-
1
-
-
4143094988
-
Circulating tumor cells, disease progression, and survival in metastatic breast cancer
-
DOI 10.1056/NEJMoa040766
-
Cristofanilli M, Budd GT, Ellis MJ, Stopeck A, Matera J, Miller MC, et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med 2004;351:781-91. (Pubitemid 39095313)
-
(2004)
New England Journal of Medicine
, vol.351
, Issue.8
, pp. 781-791
-
-
Cristofanilli, M.1
Budd, G.T.2
Ellis, M.J.3
Stopeck, A.4
Matera, J.5
Miller, M.C.6
Reuben, J.M.7
Doyle, G.V.8
Allard, W.J.9
Terstappen, L.W.M.M.10
Hayes, D.F.11
-
2
-
-
37549002543
-
Isolation of rare circulating tumour cells in cancer patients bymicrochip technology
-
Nagrath S, Sequist LV, Maheswaran S, Bell DW, Irimia D, Ulkus L, et al. Isolation of rare circulating tumour cells in cancer patients bymicrochip technology. Nature 2007;450:1235-9.
-
(2007)
Nature
, vol.450
, pp. 1235-1239
-
-
Nagrath, S.1
Sequist, L.V.2
Maheswaran, S.3
Bell, D.W.4
Irimia, D.5
Ulkus, L.6
-
3
-
-
67649506174
-
Genetic prognostic and predictive markers in colorectal cancer
-
Walther A, Johnstone E, Swanton C, Midgley R, Tomlinson I, Kerr D. Genetic prognostic and predictive markers in colorectal cancer. Nat Rev Cancer 2009;9:489-99.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 489-499
-
-
Walther, A.1
Johnstone, E.2
Swanton, C.3
Midgley, R.4
Tomlinson, I.5
Kerr, D.6
-
4
-
-
42649100970
-
Detection, clinical relevance and specific biological properties of disseminating tumour cells
-
DOI 10.1038/nrc2375, PII NRC2375
-
Pantel K, Brakenhoff RH, Brandt B. Detection, clinical relevance and specific biological properties of disseminating tumour cells. Nat Rev Cancer 2008;8:329-40. (Pubitemid 351596394)
-
(2008)
Nature Reviews Cancer
, vol.8
, Issue.5
, pp. 329-340
-
-
Pantel, K.1
Brakenhoff, R.H.2
Brandt, B.3
-
5
-
-
84872017586
-
Circulating tumor cells: Liquid biopsy of cancer
-
Alix-Panabieres C, Pantel K. Circulating tumor cells: Liquid biopsy of cancer. Clin Chem 2013;59:110-8.
-
(2013)
Clin Chem
, vol.59
, pp. 110-118
-
-
Alix-Panabieres, C.1
Pantel, K.2
-
6
-
-
79551693066
-
Circulating tumor cells: Approaches to isolation and characterization
-
Yu M, Stott S, Toner M, Maheswaran S, Haber DA. Circulating tumor cells: Approaches to isolation and characterization. J Cell Biol 2011; 192:373-82.
-
(2011)
J Cell Biol
, vol.192
, pp. 373-382
-
-
Yu, M.1
Stott, S.2
Toner, M.3
Maheswaran, S.4
Haber, D.A.5
-
7
-
-
47949114668
-
Detection of mutations in EGFR in circulating lung-cancer cells
-
Maheswaran S, Sequist LV, Nagrath S, Ulkus L, Brannigan B, Collura CV, et al. Detection of mutations in EGFR in circulating lung-cancer cells. N Engl J Med 2008;359:366-77.
-
(2008)
N Engl J Med
, vol.359
, pp. 366-377
-
-
Maheswaran, S.1
Sequist, L.V.2
Nagrath, S.3
Ulkus, L.4
Brannigan, B.5
Collura, C.V.6
-
8
-
-
79953766940
-
Tumour evolution inferred by single-cell sequencing
-
Navin N, Kendall J, Troge J, Andrews P, Rodgers L, McIndoo J, et al. Tumour evolution inferred by single-cell sequencing. Nature 2011; 472:90-4.
-
(2011)
Nature
, vol.472
, pp. 90-94
-
-
Navin, N.1
Kendall, J.2
Troge, J.3
Andrews, P.4
Rodgers, L.5
McIndoo, J.6
-
9
-
-
84863229772
-
Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm
-
Hou Y, Song L, Zhu P, Zhang B, Tao Y, Xu X, et al. Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm. Cell 2012;148:873-85.
-
(2012)
Cell
, vol.148
, pp. 873-885
-
-
Hou, Y.1
Song, L.2
Zhu, P.3
Zhang, B.4
Tao, Y.5
Xu, X.6
-
10
-
-
84863230091
-
Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor
-
Xu X, Hou Y, Yin X, Bao L, Tang A, Song L, et al. Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor. Cell 2012;148:886-95.
-
(2012)
Cell
, vol.148
, pp. 886-895
-
-
Xu, X.1
Hou, Y.2
Yin, X.3
Bao, L.4
Tang, A.5
Song, L.6
-
11
-
-
84864258558
-
Genome-wide single-cell analysis of recombination activity and de novo mutation rates in human sperm
-
Wang J, Fan HC, Behr B, Quake SR. Genome-wide single-cell analysis of recombination activity and de novo mutation rates in human sperm. Cell 2012;150:402-12.
-
(2012)
Cell
, vol.150
, pp. 402-412
-
-
Wang, J.1
Fan, H.C.2
Behr, B.3
Quake, S.R.4
-
12
-
-
79953158399
-
Exploring the genomes of cancer cells: Progress and promise
-
Stratton MR. Exploring the genomes of cancer cells: Progress and promise. Science 2011;331:1553-8.
-
(2011)
Science
, vol.331
, pp. 1553-1558
-
-
Stratton, M.R.1
-
13
-
-
78649872067
-
Isolation of circulating tumor cells using a microvortex-generating herringbone-chip
-
Stott SL, Hsu CH, Tsukrov DI, Yu M, Miyamoto DT, Waltman BA, et al. Isolation of circulating tumor cells using a microvortex-generating herringbone-chip. Proc Natl Acad Sci U S A 2010;107:18392-7.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 18392-18397
-
-
Stott, S.L.1
Hsu, C.H.2
Tsukrov, D.I.3
Yu, M.4
Miyamoto, D.T.5
Waltman, B.A.6
-
14
-
-
84863587972
-
Ultrasensitive clinical enumeration of rare cells ex vivo using a microhall detector
-
Issadore D, Chung J, Shao H, Liong M, Ghazani AA, Castro CM, et al. Ultrasensitive clinical enumeration of rare cells ex vivo using a microhall detector. Sci Transl Med 2012;4:141ra92.
-
(2012)
Sci Transl Med
, vol.4
-
-
Issadore, D.1
Chung, J.2
Shao, H.3
Liong, M.4
Ghazani, A.A.5
Castro, C.M.6
-
15
-
-
2542474181
-
Genomic profiling of viable and proliferative micrometastatic cells from early-stage breast cancer patients
-
DOI 10.1158/1078-0432.CCR-03-0818
-
Gangnus R, Langer S, Breit E, Pantel K, Speicher MR. Genomic profiling of viable and proliferative micrometastatic cells from earlystage breast cancer patients. Clin Cancer Res 2004;10:3457-64. (Pubitemid 38685453)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.10
, pp. 3457-3464
-
-
Gangnus, R.1
Langer, S.2
Breit, E.3
Pantel, K.4
Speicher, M.R.5
-
16
-
-
0037301144
-
High-resolution genomic profiling of occult micrometastatic tumor cells
-
DOI 10.1002/gcc.10160
-
Kraus J, Pantel K, Pinkel D, Albertson DG, Speicher MR. High-resolution genomic profiling of occult micrometastatic tumor cells. Genes Chromosomes Cancer 2003;36:159-66. (Pubitemid 36109559)
-
(2003)
Genes Chromosomes and Cancer
, vol.36
, Issue.2
, pp. 159-166
-
-
Kraus, J.1
Pantel, K.2
Pinkel, D.3
Albertson, D.G.4
Speicher, M.R.5
-
17
-
-
18244406590
-
Heterogeneous proliferative potential of occult metastatic cells in bone marrow of patients with solid epithelial tumors
-
DOI 10.1073/pnas.042372199
-
Solakoglu O, Maierhofer C, Lahr G, Breit E, Scheunemann P,Heumos I, et al. Heterogeneous proliferative potential of occult metastatic cells in bone marrow of patients with solid epithelial tumors. Proc Natl Acad Sci U S A 2002;99:2246-51. (Pubitemid 34169046)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.4
, pp. 2246-2251
-
-
Solakoglu, O.1
Maierhofer, C.2
Lahr, G.3
Breit, E.4
Scheunemann, P.5
Heumos, I.6
Pichlmeier, U.7
Schlimok, G.8
Oberneder, R.9
Kollermann, M.W.10
Kollermann, J.11
Speicher, M.R.12
Pantel, K.13
-
18
-
-
84860601923
-
Single cell profiling of circulating tumor cells: Transcriptional heterogeneity and diversity from breast cancer cell lines
-
Powell AA, Talasaz AH, Zhang H, Coram MA, Reddy A, Deng G, et al. Single cell profiling of circulating tumor cells: Transcriptional heterogeneity and diversity from breast cancer cell lines. PLoS ONE 2012;7: E33788.
-
(2012)
PLoS ONE
, vol.7
-
-
Powell, A.A.1
Talasaz, A.H.2
Zhang, H.3
Coram, M.A.4
Reddy, A.5
Deng, G.6
-
19
-
-
77953015030
-
Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer
-
Stott SL, Lee RJ, Nagrath S, Yu M, Miyamoto DT, Ulkus L, et al. Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer. Sci Transl Med 2010; 2:25ra3.
-
(2010)
Sci Transl Med
, vol.2
-
-
Stott, S.L.1
Lee, R.J.2
Nagrath, S.3
Yu, M.4
Miyamoto, D.T.5
Ulkus, L.6
-
20
-
-
33847402612
-
Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: A validation study of the cell search system
-
DOI 10.1158/1078-0432.CCR-06-1695
-
Riethdorf S, Fritsche H, Muller V, Rau T, Schindlbeck C, Rack B, et al. Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: A validation study of the CellSearch system. Clin Cancer Re 2007;13:920-8. (Pubitemid 46340368)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.3
, pp. 920-928
-
-
Riethdorf, S.1
Fritsche, H.2
Muller, V.3
Rau, T.4
Schindlbeck, C.5
Rack, B.6
Janni, W.7
Coith, C.8
Beck, K.9
Janicke, F.10
Jackson, S.11
Gornet, T.12
Cristofanilli, M.13
Pantel, K.14
-
21
-
-
79952238282
-
Evolution of genomic instability in diethylnitrosamine-induced hepatocarcinogenesis in mice
-
Aleksic K, Lackner C, Geigl JB, Schwarz M, Auer M, Ulz P, et al. Evolution of genomic instability in diethylnitrosamine-induced hepatocarcinogenesis in mice. Hepatology 2011;53:895-904.
-
(2011)
Hepatology
, vol.53
, pp. 895-904
-
-
Aleksic, K.1
Lackner, C.2
Geigl, J.B.3
Schwarz, M.4
Auer, M.5
Ulz, P.6
-
22
-
-
70349559751
-
P53 deletion impairs clearance of chromosomalinstable stem cells in aging telomere-dysfunctional mice
-
Begus-Nahrmann Y, Lechel A, Obenauf AC, Nalapareddy K, Peit E, Hoffmann E, et al. p53 deletion impairs clearance of chromosomalinstable stem cells in aging telomere-dysfunctional mice. Nat Genet 2009;41:1138-43.
-
(2009)
Nat Genet
, vol.41
, pp. 1138-1143
-
-
Begus-Nahrmann, Y.1
Lechel, A.2
Obenauf, A.C.3
Nalapareddy, K.4
Peit, E.5
Hoffmann, E.6
-
23
-
-
33847347259
-
High resolution array-CGH analysis of single cells
-
Fiegler H, Geigl JB, Langer S, Rigler D, Porter K, Unger K, et al. High resolution array-CGH analysis of single cells. Nucleic Acids Res 2007; 35:e15.
-
(2007)
Nucleic Acids Res
, vol.35
-
-
Fiegler, H.1
Geigl, J.B.2
Langer, S.3
Rigler, D.4
Porter, K.5
Unger, K.6
-
24
-
-
69849093233
-
Identification of small gains and losses in single cells after whole genome amplification on tiling oligo arrays
-
Geigl JB, Obenauf AC, Waldispuehl-Geigl J, Hoffmann EM, Auer M, Hormann M, et al. Identification of small gains and losses in single cells after whole genome amplification on tiling oligo arrays. Nucleic Acids Res 2009;37:e105.
-
(2009)
Nucleic Acids Res
, vol.37
-
-
Geigl, J.B.1
Obenauf, A.C.2
Waldispuehl-Geigl, J.3
Hoffmann, E.M.4
Auer, M.5
Hormann, M.6
-
25
-
-
39149094948
-
Single-cell isolation from cell suspensions and whole genome amplification from single cells to provide templates for CGH analysis
-
Geigl JB, Speicher MR. Single-cell isolation from cell suspensions and whole genome amplification from single cells to provide templates for CGH analysis. Nat Protoc 2007;2:3173-84.
-
(2007)
Nat Protoc
, vol.2
, pp. 3173-3184
-
-
Geigl, J.B.1
Speicher, M.R.2
-
26
-
-
84859413615
-
High-resolution analyses of copy number changes in disseminated tumor cells of patients with breast cancer
-
Mathiesen RR, Fjelldal R, Liestol K, Due EU, Geigl JB, Riethdorf S, et al. High-resolution analyses of copy number changes in disseminated tumor cells of patients with breast cancer. Int J Cancer 2012;131: E405-15.
-
(2012)
Int J Cancer
, vol.131
-
-
Mathiesen, R.R.1
Fjelldal, R.2
Liestol, K.3
Due, E.U.4
Geigl, J.B.5
Riethdorf, S.6
-
27
-
-
84355165246
-
Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction
-
Sperka T, Song Z, Morita Y, Nalapareddy K, Guachalla LM, Lechel A, et al. Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction. Nat Cell Biol 2011;14:73-9.
-
(2011)
Nat Cell Biol
, vol.14
, pp. 73-79
-
-
Sperka, T.1
Song, Z.2
Morita, Y.3
Nalapareddy, K.4
Guachalla, L.M.5
Lechel, A.6
-
28
-
-
75749105459
-
Ultradeep sequencing of a human ultraconserved region reveals somatic and constitutional genomic instability
-
De Grassi A, Segala C, Iannelli F, Volorio S, Bertario L, Radice P, et al. Ultradeep sequencing of a human ultraconserved region reveals somatic and constitutional genomic instability. PLoS Biol 2010;8: E1000275.
-
(2010)
PLoS Biol
, vol.8
-
-
De Grassi, A.1
Segala, C.2
Iannelli, F.3
Volorio, S.4
Bertario, L.5
Radice, P.6
-
29
-
-
2542542256
-
Ultraconserved elements in the human genome
-
DOI 10.1126/science.1098119
-
Bejerano G, Pheasant M, Makunin I, Stephen S, Kent WJ, Mattick JS, et al. Ultraconserved elements in the human genome. Science 2004; 304:1321-5. (Pubitemid 38697428)
-
(2004)
Science
, vol.304
, Issue.5675
, pp. 1321-1325
-
-
Bejerano, G.1
Pheasant, M.2
Makunin, I.3
Stephen, S.4
Kent, W.J.5
Mattick, J.S.6
Haussler, D.7
-
30
-
-
84860453712
-
Reliable detection of subclonal single-nucleotide variants in tumour cell populations
-
Gerstung M, Beisel C, Rechsteiner M, Wild P, Schraml P, Moch H, et al. Reliable detection of subclonal single-nucleotide variants in tumour cell populations. Nat Commun 2012;3:811.
-
(2012)
Nat Commun
, vol.3
, pp. 811
-
-
Gerstung, M.1
Beisel, C.2
Rechsteiner, M.3
Wild, P.4
Schraml, P.5
Moch, H.6
-
31
-
-
79957523828
-
KRAS BRAF PIK3CA, and PTEN mutations: Implications for targeted therapies in metastatic colorectal cancer
-
De Roock W, De Vriendt V, Normanno N, Ciardiello F, Tejpar S. KRAS, BRAF, PIK3CA, and PTEN mutations: Implications for targeted therapies in metastatic colorectal cancer. Lancet Oncol 2010;12:594-603.
-
(2010)
Lancet Oncol
, vol.12
, pp. 594-603
-
-
De Roock, W.1
De Vriendt, V.2
Normanno, N.3
Ciardiello, F.4
Tejpar, S.5
-
32
-
-
78149416790
-
A phase I clinical trial of FOLFIRI in combination with the pan-cyclindependent kinase (CDK) inhibitor flavopiridol
-
Dickson MA, Shah MA, Rathkopf D, Tse A, Carvajal RD, Wu N, et al. A phase I clinical trial of FOLFIRI in combination with the pan-cyclindependent kinase (CDK) inhibitor flavopiridol. Cancer Chemother Pharmacol 2010;66:1113-21.
-
(2010)
Cancer Chemother Pharmacol
, vol.66
, pp. 1113-1121
-
-
Dickson, M.A.1
Shah, M.A.2
Rathkopf, D.3
Tse, A.4
Carvajal, R.D.5
Wu, N.6
-
33
-
-
84860531850
-
A dose-finding, pharmacokinetic and pharmacodynamic study of a novel schedule of flavopiridol in patients with advanced solid tumors
-
Ramaswamy B, Phelps MA, Baiocchi R, Bekaii-Saab T, Ni W, Lai JP, et al. A dose-finding, pharmacokinetic and pharmacodynamic study of a novel schedule of flavopiridol in patients with advanced solid tumors. Invest New Drugs 2012;30:629-38.
-
(2012)
Invest New Drugs
, vol.30
, pp. 629-638
-
-
Ramaswamy, B.1
Phelps, M.A.2
Baiocchi, R.3
Bekaii-Saab, T.4
Ni, W.5
Lai, J.P.6
-
34
-
-
77956637674
-
Flavopiridol, the first cyclin-dependent kinase inhibitor: Recent advances in combination chemotherapy
-
Wang LM, Ren DM. Flavopiridol, the first cyclin-dependent kinase inhibitor: Recent advances in combination chemotherapy. Mini Rev Med Chem 2010;10:1058-70.
-
(2010)
Mini Rev Med Chem
, vol.10
, pp. 1058-1070
-
-
Wang, L.M.1
Ren, D.M.2
-
35
-
-
84860660477
-
Circulating epithelial cells in patients with benign colon diseases
-
Pantel K, Deneve E, Nocca D, Coffy A, Vendrell JP, Maudelonde T, et al. Circulating epithelial cells in patients with benign colon diseases. Clin Chem 2012;58:936-40.
-
(2012)
Clin Chem
, vol.58
, pp. 936-940
-
-
Pantel, K.1
Deneve, E.2
Nocca, D.3
Coffy, A.4
Vendrell, J.P.5
Maudelonde, T.6
-
36
-
-
84871990259
-
Biologic challenges in the detection of circulating tumor cells
-
Joosse SA, Pantel K. Biologic challenges in the detection of circulating tumor cells. Cancer Res 2013;73:8-11.
-
(2013)
Cancer Res
, vol.73
, pp. 8-11
-
-
Joosse, S.A.1
Pantel, K.2
-
37
-
-
84871447495
-
Probing meiotic recombination and aneuploidy of single sperm cells by whole-genome sequencing
-
Lu S, Zong C, Fan W, Yang M, Li J, Chapman AR, et al. Probing meiotic recombination and aneuploidy of single sperm cells by whole-genome sequencing. Science 2012;338:1627-30.
-
(2012)
Science
, vol.338
, pp. 1627-1630
-
-
Lu, S.1
Zong, C.2
Fan, W.3
Yang, M.4
Li, J.5
Chapman, A.R.6
-
38
-
-
84871461434
-
Genome-wide detection of singlenucleotide and copy-number variations of a single human cell
-
Zong C, Lu S, Chapman AR, Xie XS. Genome-wide detection of singlenucleotide and copy-number variations of a single human cell. Science 2012;338:1622-6.
-
(2012)
Science
, vol.338
, pp. 1622-1326
-
-
Zong, C.1
Lu, S.2
Chapman, A.R.3
Xie, X.S.4
-
39
-
-
70350234735
-
Revving the Throttle on an oncogene: CDK8 takes the driver seat
-
Firestein R, Hahn WC. Revving the Throttle on an oncogene: CDK8 takes the driver seat. Cancer Res 2009;69:7899-901.
-
(2009)
Cancer Res
, vol.69
, pp. 7899-7901
-
-
Firestein, R.1
Hahn, W.C.2
-
40
-
-
84865303434
-
Cyclin-dependent kinase 8 mediates chemotherapy-induced tumorpromoting paracrine activities
-
Porter DC, Farmaki E, Altilia S, Schools GP, West DK, Chen M, et al. Cyclin-dependent kinase 8 mediates chemotherapy-induced tumorpromoting paracrine activities. Proc Natl Acad Sci U S A 2012;109: 13799-804.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 13799-13804
-
-
Porter, D.C.1
Farmaki, E.2
Altilia, S.3
Schools, G.P.4
West, D.K.5
Chen, M.6
|