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Volumn 12, Issue 6, 2010, Pages

Key signaling nodes in mammary gland development and cancer: β-catenin

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; WNT PROTEIN;

EID: 79960857043     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr2723     Document Type: Review
Times cited : (122)

References (179)
  • 1
    • 0036269067 scopus 로고    scopus 로고
    • E-cadherin is a survival factor for the lactating mouse mammary gland
    • 10.1016/S0925-4773(02)00090-4, 12049767
    • Boussadia O, Kutsch S, Hierholzer A, Delmas V, Kemler R. E-cadherin is a survival factor for the lactating mouse mammary gland. Mech Dev 2002, 115:53-62. 10.1016/S0925-4773(02)00090-4, 12049767.
    • (2002) Mech Dev , vol.115 , pp. 53-62
    • Boussadia, O.1    Kutsch, S.2    Hierholzer, A.3    Delmas, V.4    Kemler, R.5
  • 4
    • 27944450454 scopus 로고    scopus 로고
    • N-cadherin expression in breast cancer: correlation with an aggressive histologic variant - invasive micropapillary carcinoma
    • 10.1007/s10549-005-7727-5, 16258702
    • Nagi C, Guttman M, Jaffer S, Qiao R, Keren R, Triana A, Li M, Godbold J, Bleiweiss IJ, Hazan RB. N-cadherin expression in breast cancer: correlation with an aggressive histologic variant - invasive micropapillary carcinoma. Breast Cancer Res Treat 2005, 94:225-235. 10.1007/s10549-005-7727-5, 16258702.
    • (2005) Breast Cancer Res Treat , vol.94 , pp. 225-235
    • Nagi, C.1    Guttman, M.2    Jaffer, S.3    Qiao, R.4    Keren, R.5    Triana, A.6    Li, M.7    Godbold, J.8    Bleiweiss, I.J.9    Hazan, R.B.10
  • 5
    • 33744938180 scopus 로고    scopus 로고
    • Quantitative in situ analysis of beta-catenin expression in breast cancer shows decreased expression is associated with poor outcome
    • 10.1158/0008-5472.CAN-06-0100, 16707478
    • Dolled-Filhart M, McCabe A, Giltnane J, Cregger M, Camp RL, Rimm DL. Quantitative in situ analysis of beta-catenin expression in breast cancer shows decreased expression is associated with poor outcome. Cancer Res 2006, 66:5487-5494. 10.1158/0008-5472.CAN-06-0100, 16707478.
    • (2006) Cancer Res , vol.66 , pp. 5487-5494
    • Dolled-Filhart, M.1    McCabe, A.2    Giltnane, J.3    Cregger, M.4    Camp, R.L.5    Rimm, D.L.6
  • 6
    • 78149485367 scopus 로고    scopus 로고
    • Key signalling nodes in mammary gland development and cancer. The Snail1-Twist1 conspiracy in malignant breast cancer progression
    • 10.1186/bcr2585, 20594364
    • Foubert E, De Craene B, Berx G. Key signalling nodes in mammary gland development and cancer. The Snail1-Twist1 conspiracy in malignant breast cancer progression. Breast Cancer Res 2010, 12:206. 10.1186/bcr2585, 20594364.
    • (2010) Breast Cancer Res , vol.12 , pp. 206
    • Foubert, E.1    De Craene, B.2    Berx, G.3
  • 7
    • 4444317116 scopus 로고    scopus 로고
    • Protecting your tail: regulation of cadherin degradation by p120-catenin
    • 10.1016/j.ceb.2004.07.001, 15363802
    • Kowalczyk AP, Reynolds AB. Protecting your tail: regulation of cadherin degradation by p120-catenin. Curr Opin Cell Biol 2004, 16:522-527. 10.1016/j.ceb.2004.07.001, 15363802.
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 522-527
    • Kowalczyk, A.P.1    Reynolds, A.B.2
  • 8
    • 0033579480 scopus 로고    scopus 로고
    • Regulation of E-cadherin/catenin association by tyrosine phosphorylation
    • 10.1074/jbc.274.51.36734, 10593980
    • Roura S, Miravet S, Piedra J, Garcia de Herreros A, Dunach M. Regulation of E-cadherin/catenin association by tyrosine phosphorylation. J Biol Chem 1999, 274:36734-36740. 10.1074/jbc.274.51.36734, 10593980.
    • (1999) J Biol Chem , vol.274 , pp. 36734-36740
    • Roura, S.1    Miravet, S.2    Piedra, J.3    Garcia de Herreros, A.4    Dunach, M.5
  • 9
    • 0034466985 scopus 로고    scopus 로고
    • Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer
    • 138776, 11250711, 10.1186/bcr55
    • Biscardi JS, Ishizawar RC, Silva CM, Parsons SJ. Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer. Breast Cancer Res 2000, 2:203-210. 138776, 11250711, 10.1186/bcr55.
    • (2000) Breast Cancer Res , vol.2 , pp. 203-210
    • Biscardi, J.S.1    Ishizawar, R.C.2    Silva, C.M.3    Parsons, S.J.4
  • 10
    • 70349142286 scopus 로고    scopus 로고
    • Tyrosinephosphorylation of the 12th armadillo-repeat of beta-catenin is associated with cadherin dysfunction in human cancer
    • Shomori K, Ochiai A, Akimoto S, Ino Y, Shudo K, Ito H, Hirohashi S. Tyrosinephosphorylation of the 12th armadillo-repeat of beta-catenin is associated with cadherin dysfunction in human cancer. Int J Oncol 2009, 35:517-524.
    • (2009) Int J Oncol , vol.35 , pp. 517-524
    • Shomori, K.1    Ochiai, A.2    Akimoto, S.3    Ino, Y.4    Shudo, K.5    Ito, H.6    Hirohashi, S.7
  • 11
    • 33745251071 scopus 로고    scopus 로고
    • Activation of Abl tyrosine kinases promotes invasion of aggressive breast cancer cells
    • 10.1158/0008-5472.CAN-06-0734, 16740702
    • Srinivasan D, Plattner R. Activation of Abl tyrosine kinases promotes invasion of aggressive breast cancer cells. Cancer Res 2006, 66:5648-5655. 10.1158/0008-5472.CAN-06-0734, 16740702.
    • (2006) Cancer Res , vol.66 , pp. 5648-5655
    • Srinivasan, D.1    Plattner, R.2
  • 12
    • 34547575677 scopus 로고    scopus 로고
    • Cables links Robo-bound Abl kinase to N-cadherin-bound beta-catenin to mediate Slit-induced modulation of adhesion and transcription
    • 10.1038/ncb1614, 17618275
    • Rhee J, Buchan T, Zukerberg L, Lilien J, Balsamo J. Cables links Robo-bound Abl kinase to N-cadherin-bound beta-catenin to mediate Slit-induced modulation of adhesion and transcription. Nat Cell Biol 2007, 9:883-892. 10.1038/ncb1614, 17618275.
    • (2007) Nat Cell Biol , vol.9 , pp. 883-892
    • Rhee, J.1    Buchan, T.2    Zukerberg, L.3    Lilien, J.4    Balsamo, J.5
  • 15
    • 0037151060 scopus 로고    scopus 로고
    • ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas
    • 10.1074/jbc.M201975200, 11950845
    • Schroeder JA, Adriance MC, McConnell EJ, Thompson MC, Pockaj B, Gendler SJ. ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas. J Biol Chem 2002, 277:22692-22698. 10.1074/jbc.M201975200, 11950845.
    • (2002) J Biol Chem , vol.277 , pp. 22692-22698
    • Schroeder, J.A.1    Adriance, M.C.2    McConnell, E.J.3    Thompson, M.C.4    Pockaj, B.5    Gendler, S.J.6
  • 16
    • 0242468905 scopus 로고    scopus 로고
    • Dysregulation of cellular signaling by HER2/neu in breast cancer
    • 10.1053/j.seminoncol.2003.08.006, 14613025
    • Zhou BP, Hung MC. Dysregulation of cellular signaling by HER2/neu in breast cancer. Semin Oncol 2003, 30(5 Suppl 16):38-48. 10.1053/j.seminoncol.2003.08.006, 14613025.
    • (2003) Semin Oncol , vol.30 , Issue.5 SUPPL. 16 , pp. 38-48
    • Zhou, B.P.1    Hung, M.C.2
  • 17
    • 77956300964 scopus 로고    scopus 로고
    • Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling
    • 2855705, 20419129, 10.1371/journal.pone.0010184
    • Maher MT, Mo R, Flozak AS, Peled ON, Gottardi CJ. Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling. PLoS One 2010, 5:e10184. 2855705, 20419129, 10.1371/journal.pone.0010184.
    • (2010) PLoS One , vol.5
    • Maher, M.T.1    Mo, R.2    Flozak, A.S.3    Peled, O.N.4    Gottardi, C.J.5
  • 18
    • 0030958706 scopus 로고    scopus 로고
    • Interaction of the DF3/MUC1 breast carcinoma-associated antigen and β-catenin in cell adhesion
    • 10.1074/jbc.272.19.12492, 9139698
    • Yamamoto M, Bharti A, Kufe D. Interaction of the DF3/MUC1 breast carcinoma-associated antigen and β-catenin in cell adhesion. J Biol Chem 1997, 272:12492-12494. 10.1074/jbc.272.19.12492, 9139698.
    • (1997) J Biol Chem , vol.272 , pp. 12492-12494
    • Yamamoto, M.1    Bharti, A.2    Kufe, D.3
  • 19
    • 0032080901 scopus 로고    scopus 로고
    • Decreased MUC1 expression induces E-cadherin-mediated cell adhesion of breast cancer cell lines
    • Kondo K, Kohno N, Yokoyama A, Hiwada K. Decreased MUC1 expression induces E-cadherin-mediated cell adhesion of breast cancer cell lines. Cancer Res 1998, 58:2014-2019.
    • (1998) Cancer Res , vol.58 , pp. 2014-2019
    • Kondo, K.1    Kohno, N.2    Yokoyama, A.3    Hiwada, K.4
  • 20
    • 4143099166 scopus 로고    scopus 로고
    • MUC1 overexpression results in mammary gland tumorigenesis and prolonged alveolar differentiation
    • 10.1038/sj.onc.1207713, 15221004
    • Schroeder JA, Masri AA, Adriance MC, Tessier JC, Kotlarczyk KL, Thompson MC, Gendler SJ. MUC1 overexpression results in mammary gland tumorigenesis and prolonged alveolar differentiation. Oncogene 2004, 23:5739-5747. 10.1038/sj.onc.1207713, 15221004.
    • (2004) Oncogene , vol.23 , pp. 5739-5747
    • Schroeder, J.A.1    Masri, A.A.2    Adriance, M.C.3    Tessier, J.C.4    Kotlarczyk, K.L.5    Thompson, M.C.6    Gendler, S.J.7
  • 21
    • 70349932747 scopus 로고    scopus 로고
    • Towards an integrated view of Wnt signaling in development
    • 10.1242/dev.033910, 19736321
    • van Amerongen R, Nusse R. Towards an integrated view of Wnt signaling in development. Development 2009, 136:3205-3214. 10.1242/dev.033910, 19736321.
    • (2009) Development , vol.136 , pp. 3205-3214
    • van Amerongen, R.1    Nusse, R.2
  • 22
    • 77952954695 scopus 로고    scopus 로고
    • When pathways collide: collaboration and connivance among signalling proteins in development
    • 10.1038/nrm2902, 20461097
    • McNeill H, Woodgett JR. When pathways collide: collaboration and connivance among signalling proteins in development. Nat Rev Mol Cell Biol 2010, 11:404-413. 10.1038/nrm2902, 20461097.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 404-413
    • McNeill, H.1    Woodgett, J.R.2
  • 23
    • 77956628008 scopus 로고    scopus 로고
    • Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture
    • 10.1016/j.stem.2010.03.020, 20569694
    • Zeng YA, Nusse R. Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell 2010, 6:568-577. 10.1016/j.stem.2010.03.020, 20569694.
    • (2010) Cell Stem Cell , vol.6 , pp. 568-577
    • Zeng, Y.A.1    Nusse, R.2
  • 24
    • 0034840950 scopus 로고    scopus 로고
    • Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC
    • 10.1038/ncb0901-793, 11533658
    • Ryo A, Nakamura M, Wulf G, Liou YC, Lu KP. Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat Cell Biol 2001, 3:793-801. 10.1038/ncb0901-793, 11533658.
    • (2001) Nat Cell Biol , vol.3 , pp. 793-801
    • Ryo, A.1    Nakamura, M.2    Wulf, G.3    Liou, Y.C.4    Lu, K.P.5
  • 25
    • 0035844886 scopus 로고    scopus 로고
    • Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation
    • 2192018, 11402061, 10.1083/jcb.153.6.1161
    • Persad S, Troussard AA, McPhee TR, Mulholland DJ, Dedhar S. Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation. J Cell Biol 2001, 153:1161-1174. 2192018, 11402061, 10.1083/jcb.153.6.1161.
    • (2001) J Cell Biol , vol.153 , pp. 1161-1174
    • Persad, S.1    Troussard, A.A.2    McPhee, T.R.3    Mulholland, D.J.4    Dedhar, S.5
  • 27
    • 0034808019 scopus 로고    scopus 로고
    • Down-regulation of beta-catenin by activated p53
    • 99855, 11564862, 10.1128/MCB.21.20.6768-6781.2001
    • Sadot E, Geiger B, Oren M, Ben-Ze'ev A. Down-regulation of beta-catenin by activated p53. Mol Cell Biol 2001, 21:6768-6781. 99855, 11564862, 10.1128/MCB.21.20.6768-6781.2001.
    • (2001) Mol Cell Biol , vol.21 , pp. 6768-6781
    • Sadot, E.1    Geiger, B.2    Oren, M.3    Ben-Ze'ev, A.4
  • 28
    • 0035947080 scopus 로고    scopus 로고
    • Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses
    • 10.1016/S1097-2765(01)00242-8, 11389839
    • Matsuzawa SI, Reed JC. Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. Mol Cell 2001, 7:915-926. 10.1016/S1097-2765(01)00242-8, 11389839.
    • (2001) Mol Cell , vol.7 , pp. 915-926
    • Matsuzawa, S.I.1    Reed, J.C.2
  • 29
    • 0035947083 scopus 로고    scopus 로고
    • Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein
    • 10.1016/S1097-2765(01)00241-6, 11389840
    • Liu J, Stevens J, Rote CA, Yost HJ, Hu Y, Neufeld KL, White RL, Matsunami N. Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol Cell 2001, 7:927-936. 10.1016/S1097-2765(01)00241-6, 11389840.
    • (2001) Mol Cell , vol.7 , pp. 927-936
    • Liu, J.1    Stevens, J.2    Rote, C.A.3    Yost, H.J.4    Hu, Y.5    Neufeld, K.L.6    White, R.L.7    Matsunami, N.8
  • 31
  • 34
    • 68949154567 scopus 로고    scopus 로고
    • The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage
    • 2720450, 19672307, 10.1371/journal.pone.0006594
    • Badders NM, Goel S, Clark RJ, Klos KS, Kim S, Bafico A, Lindvall C, Williams BO, Alexander CM. The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage. PLoS One 2009, 4:e6594. 2720450, 19672307, 10.1371/journal.pone.0006594.
    • (2009) PLoS One , vol.4
    • Badders, N.M.1    Goel, S.2    Clark, R.J.3    Klos, K.S.4    Kim, S.5    Bafico, A.6    Lindvall, C.7    Williams, B.O.8    Alexander, C.M.9
  • 35
    • 77956403050 scopus 로고    scopus 로고
    • Molecular mechanisms guiding embryonic mammary gland development
    • 2869520, 20484386, 10.1101/cshperspect.a003251
    • Cowin P, Wysolmerski J. Molecular mechanisms guiding embryonic mammary gland development. Cold Spring Harb Perspect Biol 2010, 2:a003251. 2869520, 20484386, 10.1101/cshperspect.a003251.
    • (2010) Cold Spring Harb Perspect Biol , vol.2
    • Cowin, P.1    Wysolmerski, J.2
  • 36
    • 7244261873 scopus 로고    scopus 로고
    • Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis
    • 10.1242/dev.01347, 15342465
    • Chu EY, Hens J, Andl T, Kairo A, Yamaguchi TP, Brisken C, Glick A, Wysolmerski JJ, Millar SE. Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development 2004, 131:4819-4829. 10.1242/dev.01347, 15342465.
    • (2004) Development , vol.131 , pp. 4819-4829
    • Chu, E.Y.1    Hens, J.2    Andl, T.3    Kairo, A.4    Yamaguchi, T.P.5    Brisken, C.6    Glick, A.7    Wysolmerski, J.J.8    Millar, S.E.9
  • 39
    • 33845941448 scopus 로고    scopus 로고
    • The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis
    • 10.1074/jbc.M607571200, 16973609
    • Lindvall C, Evans NC, Zylstra CR, Li Y, Alexander CM, Williams BO. The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis. J Biol Chem 2006, 281:35081-35087. 10.1074/jbc.M607571200, 16973609.
    • (2006) J Biol Chem , vol.281 , pp. 35081-35087
    • Lindvall, C.1    Evans, N.C.2    Zylstra, C.R.3    Li, Y.4    Alexander, C.M.5    Williams, B.O.6
  • 40
    • 67149111600 scopus 로고    scopus 로고
    • The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development
    • 2686096, 19503830, 10.1371/journal.pone.0005813
    • Lindvall C, Zylstra CR, Evans N, West RA, Dykema K, Furge KA, Williams BO. The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development. PLoS One 2009, 4:e5813. 2686096, 19503830, 10.1371/journal.pone.0005813.
    • (2009) PLoS One , vol.4
    • Lindvall, C.1    Zylstra, C.R.2    Evans, N.3    West, R.A.4    Dykema, K.5    Furge, K.A.6    Williams, B.O.7
  • 41
    • 33750964878 scopus 로고    scopus 로고
    • Molecular interactions between Tbx3 and Bmp4 and a model for dorsoventral positioning of mammary gland development
    • 1636533, 17071745, 10.1073/pnas.0604645103
    • Cho KW, Kim JY, Song SJ, Farrell E, Eblaghie MC, Kim HJ, Tickle C, Jung HS. Molecular interactions between Tbx3 and Bmp4 and a model for dorsoventral positioning of mammary gland development. Proc Natl Acad Sci USA 2006, 103:16788-16793. 1636533, 17071745, 10.1073/pnas.0604645103.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 16788-16793
    • Cho, K.W.1    Kim, J.Y.2    Song, S.J.3    Farrell, E.4    Eblaghie, M.C.5    Kim, H.J.6    Tickle, C.7    Jung, H.S.8
  • 44
    • 28444475509 scopus 로고    scopus 로고
    • Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway
    • 10.1002/dvdy.20575, 16222716
    • Jerome-Majewska LA, Jenkins GP, Ernstoff E, Zindy F, Sherr CJ, Papaioannou VE. Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway. Dev Dyn 2005, 234:922-933. 10.1002/dvdy.20575, 16222716.
    • (2005) Dev Dyn , vol.234 , pp. 922-933
    • Jerome-Majewska, L.A.1    Jenkins, G.P.2    Ernstoff, E.3    Zindy, F.4    Sherr, C.J.5    Papaioannou, V.E.6
  • 45
    • 0037797436 scopus 로고    scopus 로고
    • Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome
    • 10.1242/dev.00431, 12668638
    • Davenport TG, Jerome-Majewska LA, Papaioannou VE. Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome. Development 2003, 130:2263-2273. 10.1242/dev.00431, 12668638.
    • (2003) Development , vol.130 , pp. 2263-2273
    • Davenport, T.G.1    Jerome-Majewska, L.A.2    Papaioannou, V.E.3
  • 46
    • 24344431572 scopus 로고    scopus 로고
    • Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification
    • 1199577, 16140987, 10.1101/gad.338505
    • Howard B, Panchal H, McCarthy A, Ashworth A. Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification. Genes Dev 2005, 19:2078-2090. 1199577, 16140987, 10.1101/gad.338505.
    • (2005) Genes Dev , vol.19 , pp. 2078-2090
    • Howard, B.1    Panchal, H.2    McCarthy, A.3    Ashworth, A.4
  • 47
    • 4243141885 scopus 로고    scopus 로고
    • Interactions between FGF and Wnt signals and Tbx3 gene expression in mammary gland initiation in mouse embryos
    • 1571327, 15255957, 10.1111/j.0021-8782.2004.00309.x
    • Eblaghie MC, Song SJ, Kim JY, Akita K, Tickle C, Jung HS. Interactions between FGF and Wnt signals and Tbx3 gene expression in mammary gland initiation in mouse embryos. J Anat 2004, 205:1-13. 1571327, 15255957, 10.1111/j.0021-8782.2004.00309.x.
    • (2004) J Anat , vol.205 , pp. 1-13
    • Eblaghie, M.C.1    Song, S.J.2    Kim, J.Y.3    Akita, K.4    Tickle, C.5    Jung, H.S.6
  • 48
    • 0942276426 scopus 로고    scopus 로고
    • Identification of the mammary line in mouse by Wnt10b expression
    • 10.1002/dvdy.10441, 14745960
    • Veltmaat JM, Van Veelen W, Thiery JP, Bellusci S. Identification of the mammary line in mouse by Wnt10b expression. Dev Dyn 2004, 229:349-356. 10.1002/dvdy.10441, 14745960.
    • (2004) Dev Dyn , vol.229 , pp. 349-356
    • Veltmaat, J.M.1    Van Veelen, W.2    Thiery, J.P.3    Bellusci, S.4
  • 49
    • 33846486935 scopus 로고    scopus 로고
    • Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression
    • 10.1242/dev.02708, 17164417
    • Pummila M, Fliniaux I, Jaatinen R, James MJ, Laurikkala J, Schneider P, Thesleff I, Mikkola ML. Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression. Development 2007, 134:117-125. 10.1242/dev.02708, 17164417.
    • (2007) Development , vol.134 , pp. 117-125
    • Pummila, M.1    Fliniaux, I.2    Jaatinen, R.3    James, M.J.4    Laurikkala, J.5    Schneider, P.6    Thesleff, I.7    Mikkola, M.L.8
  • 50
    • 33745904737 scopus 로고    scopus 로고
    • Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland
    • 10.1016/j.ydbio.2006.03.030, 16678815
    • Boras-Granic K, Chang H, Grosschedl R, Hamel PA. Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland. Dev Biol 2006, 295:219-231. 10.1016/j.ydbio.2006.03.030, 16678815.
    • (2006) Dev Biol , vol.295 , pp. 219-231
    • Boras-Granic, K.1    Chang, H.2    Grosschedl, R.3    Hamel, P.A.4
  • 52
    • 0032842385 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein signaling is necessary for sexual dimorphism during embryonic mammary development
    • Dunbar ME, Dann PR, Robinson GW, Hennighausen L, Zhang JP, Wysolmerski JJ. Parathyroid hormone-related protein signaling is necessary for sexual dimorphism during embryonic mammary development. Development 1999, 126:3485-3493.
    • (1999) Development , vol.126 , pp. 3485-3493
    • Dunbar, M.E.1    Dann, P.R.2    Robinson, G.W.3    Hennighausen, L.4    Zhang, J.P.5    Wysolmerski, J.J.6
  • 53
    • 0035093404 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development
    • Foley J, Dann P, Hong J, Cosgrove J, Dreyer B, Rimm D, Dunbar M, Philbrick W, Wysolmerski J. Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development. Development 2001, 128:513-525.
    • (2001) Development , vol.128 , pp. 513-525
    • Foley, J.1    Dann, P.2    Hong, J.3    Cosgrove, J.4    Dreyer, B.5    Rimm, D.6    Dunbar, M.7    Philbrick, W.8    Wysolmerski, J.9
  • 54
    • 34247381705 scopus 로고    scopus 로고
    • BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction
    • 10.1242/dev.000182, 17301089
    • Hens JR, Dann P, Zhang JP, Harris S, Robinson GW, Wysolmerski J. BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Development 2007, 134:1221-1230. 10.1242/dev.000182, 17301089.
    • (2007) Development , vol.134 , pp. 1221-1230
    • Hens, J.R.1    Dann, P.2    Zhang, J.P.3    Harris, S.4    Robinson, G.W.5    Wysolmerski, J.6
  • 55
    • 0028841041 scopus 로고
    • Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development
    • Wysolmerski JJ, McCaughern-Carucci JF, Daifotis AG, Broadus AE, Philbrick WM. Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development. Development 1995, 121:3539-3547.
    • (1995) Development , vol.121 , pp. 3539-3547
    • Wysolmerski, J.J.1    McCaughern-Carucci, J.F.2    Daifotis, A.G.3    Broadus, A.E.4    Philbrick, W.M.5
  • 56
    • 0031923474 scopus 로고    scopus 로고
    • Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development
    • Wysolmerski JJ, Philbrick WM, Dunbar ME, Lanske B, Kronenberg H, Broadus AE. Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development. Development 1998, 125:1285-1294.
    • (1998) Development , vol.125 , pp. 1285-1294
    • Wysolmerski, J.J.1    Philbrick, W.M.2    Dunbar, M.E.3    Lanske, B.4    Kronenberg, H.5    Broadus, A.E.6
  • 57
    • 70350705974 scopus 로고    scopus 로고
    • Analysis of gene expression in PTHrP-/- mammary buds supports a role for BMP signaling and MMP2 in the initiation of ductal morphogenesis
    • 2862621, 19795511, 10.1002/dvdy.22097
    • Hens J, Dann P, Hiremath M, Pan TC, Chodosh L, Wysolmerski J. Analysis of gene expression in PTHrP-/- mammary buds supports a role for BMP signaling and MMP2 in the initiation of ductal morphogenesis. Dev Dyn 2009, 238:2713-2724. 2862621, 19795511, 10.1002/dvdy.22097.
    • (2009) Dev Dyn , vol.238 , pp. 2713-2724
    • Hens, J.1    Dann, P.2    Hiremath, M.3    Pan, T.C.4    Chodosh, L.5    Wysolmerski, J.6
  • 58
    • 0029114329 scopus 로고
    • Wnt-4 expression induces a pregnancy-like growth pattern in reconstituted mammary glands in virgin mice
    • 10.1006/dbio.1995.1236, 7649383
    • Bradbury JM, Edwards PA, Niemeyer CC, Dale TC. Wnt-4 expression induces a pregnancy-like growth pattern in reconstituted mammary glands in virgin mice. Dev Biol 1995, 170:553-563. 10.1006/dbio.1995.1236, 7649383.
    • (1995) Dev Biol , vol.170 , pp. 553-563
    • Bradbury, J.M.1    Edwards, P.A.2    Niemeyer, C.C.3    Dale, T.C.4
  • 59
    • 0028145283 scopus 로고
    • Developmental and hormonal regulation of Wnt gene expression in the mouse mammary gland
    • 10.1046/j.1432-0436.1994.5730205.x, 7988795
    • Weber-Hall SJ, Phippard DJ, Niemeyer CC, Dale TC. Developmental and hormonal regulation of Wnt gene expression in the mouse mammary gland. Differentiation 1994, 57:205-214. 10.1046/j.1432-0436.1994.5730205.x, 7988795.
    • (1994) Differentiation , vol.57 , pp. 205-214
    • Weber-Hall, S.J.1    Phippard, D.J.2    Niemeyer, C.C.3    Dale, T.C.4
  • 60
    • 0027415380 scopus 로고
    • Localization and quantification of Wnt-2 gene expression in mouse mammary development
    • 10.1006/dbio.1993.1009, 8416847
    • Buhler TA, Dale TC, Kieback C, Humphreys RC, Rosen JM. Localization and quantification of Wnt-2 gene expression in mouse mammary development. Dev Biol 1993, 155:87-96. 10.1006/dbio.1993.1009, 8416847.
    • (1993) Dev Biol , vol.155 , pp. 87-96
    • Buhler, T.A.1    Dale, T.C.2    Kieback, C.3    Humphreys, R.C.4    Rosen, J.M.5
  • 61
    • 0030613905 scopus 로고    scopus 로고
    • Wnt10B directs hypermorphic development and transformation in mammary glands of male and female mice
    • 10.1038/sj.onc.1201593, 9393971
    • Lane TF, Leder P. Wnt10B directs hypermorphic development and transformation in mammary glands of male and female mice. Oncogene 1997, 15:2133-2144. 10.1038/sj.onc.1201593, 9393971.
    • (1997) Oncogene , vol.15 , pp. 2133-2144
    • Lane, T.F.1    Leder, P.2
  • 63
    • 33751235462 scopus 로고    scopus 로고
    • Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis
    • 2730892, 17039550, 10.1002/dvdy.20978
    • Kouros-Mehr H, Werb Z. Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis. Dev Dyn 2006, 235:3404-3412. 2730892, 17039550, 10.1002/dvdy.20978.
    • (2006) Dev Dyn , vol.235 , pp. 3404-3412
    • Kouros-Mehr, H.1    Werb, Z.2
  • 64
    • 36549025433 scopus 로고    scopus 로고
    • Wnt5a is required for proper mammary gland development and TGF-β-mediated inhibition of ductal growth
    • 10.1242/dev.008250, 17898001
    • Roarty K, Serra R. Wnt5a is required for proper mammary gland development and TGF-β-mediated inhibition of ductal growth. Development 2007, 134:3929-3939. 10.1242/dev.008250, 17898001.
    • (2007) Development , vol.134 , pp. 3929-3939
    • Roarty, K.1    Serra, R.2
  • 65
    • 0036843992 scopus 로고    scopus 로고
    • A novel LacZ reporter mouse reveals complex regulation of the progesterone receptor promoter during mammary gland development
    • 10.1210/me.2002-0169, 12403837
    • Ismail PM, Li J, DeMayo FJ, O'Malley BW, Lydon JP. A novel LacZ reporter mouse reveals complex regulation of the progesterone receptor promoter during mammary gland development. Mol Endocrinol 2002, 16:2475-2489. 10.1210/me.2002-0169, 12403837.
    • (2002) Mol Endocrinol , vol.16 , pp. 2475-2489
    • Ismail, P.M.1    Li, J.2    DeMayo, F.J.3    O'Malley, B.W.4    Lydon, J.P.5
  • 66
    • 36148973174 scopus 로고    scopus 로고
    • The pattern of beta-catenin responsiveness within the mammary gland is regulated by progesterone receptor
    • 10.1242/dev.006585, 17881490
    • Hiremath M, Lydon JP, Cowin P. The pattern of beta-catenin responsiveness within the mammary gland is regulated by progesterone receptor. Development 2007, 134:3703-3712. 10.1242/dev.006585, 17881490.
    • (2007) Development , vol.134 , pp. 3703-3712
    • Hiremath, M.1    Lydon, J.P.2    Cowin, P.3
  • 67
    • 84887212573 scopus 로고    scopus 로고
    • MMTV-Wnt1 and -ΔN89β-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumors
    • 2639708, 19225568, 10.1371/journal.pone.0004537
    • Teissedre B, Pinderhughes A, Incassati A, Hatsell SJ, Hiremath M, Cowin P. MMTV-Wnt1 and -ΔN89β-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumors. PLoS One 2009, 4:e4537. 2639708, 19225568, 10.1371/journal.pone.0004537.
    • (2009) PLoS One , vol.4
    • Teissedre, B.1    Pinderhughes, A.2    Incassati, A.3    Hatsell, S.J.4    Hiremath, M.5    Cowin, P.6
  • 68
    • 0032574830 scopus 로고    scopus 로고
    • A paracrine role for the epithelial progesterone receptor in mammary gland development
    • 20216, 9560231, 10.1073/pnas.95.9.5076
    • Brisken C, Park S, Vass T, Lydon JP, O'Malley BW, Weinberg RA. A paracrine role for the epithelial progesterone receptor in mammary gland development. Proc Natl Acad Sci USA 1998, 95:5076-5081. 20216, 9560231, 10.1073/pnas.95.9.5076.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 5076-5081
    • Brisken, C.1    Park, S.2    Vass, T.3    Lydon, J.P.4    O'Malley, B.W.5    Weinberg, R.A.6
  • 69
    • 0034653649 scopus 로고    scopus 로고
    • Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling
    • 316462, 10733525
    • Brisken C, Heineman A, Chavarra T, Elenbaas B, Tan J, Dey SK, McMahon AP, Weinberg R. Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev 2000, 14:650-654. 316462, 10733525.
    • (2000) Genes Dev , vol.14 , pp. 650-654
    • Brisken, C.1    Heineman, A.2    Chavarra, T.3    Elenbaas, B.4    Tan, J.5    Dey, S.K.6    McMahon, A.P.7    Weinberg, R.8
  • 72
    • 72449141809 scopus 로고    scopus 로고
    • Wnt4 is not sufficient to induce lobuloalveolar mammary development
    • 2777140, 19878558, 10.1186/1471-213X-9-55
    • Kim YC, Clark RJ, Pelegri F, Alexander CM. Wnt4 is not sufficient to induce lobuloalveolar mammary development. BMC Dev Biol 2009, 9:55. 2777140, 19878558, 10.1186/1471-213X-9-55.
    • (2009) BMC Dev Biol , vol.9 , pp. 55
    • Kim, Y.C.1    Clark, R.J.2    Pelegri, F.3    Alexander, C.M.4
  • 74
    • 13944259795 scopus 로고    scopus 로고
    • Targeted activation of beta-catenin signaling in basal mammary epithelial cells affects mammary development and leads to hyperplasia
    • 10.1242/dev.01583, 15590737
    • Teuliere J, Faraldo MM, Deugnier MA, Shtutman M, Ben-Ze'ev A, Thiery JP, Glukhova MA. Targeted activation of beta-catenin signaling in basal mammary epithelial cells affects mammary development and leads to hyperplasia. Development 2005, 132:267-277. 10.1242/dev.01583, 15590737.
    • (2005) Development , vol.132 , pp. 267-277
    • Teuliere, J.1    Faraldo, M.M.2    Deugnier, M.A.3    Shtutman, M.4    Ben-Ze'ev, A.5    Thiery, J.P.6    Glukhova, M.A.7
  • 75
    • 0035972159 scopus 로고    scopus 로고
    • ΔN89β-catenin induces precocious development, differentiation, and neoplasia in mammary gland
    • 2190562, 11331306, 10.1083/jcb.153.3.555
    • Imbert A, Eelkema R, Jordan S, Feiner H, Cowin P. ΔN89β-catenin induces precocious development, differentiation, and neoplasia in mammary gland. J Cell Biol 2001, 153:555-568. 2190562, 11331306, 10.1083/jcb.153.3.555.
    • (2001) J Cell Biol , vol.153 , pp. 555-568
    • Imbert, A.1    Eelkema, R.2    Jordan, S.3    Feiner, H.4    Cowin, P.5
  • 76
    • 0035842902 scopus 로고    scopus 로고
    • Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice
    • 2150907, 11739413, 10.1083/jcb.200107066
    • Hsu W, Shakya R, Costantini F. Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice. J Cell Biol 2001, 155:1055-1064. 2150907, 11739413, 10.1083/jcb.200107066.
    • (2001) J Cell Biol , vol.155 , pp. 1055-1064
    • Hsu, W.1    Shakya, R.2    Costantini, F.3
  • 77
    • 0037444482 scopus 로고    scopus 로고
    • A beta-catenin survival signal is required for normal lobular development in the mammary gland
    • 10.1242/jcs.00334, 12584256
    • Tepera SB, McCrea PD, Rosen JM. A beta-catenin survival signal is required for normal lobular development in the mammary gland. J Cell Sci 2003, 116(Pt 6):1137-1149. 10.1242/jcs.00334, 12584256.
    • (2003) J Cell Sci , vol.116 , Issue.PART 6 , pp. 1137-1149
    • Tepera, S.B.1    McCrea, P.D.2    Rosen, J.M.3
  • 79
    • 77649259667 scopus 로고    scopus 로고
    • Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland
    • 2840294, 20133621, 10.1073/pnas.0915148107
    • Beleut M, Rajaram RD, Caikovski M, Ayyanan A, Germano D, Choi Y, Schneider P, Brisken C. Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. Proc Natl Acad Sci USA 2010, 107:2989-2994. 2840294, 20133621, 10.1073/pnas.0915148107.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 2989-2994
    • Beleut, M.1    Rajaram, R.D.2    Caikovski, M.3    Ayyanan, A.4    Germano, D.5    Choi, Y.6    Schneider, P.7    Brisken, C.8
  • 80
    • 0037022355 scopus 로고    scopus 로고
    • Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes
    • 122191, 11805292, 10.1073/pnas.032404099
    • Liou YC, Ryo A, Huang HK, Lu PJ, Bronson R, Fujimori F, Uchida T, Hunter T, Lu KP. Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes. Proc Natl Acad Sci USA 2002, 99:1335-1340. 122191, 11805292, 10.1073/pnas.032404099.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 1335-1340
    • Liou, Y.C.1    Ryo, A.2    Huang, H.K.3    Lu, P.J.4    Bronson, R.5    Fujimori, F.6    Uchida, T.7    Hunter, T.8    Lu, K.P.9
  • 81
    • 0035963435 scopus 로고    scopus 로고
    • Specific protection against breast cancers by cyclin D1 ablation
    • 10.1038/35082500, 11429595
    • Yu Q, Geng Y, Sicinski P. Specific protection against breast cancers by cyclin D1 ablation. Nature 2001, 411:1017-1021. 10.1038/35082500, 11429595.
    • (2001) Nature , vol.411 , pp. 1017-1021
    • Yu, Q.1    Geng, Y.2    Sicinski, P.3
  • 82
    • 0141816802 scopus 로고    scopus 로고
    • Dissecting the roles of beta-catenin and cyclin D1 during mammary development and neoplasia
    • 208769, 13679587, 10.1073/pnas.1534601100
    • Rowlands TM, Pechenkina IV, Hatsell SJ, Pestell RG, Cowin P. Dissecting the roles of beta-catenin and cyclin D1 during mammary development and neoplasia. Proc Natl Acad Sci USA 2003, 100:11400-11405. 208769, 13679587, 10.1073/pnas.1534601100.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11400-11405
    • Rowlands, T.M.1    Pechenkina, I.V.2    Hatsell, S.J.3    Pestell, R.G.4    Cowin, P.5
  • 83
    • 0020216124 scopus 로고
    • Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
    • 10.1016/0092-8674(82)90409-3, 6297757
    • Nusse R, Varmus HE. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 1982, 31:99-109. 10.1016/0092-8674(82)90409-3, 6297757.
    • (1982) Cell , vol.31 , pp. 99-109
    • Nusse, R.1    Varmus, H.E.2
  • 84
    • 0024162530 scopus 로고
    • Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice
    • 10.1016/0092-8674(88)90220-6, 3180222
    • Tsukamoto A, Grosschedl R, Guzman R, Parslow T, Varmus H. Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell 1988, 55:619-625. 10.1016/0092-8674(88)90220-6, 3180222.
    • (1988) Cell , vol.55 , pp. 619-625
    • Tsukamoto, A.1    Grosschedl, R.2    Guzman, R.3    Parslow, T.4    Varmus, H.5
  • 86
    • 1642580618 scopus 로고    scopus 로고
    • Mammary gland development requires syndecan-1 to create a beta-catenin/TCF-responsive mammary epithelial subpopulation
    • 10.1038/sj.onc.1207217, 14681683
    • Liu BY, Kim YC, Leatherberry V, Cowin P, Alexander CM. Mammary gland development requires syndecan-1 to create a beta-catenin/TCF-responsive mammary epithelial subpopulation. Oncogene 2003, 22:9243-9253. 10.1038/sj.onc.1207217, 14681683.
    • (2003) Oncogene , vol.22 , pp. 9243-9253
    • Liu, B.Y.1    Kim, Y.C.2    Leatherberry, V.3    Cowin, P.4    Alexander, C.M.5
  • 87
    • 1642570244 scopus 로고    scopus 로고
    • The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells
    • 384711, 15020770, 10.1073/pnas.0400699101
    • Liu BY, McDermott SP, Khwaja SS, Alexander CM. The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells. Proc Natl Acad Sci USA 2004, 101:4158-4163. 384711, 15020770, 10.1073/pnas.0400699101.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4158-4163
    • Liu, B.Y.1    McDermott, S.P.2    Khwaja, S.S.3    Alexander, C.M.4
  • 88
    • 75749104600 scopus 로고    scopus 로고
    • Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis
    • 2813429, 19881541, 10.1038/onc.2009.339
    • Zhang J, Li Y, Liu Q, Lu W, Bu G. Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis. Oncogene 2010, 29:539-549. 2813429, 19881541, 10.1038/onc.2009.339.
    • (2010) Oncogene , vol.29 , pp. 539-549
    • Zhang, J.1    Li, Y.2    Liu, Q.3    Lu, W.4    Bu, G.5
  • 89
    • 0037442760 scopus 로고    scopus 로고
    • Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis
    • 195997, 12600942, 10.1101/gad.1051603
    • Gunther EJ, Moody SE, Belka GK, Hahn KT, Innocent N, Dugan KD, Cardiff RD, Chodosh LA. Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis. Genes Dev 2003, 17:488-501. 195997, 12600942, 10.1101/gad.1051603.
    • (2003) Genes Dev , vol.17 , pp. 488-501
    • Gunther, E.J.1    Moody, S.E.2    Belka, G.K.3    Hahn, K.T.4    Innocent, N.5    Dugan, K.D.6    Cardiff, R.D.7    Chodosh, L.A.8
  • 90
    • 0035939818 scopus 로고    scopus 로고
    • β-catenin is a downstream effector of Wnt-mediated tumorigenesis in the mammary gland
    • 10.1038/sj.onc.1204586, 11526497
    • Michaelson JS, Leder P. β-catenin is a downstream effector of Wnt-mediated tumorigenesis in the mammary gland. Oncogene 2001, 20:5093-5099. 10.1038/sj.onc.1204586, 11526497.
    • (2001) Oncogene , vol.20 , pp. 5093-5099
    • Michaelson, J.S.1    Leder, P.2
  • 91
    • 3843113598 scopus 로고    scopus 로고
    • Beta-catenin and cyclin D1: connecting development to breast cancer
    • Rowlands TM, Pechenkina IV, Hatsell S, Cowin P. Beta-catenin and cyclin D1: connecting development to breast cancer. Cell Cycle 2004, 3:145-148.
    • (2004) Cell Cycle , vol.3 , pp. 145-148
    • Rowlands, T.M.1    Pechenkina, I.V.2    Hatsell, S.3    Cowin, P.4
  • 92
    • 33846287519 scopus 로고    scopus 로고
    • WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells
    • 1766434, 17202265, 10.1073/pnas.0606599104
    • Woodward WA, Chen MS, Behbod F, Alfaro MP, Buchholz TA, Rosen JM. WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells. Proc Natl Acad Sci USA 2007, 104:618-623. 1766434, 17202265, 10.1073/pnas.0606599104.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 618-623
    • Woodward, W.A.1    Chen, M.S.2    Behbod, F.3    Alfaro, M.P.4    Buchholz, T.A.5    Rosen, J.M.6
  • 94
    • 61449101684 scopus 로고    scopus 로고
    • Genetic mechanisms in Apc-mediated mammary tumorigenesis
    • 2629572, 19197353, 10.1371/journal.pgen.1000367
    • Kuraguchi M, Ohene-Baah NY, Sonkin D, Bronson RT, Kucherlapati R. Genetic mechanisms in Apc-mediated mammary tumorigenesis. PLoS Genet 2009, 5:e1000367. 2629572, 19197353, 10.1371/journal.pgen.1000367.
    • (2009) PLoS Genet , vol.5
    • Kuraguchi, M.1    Ohene-Baah, N.Y.2    Sonkin, D.3    Bronson, R.T.4    Kucherlapati, R.5
  • 95
    • 68249083454 scopus 로고    scopus 로고
    • A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis
    • 2697381, 19578404, 10.1371/journal.pgen.1000547
    • Gaspar C, Franken P, Molenaar L, Breukel C, van der Valk M, Smits R, Fodde R. A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis. PLoS Genet 2009, 5:e1000547. 2697381, 19578404, 10.1371/journal.pgen.1000547.
    • (2009) PLoS Genet , vol.5
    • Gaspar, C.1    Franken, P.2    Molenaar, L.3    Breukel, C.4    van der Valk, M.5    Smits, R.6    Fodde, R.7
  • 96
    • 37049035726 scopus 로고    scopus 로고
    • Identification of novel modifier loci of Apc Min affecting mammary tumor development
    • 10.1158/0008-5472.CAN-07-2487, 18056448
    • Wang H, Teske D, Tess A, Kohlhepp R, Choi Y, Kendziorski C, Moser AR. Identification of novel modifier loci of Apc Min affecting mammary tumor development. Cancer Res 2007, 67:11226-11233. 10.1158/0008-5472.CAN-07-2487, 18056448.
    • (2007) Cancer Res , vol.67 , pp. 11226-11233
    • Wang, H.1    Teske, D.2    Tess, A.3    Kohlhepp, R.4    Choi, Y.5    Kendziorski, C.6    Moser, A.R.7
  • 97
    • 68349123821 scopus 로고    scopus 로고
    • Loss of TGF-β or Wnt5a results in an increase in Wnt/beta-catenin activity and redirects mammary tumour phenotype
    • 2688948, 19344510, 10.1186/bcr2244
    • Roarty K, Baxley SE, Crowley MR, Frost AR, Serra R. Loss of TGF-β or Wnt5a results in an increase in Wnt/beta-catenin activity and redirects mammary tumour phenotype. Breast Cancer Res 2009, 11:R19. 2688948, 19344510, 10.1186/bcr2244.
    • (2009) Breast Cancer Res , vol.11
    • Roarty, K.1    Baxley, S.E.2    Crowley, M.R.3    Frost, A.R.4    Serra, R.5
  • 98
    • 57749105327 scopus 로고    scopus 로고
    • Wnt1 expression induces short-range and long-range cell recruitments that modify mammary tumor development and are not induced by a cell-autonomous betacatenin effector
    • 2827297, 19074881, 10.1158/0008-5472.CAN-08-2992
    • Kim YC, Clark RJ, Ranheim EA, Alexander CM. Wnt1 expression induces short-range and long-range cell recruitments that modify mammary tumor development and are not induced by a cell-autonomous betacatenin effector. Cancer Res 2008, 68:10145-10153. 2827297, 19074881, 10.1158/0008-5472.CAN-08-2992.
    • (2008) Cancer Res , vol.68 , pp. 10145-10153
    • Kim, Y.C.1    Clark, R.J.2    Ranheim, E.A.3    Alexander, C.M.4
  • 99
    • 40949116308 scopus 로고    scopus 로고
    • Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors
    • 10.1634/stemcells.2007-0440, 17975224
    • Cho RW, Wang X, Diehn M, Shedden K, Chen GY, Sherlock G, Gurney A, Lewicki J, Clarke MF. Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors. Stem Cells 2008, 26:364-371. 10.1634/stemcells.2007-0440, 17975224.
    • (2008) Stem Cells , vol.26 , pp. 364-371
    • Cho, R.W.1    Wang, X.2    Diehn, M.3    Shedden, K.4    Chen, G.Y.5    Sherlock, G.6    Gurney, A.7    Lewicki, J.8    Clarke, M.F.9
  • 100
    • 67650496215 scopus 로고    scopus 로고
    • A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer
    • 2782448, 19549913, 10.1158/0008-5472.CAN-08-4135
    • DiMeo TA, Anderson K, Phadke P, Fan C, Perou CM, Naber S, Kuperwasser C. A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer. Cancer Res 2009, 69:5364-5373. 2782448, 19549913, 10.1158/0008-5472.CAN-08-4135.
    • (2009) Cancer Res , vol.69 , pp. 5364-5373
    • DiMeo, T.A.1    Anderson, K.2    Phadke, P.3    Fan, C.4    Perou, C.M.5    Naber, S.6    Kuperwasser, C.7
  • 101
    • 77953183234 scopus 로고    scopus 로고
    • Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome
    • 10.2353/ajpath.2010.091125, 20395444
    • Khramtsov AI, Khramtsova GF, Tretiakova M, Huo D, Olopade OI, Goss KH. Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome. Am J Pathol 2010, 176:2911-2920. 10.2353/ajpath.2010.091125, 20395444.
    • (2010) Am J Pathol , vol.176 , pp. 2911-2920
    • Khramtsov, A.I.1    Khramtsova, G.F.2    Tretiakova, M.3    Huo, D.4    Olopade, O.I.5    Goss, K.H.6
  • 102
    • 77950394022 scopus 로고    scopus 로고
    • LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy
    • 2841938, 20194742, 10.1073/pnas.0911220107
    • Liu CC, Prior J, Piwnica-Worms D, Bu G. LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy. Proc Natl Acad Sci USA 2010, 107:5136-5141. 2841938, 20194742, 10.1073/pnas.0911220107.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 5136-5141
    • Liu, C.C.1    Prior, J.2    Piwnica-Worms, D.3    Bu, G.4
  • 106
    • 48249155834 scopus 로고    scopus 로고
    • Genetic changes of Wnt pathway genes are common events in metaplastic carcinomas of the breast
    • 10.1158/1078-0432.CCR-07-4379, 18593979
    • Hayes MJ, Thomas D, Emmons A, Giordano TJ, Kleer CG. Genetic changes of Wnt pathway genes are common events in metaplastic carcinomas of the breast. Clin Cancer Res 2008, 14:4038-4044. 10.1158/1078-0432.CCR-07-4379, 18593979.
    • (2008) Clin Cancer Res , vol.14 , pp. 4038-4044
    • Hayes, M.J.1    Thomas, D.2    Emmons, A.3    Giordano, T.J.4    Kleer, C.G.5
  • 107
    • 0034636153 scopus 로고    scopus 로고
    • Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression
    • 18221, 10759547, 10.1073/pnas.060025397
    • Lin SY, Xia W, Wang JC, Kwong KY, Spohn B, Wen Y, Pestell RG, Hung MC. Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci USA 2000, 97:4262-4266. 18221, 10759547, 10.1073/pnas.060025397.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 4262-4266
    • Lin, S.Y.1    Xia, W.2    Wang, J.C.3    Kwong, K.Y.4    Spohn, B.5    Wen, Y.6    Pestell, R.G.7    Hung, M.C.8
  • 108
    • 0033976526 scopus 로고    scopus 로고
    • Involvement of adenomatous polyposis coli (APC)/beta-catenin signalling in human breast cancer
    • 10.1016/S0959-8049(99)00276-2, 10741284
    • Jonsson M, Borg A, Nilbert M, Andersson T. Involvement of adenomatous polyposis coli (APC)/beta-catenin signalling in human breast cancer. Eur J Cancer 2000, 36:242-248. 10.1016/S0959-8049(99)00276-2, 10741284.
    • (2000) Eur J Cancer , vol.36 , pp. 242-248
    • Jonsson, M.1    Borg, A.2    Nilbert, M.3    Andersson, T.4
  • 110
    • 0032980637 scopus 로고    scopus 로고
    • Immunolocalization of the fodrin, E-cadherin, and beta-catenin adhesion complex in infiltrating ductal carcinoma of the breast-comparison with an in vitro model
    • 10.1002/(SICI)1096-9896(199903)187:4<416::AID-PATH255>3.0.CO;2-D, 10398100
    • Sormunen RT, Leong AS, Vaaraniemi JP, Fernando SS, Eskelinen SM. Immunolocalization of the fodrin, E-cadherin, and beta-catenin adhesion complex in infiltrating ductal carcinoma of the breast-comparison with an in vitro model. J Pathol 1999, 187:416-423. 10.1002/(SICI)1096-9896(199903)187:4<416::AID-PATH255>3.0.CO;2-D, 10398100.
    • (1999) J Pathol , vol.187 , pp. 416-423
    • Sormunen, R.T.1    Leong, A.S.2    Vaaraniemi, J.P.3    Fernando, S.S.4    Eskelinen, S.M.5
  • 112
    • 0036154038 scopus 로고    scopus 로고
    • Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours
    • 10.1002/path.1035, 11793365
    • Wong SC, Lo SF, Lee KC, Yam JW, Chan JK, Wendy Hsiao WL. Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours. J Pathol 2002, 196:145-153. 10.1002/path.1035, 11793365.
    • (2002) J Pathol , vol.196 , pp. 145-153
    • Wong, S.C.1    Lo, S.F.2    Lee, K.C.3    Yam, J.W.4    Chan, J.K.5    Wendy Hsiao, W.L.6
  • 113
    • 41549152176 scopus 로고    scopus 로고
    • Wnt signaling pathway in invasive ductal carcinoma of the breast: relationship between beta-catenin, dishevelled and cyclin D1 expression
    • 10.1159/000120999, 18337623
    • Prasad CP, Gupta SD, Rath G, Ralhan R. Wnt signaling pathway in invasive ductal carcinoma of the breast: relationship between beta-catenin, dishevelled and cyclin D1 expression. Oncology 2007, 73:112-117. 10.1159/000120999, 18337623.
    • (2007) Oncology , vol.73 , pp. 112-117
    • Prasad, C.P.1    Gupta, S.D.2    Rath, G.3    Ralhan, R.4
  • 114
    • 49549086856 scopus 로고    scopus 로고
    • Epigenetic alterations of CDH1 and APC genes: relationship with activation of Wnt/beta-catenin pathway in invasive ductal carcinoma of breast
    • 10.1016/j.lfs.2008.06.019, 18662704
    • Prasad CP, Mirza S, Sharma G, Prashad R, DattaGupta S, Rath G, Ralhan R. Epigenetic alterations of CDH1 and APC genes: relationship with activation of Wnt/beta-catenin pathway in invasive ductal carcinoma of breast. Life Sci 2008, 83:318-325. 10.1016/j.lfs.2008.06.019, 18662704.
    • (2008) Life Sci , vol.83 , pp. 318-325
    • Prasad, C.P.1    Mirza, S.2    Sharma, G.3    Prashad, R.4    DattaGupta, S.5    Rath, G.6    Ralhan, R.7
  • 117
    • 33746218212 scopus 로고    scopus 로고
    • Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer
    • 10.1038/sj.onc.1209470, 16532032
    • Shulewitz M, Soloviev I, Wu T, Koeppen H, Polakis P, Sakanaka C. Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer. Oncogene 2006, 25:4361-4369. 10.1038/sj.onc.1209470, 16532032.
    • (2006) Oncogene , vol.25 , pp. 4361-4369
    • Shulewitz, M.1    Soloviev, I.2    Wu, T.3    Koeppen, H.4    Polakis, P.5    Sakanaka, C.6
  • 118
    • 33745634864 scopus 로고    scopus 로고
    • Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer
    • 10.1093/carcin/bgi379, 16501252
    • Ai L, Tao Q, Zhong S, Fields CR, Kim WJ, Lee MW, Cui Y, Brown KD, Robertson KD. Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer. Carcinogenesis 2006, 27:1341-1348. 10.1093/carcin/bgi379, 16501252.
    • (2006) Carcinogenesis , vol.27 , pp. 1341-1348
    • Ai, L.1    Tao, Q.2    Zhong, S.3    Fields, C.R.4    Kim, W.J.5    Lee, M.W.6    Cui, Y.7    Brown, K.D.8    Robertson, K.D.9
  • 119
    • 74049105681 scopus 로고    scopus 로고
    • WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth
    • 2716500, 19473496, 10.1186/bcr2317
    • Matsuda Y, Schlange T, Oakeley EJ, Boulay A, Hynes NE. WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth. Breast Cancer Res 2009, 11:R32. 2716500, 19473496, 10.1186/bcr2317.
    • (2009) Breast Cancer Res , vol.11
    • Matsuda, Y.1    Schlange, T.2    Oakeley, E.J.3    Boulay, A.4    Hynes, N.E.5
  • 120
    • 66749092153 scopus 로고    scopus 로고
    • Down-regulation of sfrp1 in a mammary epithelial cell line promotes the development of a cd44high/cd24low population which is invasive and resistant to anoikis
    • 2687411, 19422694, 10.1186/1475-2867-9-11
    • Gauger KJ, Hugh JM, Troester MA, Schneider SS. Down-regulation of sfrp1 in a mammary epithelial cell line promotes the development of a cd44high/cd24low population which is invasive and resistant to anoikis. Cancer Cell Int 2009, 9:11. 2687411, 19422694, 10.1186/1475-2867-9-11.
    • (2009) Cancer Cell Int , vol.9 , pp. 11
    • Gauger, K.J.1    Hugh, J.M.2    Troester, M.A.3    Schneider, S.S.4
  • 121
    • 68549133226 scopus 로고    scopus 로고
    • Methylationassociated silencing of SFRP1 with an 8p11-12 amplification inhibits canonical and non-canonical WNT pathways in breast cancers
    • 2735097, 19569235, 10.1002/ijc.24518
    • Yang ZQ, Liu G, Bollig-Fischer A, Haddad R, Tarca AL, Ethier SP. Methylationassociated silencing of SFRP1 with an 8p11-12 amplification inhibits canonical and non-canonical WNT pathways in breast cancers. Int J Cancer 2009, 125:1613-1621. 2735097, 19569235, 10.1002/ijc.24518.
    • (2009) Int J Cancer , vol.125 , pp. 1613-1621
    • Yang, Z.Q.1    Liu, G.2    Bollig-Fischer, A.3    Haddad, R.4    Tarca, A.L.5    Ethier, S.P.6
  • 123
    • 47249164378 scopus 로고    scopus 로고
    • Epigenetic inactivation of the secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis
    • 10.1093/carcin/bgn076, 18356147
    • Veeck J, Geisler C, Noetzel E, Alkaya S, Hartmann A, Knuchel R, Dahl E. Epigenetic inactivation of the secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis. Carcinogenesis 2008, 29:991-998. 10.1093/carcin/bgn076, 18356147.
    • (2008) Carcinogenesis , vol.29 , pp. 991-998
    • Veeck, J.1    Geisler, C.2    Noetzel, E.3    Alkaya, S.4    Hartmann, A.5    Knuchel, R.6    Dahl, E.7
  • 124
    • 68349139365 scopus 로고    scopus 로고
    • Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer
    • 2717119, 19570204, 10.1186/1471-2407-9-217
    • Veeck J, Wild PJ, Fuchs T, Schuffler PJ, Hartmann A, Knuchel R, Dahl E. Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer. BMC Cancer 2009, 9:217. 2717119, 19570204, 10.1186/1471-2407-9-217.
    • (2009) BMC Cancer , vol.9 , pp. 217
    • Veeck, J.1    Wild, P.J.2    Fuchs, T.3    Schuffler, P.J.4    Hartmann, A.5    Knuchel, R.6    Dahl, E.7
  • 126
    • 33847224852 scopus 로고    scopus 로고
    • The Wnt pathway regulator DKK1 is preferentially expressed in hormone-resistant breast tumours and in some common cancer types
    • 2360041, 17245340, 10.1038/sj.bjc.6603579
    • Forget MA, Turcotte S, Beauseigle D, Godin-Ethier J, Pelletier S, Martin J, Tanguay S, Lapointe R. The Wnt pathway regulator DKK1 is preferentially expressed in hormone-resistant breast tumours and in some common cancer types. Br J Cancer 2007, 96:646-653. 2360041, 17245340, 10.1038/sj.bjc.6603579.
    • (2007) Br J Cancer , vol.96 , pp. 646-653
    • Forget, M.A.1    Turcotte, S.2    Beauseigle, D.3    Godin-Ethier, J.4    Pelletier, S.5    Martin, J.6    Tanguay, S.7    Lapointe, R.8
  • 127
    • 0035656179 scopus 로고    scopus 로고
    • Expression of WNT14 and WNT14B mRNAs in human cancer, up-regulation of WNT14 by IFNγ and up-regulation of WNT14B by beta-estradiol
    • Kirikoshi H, Sekihara H, Katoh M. Expression of WNT14 and WNT14B mRNAs in human cancer, up-regulation of WNT14 by IFNγ and up-regulation of WNT14B by beta-estradiol. Int J Oncol 2001, 19:1221-1225.
    • (2001) Int J Oncol , vol.19 , pp. 1221-1225
    • Kirikoshi, H.1    Sekihara, H.2    Katoh, M.3
  • 128
    • 0028272485 scopus 로고
    • Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue
    • Huguet EL, McMahon JA, McMahon AP, Bicknell R, Harris AL. Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Cancer Res 1994, 54:2615-2621.
    • (1994) Cancer Res , vol.54 , pp. 2615-2621
    • Huguet, E.L.1    McMahon, J.A.2    McMahon, A.P.3    Bicknell, R.4    Harris, A.L.5
  • 130
    • 33645750603 scopus 로고    scopus 로고
    • Redundant expression of canonical Wnt ligands in human breast cancer cell lines
    • Benhaj K, Akcali KC, Ozturk M. Redundant expression of canonical Wnt ligands in human breast cancer cell lines. Oncol Rep 2006, 15:701-707.
    • (2006) Oncol Rep , vol.15 , pp. 701-707
    • Benhaj, K.1    Akcali, K.C.2    Ozturk, M.3
  • 131
    • 0028902359 scopus 로고
    • Wnt5a cloning, expression, and up-regulation in human primary breast cancers
    • Lejeune S, Huguet EL, Hamby A, Poulsom R, Harris AL. Wnt5a cloning, expression, and up-regulation in human primary breast cancers. Clin Cancer Res 1995, 1:215-222.
    • (1995) Clin Cancer Res , vol.1 , pp. 215-222
    • Lejeune, S.1    Huguet, E.L.2    Hamby, A.3    Poulsom, R.4    Harris, A.L.5
  • 132
    • 0035513435 scopus 로고    scopus 로고
    • Frequent up-regulation of WNT2 in primary gastric cancer and colorectal cancer
    • Katoh M. Frequent up-regulation of WNT2 in primary gastric cancer and colorectal cancer. Int J Oncol 2001, 19:1003-1007.
    • (2001) Int J Oncol , vol.19 , pp. 1003-1007
    • Katoh, M.1
  • 133
    • 0030899334 scopus 로고    scopus 로고
    • A novel human Wnt gene, WNT10B, maops to 12q13 and is expressed in human breast carcinomas
    • 10.1038/sj.onc.1200936, 9121776
    • Bui TD, Rankin J, Smith K, Huguet EL, Ruben S, Strachan T, Harris AL, Lindsay S. A novel human Wnt gene, WNT10B, maops to 12q13 and is expressed in human breast carcinomas. Oncogene 1997, 14:1249-1253. 10.1038/sj.onc.1200936, 9121776.
    • (1997) Oncogene , vol.14 , pp. 1249-1253
    • Bui, T.D.1    Rankin, J.2    Smith, K.3    Huguet, E.L.4    Ruben, S.5    Strachan, T.6    Harris, A.L.7    Lindsay, S.8
  • 135
    • 0037081290 scopus 로고    scopus 로고
    • Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas
    • Jonsson M, Dejmek J, Bendahl PO, Andersson T. Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas. Cancer Res 2002, 62:409-416.
    • (2002) Cancer Res , vol.62 , pp. 409-416
    • Jonsson, M.1    Dejmek, J.2    Bendahl, P.O.3    Andersson, T.4
  • 136
    • 16644366891 scopus 로고    scopus 로고
    • Expression of Wnt genes and frizzled 1 and 2 receptors in normal breast epithelium and infiltrating breast carcinoma
    • Milovanovic T, Planutis K, Nguyen A, Marsh JL, Lin F, Hope C, Holcombe RF. Expression of Wnt genes and frizzled 1 and 2 receptors in normal breast epithelium and infiltrating breast carcinoma. Int J Oncol 2004, 25:1337-1342.
    • (2004) Int J Oncol , vol.25 , pp. 1337-1342
    • Milovanovic, T.1    Planutis, K.2    Nguyen, A.3    Marsh, J.L.4    Lin, F.5    Hope, C.6    Holcombe, R.F.7
  • 137
    • 64149087593 scopus 로고    scopus 로고
    • The internally truncated LRP5 receptor presents a therapeutic target in breast cancer
    • 2627768, 19158955, 10.1371/journal.pone.0004243
    • Bjorklund P, Svedlund J, Olsson AK, Akerstrom G, Westin G. The internally truncated LRP5 receptor presents a therapeutic target in breast cancer. PLoS One 2009, 4:e4243. 2627768, 19158955, 10.1371/journal.pone.0004243.
    • (2009) PLoS One , vol.4
    • Bjorklund, P.1    Svedlund, J.2    Olsson, A.K.3    Akerstrom, G.4    Westin, G.5
  • 138
    • 0038301969 scopus 로고    scopus 로고
    • Amplification, up-regulation and over-expression of DVL-1, the human counterpart of the Drosophila disheveled gene, in primary breast cancers
    • 10.1111/j.1349-7006.2003.tb01475.x, 12824876
    • Nagahata T, Shimada T, Harada A, Nagai H, Onda M, Yokoyama S, Shiba T, Jin E, Kawanami O, Emi M. Amplification, up-regulation and over-expression of DVL-1, the human counterpart of the Drosophila disheveled gene, in primary breast cancers. Cancer Sci 2003, 94:515-518. 10.1111/j.1349-7006.2003.tb01475.x, 12824876.
    • (2003) Cancer Sci , vol.94 , pp. 515-518
    • Nagahata, T.1    Shimada, T.2    Harada, A.3    Nagai, H.4    Onda, M.5    Yokoyama, S.6    Shiba, T.7    Jin, E.8    Kawanami, O.9    Emi, M.10
  • 139
    • 0032222643 scopus 로고    scopus 로고
    • Truncating somatic mutation in exon 15 of the APC gene is a rare event in human breast carcinomas. Mutations in brief no. 179. Online
    • Sorlie T, Bukholm I, Borresen-Dale AL. Truncating somatic mutation in exon 15 of the APC gene is a rare event in human breast carcinomas. Mutations in brief no. 179. Online. Hum Mutat 1998, 12:215-216.
    • (1998) Hum Mutat , vol.12 , pp. 215-216
    • Sorlie, T.1    Bukholm, I.2    Borresen-Dale, A.L.3
  • 143
    • 0027280477 scopus 로고
    • Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer
    • 1968317, 8318422
    • Thompson AM, Morris RG, Wallace M, Wyllie AH, Steel CM, Carter DC. Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer. Br J Cancer 1993, 68:64-68. 1968317, 8318422.
    • (1993) Br J Cancer , vol.68 , pp. 64-68
    • Thompson, A.M.1    Morris, R.G.2    Wallace, M.3    Wyllie, A.H.4    Steel, C.M.5    Carter, D.C.6
  • 144
    • 0037479867 scopus 로고    scopus 로고
    • Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: relationships with abnormal E-cadherin and catenin expression and microsatellite instability
    • 10.1002/ijc.11197, 12800196
    • Sarrio D, Moreno-Bueno G, Hardisson D, Sanchez-Estevez C, Guo M, Herman JG, Gamallo C, Esteller M, Palacios J. Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: relationships with abnormal E-cadherin and catenin expression and microsatellite instability. Int J Cancer 2003, 106:208-215. 10.1002/ijc.11197, 12800196.
    • (2003) Int J Cancer , vol.106 , pp. 208-215
    • Sarrio, D.1    Moreno-Bueno, G.2    Hardisson, D.3    Sanchez-Estevez, C.4    Guo, M.5    Herman, J.G.6    Gamallo, C.7    Esteller, M.8    Palacios, J.9
  • 145
    • 0028073008 scopus 로고
    • Aberrations of the APC gene in primary breast carcinoma
    • 10.1007/BF01194271, 7798298
    • Kashiwaba M, Tamura G, Ishida M. Aberrations of the APC gene in primary breast carcinoma. J Cancer Res Clin Oncol 1994, 120:727-731. 10.1007/BF01194271, 7798298.
    • (1994) J Cancer Res Clin Oncol , vol.120 , pp. 727-731
    • Kashiwaba, M.1    Tamura, G.2    Ishida, M.3
  • 146
    • 0028198925 scopus 로고
    • Loss of heterozygosity affecting the APC and MCC genetic loci in patients with primary breast carcinomas
    • Medeiros AC, Nagai MA, Neto MM, Brentani RR. Loss of heterozygosity affecting the APC and MCC genetic loci in patients with primary breast carcinomas. Cancer Epidemiol Biomarkers Prev 1994, 3:331-333.
    • (1994) Cancer Epidemiol Biomarkers Prev , vol.3 , pp. 331-333
    • Medeiros, A.C.1    Nagai, M.A.2    Neto, M.M.3    Brentani, R.R.4
  • 147
    • 0032833946 scopus 로고    scopus 로고
    • Reduced expression of APC and DCC gene protein in breast cancer
    • 10.1046/j.1365-2559.1999.00725.x, 10469217
    • Ho KY, Kalle WH, Lo TH, Lam WY, Tang CM. Reduced expression of APC and DCC gene protein in breast cancer. Histopathology 1999, 35:249-256. 10.1046/j.1365-2559.1999.00725.x, 10469217.
    • (1999) Histopathology , vol.35 , pp. 249-256
    • Ho, K.Y.1    Kalle, W.H.2    Lo, T.H.3    Lam, W.Y.4    Tang, C.M.5
  • 148
    • 0033948526 scopus 로고    scopus 로고
    • Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding
    • 10.1002/1098-2264(200008)28:4<443::AID-GCC10>3.0.CO;2-D, 10862053
    • Webster MT, Rozycka M, Sara E, Davis E, Smalley M, Young N, Dale TC, Wooster R. Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding. Genes Chromosomes Cancer 2000, 28:443-453. 10.1002/1098-2264(200008)28:4<443::AID-GCC10>3.0.CO;2-D, 10862053.
    • (2000) Genes Chromosomes Cancer , vol.28 , pp. 443-453
    • Webster, M.T.1    Rozycka, M.2    Sara, E.3    Davis, E.4    Smalley, M.5    Young, N.6    Dale, T.C.7    Wooster, R.8
  • 149
    • 0035816342 scopus 로고    scopus 로고
    • Adenomatous polyposis coli (APC) gene promoter hypermethylation in primary breast cancers
    • 2363914, 11437404, 10.1054/bjoc.2001.1853
    • Jin Z, Tamura G, Tsuchiya T, Sakata K, Kashiwaba M, Osakabe M, Motoyama T. Adenomatous polyposis coli (APC) gene promoter hypermethylation in primary breast cancers. Br J Cancer 2001, 85:69-73. 2363914, 11437404, 10.1054/bjoc.2001.1853.
    • (2001) Br J Cancer , vol.85 , pp. 69-73
    • Jin, Z.1    Tamura, G.2    Tsuchiya, T.3    Sakata, K.4    Kashiwaba, M.5    Osakabe, M.6    Motoyama, T.7
  • 151
    • 2342648692 scopus 로고    scopus 로고
    • Gene expression profiling of breast cancers with emphasis of beta-catenin regulation
    • 2822311, 15082903, 10.3346/jkms.2004.19.2.275
    • Roh MS, Hong SH, Jeong JS, Kwon HC, Kim MC, Cho SH, Yoon JH, Hwang TH. Gene expression profiling of breast cancers with emphasis of beta-catenin regulation. J Korean Med Sci 2004, 19:275-282. 2822311, 15082903, 10.3346/jkms.2004.19.2.275.
    • (2004) J Korean Med Sci , vol.19 , pp. 275-282
    • Roh, M.S.1    Hong, S.H.2    Jeong, J.S.3    Kwon, H.C.4    Kim, M.C.5    Cho, S.H.6    Yoon, J.H.7    Hwang, T.H.8
  • 154
    • 34447544566 scopus 로고    scopus 로고
    • Integration of estrogen and Wnt signaling circuits by the polycomb group protein EZH2 in breast cancer cells
    • 1951944, 17502350, 10.1128/MCB.00162-07
    • Shi B, Liang J, Yang X, Wang Y, Zhao Y, Wu H, Sun L, Zhang Y, Chen Y, Li R, Zhang Y, Hong M, Shang Y. Integration of estrogen and Wnt signaling circuits by the polycomb group protein EZH2 in breast cancer cells. Mol Cell Biol 2007, 27:5105-5119. 1951944, 17502350, 10.1128/MCB.00162-07.
    • (2007) Mol Cell Biol , vol.27 , pp. 5105-5119
    • Shi, B.1    Liang, J.2    Yang, X.3    Wang, Y.4    Zhao, Y.5    Wu, H.6    Sun, L.7    Zhang, Y.8    Chen, Y.9    Li, R.10    Zhang, Y.11    Hong, M.12    Shang, Y.13
  • 155
    • 0035987974 scopus 로고    scopus 로고
    • C-myc oncogene amplification in ductal carcinoma in situ of the breast
    • 10.1023/A:1016061327812, 12150449
    • Aulmann S, Bentz M, Sinn HP. C-myc oncogene amplification in ductal carcinoma in situ of the breast. Breast Cancer Res Treat 2002, 74:25-31. 10.1023/A:1016061327812, 12150449.
    • (2002) Breast Cancer Res Treat , vol.74 , pp. 25-31
    • Aulmann, S.1    Bentz, M.2    Sinn, H.P.3
  • 156
    • 0028331092 scopus 로고
    • Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining
    • Gillett C, Fantl V, Smith R, Fisher C, Bartek J, Dickson C, Barnes D, Peters G. Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining. Cancer Res 1994, 54:1812-1817.
    • (1994) Cancer Res , vol.54 , pp. 1812-1817
    • Gillett, C.1    Fantl, V.2    Smith, R.3    Fisher, C.4    Bartek, J.5    Dickson, C.6    Barnes, D.7    Peters, G.8
  • 158
    • 0141765653 scopus 로고    scopus 로고
    • Quantitation of MYC gene expression in sporadic breast tumors with a real-time reverse transcription-PCR assay
    • Bieche I, Laurendeau I, Tozlu S, Olivi M, Vidaud D, Lidereau R, Vidaud M. Quantitation of MYC gene expression in sporadic breast tumors with a real-time reverse transcription-PCR assay. Cancer Res 1999, 59:2759-2765.
    • (1999) Cancer Res , vol.59 , pp. 2759-2765
    • Bieche, I.1    Laurendeau, I.2    Tozlu, S.3    Olivi, M.4    Vidaud, D.5    Lidereau, R.6    Vidaud, M.7
  • 159
    • 34447530928 scopus 로고    scopus 로고
    • C-Myc transforms human mammary epithelial cells through repression of the Wnt inhibitors DKK1 and SFRP1
    • 1951955, 17485441, 10.1128/MCB.02282-06
    • Cowling VH, D'Cruz CM, Chodosh LA, Cole MD. c-Myc transforms human mammary epithelial cells through repression of the Wnt inhibitors DKK1 and SFRP1. Mol Cell Biol 2007, 27:5135-5146. 1951955, 17485441, 10.1128/MCB.02282-06.
    • (2007) Mol Cell Biol , vol.27 , pp. 5135-5146
    • Cowling, V.H.1    D'Cruz, C.M.2    Chodosh, L.A.3    Cole, M.D.4
  • 160
    • 0034161886 scopus 로고    scopus 로고
    • WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene
    • 316421, 10716946
    • Xu L, Corcoran RB, Welsh JW, Pennica D, Levine AJ. WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene. Genes Dev 2000, 14:585-595. 316421, 10716946.
    • (2000) Genes Dev , vol.14 , pp. 585-595
    • Xu, L.1    Corcoran, R.B.2    Welsh, J.W.3    Pennica, D.4    Levine, A.J.5
  • 161
    • 0035893738 scopus 로고    scopus 로고
    • Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features
    • Xie D, Nakachi K, Wang H, Elashoff R, Koeffler HP. Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features. Cancer Res 2001, 61:8917-8923.
    • (2001) Cancer Res , vol.61 , pp. 8917-8923
    • Xie, D.1    Nakachi, K.2    Wang, H.3    Elashoff, R.4    Koeffler, H.P.5
  • 162
    • 74849121190 scopus 로고    scopus 로고
    • Sox17, the canonical Wnt antagonist, is epigenetically inactivated by promoter methylation in human breast cancer
    • 10.1007/s10549-009-0339-8, 19301122
    • Fu DY, Wang ZM, Li C, Wang BL, Shen ZZ, Huang W, Shao ZM. Sox17, the canonical Wnt antagonist, is epigenetically inactivated by promoter methylation in human breast cancer. Breast Cancer Res Treat 2010, 119:601-612. 10.1007/s10549-009-0339-8, 19301122.
    • (2010) Breast Cancer Res Treat , vol.119 , pp. 601-612
    • Fu, D.Y.1    Wang, Z.M.2    Li, C.3    Wang, B.L.4    Shen, Z.Z.5    Huang, W.6    Shao, Z.M.7
  • 163
    • 77956264304 scopus 로고    scopus 로고
    • The embryonic transcription cofactor LBH is a direct target of the WNT signaling pathway in epithelial development and in aggressive basal subtype breast cancers
    • 10.1128/MCB.01418-09, 20606007
    • Rieger ME, Sims AH, Coats ER, Clarke RB, Briegel KJ. The embryonic transcription cofactor LBH is a direct target of the WNT signaling pathway in epithelial development and in aggressive basal subtype breast cancers. Mol Cell Biol 2010, 30:4267-4279. 10.1128/MCB.01418-09, 20606007.
    • (2010) Mol Cell Biol , vol.30 , pp. 4267-4279
    • Rieger, M.E.1    Sims, A.H.2    Coats, E.R.3    Clarke, R.B.4    Briegel, K.J.5
  • 164
    • 0035796405 scopus 로고    scopus 로고
    • Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1
    • 125530, 11432833, 10.1093/emboj/20.13.3459
    • Wulf GM, Ryo A, Wulf GG, Lee SW, Niu T, Petkova V, Lu KP. Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1. EMBO J 2001, 20:3459-3472. 125530, 11432833, 10.1093/emboj/20.13.3459.
    • (2001) EMBO J , vol.20 , pp. 3459-3472
    • Wulf, G.M.1    Ryo, A.2    Wulf, G.G.3    Lee, S.W.4    Niu, T.5    Petkova, V.6    Lu, K.P.7
  • 165
    • 3042716638 scopus 로고    scopus 로고
    • NF-κB activation in human breast cancer specimens and its role in cell proliferation and apoptosis
    • 454178, 15220474, 10.1073/pnas.0403621101
    • Biswas DK, Shi Q, Baily S, Strickland I, Ghosh S, Pardee AB, Iglehart JD. NF-κB activation in human breast cancer specimens and its role in cell proliferation and apoptosis. Proc Natl Acad Sci USA 2004, 101:10137-10142. 454178, 15220474, 10.1073/pnas.0403621101.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10137-10142
    • Biswas, D.K.1    Shi, Q.2    Baily, S.3    Strickland, I.4    Ghosh, S.5    Pardee, A.B.6    Iglehart, J.D.7
  • 167
    • 0034920457 scopus 로고    scopus 로고
    • Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer
    • 10.1038/modpathol.3880371, 11454999
    • Depowski PL, Rosenthal SI, Ross JS. Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer. Mod Pathol 2001, 14:672-676. 10.1038/modpathol.3880371, 11454999.
    • (2001) Mod Pathol , vol.14 , pp. 672-676
    • Depowski, P.L.1    Rosenthal, S.I.2    Ross, J.S.3
  • 168
    • 23044480599 scopus 로고    scopus 로고
    • Overexpression of the tumor suppressor gene phosphatase and tensin homologue partially inhibits wnt-1-induced mammary tumorigenesis
    • 10.1158/0008-5472.CAN-05-0181, 16061670
    • Zhao H, Cui Y, Dupont J, Sun H, Hennighausen L, Yakar S. Overexpression of the tumor suppressor gene phosphatase and tensin homologue partially inhibits wnt-1-induced mammary tumorigenesis. Cancer Res 2005, 65:6864-6873. 10.1158/0008-5472.CAN-05-0181, 16061670.
    • (2005) Cancer Res , vol.65 , pp. 6864-6873
    • Zhao, H.1    Cui, Y.2    Dupont, J.3    Sun, H.4    Hennighausen, L.5    Yakar, S.6
  • 169
    • 60149087777 scopus 로고    scopus 로고
    • Id-1 activates Akt-mediated Wnt signaling and p27(Kip1) phosphorylation through PTEN inhibition
    • 10.1038/onc.2008.451, 19079342
    • Lee JY, Kang MB, Jang SH, Qian T, Kim HJ, Kim CH, Kim Y, Kong G. Id-1 activates Akt-mediated Wnt signaling and p27(Kip1) phosphorylation through PTEN inhibition. Oncogene 2009, 28:824-831. 10.1038/onc.2008.451, 19079342.
    • (2009) Oncogene , vol.28 , pp. 824-831
    • Lee, J.Y.1    Kang, M.B.2    Jang, S.H.3    Qian, T.4    Kim, H.J.5    Kim, C.H.6    Kim, Y.7    Kong, G.8
  • 170
    • 55549115695 scopus 로고    scopus 로고
    • Slit-2 induces a tumorsuppressive effect by regulating beta-catenin in breast cancer cells
    • 2546548, 18611862, 10.1074/jbc.M800679200
    • Prasad A, Paruchuri V, Preet A, Latif F, Ganju RK. Slit-2 induces a tumorsuppressive effect by regulating beta-catenin in breast cancer cells. J Biol Chem 2008, 283:26624-26633. 2546548, 18611862, 10.1074/jbc.M800679200.
    • (2008) J Biol Chem , vol.283 , pp. 26624-26633
    • Prasad, A.1    Paruchuri, V.2    Preet, A.3    Latif, F.4    Ganju, R.K.5
  • 172
    • 0036129489 scopus 로고    scopus 로고
    • The p53 pathway in breast cancer
    • 138723, 11879567, 10.1186/bcr426
    • Gasco M, Shami S, Crook T. The p53 pathway in breast cancer. Breast Cancer Res 2002, 4:70-76. 138723, 11879567, 10.1186/bcr426.
    • (2002) Breast Cancer Res , vol.4 , pp. 70-76
    • Gasco, M.1    Shami, S.2    Crook, T.3
  • 173
    • 34648823103 scopus 로고    scopus 로고
    • Siah-1 S, a novel splice variant of Siah-1 (seven in absentia homolog), counteracts Siah-1-mediated downregulation of beta-catenin
    • 10.1038/sj.onc.1210449, 17420721
    • Mei Y, Xie C, Xie W, Wu Z, Wu M. Siah-1 S, a novel splice variant of Siah-1 (seven in absentia homolog), counteracts Siah-1-mediated downregulation of beta-catenin. Oncogene 2007, 26:6319-6331. 10.1038/sj.onc.1210449, 17420721.
    • (2007) Oncogene , vol.26 , pp. 6319-6331
    • Mei, Y.1    Xie, C.2    Xie, W.3    Wu, Z.4    Wu, M.5
  • 174
    • 6344229325 scopus 로고    scopus 로고
    • Siah-1L, a novel transcript variant belonging to the human Siah family of proteins, regulates beta-catenin activity in a p53-dependent manner
    • 10.1038/sj.onc.1208016, 15326481
    • Iwai A, Marusawa H, Matsuzawa S, Fukushima T, Hijikata M, Reed JC, Shimotohno K, Chiba T. Siah-1L, a novel transcript variant belonging to the human Siah family of proteins, regulates beta-catenin activity in a p53-dependent manner. Oncogene 2004, 23:7593-7600. 10.1038/sj.onc.1208016, 15326481.
    • (2004) Oncogene , vol.23 , pp. 7593-7600
    • Iwai, A.1    Marusawa, H.2    Matsuzawa, S.3    Fukushima, T.4    Hijikata, M.5    Reed, J.C.6    Shimotohno, K.7    Chiba, T.8
  • 175
    • 33745140523 scopus 로고    scopus 로고
    • P53 levels determine outcome during beta-catenin tumor initiation and metastasis in the mammary gland and male germ cells
    • 10.1038/sj.onc.1209391, 16434961
    • Ridgeway AG, McMenamin J, Leder P. P53 levels determine outcome during beta-catenin tumor initiation and metastasis in the mammary gland and male germ cells. Oncogene 2006, 25:3518-3527. 10.1038/sj.onc.1209391, 16434961.
    • (2006) Oncogene , vol.25 , pp. 3518-3527
    • Ridgeway, A.G.1    McMenamin, J.2    Leder, P.3
  • 177
    • 7044246236 scopus 로고    scopus 로고
    • P63 expression in breast cancer: a highly sensitive and specific marker of metaplastic carcinoma
    • 10.1097/01.pas.0000138183.97366.fd, 15489655
    • Koker MM, Kleer CG. p63 expression in breast cancer: a highly sensitive and specific marker of metaplastic carcinoma. Am J Surg Pathol 2004, 28:1506-1512. 10.1097/01.pas.0000138183.97366.fd, 15489655.
    • (2004) Am J Surg Pathol , vol.28 , pp. 1506-1512
    • Koker, M.M.1    Kleer, C.G.2
  • 178
    • 0027340690 scopus 로고
    • ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias
    • 47484, 8415640, 10.1073/pnas.90.19.8977
    • Moser AR, Mattes EM, Dove WF, Lindstrom MJ, Haag JD, Gould MN. ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias. Proc Natl Acad Sci USA 1993, 90:8977-8981. 47484, 8415640, 10.1073/pnas.90.19.8977.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8977-8981
    • Moser, A.R.1    Mattes, E.M.2    Dove, W.F.3    Lindstrom, M.J.4    Haag, J.D.5    Gould, M.N.6


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