
Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC
-
Turke, A. B. et al. Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC. Cancer Cell 17, 77-88 (2010).
-
(2010)
Cancer Cell
, vol.17
, pp. 77-88
-
-
Turke, A.B.1
-
93
-
-
79953283356
-
Genetic interactions in cancer progression and treatment
-
Ashworth, A., Lord, C. J. & Reis-Filho, J. S. Genetic interactions in cancer progression and treatment. Cell 145, 30-38 (2011).
-
(2011)
Cell
, vol.145
, pp. 30-38
-
-
Ashworth, A.1
Lord, C.J.2
Reis-Filho, J.S.3
-
94
-
-
77952105211
-
Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate
-
Zhang, B. et al. Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Cancer Cell 17, 427-442 (2010).
-
(2010)
Cancer Cell
, vol.17
, pp. 427-442
-
-
Zhang, B.1
-
95
-
-
79956305728
-
BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition
-
Duy, C. et al. BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Nature 473, 384-388 (2011).
-
(2011)
Nature
, vol.473
, pp. 384-388
-
-
Duy, C.1
-
96
-
-
70350716805
-
Ecological therapy for cancer: Defining tumors using an ecosystem paradigm suggests new opportunities for novel cancer treatments
-
Pienta, K. J., McGregor, N., Axelrod, R. & Axelrod, D. E. Ecological therapy for cancer: defining tumors using an ecosystem paradigm suggests new opportunities for novel cancer treatments. Trans. Oncol. 1, 158-164 (2008).
-
(2008)
Trans. Oncol.
, vol.1
, pp. 158-164
-
-
Pienta, K.J.1
McGregor, N.2
Axelrod, R.3
Axelrod, D.E.4
-
97
-
-
33846029123
-
A perivascular niche for brain tumor stem cells
-
DOI 10.1016/j.ccr.2006.11.020, PII S1535610806003692
-
Calabrese, C. et al. A perivascular niche for brain tumor stem cells. Cancer Cell 11, 69-82 (2007). (Pubitemid 46054518)
-
(2007)
Cancer Cell
, vol.11
, Issue.1
, pp. 69-82
-
-
Calabrese, C.1
Poppleton, H.2
Kocak, M.3
Hogg, T.L.4
Fuller, C.5
Hamner, B.6
Oh, E.Y.7
Gaber, M.W.8
Finklestein, D.9
Allen, M.10
Frank, A.11
Bayazitov, I.T.12
Zakharenko, S.S.13
Gajjar, A.14
Davidoff, A.15
Gilbertson, R.J.16
-
98
-
-
79952392467
-
Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
-
Bissell, M. J. & Hines, W. C. Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nature Med. 17, 320-329 (2011).
-
(2011)
Nature Med.
, vol.17
, pp. 320-329
-
-
Bissell, M.J.1
Hines, W.C.2
-
99
-
-
38049160116
-
Competitive release and facilitation of drug-resistant parasites after therapeutic chemotherapy in a rodent malaria model
-
Wargo, A. R., Huijben, S., de Roode, J. C., Shepherd, J. & Read, A. F. Competitive release and facilitation of drug-resistant parasites after therapeutic chemotherapy in a rodent malaria model. Proc. Natl Acad. Sci. USA 104, 19914-19919 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 19914-19919
-
-
Wargo, A.R.1
Huijben, S.2
De Roode, J.C.3
Shepherd, J.4
Read, A.F.5
-
100
-
-
66349121917
-
Adaptive therapy
-
Gatenby, R. A., Silva, A. S., Gillies, R. J. & Frieden, B. R. Adaptive therapy. Cancer Res. 69, 4894-4903 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 4894-4903
-
-
Gatenby, R.A.1
Silva, A.S.2
Gillies, R.J.3
Frieden, B.R.4
|