메뉴 건너뛰기




Volumn 105, Issue 9, 2014, Pages 1087-1092

Safely targeting cancer stem cells via selective catenin coactivator antagonism

Author keywords

Asymmetric; CREB binding protein; P300; Symmetric; Wnt catenin

Indexed keywords

ANTINEOPLASTIC AGENT; CATENIN; CYTOKERATIN 20; E1A ASSOCIATED P300 PROTEIN; GEMCITABINE; N BENZYL 1,2,3,4,8,9 HEXAHYDRO 6 (4 HYDROXYBENZYL) 8 (1 NAPHTHYLMETHYL) 4,7 DIOXO 2H PYRAZINO[1,2 A]PYRIMIDINE 1(6H) CARBOXAMIDE; PRI 724; SURVIVIN; UNCLASSIFIED DRUG; UVOMORULIN; BONE SIALOPROTEIN (35 62), HUMAN; BONE SIALOPROTEIN (35-62), HUMAN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; FUSED HETEROCYCLIC RINGS; ICG 001; PEPTIDE FRAGMENT; PYRIMIDINONE DERIVATIVE; SIALOGLYCOPROTEIN;

EID: 84908185262     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.12471     Document Type: Review
Times cited : (154)

References (80)
  • 2
    • 84871335417 scopus 로고    scopus 로고
    • Stem cell niche in tissue homeostasis, aging and cancer
    • Singh SR. Stem cell niche in tissue homeostasis, aging and cancer. Curr Med Chem 2012; 19: 5965-74.
    • (2012) Curr Med Chem , vol.19 , pp. 5965-5974
    • Singh, S.R.1
  • 3
    • 82355186665 scopus 로고    scopus 로고
    • "Wnt/Β-catenin signaling in embryonic stem cell self-renewal and somatic cell reprogramming
    • Miki T, Yasuda SY, Kahn M. "Wnt/Β-catenin signaling in embryonic stem cell self-renewal and somatic cell reprogramming. Stem Cell Rev 2011; 7: 836-46.
    • (2011) Stem Cell Rev , vol.7 , pp. 836-846
    • Miki, T.1    Yasuda, S.Y.2    Kahn, M.3
  • 4
    • 77953715690 scopus 로고    scopus 로고
    • Targeting Wnt signaling: can we safely eradicate cancer stem cells?
    • Takahashi-Yanaga F, Kahn M. Targeting Wnt signaling: can we safely eradicate cancer stem cells? Clin Cancer Res 2010; 16: 3153-62.
    • (2010) Clin Cancer Res , vol.16 , pp. 3153-3162
    • Takahashi-Yanaga, F.1    Kahn, M.2
  • 5
    • 77953693899 scopus 로고    scopus 로고
    • Targeting hedgehog - a cancer stem cell pathway
    • Merchant AA, Matsui W. Targeting hedgehog - a cancer stem cell pathway. Clin Cancer Res 2010; 16: 3130-40.
    • (2010) Clin Cancer Res , vol.16 , pp. 3130-3140
    • Merchant, A.A.1    Matsui, W.2
  • 6
    • 77956331142 scopus 로고    scopus 로고
    • Notch signaling in the regulation of stem cell self-renewal and differentiation
    • Liu J, Sato C, Cerletti M, Wagers A. Notch signaling in the regulation of stem cell self-renewal and differentiation. Curr Top Dev Biol 2010; 92: 367-409.
    • (2010) Curr Top Dev Biol , vol.92 , pp. 367-409
    • Liu, J.1    Sato, C.2    Cerletti, M.3    Wagers, A.4
  • 7
    • 84918732190 scopus 로고
    • Ueber Entzuendung und Eiterung [in German]
    • Cohnheim J. Ueber Entzuendung und Eiterung [in German]. Path Anat Physiol Klin Med 1867; 40: 1-79.
    • (1867) Path Anat Physiol Klin Med , vol.40 , pp. 1-79
    • Cohnheim, J.1
  • 8
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
    • Visvader JE, Lindeman GJ. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 2008; 8: 755-68.
    • (2008) Nat Rev Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 11
    • 79952370202 scopus 로고    scopus 로고
    • The cancer stem cell: premises, promises and challenges
    • Clevers H. The cancer stem cell: premises, promises and challenges. Nat Med 2011; 17: 313-9.
    • (2011) Nat Med , vol.17 , pp. 313-319
    • Clevers, H.1
  • 12
    • 77956619560 scopus 로고    scopus 로고
    • Stem cells and cancer - the promise and puzzles
    • Visvader JE, Lindeman GJ. Stem cells and cancer - the promise and puzzles. Mol Oncol 2010; 4: 369-72.
    • (2010) Mol Oncol , vol.4 , pp. 369-372
    • Visvader, J.E.1    Lindeman, G.J.2
  • 14
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997; 3: 730-7.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 15
    • 10944235028 scopus 로고    scopus 로고
    • Chronic versus acute myelogenous leukemia: a question of self-renewal
    • Jamieson CH, Weissman IL, Passegué E. Chronic versus acute myelogenous leukemia: a question of self-renewal. Cancer Cell 2004; 6: 531-3.
    • (2004) Cancer Cell , vol.6 , pp. 531-533
    • Jamieson, C.H.1    Weissman, I.L.2    Passegué, E.3
  • 16
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • Singh SK, Hawkins C, Clarke ID et al. Identification of human brain tumour initiating cells. Nature 2004; 432: 396-401.
    • (2004) Nature , vol.432 , pp. 396-401
    • Singh, S.K.1    Hawkins, C.2    Clarke, I.D.3
  • 17
    • 27144557960 scopus 로고    scopus 로고
    • A tumorigenic subpopulation with stem cell properties in melanomas
    • Fang D, Nguyen TK, Leishear K et al. A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res 2005; 65: 9328-37.
    • (2005) Cancer Res , vol.65 , pp. 9328-9337
    • Fang, D.1    Nguyen, T.K.2    Leishear, K.3
  • 18
    • 3042525924 scopus 로고    scopus 로고
    • Breast cancer, stem/progenitor cells and the estrogen receptor
    • Dontu G, El-Ashry D, Wicha MS. Breast cancer, stem/progenitor cells and the estrogen receptor. Trends Endocrinol Metab 2004; 15: 193-7.
    • (2004) Trends Endocrinol Metab , vol.15 , pp. 193-197
    • Dontu, G.1    El-Ashry, D.2    Wicha, M.S.3
  • 19
    • 34249980343 scopus 로고    scopus 로고
    • Identification and characterization of tumorigenic liver cancer stem/progenitor cells
    • Ma S, Chan KW, Hu L et al. Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology 2007; 132: 2542-56.
    • (2007) Gastroenterology , vol.132 , pp. 2542-2556
    • Ma, S.1    Chan, K.W.2    Hu, L.3
  • 20
    • 33847052127 scopus 로고    scopus 로고
    • Identification of Pancreatic Cancer Stem Cells
    • Li C, Heidt DG, Dalerba P et al. Identification of Pancreatic Cancer Stem Cells. Cancer Res 2007; 67: 1030-7.
    • (2007) Cancer Res , vol.67 , pp. 1030-1037
    • Li, C.1    Heidt, D.G.2    Dalerba, P.3
  • 21
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • O'Brien CA, Pollett A, Gallinger S, Dick JE. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007; 445: 106-10.
    • (2007) Nature , vol.445 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 22
    • 79551634544 scopus 로고    scopus 로고
    • The gamma catenin/CBP complex maintains survivin transcription in β-catenin deficient/depleted cancer cells
    • Kim YM, Ma H, Oehler V et al. The gamma catenin/CBP complex maintains survivin transcription in β-catenin deficient/depleted cancer cells. Curr Cancer Drug Targets 2011; 11: 213-25.
    • (2011) Curr Cancer Drug Targets , vol.11 , pp. 213-225
    • Kim, Y.M.1    Ma, H.2    Oehler, V.3
  • 23
    • 44449111555 scopus 로고    scopus 로고
    • Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
    • Onder TT, Gupta PB, Mani SA et al. Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res 2008; 68: 3645-54.
    • (2008) Cancer Res , vol.68 , pp. 3645-3654
    • Onder, T.T.1    Gupta, P.B.2    Mani, S.A.3
  • 24
    • 0031741386 scopus 로고    scopus 로고
    • Tissue-specific expression of beta-catenin in normal mesenchyme and uveal melanomas and its effect on invasiveness
    • Kim K, Daniels KJ, Ha ED. Tissue-specific expression of beta-catenin in normal mesenchyme and uveal melanomas and its effect on invasiveness. Exp Cell Res 1998; 245: 79-90.
    • (1998) Exp Cell Res , vol.245 , pp. 79-90
    • Kim, K.1    Daniels, K.J.2    Ha, E.D.3
  • 25
    • 80054686286 scopus 로고    scopus 로고
    • Tumor metastasis: molecular insights and evolving paradigms
    • Valastyan S, Weinberg RA. Tumor metastasis: molecular insights and evolving paradigms. Cell 2011; 147: 275-92.
    • (2011) Cell , vol.147 , pp. 275-292
    • Valastyan, S.1    Weinberg, R.A.2
  • 26
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani SA, Guo W, Liao MJ et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008; 133: 704-15.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3
  • 27
    • 80052071814 scopus 로고    scopus 로고
    • β-Catenin is required for Ron receptor-induced mammary tumorigenesis
    • Wagh PK, Gary JK, Zinser GM et al. β-Catenin is required for Ron receptor-induced mammary tumorigenesis. Oncogene 2011; 30: 3694-704.
    • (2011) Oncogene , vol.30 , pp. 3694-3704
    • Wagh, P.K.1    Gary, J.K.2    Zinser, G.M.3
  • 28
    • 33644532202 scopus 로고    scopus 로고
    • SKI-606 decreases growth and motility of colorectal cancer cells by preventing pp60(c-Src)-dependent tyrosine phosphorylation of beta-catenin and its nuclear signaling
    • Coluccia AM, Benati D, Dekhil H et al. SKI-606 decreases growth and motility of colorectal cancer cells by preventing pp60(c-Src)-dependent tyrosine phosphorylation of beta-catenin and its nuclear signaling. Cancer Res 2006; 66: 2279-86.
    • (2006) Cancer Res , vol.66 , pp. 2279-2286
    • Coluccia, A.M.1    Benati, D.2    Dekhil, H.3
  • 29
    • 32444440622 scopus 로고    scopus 로고
    • Bcr interferes with beta-catenin-Tcf1 interaction
    • Ress A, Moelling K. Bcr interferes with beta-catenin-Tcf1 interaction. FEBS Lett 2006; 580: 1227-30.
    • (2006) FEBS Lett , vol.580 , pp. 1227-1230
    • Ress, A.1    Moelling, K.2
  • 30
    • 77957584397 scopus 로고    scopus 로고
    • O2 regulates stem cells through Wnt/β-catenin signalling
    • Mazumdar J, Obrien WT, Johnson RS et al. O2 regulates stem cells through Wnt/β-catenin signalling. Nat Cell Biol 2010; 12: 1007-13.
    • (2010) Nat Cell Biol , vol.12 , pp. 1007-1013
    • Mazumdar, J.1    Obrien, W.T.2    Johnson, R.S.3
  • 31
    • 84901285520 scopus 로고    scopus 로고
    • Hypoxia selects for a quiescent, CML stem/leukemia initiating-like population dependent on CBP/catenin transcription
    • Kida A, Kahn M. Hypoxia selects for a quiescent, CML stem/leukemia initiating-like population dependent on CBP/catenin transcription. Curr Mol Pharmacol 2013; 6: 204-10.
    • (2013) Curr Mol Pharmacol , vol.6 , pp. 204-210
    • Kida, A.1    Kahn, M.2
  • 33
    • 30644458570 scopus 로고    scopus 로고
    • Balancing cell adhesion and Wnt signaling, the key role of beta-catenin
    • Brembeck FH, Rosário M, Birchmeier W. Balancing cell adhesion and Wnt signaling, the key role of beta-catenin. Curr Opin Genet Dev 2006; 16: 51-9.
    • (2006) Curr Opin Genet Dev , vol.16 , pp. 51-59
    • Brembeck, F.H.1    Rosário, M.2    Birchmeier, W.3
  • 34
    • 80051544746 scopus 로고    scopus 로고
    • β-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis
    • van Veelen W, Le NH, Helvensteijn W et al. β-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis. Gut 2011; 60: 1204-12.
    • (2011) Gut , vol.60 , pp. 1204-1212
    • van Veelen, W.1    Le, N.H.2    Helvensteijn, W.3
  • 35
    • 80051497162 scopus 로고    scopus 로고
    • Prostaglandin E2 and pain - an update
    • Kawabata A. Prostaglandin E2 and pain - an update. Biol Pharm Bull 2011; 34: 1170-3.
    • (2011) Biol Pharm Bull , vol.34 , pp. 1170-1173
    • Kawabata, A.1
  • 36
    • 11144357877 scopus 로고    scopus 로고
    • Differences between human and mouse embryonic stem cells
    • Ginis  , Luo Y, Miura T et al. Differences between human and mouse embryonic stem cells. Dev Biol 2004; 269: 360-80.
    • (2004) Dev Biol , vol.269 , pp. 360-380
    • Ginis,  .1    Luo, Y.2    Miura, T.3
  • 37
    • 1242267927 scopus 로고    scopus 로고
    • Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
    • Sato N, Meijer L, Skaltsounis L, Greengard P, Brivanlou AH. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med 2004; 10: 55-63.
    • (2004) Nat Med , vol.10 , pp. 55-63
    • Sato, N.1    Meijer, L.2    Skaltsounis, L.3    Greengard, P.4    Brivanlou, A.H.5
  • 38
    • 0347359163 scopus 로고    scopus 로고
    • Wnt proteins promote neuronal differentiation in neural stem cell culture
    • Muroyama Y, Kondoh H, Takada S. Wnt proteins promote neuronal differentiation in neural stem cell culture. Biochem Biophys Res Commun 2004; 313: 915-21.
    • (2004) Biochem Biophys Res Commun , vol.313 , pp. 915-921
    • Muroyama, Y.1    Kondoh, H.2    Takada, S.3
  • 39
    • 28444438841 scopus 로고    scopus 로고
    • Defining the role of Wnt/beta-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells
    • Dravid G, Ye Z, Hammond H et al. Defining the role of Wnt/beta-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells. Stem Cells 2005; 23: 1489-501.
    • (2005) Stem Cells , vol.23 , pp. 1489-1501
    • Dravid, G.1    Ye, Z.2    Hammond, H.3
  • 40
    • 0037135177 scopus 로고    scopus 로고
    • Regulation of cerebral cortical size by control of cell cycle exit in neural precursors
    • Chenn A, Walsh CA. Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science 2002; 297: 365-9.
    • (2002) Science , vol.297 , pp. 365-369
    • Chenn, A.1    Walsh, C.A.2
  • 41
    • 0038517899 scopus 로고    scopus 로고
    • beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system
    • Zehner D, Fujita Y, Hulsken J et al. beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system. Dev Biol 2003; 258: 406-18.
    • (2003) Dev Biol , vol.258 , pp. 406-418
    • Zehner, D.1    Fujita, Y.2    Hulsken, J.3
  • 42
    • 0037049631 scopus 로고    scopus 로고
    • Lineage-specific requirements of beta-catenin in neural crest development
    • Hari L, Brault V, Kleber M et al. Lineage-specific requirements of beta-catenin in neural crest development. J Cell Biol 2002; 159: 867-80.
    • (2002) J Cell Biol , vol.159 , pp. 867-880
    • Hari, L.1    Brault, V.2    Kleber, M.3
  • 43
    • 84872498040 scopus 로고    scopus 로고
    • On the role of Wnt/β-catenin signaling in stem cells
    • Kühl SJ, Kühl M. On the role of Wnt/β-catenin signaling in stem cells. Biochim Biophys Acta 2013; 1830: 2297-306.
    • (2013) Biochim Biophys Acta , vol.1830 , pp. 2297-2306
    • Kühl, S.J.1    Kühl, M.2
  • 44
    • 84862170024 scopus 로고    scopus 로고
    • Drugging Wnt signalling in cancer
    • Erratum in: EMBO J. 2012; 31: 3375.
    • Polakis P. Drugging Wnt signalling in cancer. EMBO J 2012; 31: 2737-46. Erratum in: EMBO J. 2012; 31: 3375.
    • (2012) EMBO J , vol.31 , pp. 2737-2746
    • Polakis, P.1
  • 45
    • 84871846692 scopus 로고    scopus 로고
    • WNT signalling pathways as therapeutic targets in cancer
    • Anastas JN, Moon RT. WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer 2013; 13: 11-26.
    • (2013) Nat Rev Cancer , vol.13 , pp. 11-26
    • Anastas, J.N.1    Moon, R.T.2
  • 46
    • 0025938038 scopus 로고
    • Identification and characterization of the familial adenomatous polyposis coli gene
    • Groden J, Thliveris A, Samowitz W et al. Identification and characterization of the familial adenomatous polyposis coli gene. Cell 1991; 66: 589-600.
    • (1991) Cell , vol.66 , pp. 589-600
    • Groden, J.1    Thliveris, A.2    Samowitz, W.3
  • 47
    • 0025817880 scopus 로고
    • Identification of FAP locus genes from chromosome 5q21
    • Kinzler KW, Nilbert MC, Su LK et al. Identification of FAP locus genes from chromosome 5q21. Science 1991; 253: 661-5.
    • (1991) Science , vol.253 , pp. 661-665
    • Kinzler, K.W.1    Nilbert, M.C.2    Su, L.K.3
  • 48
    • 0041380990 scopus 로고    scopus 로고
    • Adenomatous polyposis coli/beta-catenin interaction and downstream targets: altered gene expression in gastrointestinal tumors
    • Clements WM, Lowy AM, Grode J. Adenomatous polyposis coli/beta-catenin interaction and downstream targets: altered gene expression in gastrointestinal tumors. Clin Colorectal Cancer 2003; 3: 113-20.
    • (2003) Clin Colorectal Cancer , vol.3 , pp. 113-120
    • Clements, W.M.1    Lowy, A.M.2    Grode, J.3
  • 49
    • 84873390533 scopus 로고    scopus 로고
    • Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability
    • Drier Y, Lawrence MS, Carter SL et al. Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability. Genome Res 2013; 23: 228-35.
    • (2013) Genome Res , vol.23 , pp. 228-235
    • Drier, Y.1    Lawrence, M.S.2    Carter, S.L.3
  • 51
    • 84864395840 scopus 로고    scopus 로고
    • WNT secretion and signalling in human disease
    • Herr P, Hausmann G, Basler K. WNT secretion and signalling in human disease. Trends Mol Med 2012; 18: 483-93.
    • (2012) Trends Mol Med , vol.18 , pp. 483-493
    • Herr, P.1    Hausmann, G.2    Basler, K.3
  • 52
    • 84872453498 scopus 로고    scopus 로고
    • Functional genomic studies: insights into the pathogenesis of liver cancer
    • Han ZG. Functional genomic studies: insights into the pathogenesis of liver cancer. Annu Rev Genomics Hum Genet 2012; 13: 171-205.
    • (2012) Annu Rev Genomics Hum Genet , vol.13 , pp. 171-205
    • Han, Z.G.1
  • 55
    • 84870252814 scopus 로고    scopus 로고
    • The complex world of WNT receptor signalling
    • Niehrs C. The complex world of WNT receptor signalling. Nat Rev Mol Cell Biol 2012; 13: 767-79.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 767-779
    • Niehrs, C.1
  • 56
    • 44949226873 scopus 로고    scopus 로고
    • Tumour-stroma interactions in colorectal cancer: converging on beta-catenin activation and cancer stemness
    • Le NH, Franken P, Fodde R. Tumour-stroma interactions in colorectal cancer: converging on beta-catenin activation and cancer stemness. Br J Cancer 2008; 98: 1886-93.
    • (2008) Br J Cancer , vol.98 , pp. 1886-1893
    • Le, N.H.1    Franken, P.2    Fodde, R.3
  • 57
    • 18244377210 scopus 로고    scopus 로고
    • Wnt/beta-catenin pathway
    • Moon RT. Wnt/beta-catenin pathway. Sci STKE 2005; 271: cm1.
    • (2005) Sci STKE , vol.271 , pp. cm1
    • Moon, R.T.1
  • 58
    • 78649318098 scopus 로고    scopus 로고
    • The Wnt signaling pathway in cellular proliferation and differentiation: a tale of two coactivators
    • Teo J-L, Kahn M. The Wnt signaling pathway in cellular proliferation and differentiation: a tale of two coactivators. Adv Drug Deliv Rev 2010; 62: 1149-55.
    • (2010) Adv Drug Deliv Rev , vol.62 , pp. 1149-1155
    • Teo, J.-L.1    Kahn, M.2
  • 59
    • 67649470380 scopus 로고    scopus 로고
    • Proximal events in Wnt signal transduction
    • Angers S, Moon RT. Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol 2009; 10: 468-77.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 468-477
    • Angers, S.1    Moon, R.T.2
  • 60
    • 0034141475 scopus 로고    scopus 로고
    • Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP
    • Kung AL, Rebel VI, Bronson RT et al. Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev 2000; 14: 272-7.
    • (2000) Genes Dev , vol.14 , pp. 272-277
    • Kung, A.L.1    Rebel, V.I.2    Bronson, R.T.3
  • 61
    • 0036478904 scopus 로고    scopus 로고
    • Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice
    • Yamauchi T, Oike Y, Kamon J et al. Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice. Nat Genet 2002; 30: 221-6.
    • (2002) Nat Genet , vol.30 , pp. 221-226
    • Yamauchi, T.1    Oike, Y.2    Kamon, J.3
  • 62
    • 0141753139 scopus 로고    scopus 로고
    • Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5
    • Roth FJ, Shikama N, Henzen C et al. Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5. EMBO J 2003; 2003: 5186-96.
    • (2003) EMBO J , vol.2003 , pp. 5186-5196
    • Roth, F.J.1    Shikama, N.2    Henzen, C.3
  • 63
    • 26944439459 scopus 로고    scopus 로고
    • Investigating Wnt signaling: a chemogenomic safari
    • McMillan M, Kahn M. Investigating Wnt signaling: a chemogenomic safari. Drug Discov Today 2005; 10: 1467-74.
    • (2005) Drug Discov Today , vol.10 , pp. 1467-1474
    • McMillan, M.1    Kahn, M.2
  • 64
    • 4344587136 scopus 로고    scopus 로고
    • A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]
    • Emami KH, Nguyen C, Ma H et al. A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]. Proc Natl Acad Sci USA 2004; 101: 12682-7.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 12682-12687
    • Emami, K.H.1    Nguyen, C.2    Ma, H.3
  • 65
    • 84872006171 scopus 로고    scopus 로고
    • Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion
    • Hasegawa K, Yasuda SY, Teo JL et al. Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion. Stem Cells Transl Med 2012; 1: 18-28.
    • (2012) Stem Cells Transl Med , vol.1 , pp. 18-28
    • Hasegawa, K.1    Yasuda, S.Y.2    Teo, J.L.3
  • 66
    • 84859098977 scopus 로고    scopus 로고
    • Human embryonic stem cells differentiated to lung lineage-specific cells ameliorate pulmonary fibrosis in a xenograft transplant mouse model
    • Banerjee ER, Laflamme MA, Papayannopoulou T, Kahn M, Murry CE, Henderson WR Jr. Human embryonic stem cells differentiated to lung lineage-specific cells ameliorate pulmonary fibrosis in a xenograft transplant mouse model. PLoS ONE 2012; 7: e33165.
    • (2012) PLoS ONE , vol.7 , pp. e33165
    • Banerjee, E.R.1    Laflamme, M.A.2    Papayannopoulou, T.3    Kahn, M.4    Murry, C.E.5    Henderson Jr, W.R.6
  • 68
    • 48149107133 scopus 로고    scopus 로고
    • Wnt signaling promotes reprogramming of somatic cells to pluripotency
    • Marson A, Foreman R, Chevalier B et al. Wnt signaling promotes reprogramming of somatic cells to pluripotency. Cell Stem Cell 2008; 3: 132-5.
    • (2008) Cell Stem Cell , vol.3 , pp. 132-135
    • Marson, A.1    Foreman, R.2    Chevalier, B.3
  • 69
    • 79951577787 scopus 로고    scopus 로고
    • Recapitulation of the embryonic cardiovascular progenitor cell niche
    • Schenke-Layland K, Nsair A, Van Handel B et al. Recapitulation of the embryonic cardiovascular progenitor cell niche. Biomaterials 2011; 2: 2748-56.
    • (2011) Biomaterials , vol.2 , pp. 2748-2756
    • Schenke-Layland, K.1    Nsair, A.2    Van Handel, B.3
  • 70
    • 84880326552 scopus 로고    scopus 로고
    • Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours
    • Wend P, Fang L, Zhu Q et al. Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours. EMBO J 2013; 32: 1977-89.
    • (2013) EMBO J , vol.32 , pp. 1977-1989
    • Wend, P.1    Fang, L.2    Zhu, Q.3
  • 71
    • 84899625247 scopus 로고    scopus 로고
    • Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia
    • Gang EJ, Hsieh YT, Pham J et al. Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia. Oncogene 2014; 33: 2169-78.
    • (2014) Oncogene , vol.33 , pp. 2169-2178
    • Gang, E.J.1    Hsieh, Y.T.2    Pham, J.3
  • 72
    • 84885950154 scopus 로고    scopus 로고
    • Cancer cells acquire a drug resistant, highly tumorigenic, cancer stem-like phenotype through modulation of the PI3K/Akt/β-catenin/CBP pathway
    • He K, Xu T, Xu Y, Ring A, Kahn M, Goldkorn A. Cancer cells acquire a drug resistant, highly tumorigenic, cancer stem-like phenotype through modulation of the PI3K/Akt/β-catenin/CBP pathway. Int J Cancer 2014; 134: 43-54.
    • (2014) Int J Cancer , vol.134 , pp. 43-54
    • He, K.1    Xu, T.2    Xu, Y.3    Ring, A.4    Kahn, M.5    Goldkorn, A.6
  • 73
    • 77956288500 scopus 로고    scopus 로고
    • Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis
    • Henderson WR Jr, Chi EY, Ye X et al. Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci USA 2010; 107: 14309-14.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 14309-14314
    • Henderson Jr, W.R.1    Chi, E.Y.2    Ye, X.3
  • 74
    • 80052335469 scopus 로고    scopus 로고
    • Targeted inhibition of β-catenin/CBP signaling ameliorates renal interstitial fibrosis
    • Hao S, He W, Li Y et al. Targeted inhibition of β-catenin/CBP signaling ameliorates renal interstitial fibrosis. J Am Soc Nephrol 2011; 22: 1642-53.
    • (2011) J Am Soc Nephrol , vol.22 , pp. 1642-1653
    • Hao, S.1    He, W.2    Li, Y.3
  • 75
    • 84884172819 scopus 로고    scopus 로고
    • The small molecule Wnt signaling modulator ICG-001 improves contractile function in chronically infarcted rat myocardium
    • Sasaki T, Hwang H, Nguyen C, Kloner RA, Kahn M. The small molecule Wnt signaling modulator ICG-001 improves contractile function in chronically infarcted rat myocardium. PLoS ONE 2013; 8: e75010.
    • (2013) PLoS ONE , vol.8 , pp. e75010
    • Sasaki, T.1    Hwang, H.2    Nguyen, C.3    Kloner, R.A.4    Kahn, M.5
  • 76
    • 70349123829 scopus 로고    scopus 로고
    • The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells
    • Cicalese A, Bonizzi G, Pasi CE et al. The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. Cell 2009; 138: 1083-95.
    • (2009) Cell , vol.138 , pp. 1083-1095
    • Cicalese, A.1    Bonizzi, G.2    Pasi, C.E.3
  • 77
    • 78049496814 scopus 로고    scopus 로고
    • mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion
    • Lee JY, Nakada D, Yilmaz OH et al. mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion. Cell Stem Cell 2010; 7: 593-905.
    • (2010) Cell Stem Cell , vol.7 , pp. 593-905
    • Lee, J.Y.1    Nakada, D.2    Yilmaz, O.H.3
  • 78
    • 80054959395 scopus 로고    scopus 로고
    • Symmetric division versus asymmetric division: a tale of two coactivators
    • Kahn M. Symmetric division versus asymmetric division: a tale of two coactivators. Future Med Chem 2011; 3: 1745-63.
    • (2011) Future Med Chem , vol.3 , pp. 1745-1763
    • Kahn, M.1
  • 79
    • 79960474805 scopus 로고    scopus 로고
    • Chemical 'Jekyll and Hyde's: small-molecule inhibitors of developmental signaling pathways
    • Sakata T, Chen JK. Chemical 'Jekyll and Hyde's: small-molecule inhibitors of developmental signaling pathways. Chem Soc Rev 2011; 40: 4318-31.
    • (2011) Chem Soc Rev , vol.40 , pp. 4318-4331
    • Sakata, T.1    Chen, J.K.2
  • 80
    • 84884194711 scopus 로고    scopus 로고
    • A phase I first-in-human study of PRI-724 in patients (pts) with advanced solid tumors
    • Abstract .
    • El-Khoueiry AB, Ning Y, Yang D et al. A phase I first-in-human study of PRI-724 in patients (pts) with advanced solid tumors. J Clin Oncol 2013; 31(Suppl): Abstract 2501.
    • (2013) J Clin Oncol , vol.31 , pp. 2501
    • El-Khoueiry, A.B.1    Ning, Y.2    Yang, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.