Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data

Blood

Volumn 111, Issue 12, 2008, Pages 5654-5662

  Hassane, Duane C ^a   Guzman, Monica L ^a   Corbett, Cheryl ^a   Li, Xiaojie ^a   Abboud, Ramzi ^a   Young, Fay ^a   Liesveld, Jane L ^a   Carroll, Martin ^b   Jordan, Craig T ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; ANTILEUKEMIC AGENT; CELASTROL; PARTHENOLIDE; 4-HYDROXY-2-NONENAL; ALDEHYDE; ANTINEOPLASTIC AGENT; CYSTEINE PROTEINASE INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; SESQUITERPENE; TERPENE; TRIPTERINE; TRITERPENE;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CANCER STEM CELL; CELL VIABILITY; COMPUTER MODEL; CONTROLLED STUDY; DRUG STRUCTURE; DRUG TARGETING; GENE EXPRESSION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LEUKEMIA CELL; MICROARRAY ANALYSIS; PRIORITY JOURNAL; ANIMAL; BIOLOGICAL MODEL; CELL DEATH; CHEMISTRY; DNA MICROARRAY; DRUG EFFECT; DRUG SCREENING; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC DATABASE; MOUSE; MOUSE MUTANT; NONOBESE DIABETIC MOUSE; PATHOLOGY; PHYSIOLOGY;

ALDEHYDES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS; CELL DEATH; CYSTEINE PROTEINASE INHIBITORS; DATABASES, GENETIC; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; LEUKEMIA, MYELOID, ACUTE; MICE; MICE, INBRED NOD; MICE, SCID; MODELS, GENETIC; NEOPLASTIC STEM CELLS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SESQUITERPENES; TERPENES; TRITERPENES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 47049105891     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2007-11-126003     Document Type: Article

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