SCOPUS 정보 검색 플랫폼

Volumn 26, Issue 1, 2014, Pages 149-161

New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia

(3) Hales, Eric C a Taub, Jeffrey W a,b Matherly, Larry H a,b

a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE (United States)

b KARMANOS CANCER INSTITUTE (United States)

Author keywords

Secretase inhibitor resistance; AKT; Leukemia; MTOR; Notch1; Protein phosphatase 2A

Indexed keywords

2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; ALVESPIMYCIN; ANTINEOPLASTIC AGENT; FINGOLIMOD; GAMMA SECRETASE INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; L 685; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MYC PROTEIN; NOTCH1 RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE B; PROTEIN P53; UNCLASSIFIED DRUG; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENTIATION; DRUG TARGETING; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GENE MUTATION; HUMAN; LEUKEMIA CELL; NONHUMAN; NOTCH1 GENE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DEPHOSPHORYLATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION;

5-AMINOIMIDAZOLE-4-CARBOXAMIDE RIBONUCLEOTIDE; A DISINTEGRIN AND METALLOPROTEASE; ACUTE LYMPHOBLASTIC LEUKEMIA; ACUTE MYELOID LEUKEMIA; ADAM; ADENOSINE MONOPHOSPHATE (AMP) ACTIVATED PROTEIN KINASE; AICAR; AKT; ALL; AML; AMPK; ANK; ANKYRIN-LIKE REPEATS; B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA; B-PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA; BAD; BCL-2 ASSOCIATED DEATH PROMOTER; BCL-2 HOMOLOGY DOMAIN 3 (BH3)-ONLY PROTEIN, B-CELL LYMPHOMA 2 INTERACTING MEDIATOR OF CELL DEATH; BIM; BP-ALL; CALMODULIN-DEPENDENT PROTEIN KINASE KINASE BETA; CAMKKΒ; CASEIN KINASE 2; CBF1/SU(H)/LAG-1; CDK8; CK2; CLL; CSL; CYCLIN-DEPENDENT KINASE 8; DELTA-LIKE; DELTA-SERRATE-LAG1; DLL; DSL; EFS; EGF; EIF2A AND EIF4E; EPIDERMAL GROWTH FACTOR; ERK; EUKARYOTIC TRANSLATION INITIATING FACTORS 2A AND 4E; EVENT FREE SURVIVAL; EXTRACELLULAR SIGNAL-REGULATED PROTEIN KINASE; F-BOX/WD-REPEAT CONTAINING PROTEIN 7; FBW7; FORK HEAD BOX O TRANSCRIPTION FACTORS; FOXO; GLYCOGEN SYNTHASE KINASE 3; GSC; GSI; GSK3; HAIRY AND ENHANCER OF SPLIT-1; HD; HES1; HETERODIMERIZATION DOMAIN; ICN1; IGF1R; IGFBP3; IL7RΑ; INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 3; INTERLEUKIN-7 RECEPTOR SUBUNIT Α; INTRACELLULAR DOMAIN OF NOTCH1; IRS1; JAG; JAGGED; JME; JUXTAMEMBRANE EXPANSION; LEUKEMIA; LIN12/NOTCH1 REPEATS; LIVER KINASE B1; LKB1; LNR; MAML1; MAMMALIAN STRESS-ACTIVATED PROTEIN KINASE INTERACTING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MAPK; MASTERMIND-LIKE PROTEIN 1; MCL1; MDM2; MICRO-RNA; MIR/MIRNA; MITOGEN ACTIVATE PROTEIN KINASES; MOUSE DOUBLE MINUTE 2 HOMOLOG; MSIN1; MTOR; NEC; NOTCH1; NOTCH1 EXTRACELLULAR DOMAIN; NOTCH1 TRANSMEMBRANE DOMAIN; NTM; PDK1; PEST; PHOSPHATASE AND TENSIN HOMOLOG DELETED ON CHROMOSOME TEN; PHOSPHATIDYLINOSITIDE 3-KINASE; PHOSPHATIDYLINOSITOL (3,4,5)-TRISPHOSPHATE; PHOSPHATIDYLINOSITOL (4,5)-BISPHOSPHATE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1; PI3K; PIP(2); PIP(3); PKCΘ; PP2A; PRAS40; PRO, GLU, SER, AND THR-RICH DOMAIN; PROLINE-RICH AKT SUBSTRATE 40KDA; PROTEIN KINASE B (PKB); PROTEIN KINASE C THETA; PROTEIN PHOSPHATASE 2A; PTEN; RAPAMYCIN-INSENSITIVE COMPANION OF MTOR; RAPTOR; REACTIVE OXYGEN SPECIES; REGULATORY-ASSOCIATED PROTEIN OF MTOR; RICTOR; ROS; RUNT-RELATED TRANSCRIPTION FACTORS 1 AND 3; RUNX1 AND RUNX3; SER/THR-PROTEIN PHOSPHATASE 2A; T-ALL; T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA; TACE; TAN1; TRANSLOCATION ASSOCIATED NOTCH1 HOMOLOG; TUMOR NECROSIS FACTOR Α-CONVERTING ENZYME; Γ-SECRETASE COMPLEX; Γ-SECRETASE COMPLEX INHIBITORS; Γ-SECRETASE INHIBITOR RESISTANCE;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; HUMANS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 84887242051 PISSN: 08986568 EISSN: 18733913 Source Type: Journal
DOI: 10.1016/j.cellsig.2013.09.021 Document Type: Review

Times cited : (166)

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