Cytotoxic diarylheptanoid induces cell cycle arrest and apoptosis via increasing ATF3 and stabilizing p53 in SH-SY5Y cells

Cancer Chemotherapy and Pharmacology

Volumn 63, Issue 6, 2009, Pages 1131-1139

  Tian, Ze ^a,b   An, Ning ^c   Zhou, Bin ^a   Xiao, Peigen ^c   Kohane, Isaac S ^a,b   Wu, Erxi ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD UNIVERSITY   (United States)

^c INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

Author keywords

Apoptosis; ATF3; Cell cycle arrest; Diarylheptanoid; P53

Indexed keywords

1 (4 HYDROXY 3 METHOXYPHENYL) 7 (3,4 DIHYDROXYPHENYL) 3,5 HEPTANOIDIOL; 1 (4 HYDROXY 3 METHOXYPHENYL) 7 (3,4 DIHYDROXYPHENYL) 4 EN 3 HEPTANONE; 1 (4 HYDROXY 3 METHOXYPHENYL) 7 PHENYL 3,5 HEPTANDIOL; 1 (4 HYDROXY 3 METHOXYPHENYL) 7 PHENYL 3,5 HEPTANOIDIOL; 1,7 BIS(4 HYDROXYPHENYL) 3,5 HEPTANOIDIOL; 5 HYDROXY 1 (3 METHOXY 4 HYDROXYPHENYL) 7 PHENYL 4,6 DIEN 3 HEPTANONE; 5 HYDROXY 1 (3,4 DIHYDROXYPHENYL) 7 (4 HYDROXY 3 METHOXYPHENYL) 3 HEPTANONE; 5 HYDROXY 1 PHENYL 7 (3,4 DIHYDROXYPHENYL) 3 HEPATANONE; 5 HYDROXY 1 PHENYL 7 (4,5 DIHYDROXY 3 METHOXYPHENYL) 3 HEPTANONE; ACTIVATING TRANSCRIPTION FACTOR 3; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; AURORA A KINASE; BROXURIDINE; CASPASE; CASPASE 3; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLINE; CYTOTOXIC AGENT; HEPTANE DERIVATIVE; MESSENGER RNA; PROTEIN BCL 2; PROTEIN MDM2; PROTEIN P53; PUMA PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ALPINIA OFFICINARUM; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CELL CYCLE ARREST; CELL CYCLE S PHASE; CHROMATOGRAPHY; CYTOTOXICITY; DOWN REGULATION; DRUG ISOLATION; DRUG SCREENING; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MEDICINAL PLANT; NEUROBLASTOMA; NEUROBLASTOMA CELL; NUCLEAR MAGNETIC RESONANCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; RECEPTOR UPREGULATION; UPREGULATION; WESTERN BLOTTING;

ACTIVATING TRANSCRIPTION FACTOR 3; ALPINIA; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; DIARYLHEPTANOIDS; HUMANS; MOLECULAR STRUCTURE; NEUROBLASTOMA; PROTEIN STABILITY; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEIN P53;

EID: 63949087469     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-008-0832-5     Document Type: Article

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