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Volumn 3, Issue 1, 2015, Pages

Related mechanisms of antibody somatic hypermutation and class switch recombination

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY;

EID: 84947705376     PISSN: None     EISSN: 21650497     Source Type: Journal    
DOI: 10.1128/microbiolspec.MDNA3-0037-2014     Document Type: Article
Times cited : (95)

References (208)
  • 1
    • 43049165459 scopus 로고    scopus 로고
    • New insights into the early molecular events underlying B cell activation
    • Harwood NE, Batista FD. 2008. New insights into the early molecular events underlying B cell activation. Immunity 28(5):609-619.
    • (2008) Immunity , vol.28 , Issue.5 , pp. 609-619
    • Harwood, N.E.1    Batista, F.D.2
  • 3
    • 33947327732 scopus 로고    scopus 로고
    • Class switch recombination: a comparison between mouse and human
    • Pan-Hammarstrom Q, Zhao Y, Hammarstrom L. Class switch recombination: a comparison between mouse and human. Adv Immunol 93:1-61.
    • Adv Immunol , vol.93 , pp. 1-61
    • Pan-Hammarstrom, Q.1    Zhao, Y.2    Hammarstrom, L.3
  • 4
    • 80355122714 scopus 로고    scopus 로고
    • V(D)J recombination: mechanisms of initiation
    • Schatz DG, Swanson PC. 2011. V(D)J recombination: mechanisms of initiation. Annu Rev Genet 45:167-202.
    • (2011) Annu Rev Genet , vol.45 , pp. 167-202
    • Schatz, D.G.1    Swanson, P.C.2
  • 5
    • 84888626405 scopus 로고    scopus 로고
    • Modernizing the nonhomologous endjoining repertoire: alternative and classical NHEJ share the stage
    • Deriano L, Roth DB. 2013. Modernizing the nonhomologous endjoining repertoire: alternative and classical NHEJ share the stage. Annu Rev Genet 47:433-455.
    • (2013) Annu Rev Genet , vol.47 , pp. 433-455
    • Deriano, L.1    Roth, D.B.2
  • 6
    • 84873320525 scopus 로고    scopus 로고
    • Mechanisms of programmed DNA lesions and genomic instability in the immune system
    • Alt FW, Zhang Y, Meng FL, Guo C, Schwer B. 2013. Mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell 152(3):417-429.
    • (2013) Cell , vol.152 , Issue.3 , pp. 417-429
    • Alt, F.W.1    Zhang, Y.2    Meng, F.L.3    Guo, C.4    Schwer, B.5
  • 7
    • 0041646843 scopus 로고
    • Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions
    • Alt FW, Baltimore D. 1982. Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. Proc Natl Acad Sci USA 79(13):4118-4122.
    • (1982) Proc Natl Acad Sci USA , vol.79 , Issue.13 , pp. 4118-4122
    • Alt, F.W.1    Baltimore, D.2
  • 8
    • 0023720148 scopus 로고
    • T-cell antigen receptor genes and T-cell recognition
    • Davis MM, Bjorkman PJ. 1988. T-cell antigen receptor genes and T-cell recognition. Nature 334(6181):395-402.
    • (1988) Nature , vol.334 , Issue.6181 , pp. 395-402
    • Davis, M.M.1    Bjorkman, P.J.2
  • 9
    • 34249790004 scopus 로고    scopus 로고
    • Molecular mechanisms of antibody somatic hypermutation
    • Di Noia JM, Neuberger MS. 2007. Molecular mechanisms of antibody somatic hypermutation. Annu Rev Biochem 76:1-22.
    • (2007) Annu Rev Biochem , vol.76 , pp. 1-22
    • Di Noia, J.M.1    Neuberger, M.S.2
  • 10
    • 0028217004 scopus 로고
    • Immunoglobulin V regions and the B cell
    • Stewart AK, Schwartz RS. 1994. Immunoglobulin V regions and the B cell. Blood 83(7):1717-1730.
    • (1994) Blood , vol.83 , Issue.7 , pp. 1717-1730
    • Stewart, A.K.1    Schwartz, R.S.2
  • 11
    • 82455164195 scopus 로고    scopus 로고
    • Enhancer-promoter communication and transcriptional regulation of Igh
    • Roy AL, Sen R, Roeder RG. 2011. Enhancer-promoter communication and transcriptional regulation of Igh. Trends Immunol 32(11):532- 539.
    • (2011) Trends Immunol , vol.32 , Issue.11 , pp. 532- 539
    • Roy, A.L.1    Sen, R.2    Roeder, R.G.3
  • 12
    • 34249801641 scopus 로고    scopus 로고
    • Discovery of activation-induced cytidine deaminase, the engraver of antibody memory
    • Muramatsu M, Nagaoka H, Shinkura R, Begum NA, Honjo T. 2007. Discovery of activation-induced cytidine deaminase, the engraver of antibody memory. Adv Immunol 94:1-36.
    • (2007) Adv Immunol , vol.94 , pp. 1-36
    • Muramatsu, M.1    Nagaoka, H.2    Shinkura, R.3    Begum, NA.4    Honjo, T.5
  • 14
    • 77955910064 scopus 로고    scopus 로고
    • New insights into the enigma of immunoglobulin D
    • Chen K, Cerutti A. 2010. New insights into the enigma of immunoglobulin D. Immunol Rev 237(1):160-179.
    • (2010) Immunol Rev , vol.237 , Issue.1 , pp. 160-179
    • Chen, K.1    Cerutti, A.2
  • 16
    • 4444342835 scopus 로고    scopus 로고
    • The lingering enigma of the allelic exclusion mechanism
    • Mostoslavsky R, Alt RW, Rajewsky K. 2004. The lingering enigma of the allelic exclusion mechanism. Cell 118(5):539-544.
    • (2004) Cell , vol.118 , Issue.5 , pp. 539-544
    • Mostoslavsky, R.1    Alt, R.W.2    Rajewsky, K.3
  • 19
    • 77952311371 scopus 로고    scopus 로고
    • Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis
    • Fagarasan S, Kawamoto S, Kanagawa O, Suzuki K. 2010. Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis. Annu Rev Immunol 28:243-273.
    • (2010) Annu Rev Immunol , vol.28 , pp. 243-273
    • Fagarasan, S.1    Kawamoto, S.2    Kanagawa, O.3    Suzuki, K.4
  • 20
    • 42649123314 scopus 로고    scopus 로고
    • Mechanism and regulation of class switch recombination
    • Stavnezer J, Guikema JE, Schrader CE. 2008. Mechanism and regulation of class switch recombination. Annu Rev Immunol 26:261-292.
    • (2008) Annu Rev Immunol , vol.26 , pp. 261-292
    • Stavnezer, J.1    Guikema, J.E.2    Schrader, C.E.3
  • 21
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T. 2000. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102(5):553-563.
    • (2000) Cell , vol.102 , Issue.5 , pp. 553-563
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5    Honjo, T.6
  • 24
    • 0032478071 scopus 로고    scopus 로고
    • Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease
    • Goossens T, Klein U, Kuppers R. 1998. Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease. Proc Natl Acad Sci USA 95(5):2463-2468.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.5 , pp. 2463-2468
    • Goossens, T.1    Klein, U.2    Kuppers, R.3
  • 25
    • 0037108463 scopus 로고    scopus 로고
    • Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
    • Rada C, Williams GT, Nilsen H, Barnes DE, Lindahl T, Neuberger MS. 2002. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr Biol 12(20):1748- 1755.
    • (2002) Curr Biol , vol.12 , Issue.20 , pp. 1748- 1755
    • Rada, C.1    Williams, G.T.2    Nilsen, H.3    Barnes, D.E.4    Lindahl, T.5    Neuberger, M.S.6
  • 26
    • 77955964086 scopus 로고    scopus 로고
    • AID and somatic hypermutation
    • Maul RW, Gearhart PJ. 2010. AID and somatic hypermutation. Adv Immunol 105:159-191.
    • (2010) Adv Immunol , vol.105 , pp. 159-191
    • Maul, R.W.1    Gearhart, P.J.2
  • 28
    • 84893411589 scopus 로고    scopus 로고
    • Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair
    • Matthews AJ, Zheng S, DiMenna LJ, Chaudhuri J. 2014. Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair. Adv Immunol 122:1-57.
    • (2014) Adv Immunol , vol.122 , pp. 1-57
    • Matthews, A.J.1    Zheng, S.2    DiMenna, L.J.3    Chaudhuri, J.4
  • 29
    • 31144457922 scopus 로고    scopus 로고
    • The function of immunoglobulin A in immunity
    • Woof JM, Kerr MA. 2006. The function of immunoglobulin A in immunity. J Pathol 208(2):270-282.
    • (2006) J Pathol , vol.208 , Issue.2 , pp. 270-282
    • Woof, J.M.1    Kerr, M.A.2
  • 30
    • 84897115704 scopus 로고    scopus 로고
    • The production and regulation of IgE by the immune system
    • Wu LC, Zarrin AA. 2014. The production and regulation of IgE by the immune system. Nat Rev Immunol 14(4):247-259.
    • (2014) Nat Rev Immunol , vol.14 , Issue.4 , pp. 247-259
    • Wu, L.C.1    Zarrin, A.A.2
  • 31
    • 37549036732 scopus 로고    scopus 로고
    • Fcgamma receptors as regulators of immune responses
    • Nimmerjahn F., Ravetch JV. 2008. Fcgamma receptors as regulators of immune responses. Nat Rev Immunol 8(1):34-47.
    • (2008) Nat Rev Immunol , vol.8 , Issue.1 , pp. 34-47
    • Nimmerjahn, F.1    Ravetch, J.V.2
  • 32
    • 0033603340 scopus 로고    scopus 로고
    • Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
    • Muramatsu M, Sankaranand VS, Anant S, Sugai M, Kinoshita K, Davidson NO, Honjo T. 1999. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J Biol Chem 274(26):18470-18476.
    • (1999) J Biol Chem , vol.274 , Issue.26 , pp. 18470-18476
    • Muramatsu, M.1    Sankaranand, V.S.2    Anant, S.3    Sugai, M.4    Kinoshita, K.5    Davidson, N.O.6    Honjo, T.7
  • 33
    • 0037083364 scopus 로고    scopus 로고
    • Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion
    • Arakawa H, Hauschild J, Buerstedde JM. 2002. Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion. Science 295(5558):1301-1306.
    • (2002) Science , vol.295 , Issue.5558 , pp. 1301-1306
    • Arakawa, H.1    Hauschild, J.2    Buerstedde, J.M.3
  • 34
    • 0037388165 scopus 로고    scopus 로고
    • Activationinduced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
    • Bransteitter R, Pham P, Scharff MD, Goodman MF. 2003. Activationinduced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc Natl Acad Sci USA 100 (7):4102-4107.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.7 , pp. 4102-4107
    • Bransteitter, R.1    Pham, P.2    Scharff, M.D.3    Goodman, M.F.4
  • 35
    • 0037452080 scopus 로고    scopus 로고
    • Transcription-targeted DNA deamination by the AID antibody diversification enzyme
    • Chaudhuri J, Tian M, Khuong C, Chua K, Pinaud E, Alt FW. 2003. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature 422(6933):726-730.
    • (2003) Nature , vol.422 , Issue.6933 , pp. 726-730
    • Chaudhuri, J.1    Tian, M.2    Khuong, C.3    Chua, K.4    Pinaud, E.5    Alt, F.W.6
  • 36
    • 0037561998 scopus 로고    scopus 로고
    • AID mediates hypermutation by deaminating single stranded DNA
    • Dickerson SK, Market E, Besmer E, Papavasiliou FN. 2003. AID mediates hypermutation by deaminating single stranded DNA. J Exp Med 197(10):1291-1296.
    • (2003) J Exp Med , vol.197 , Issue.10 , pp. 1291-1296
    • Dickerson, S.K.1    Market, E.2    Besmer, E.3    Papavasiliou, F.N.4
  • 37
    • 0037926476 scopus 로고    scopus 로고
    • Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
    • Pham P, Bransteitter R, Petruska J, Goodman MF. 2003. Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation. Nature 424(6944):103-107.
    • (2003) Nature , vol.424 , Issue.6944 , pp. 103-107
    • Pham, P.1    Bransteitter, R.2    Petruska, J.3    Goodman, M.F.4
  • 38
    • 1542619234 scopus 로고    scopus 로고
    • Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process
    • Rogozin IB, Diaz M. 2004. Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process. J Immunol 172 (6):3382-3384.
    • (2004) J Immunol , vol.172 , Issue.6 , pp. 3382-3384
    • Rogozin, I.B.1    Diaz, M.2
  • 39
    • 60749084171 scopus 로고    scopus 로고
    • DNA targets of AID evolutionary link between antibody somatic hypermutation and class switch recombination
    • Hackney JA, Misaghi S, Senger K, Garris C, Sun Y, Lorenzo MN, Zarrin AA. 2009. DNA targets of AID evolutionary link between antibody somatic hypermutation and class switch recombination. Adv Immunol 101:163-189.
    • (2009) Adv Immunol , vol.101 , pp. 163-189
    • Hackney, J.A.1    Misaghi, S.2    Senger, K.3    Garris, C.4    Sun, Y.5    Lorenzo, M.N.6    Zarrin, A.A.7
  • 40
    • 0031569118 scopus 로고    scopus 로고
    • Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes
    • Dorner T, Brezinschek HP, Brezinschek RI, Foster SJ, Domiati-Saad R, Lipsky PE. 1997. Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes. J Immunol 158(6):2779-2789.
    • (1997) J Immunol , vol.158 , Issue.6 , pp. 2779-2789
    • Dorner, T.1    Brezinschek, HP.2    Brezinschek, R.I.3    Foster, S.J.4    Domiati-Saad, R.5    Lipsky, P.E.6
  • 44
    • 62349120246 scopus 로고    scopus 로고
    • DNA repair in mammalian cells: Base excision repair: the long and short of it
    • Robertson AB, Klungland A, Rognes T, Leiros I. 2009. DNA repair in mammalian cells: Base excision repair: the long and short of it. Cell Mol Life Sci 66(6):981-993.
    • (2009) Cell Mol Life Sci , vol.66 , Issue.6 , pp. 981-993
    • Robertson, A.B.1    Klungland, A.2    Rognes, T.3    Leiros, I.4
  • 45
    • 33646187811 scopus 로고    scopus 로고
    • The multifaceted mismatch-repair system
    • Jiricny J. 2006. The multifaceted mismatch-repair system. Nat Rev Mol Cell Biol 7(5):335-346.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , Issue.5 , pp. 335-346
    • Jiricny, J.1
  • 46
    • 84865155904 scopus 로고    scopus 로고
    • Does DNA repair occur during somatic hypermutation
    • Saribasak H, Gearhart PJ. 2012. Does DNA repair occur during somatic hypermutation? Semin Immunol 24(4):287-292.
    • (2012) Semin Immunol , vol.24 , Issue.4 , pp. 287-292
    • Saribasak, H.1    Gearhart, P.J.2
  • 48
    • 33846415063 scopus 로고    scopus 로고
    • Somatic hypermutation: activationinduced deaminase for C/G followed by polymerase eta for A/T
    • Neuberger MS, Rada C. 2007. Somatic hypermutation: activationinduced deaminase for C/G followed by polymerase eta for A/T. J Exp Med 204(1):7-10.
    • (2007) J Exp Med , vol.204 , Issue.1 , pp. 7-10
    • Neuberger, M.S.1    Rada, C.2
  • 49
    • 0034614916 scopus 로고    scopus 로고
    • Somatic hypermutation in MutS homologue (MSH)3-., MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern
    • Wiesendanger M, Kneitz B, Edelmann W, Scharff MD. 2000. Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern. J Exp Med 191(3):579- 584.
    • (2000) J Exp Med , vol.191 , Issue.3 , pp. 579- 584
    • Wiesendanger, M.1    Kneitz, B.2    Edelmann, W.3    Scharff, M.D.4
  • 50
    • 33749519393 scopus 로고    scopus 로고
    • Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice
    • Shen HM, Tanaka A, Bozek G, Nicolae D, Storb U. 2006. Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice. J Immunol 177(8):5386-5392.
    • (2006) J Immunol , vol.177 , Issue.8 , pp. 5386-5392
    • Shen, H.M.1    Tanaka, A.2    Bozek, G.3    Nicolae, D.4    Storb, U.5
  • 52
    • 0035377269 scopus 로고    scopus 로고
    • DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes
    • Zeng X, Winter DB, Kasmer C, Kraemer KH, Lehmann AR, Gearhart PJ. 2001. DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes. Nat Immunol 2(6):537-541.
    • (2001) Nat Immunol , vol.2 , Issue.6 , pp. 537-541
    • Zeng, X.1    Winter, D.B.2    Kasmer, C.3    Kraemer, K.H.4    Lehmann, A.R.5    Gearhart, P.J.6
  • 53
    • 33846404877 scopus 로고    scopus 로고
    • DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse
    • Delbos F, Aoufouchi S, Faili A, Weill JC, Reynaud CA. 2007. DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse. J Exp Med 204(1): 17-23.
    • (2007) J Exp Med , vol.204 , Issue.1 , pp. 17-23
    • Delbos, F.1    Aoufouchi, S.2    Faili, A.3    Weill, J.C.4    Reynaud, C.A.5
  • 55
    • 6344256944 scopus 로고    scopus 로고
    • Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation
    • Rada C, Di Noia JM, Neuberger MS. 2004. Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation. Mol Cell 16(2):163- 171.
    • (2004) Mol Cell , vol.16 , Issue.2 , pp. 163-171
    • Rada, C.1    Di Noia, J.M.2    Neuberger, M.S.3
  • 56
    • 84865166222 scopus 로고    scopus 로고
    • AIDing antibody diversity by error-prone mismatch repair
    • Chahwan R, Edelmann W, Scharff MD, Roa S. 2012. AIDing antibody diversity by error-prone mismatch repair. Semin Immunol 24(4):293-300.
    • (2012) Semin Immunol , vol.24 , Issue.4 , pp. 293-300
    • Chahwan, R.1    Edelmann, W.2    Scharff, M.D.3    Roa, S.4
  • 57
    • 33748443257 scopus 로고    scopus 로고
    • The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice
    • Xue K, Rada C, Neuberger MS. 2006. The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice. J Exp Med 203(9):2085-2094.
    • (2006) J Exp Med , vol.203 , Issue.9 , pp. 2085-2094
    • Xue, K.1    Rada, C.2    Neuberger, M.S.3
  • 58
    • 39749182247 scopus 로고    scopus 로고
    • Antibody diversification by somatic mutation: from Burnet onwards
    • Neuberger MS. 2008. Antibo. dy diversification by somatic mutation: from Burnet onwards. Immunol Cell Biol 86(2):124-132.
    • (2008) Immunol Cell Biol , vol.86 , Issue.2 , pp. 124-132
    • Neuberger, M.S.1
  • 59
    • 0019794854 scopus 로고
    • Differences between germ-line and rearranged immunoglobulin V kappa coding sequences suggest a localized mutation mechanism
    • Pech M, Hochtl J, Schnell H, Zachau HG. 1981. Differences between germ-line and rearranged immunoglobulin V kappa coding sequences suggest a localized mutation mechanism. Nature 291(5817):668-670.
    • (1981) Nature , vol.291 , Issue.5817 , pp. 668-670
    • Pech, M.1    Hochtl, J.2    Schnell, H.3    Zachau, H.G.4
  • 60
    • 0024517665 scopus 로고
    • V gene rearrangement is required to fully activate the hypermutation mechanism in B cells
    • Roes J, Huppi K, Rajewsky K, Sablitzky F. 1989. V gene rearrangement is required to fully activate the hypermutation mechanism in B cells. J Immunol 142(3):1022-1026.
    • (1989) J Immunol , vol.142 , Issue.3 , pp. 1022-1026
    • Roes, J.1    Huppi, K.2    Rajewsky, K.3    Sablitzky, F.4
  • 61
    • 0342711256 scopus 로고    scopus 로고
    • In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
    • Lam KP, Kuhn R, Rajewsky K. 1997. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 90(6):1073-1083.
    • (1997) Cell , vol.90 , Issue.6 , pp. 1073-1083
    • Lam, K.P.1    Kuhn, R.2    Rajewsky, K.3
  • 62
    • 0027227311 scopus 로고
    • Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes
    • Betz AG, Neuberger MS, Milstein C. 1993. Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes. Immunol Today 14(8):405-411.
    • (1993) Immunol Today , vol.14 , Issue.8 , pp. 405-411
    • Betz, A.G.1    Neuberger, M.S.2    Milstein, C.3
  • 63
    • 0027499308 scopus 로고
    • Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots
    • Betz AG, Rada C, Pannell R, Milstein C, Neuberger MS. 1993. Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. Proc Natl Acad Sci USA 90(6):2385-2388.
    • (1993) Proc Natl Acad Sci USA , vol.90 , Issue.6 , pp. 2385-2388
    • Betz, A.G.1    Rada, C.2    Pannell, R.3    Milstein, C.4    Neuberger, M.S.5
  • 66
    • 0030978963 scopus 로고    scopus 로고
    • Codon bias and plasticity in immunoglobulins
    • Kepler TB. 1997. Codon bias and plasticity in immunoglobulins. Mol Biol Evol 14(6):637-643.
    • (1997) Mol Biol Evol , vol.14 , Issue.6 , pp. 637-643
    • Kepler, T.B.1
  • 67
    • 0032585719 scopus 로고    scopus 로고
    • Somatic hypermutation of VkappaJkappa rearrangements: targeting of RGYW motifs on both DNA strands and preferential selection of mutated codons within RGYW motifs
    • Foster SJ, Dorner T, Lipsky PE. 1999. Somatic hypermutation of VkappaJkappa rearrangements: targeting of RGYW motifs on both DNA strands and preferential selection of mutated codons within RGYW motifs. Eur J Immunol 29(12):4011-4021.
    • (1999) Eur J Immunol , vol.29 , Issue.12 , pp. 4011-4021
    • Foster, S.J.1    Dorner, T.2    Lipsky, P.E.3
  • 68
    • 0035881820 scopus 로고    scopus 로고
    • The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially
    • Rada C, Milstein C. 2001. The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially. EMBO J 20(16):4570-4576.
    • (2001) EMBO J , vol.20 , Issue.16 , pp. 4570-4576
    • Rada, C.1    Milstein, C.2
  • 70
    • 0027510316 scopus 로고
    • Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer
    • Azuma T, Motoyama N, Fields LE, Loh DY. 1993. Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer. Int Immunol 5(2):121-130.
    • (1993) Int Immunol , vol.5 , Issue.2 , pp. 121-130
    • Azuma, T.1    Motoyama, N.2    Fields, L.E.3    Loh, D.Y.4
  • 71
    • 0030063726 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
    • Peters A, Storb U. 1996. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity 4(1):57-65.
    • (1996) Immunity , vol.4 , Issue.1 , pp. 57-65
    • Peters, A.1    Storb, U.2
  • 72
    • 0033637358 scopus 로고    scopus 로고
    • DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation
    • Bross L, Fukita Y, McBlane F, Demolliere C, Rajewsky K, Jacobs H. 2000. DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation. Immunity 13(5):589-597.
    • (2000) Immunity , vol.13 , Issue.5 , pp. 589-597
    • Bross, L.1    Fukita, Y.2    McBlane, F.3    Demolliere, C.4    Rajewsky, K.5    Jacobs, H.6
  • 74
    • 84867742557 scopus 로고    scopus 로고
    • Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity
    • Briney BS, Willis JR, Crowe EF, Jr. 2012. Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity. Genes Immun 13 (7):523-529.
    • (2012) Genes Immun , vol.13 , Issue.7 , pp. 523-529
    • Briney, B.S.1    Willis, J.R.2    Crowe, E.F.3
  • 75
    • 0026515436 scopus 로고
    • Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell-dependent antigen
    • Weiss U, Zoebelein R, Rajewsky K. 1992. Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell-dependent antigen. Eur J Immunol 22(2):511-517.
    • (1992) Eur J Immunol , vol.22 , Issue.2 , pp. 511-517
    • Weiss, U.1    Zoebelein, R.2    Rajewsky, K.3
  • 76
    • 0025630537 scopus 로고
    • Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene
    • Lebecque SG, Gearhart PJ. 1990. Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene. J Exp Med 172 (6):1717-1727.
    • (1990) J Exp Med , vol.172 , Issue.6 , pp. 1717-1727
    • Lebecque, S.G.1    Gearhart, P.J.2
  • 78
    • 84879302728 scopus 로고    scopus 로고
    • HIV-1 neutralizing antibodies: understanding nature's pathways
    • Mascola JR, Haynes BF. 2013. HIV-1 neutralizing antibodies: understanding nature's pathways. Immunol Rev 254(1):225-244.
    • (2013) Immunol Rev , vol.254 , Issue.1 , pp. 225-244
    • Mascola, J.R.1    Haynes, B.F.2
  • 79
    • 0035839959 scopus 로고    scopus 로고
    • Mechanisms of chromosomal translocations in B cell lymphomas
    • Kuppers R, Dalla-Favera R. 2001. Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene 20(40):5580-5594.
    • (2001) Oncogene , vol.20 , Issue.40 , pp. 5580-5594
    • Kuppers, R.1    Dalla-Favera, R.2
  • 80
    • 79953032797 scopus 로고    scopus 로고
    • Mechanisms that promote and suppress chromosomal translocations in lymphocytes
    • Gostissa M, Alt FW, Chiarle R. 2011. Mechanisms that promote and suppress chromosomal translocations in lymphocytes. Annu Rev Immunol 29:319-350.
    • (2011) Annu Rev Immunol , vol.29 , pp. 319-350
    • Gostissa, M.1    Alt, F.W.2    Chiarle, R.3
  • 81
    • 84893404966 scopus 로고    scopus 로고
    • Why does somatic hypermutation by AID require transcription of its target genes
    • Storb U. 2014. Why does somatic hypermutation by AID require transcription of its target genes? Adv Immunol 122:253-277.
    • (2014) Adv Immunol , vol.122 , pp. 253-277
    • Storb, U.1
  • 82
    • 33746574474 scopus 로고    scopus 로고
    • Targeting of somatic hypermutation
    • Odegard VH, Schatz DG. 2006. Targeting of somatic hypermutation. Nat Rev Immunol 6(8):573-583.
    • (2006) Nat Rev Immunol , vol.6 , Issue.8 , pp. 573-583
    • Odegard, V.H.1    Schatz, D.G.2
  • 83
    • 0032127810 scopus 로고    scopus 로고
    • Somatic hypermutation in the heavy chain locus correlates with transcription
    • Fukita Y, Jacobs H, Rajewsky K. 1998. Somatic hypermutation in the heavy chain locus correlates with transcription. Immunity 9(1):105-114.
    • (1998) Immunity , vol.9 , Issue.1 , pp. 105-114
    • Fukita, Y.1    Jacobs, H.2    Rajewsky, K.3
  • 84
    • 0028270307 scopus 로고
    • Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region
    • Betz AG, Milstein C, Gonzalez-Fernandez A, Pannell R, Larson T, Neuberger MS. 1994. Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region. Cell 77(2):239-248.
    • (1994) Cell , vol.77 , Issue.2 , pp. 239-248
    • Betz, A.G.1    Milstein, C.2    Gonzalez-Fernandez, A.3    Pannell, R.4    Larson, T.5    Neuberger, M.S.6
  • 85
    • 0031041632 scopus 로고    scopus 로고
    • The transcriptional promoter regulates hypermutation of the antibody heavy chain locus
    • Tumas-Brundage K, Manser T. 1997. The transcriptional promoter regulates hypermutation of the antibody heavy chain locus. J Exp Med 185(2):239-250.
    • (1997) J Exp Med , vol.185 , Issue.2 , pp. 239-250
    • Tumas-Brundage, K.1    Manser, T.2
  • 86
    • 0025900034 scopus 로고
    • Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes
    • Sharpe MJ, Milstein C, Jarvis JM, Neuberger MS. 1991. Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes. EMBO J 10(8):2139-2145.
    • (1991) EMBO J , vol.10 , Issue.8 , pp. 2139-2145
    • Sharpe, M.J.1    Milstein, C.2    Jarvis, J.M.3    Neuberger, M.S.4
  • 87
    • 0035879125 scopus 로고    scopus 로고
    • A pivotal role for DNase I-sensitive regions 3b and/or 4 in the induction of somatic hypermutation of IgH genes
    • Terauchi A, Hayashi K, Kitamura D, Kozono Y, Motoyama N, Azuma T. 2001. A pivotal role for DNase I-sensitive regions 3b and/or 4 in the induction of somatic hypermutation of IgH genes. J Immunol 167 (2):811-820.
    • (2001) J Immunol , vol.167 , Issue.2 , pp. 811-820
    • Terauchi, A.1    Hayashi, K.2    Kitamura, D.3    Kozono, Y.4    Motoyama, N.5    Azuma, T.6
  • 88
    • 33745854188 scopus 로고    scopus 로고
    • Roles of the Ig kappa light chain intronic and 3' enhancers in Igk somatic hypermutation
    • Inlay MA, Gao HH, Odegard VH, Lin T, Schatz DG, Xu Y. 2006. Roles of the Ig kappa light chain intronic and 3' enhancers in Igk somatic hypermutation. J Immunol 177(2):1146-1151.
    • (2006) J Immunol , vol.177 , Issue.2 , pp. 1146-1151
    • Inlay, M.A.1    Gao, H.H.2    Odegard, V.H.3    Lin, T.4    Schatz, D.G.5    Xu, Y.6
  • 89
    • 0032081254 scopus 로고    scopus 로고
    • Reevaluation of 3' Ekappa function in stage- and lineage-specific rearrangement and somatic hypermutation
    • Van der Stoep N, Gorman JR, Alt FW. 1998. Reevaluation of 3' Ekappa function in stage- and lineage-specific rearrangement and somatic hypermutation. Immunity 8(6):743-750.
    • (1998) Immunity , vol.8 , Issue.6 , pp. 743-750
    • Van der Stoep, N.1    Gorman, J.R.2    Alt, F.W.3
  • 90
    • 26444515533 scopus 로고    scopus 로고
    • Elucidation of IgH intronic enhancer functions via germ-line deletion
    • Perlot T, Alt FW, Bassing CH, Suh H, Pinaud E. 2005. Elucidation of IgH intronic enhancer functions via germ-line deletion. Proc Natl Acad Sci USA 102(40):14362-14367.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.40 , pp. 14362-14367
    • Perlot, T.1    Alt, F.W.2    Bassing, C.H.3    Suh, H.4    Pinaud, E.5
  • 91
    • 0034741932 scopus 로고    scopus 로고
    • Localization of the 3' IgHlocus elements that effect longdistance regulation of class switch recombination
    • Pinaud E, Khamlichi AA, Le Morvan C, DrouetM, Nalesso V, Le Bert M, Cogne M. 2001. Localization of the 3' IgHlocus elements that effect longdistance regulation of class switch recombination. Immunity 15(2):187-199.
    • (2001) Immunity , vol.15 , Issue.2 , pp. 187-199
    • Pinaud, E.1    Khamlichi, A.A.2    Le Morvan, C.3    Drouet, M.4    Nalesso, V.5    Le Bert, M.6    Cogne, M.7
  • 92
    • 0041737474 scopus 로고    scopus 로고
    • The immunoglobulin heavy-chain locus hs3b and hs4 3' enhancers are dispensable for VDJ assembly and somatic hypermutation
    • Morvan CL, Pinaud E, Decourt C, Cuvillier A, Cogne M. 2003. The immunoglobulin heavy-chain locus hs3b and hs4 3' enhancers are dispensable for VDJ assembly and somatic hypermutation. Blood 102 (4):1421-1427.
    • (2003) Blood , vol.102 , Issue.4 , pp. 1421-1427
    • Morvan, C.L.1    Pinaud, E.2    Decourt, C.3    Cuvillier, A.4    Cogne, M.5
  • 93
    • 77956899151 scopus 로고    scopus 로고
    • Genomic deletion of the whole IgH 3' regulatory region (hs3a, hs1,2, hs3b, and hs4) dramatically affects class switch recombination and Ig secretion to all isotypes
    • Vincent-Fabert C, Fiancette R, Pinaud E, Truffinet V, Cogne N, Cogne M, Denizot Y. 2010. Genomic deletion of the whole IgH 3' regulatory region (hs3a, hs1,2, hs3b, and hs4) dramatically affects class switch recombination and Ig secretion to all isotypes. Blood 116(11):1895-1898.
    • (2010) Blood , vol.116 , Issue.11 , pp. 1895-1898
    • Vincent-Fabert, C.1    Fiancette, R.2    Pinaud, E.3    Truffinet, V.4    Cogne, N.5    Cogne, M.6    Denizot, Y.7
  • 95
    • 84900400827 scopus 로고    scopus 로고
    • Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences
    • Buerstedde JM, Alinikula J, Arakawa H, McDonald JJ, Schatz DG. 2014. Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences. PLoS Biol 12(4):e1001831.
    • (2014) PLoS Biol , vol.12 , Issue.4 , pp. e1001831
    • Buerstedde, J.M.1    Alinikula, J.2    Arakawa, H.3    McDonald, J.J.4    Schatz, D.G.5
  • 96
    • 84862865669 scopus 로고    scopus 로고
    • Immunoglobulin classswitch DNA recombination: induction, targeting and beyond
    • Xu Z, Zan H, Pone EJ, Mai T, Casali P. 2012. Immunoglobulin classswitch DNA recombination: induction, targeting and beyond. Nat Rev Immunol 12(7):517-31.
    • (2012) Nat Rev Immunol , vol.12 , Issue.7 , pp. 517-531
    • Xu, Z.1    Zan, H.2    Pone, E.J.3    Mai, T.4    Casali, P.5
  • 97
    • 84886717582 scopus 로고    scopus 로고
    • The AID-induced DNA damage response in chromatin
    • Daniel JA, Nussenzweig A. 2013. The AID-induced DNA damage response in chromatin. Mol Cell 50(3):309-321.
    • (2013) Mol Cell , vol.50 , Issue.3 , pp. 309-321
    • Daniel, J.A.1    Nussenzweig, A.2
  • 100
    • 0032004953 scopus 로고    scopus 로고
    • Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae
    • Hartzog GA, Wada T, Handa H, Winston F. 1998. Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae. Genes Dev 12(3):357-369.
    • (1998) Genes Dev , vol.12 , Issue.3 , pp. 357-369
    • Hartzog, G.A.1    Wada, T.2    Handa, H.3    Winston, F.4
  • 101
    • 4344700569 scopus 로고    scopus 로고
    • Replication protein A interacts with AID to promote deamination of somatic hypermutation targets
    • Chaudhuri J, Khuong C, Alt FW. 2004. Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature 430(7003):992-998.
    • (2004) Nature , vol.430 , Issue.7003 , pp. 992-998
    • Chaudhuri, J.1    Khuong, C.2    Alt, F.W.3
  • 106
    • 4444239054 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled
    • Shen HM, Storb U. 2004. Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled. Proc Natl Acad Sci USA 101(35):12997-13002.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.35 , pp. 12997-13002
    • Shen, H.M.1    Storb, U.2
  • 107
    • 33644636246 scopus 로고    scopus 로고
    • AID in somatic hypermutation and class switch recombination
    • Longerich S, Basu U, Alt F, Storb U. 2006. AID in somatic hypermutation and class switch recombination. Curr Opin Immunol 18 (2):164-174.
    • (2006) Curr Opin Immunol , vol.18 , Issue.2 , pp. 164-174
    • Longerich, S.1    Basu, U.2    Alt, F.3    Storb, U.4
  • 110
    • 2642623612 scopus 로고    scopus 로고
    • Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes
    • Shen HM, Peters A, Baron B, Zhu X, Storb U. 1998. Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. Science 280(5370):1750-1752.
    • (1998) Science , vol.280 , Issue.5370 , pp. 1750-1752
    • Shen, H.M.1    Peters, A.2    Baron, B.3    Zhu, X.4    Storb, U.5
  • 114
    • 0023889066 scopus 로고
    • Mitogen- and IL-4-regulated expression of germ-line Ig gamma 2b transcripts: evidence for directed heavy chain class switching
    • Lutzker S, Rothman P, Pollock R, Coffman R, Alt FW. 1988. Mitogen- and IL-4-regulated expression of germ-line Ig gamma 2b transcripts: evidence for directed heavy chain class switching. Cell 53(2):177-184.
    • (1988) Cell , vol.53 , Issue.2 , pp. 177-184
    • Lutzker, S.1    Rothman, P.2    Pollock, R.3    Coffman, R.4    Alt, F.W.5
  • 115
    • 0025214025 scopus 로고
    • Structure and expression of germ line immunoglobulin heavychain epsilon transcripts: interleukin-4 plus lipopolysaccharide-directed switching to C epsilon
    • Rothman P, Chen YY, Lutzker S, Li SC, Stewart V, Coffman R, Alt FW. 1990. Structure and expression of germ line immunoglobulin heavychain epsilon transcripts: interleukin-4 plus lipopolysaccharide-directed switching to C epsilon. Mol Cell Biol 10(4):1672-1679.
    • (1990) Mol Cell Biol , vol.10 , Issue.4 , pp. 1672-1679
    • Rothman, P.1    Chen, Y.Y.2    Lutzker, S.3    Li, S.C.4    Stewart, V.5    Coffman, R.6    Alt, F.W.7
  • 116
    • 0024385049 scopus 로고
    • Rapid induction of transcription of unrearranged S gamma 1 switch regions in activated murine B cells by interleukin 4
    • Esser C, Radbruch A. 1989. Rapid induction of transcription of unrearranged S gamma 1 switch regions in activated murine B cells by interleukin 4. EMBO J 8(2):483-488.
    • (1989) EMBO J , vol.8 , Issue.2 , pp. 483-488
    • Esser, C.1    Radbruch, A.2
  • 117
    • 0038664358 scopus 로고    scopus 로고
    • The influence of transcriptional orientation on endogenous switch region function
    • Shinkura R, Tian M, Smith M, Chua K, Fujiwara Y, Alt FW. 2003. The influence of transcriptional orientation on endogenous switch region function. Nat Immunol 4(5):435-441.
    • (2003) Nat Immunol , vol.4 , Issue.5 , pp. 435-441
    • Shinkura, R.1    Tian, M.2    Smith, M.3    Chua, K.4    Fujiwara, Y.5    Alt, F.W.6
  • 118
    • 0021011005 scopus 로고
    • Deletion of Cmu genes in mouse B lymphocytes upon stimulation with LPS
    • Radbruch A, Sablitzky F. 1983. Deletion of Cmu genes in mouse B lymphocytes upon stimulation with LPS. EMBO J 2(11):1929-1935.
    • (1983) EMBO J , vol.2 , Issue.11 , pp. 1929-1935
    • Radbruch, A.1    Sablitzky, F.2
  • 119
    • 0345671747 scopus 로고
    • Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG1-secreting Bcell blasts
    • Radbruch A, Muller W, Rajewsky K. 1986. Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG1-secreting Bcell blasts. Proc Natl Acad Sci USA 83(11):3954-3957.
    • (1986) Proc Natl Acad Sci USA , vol.83 , Issue.11 , pp. 3954-3957
    • Radbruch, A.1    Muller, W.2    Rajewsky, K.3
  • 120
    • 0027417869 scopus 로고
    • Shutdown of class switch recombination by deletion of a switch region control element
    • Jung S, Rajewsky K, Radbruch A. 1993. Shutdown of class switch recombination by deletion of a switch region control element. Science 259 (5097):984-987.
    • (1993) Science , vol.259 , Issue.5097 , pp. 984-987
    • Jung, S.1    Rajewsky, K.2    Radbruch, A.3
  • 121
    • 0027273019 scopus 로고
    • A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon
    • Zhang J, Bottaro A, Li S, Stewart V, Alt FW. 1993. A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon. EMBO J 12(9):3529-3537.
    • (1993) EMBO J , vol.12 , Issue.9 , pp. 3529-3537
    • Zhang, J.1    Bottaro, A.2    Li, S.3    Stewart, V.4    Alt, F.W.5
  • 122
    • 0027952630 scopus 로고
    • S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process
    • Bottaro A, Lansford R, Xu L, Zhang J, Rothman P, Alt FW. 1994. S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process. EMBO J 13(3):665-674.
    • (1994) EMBO J , vol.13 , Issue.3 , pp. 665-674
    • Bottaro, A.1    Lansford, R.2    Xu, L.3    Zhang, J.4    Rothman, P.5    Alt, F.W.6
  • 123
    • 0031784464 scopus 로고    scopus 로고
    • An expressed neo(r) cassette provides required functions of the 1gamma2b exon for class switching
    • Seidl KJ, Bottaro A, Vo A, Zhang J, Davidson L, Alt FW. 1998. An expressed neo(r) cassette provides required functions of the 1gamma2b exon for class switching. Int Immunol 10(11):1683-1692.
    • (1998) Int Immunol , vol.10 , Issue.11 , pp. 1683-1692
    • Seidl, K.J.1    Bottaro, A.2    Vo, A.3    Zhang, J.4    Davidson, L.5    Alt, F.W.6
  • 124
    • 0028968667 scopus 로고
    • Switch transcripts in immunoglobulin class switching
    • Lorenz M, Jung S, Radbruch A. 1995. Switch transcripts in immunoglobulin class switching. Science 267(5205):1825-1828.
    • (1995) Science , vol.267 , Issue.5205 , pp. 1825-1828
    • Lorenz, M.1    Jung, S.2    Radbruch, A.3
  • 125
    • 0032589096 scopus 로고    scopus 로고
    • Ialpha exon-replacement mice synthesize a spliced HPRT-C(alpha) transcript which may explain their ability to switch to IgA
    • Qiu G, Harriman GR, Stavnezer J. 1999. Ialpha exon-replacement mice synthesize a spliced HPRT-C(alpha) transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice. Int Immunol 11(1):37-46.
    • (1999) Inhibition of switching to IgG in these mice. Int Immunol , vol.11 , Issue.1 , pp. 37-46
    • Qiu, G.1    Harriman, G.R.2    Stavnezer, J.3
  • 126
  • 127
    • 0033021138 scopus 로고    scopus 로고
    • Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus
    • Seidl KJ, Manis JP, Bottaro A, Zhang J, Davidson L, Kisselgof A, Oettgen H, Alt FW. 1999. Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus. Proc Natl Acad Sci USA 96(6):3000-3005.
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.6 , pp. 3000-3005
    • Seidl, K.J.1    Manis, J.P.2    Bottaro, A.3    Zhang, J.4    Davidson, L.5    Kisselgof, A.6    Oettgen, H.7    Alt, F.W.8
  • 128
    • 36148940618 scopus 로고    scopus 로고
    • S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase
    • Wuerffel R, Wang L, Grigera F, Manis J, Selsing E, Perlot T, Alt FW, Cogne M, Pinaud E, Kenter AL. 2007. S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase. Immunity 27(5):711-722.
    • (2007) Immunity , vol.27 , Issue.5 , pp. 711-722
    • Wuerffel, R.1    Wang, L.2    Grigera, F.3    Manis, J.4    Selsing, E.5    Perlot, T.6    Alt, F.W.7    Cogne, M.8    Pinaud, E.9    Kenter, A.L.10
  • 129
    • 79961002783 scopus 로고    scopus 로고
    • Homologous elements hs3a and hs3b in the 3' regulatory region of the murine immunoglobulin heavy chain (Igh) locus are both dispensable for class-switch recombination
    • Yan Y, Pieretti J, Ju Z, Wei S, Christin JR, Bah F, Birshtein BK, Eckhardt LA. 2011. Homologous elements hs3a and hs3b in the 3' regulatory region of the murine immunoglobulin heavy chain (Igh) locus are both dispensable for class-switch recombination. J Biol Chem 286 (31):27123-27131.
    • (2011) J Biol Chem , vol.286 , Issue.31 , pp. 27123-27131
    • Yan, Y.1    Pieretti, J.2    Ju, Z.3    Wei, S.4    Christin, J.R.5    Bah, F.6    Birshtein, B.K.7    Eckhardt, L.A.8
  • 130
    • 79960990878 scopus 로고    scopus 로고
    • Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination
    • Han L, Masani S, Yu K. 2011. Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination. Proc Natl Acad Sci USA 108(28):11584-11589.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.28 , pp. 11584-11589
    • Han, L.1    Masani, S.2    Yu, K.3
  • 132
    • 1842298136 scopus 로고    scopus 로고
    • Microsites for immunoglobulin switch recombination breakpoints from Xenopus to mammals
    • Mussmann R, Courtet M, Schwager J, Du Pasquier L. 1997. Microsites for immunoglobulin switch recombination breakpoints from Xenopus to mammals. Eur J Immunol 27(10):2610-2619.
    • (1997) Eur J Immunol , vol.27 , Issue.10 , pp. 2610-2619
    • Mussmann, R.1    Courtet, M.2    Schwager, J.3    Du Pasquier, L.4
  • 133
    • 0037650190 scopus 로고    scopus 로고
    • R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
    • Yu K, Chedin F, Hsieh CL, Wilson TE, Lieber MR. 2003. R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat Immunol 4(5):442-451.
    • (2003) Nat Immunol , vol.4 , Issue.5 , pp. 442-451
    • Yu, K.1    Chedin, F.2    Hsieh, C.L.3    Wilson, T.E.4    Lieber, M.R.5
  • 134
    • 0025225502 scopus 로고
    • Induction of RNA-stabilized DNA conformers by transcription of an immunoglobulin switch region
    • Reaban ME, Griffin JA. 1990. Induction of RNA-stabilized DNA conformers by transcription of an immunoglobulin switch region. Nature 348(6299):342-344.
    • (1990) Nature , vol.348 , Issue.6299 , pp. 342-344
    • Reaban, M.E.1    Griffin, J.A.2
  • 135
    • 0029598833 scopus 로고
    • RNA:DNA complex formation upon transcription of immunoglobulin switch regions: implications for the mechanism and regulation of class switch recombination
    • Daniels GA, Lieber MR. 1995. RNA:DNA complex formation upon transcription of immunoglobulin switch regions: implications for the mechanism and regulation of class switch recombination. Nucleic Acids Res 23(24):5006-5011.
    • (1995) Nucleic Acids Res , vol.23 , Issue.24 , pp. 5006-5011
    • Daniels, G.A.1    Lieber, M.R.2
  • 136
    • 0034604622 scopus 로고    scopus 로고
    • Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro
    • Tian M, Alt FW. 2000. Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro. J Biol Chem 275(31):24163-24172.
    • (2000) J Biol Chem , vol.275 , Issue.31 , pp. 24163-24172
    • Tian, M.1    Alt, F.W.2
  • 137
    • 0013277286 scopus 로고    scopus 로고
    • Molecular visualization of immunoglobulin switch region RNA/DNA complex by atomic force microscope
    • Mizuta R, Iwai K, Shigeno M, Mizuta M, Uemura T, Ushiki T, Kitamura D. 2003. Molecular visualization of immunoglobulin switch region RNA/DNA complex by atomic force microscope. J Biol Chem 278 (7):4431-4434.
    • (2003) J Biol Chem , vol.278 , Issue.7 , pp. 4431-4434
    • Mizuta, R.1    Iwai, K.2    Shigeno, M.3    Mizuta, M.4    Uemura, T.5    Ushiki, T.6    Kitamura, D.7
  • 138
    • 37549036739 scopus 로고    scopus 로고
    • Mechanism of R-loop formation at immunoglobulin class switch sequences
    • Roy D, Yu K, Lieber MR. 2008. Mechanism of R-loop formation at immunoglobulin class switch sequences. Mol Cell Biol 28(1):50-60.
    • (2008) Mol Cell Biol , vol.28 , Issue.1 , pp. 50-60
    • Roy, D.1    Yu, K.2    Lieber, M.R.3
  • 139
    • 67449161835 scopus 로고    scopus 로고
    • Immunoglobulin switch mu sequence causes RNA polymerase II accumulation and reduces dA hypermutation
    • Rajagopal D, Maul RW, Ghosh A, Chakraborty T, Khamlichi AA, Sen R, Gearhart PJ. 2009. Immunoglobulin switch mu sequence causes RNA polymerase II accumulation and reduces dA hypermutation. J Exp Med 206(6):1237-1244.
    • (2009) J Exp Med , vol.206 , Issue.6 , pp. 1237-1244
    • Rajagopal, D.1    Maul, R.W.2    Ghosh, A.3    Chakraborty, T.4    Khamlichi, A.A.5    Sen, R.6    Gearhart, P.J.7
  • 140
    • 68149158825 scopus 로고    scopus 로고
    • S region sequence, RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombination
    • Wang L, Wuerffel R, Feldman S, Khamlichi AA, Kenter AL. 2009. S region sequence, RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombination. J Exp Med 206 (8):1817-1830.
    • (2009) J Exp Med , vol.206 , Issue.8 , pp. 1817-1830
    • Wang, L.1    Wuerffel, R.2    Feldman, S.3    Khamlichi, A.A.4    Kenter, A.L.5
  • 141
    • 62849104777 scopus 로고    scopus 로고
    • Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination
    • Vuong BQ, Lee M, Kabir S, Irimia C, Macchiarulo S, McKnight GS, Chaudhuri J. 2009. Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination. Nat Immunol 10(4):420-426.
    • (2009) Nat Immunol , vol.10 , Issue.4 , pp. 420-426
    • Vuong, B.Q.1    Lee, M.2    Kabir, S.3    Irimia, C.4    Macchiarulo, S.5    McKnight, G.S.6    Chaudhuri, J.7
  • 145
    • 84872287592 scopus 로고    scopus 로고
    • Regulation of AID, the B-cell genome mutator
    • Keim C, Kazadi D, Rothschild G, Basu U. 2013. Regulation of AID, the B-cell genome mutator. Genes Dev 27(1):1-17.
    • (2013) Genes Dev , vol.27 , Issue.1 , pp. 1-17
    • Keim, C.1    Kazadi, D.2    Rothschild, G.3    Basu, U.4
  • 146
    • 3242881303 scopus 로고    scopus 로고
    • The phylogenetic origins of the antigen-binding receptors and somatic diversification mechanisms
    • Cannon JP, Haire RN, Rast JP, Litman GW. 2004. The phylogenetic origins of the antigen-binding receptors and somatic diversification mechanisms. Immunol Rev 200:12-22.
    • (2004) Immunol Rev , vol.200 , pp. 12-22
    • Cannon, J.P.1    Haire, R.N.2    Rast, J.P.3    Litman, G.W.4
  • 147
    • 7444271524 scopus 로고    scopus 로고
    • Evolution of isotype switching
    • Stavnezer J, Amemiya CT. 2004. Evolution of isotype switching. Semin Immunol 16(4):257-275.
    • (2004) Semin Immunol , vol.16 , Issue.4 , pp. 257-275
    • Stavnezer, J.1    Amemiya, C.T.2
  • 148
    • 14744275872 scopus 로고    scopus 로고
    • MutSalpha binds to and promotes synapsis of transcriptionally activated immunoglobulin switch regions
    • Larson ED, Duquette ML, Cummings WJ, Streiff RJ, Maizels N. 2005. MutSalpha binds to and promotes synapsis of transcriptionally activated immunoglobulin switch regions. Curr Biol +15(5):470-474.
    • (2005) Curr Biol , vol.15 , Issue.5 , pp. 470-474
    • Larson, E.D.1    Duquette, M.L.2    Cummings, W.J.3    Streiff, R.J.4    Maizels, N.5
  • 151
    • 0037162518 scopus 로고    scopus 로고
    • Internal IgH class switch region deletions are position-independent and enhanced by AID expression
    • Dudley DD, Manis JP, Zarrin AA, Kaylor L, Tian M, Alt FW. 2002. Internal IgH class switch region deletions are position-independent and enhanced by AID expression. Proc Natl Acad Sci USA 99(15):9984- 9989.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.15 , pp. 9984- 9989
    • Dudley, D.D.1    Manis, J.P.2    Zarrin, A.A.3    Kaylor, L.4    Tian, M.5    Alt, F.W.6
  • 152
    • 33846606769 scopus 로고    scopus 로고
    • Antibody class switching mediated by yeast endonucleasegenerated DNA breaks
    • Zarrin AA, Del Vecchio C, Tseng E, Gleason M, Zarin P, Tian M, Alt FW. 2007. Antibody class switching mediated by yeast endonucleasegenerated DNA breaks. Science 315(5810):377-381.
    • (2007) Science , vol.315 , Issue.5810 , pp. 377-381
    • Zarrin, A.A.1    Del Vecchio, C.2    Tseng, E.3    Gleason, M.4    Zarin, P.5    Tian, M.6    Alt, F.W.7
  • 154
    • 84861095603 scopus 로고    scopus 로고
    • Topological domains in mammalian genomes identified by analysis of chromatin interactions
    • Dixon JR, Selvaraj S, Yue F, Kim A, Li Y, Shen Y, Hu M, Liu JS, Ren B. 2012. Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature 485(7398):376-380.
    • (2012) Nature , vol.485 , Issue.7398 , pp. 376-380
    • Dixon, J.R.1    Selvaraj, S.2    Yue, F.3    Kim, A.4    Li, Y.5    Shen, Y.6    Hu, M.7    Liu, J.S.8    Ren, B.9
  • 158
    • 84865975625 scopus 로고    scopus 로고
    • Three-dimensional architecture of the IgH locus facilitates class switch recombination
    • Kenter AL, Feldman S, Wuerffel R, Achour I, Wang L, Kumar S. 2012. Three-dimensional architecture of the IgH locus facilitates class switch recombination. Ann N Y Acad Sci 1267:86-94.
    • (2012) Ann N Y Acad Sci , vol.1267 , pp. 86-94
    • Kenter, A.L.1    Feldman, S.2    Wuerffel, R.3    Achour, I.4    Wang, L.5    Kumar, S.6
  • 159
    • 2442706035 scopus 로고    scopus 로고
    • H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity
    • Bassing CH, Alt FW. 2004. H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity. Cell Cycle 3(2):149-153.
    • (2004) Cell Cycle , vol.3 , Issue.2 , pp. 149-153
    • Bassing, C.H.1    Alt, F.W.2
  • 160
    • 77950955761 scopus 로고    scopus 로고
    • Origin of chromosomal translocations in lymphoid cancer
    • Nussenzweig A, Nussenzweig MC. 2010. Origin of chromosomal translocations in lymphoid cancer. Cell 141(1):27-38.
    • (2010) Cell , vol.141 , Issue.1 , pp. 27-38
    • Nussenzweig, A.1    Nussenzweig, M.C.2
  • 161
    • 0032861343 scopus 로고    scopus 로고
    • Megabase chromatin domains involved in DNA double-strand breaks in vivo
    • Rogakou EP, Boon C, Redon C, Bonner WM. 1999. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 146(5):905-916.
    • (1999) J Cell Biol , vol.146 , Issue.5 , pp. 905-916
    • Rogakou, E.P.1    Boon, C.2    Redon, C.3    Bonner, W.M.4
  • 164
    • 2442707746 scopus 로고    scopus 로고
    • 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination
    • Manis JP, Morales JC, Xia Z, Kutok JL, Alt FW, Carpenter PB. 2004. 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat Immunol 5(5):481-487.
    • (2004) Nat Immunol , vol.5 , Issue.5 , pp. 481-487
    • Manis, J.P.1    Morales, J.C.2    Xia, Z.3    Kutok, J.L.4    Alt, F.W.5    Carpenter, P.B.6
  • 166
    • 77951057068 scopus 로고    scopus 로고
    • 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
    • Bothmer A, Robbiani DF, Feldhahn N, Gazumyan A, Nussenzweig A, Nussenzweig MC. 2010. 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. J Exp Med 207(4):855-865.
    • (2010) J Exp Med , vol.207 , Issue.4 , pp. 855-865
    • Bothmer, A.1    Robbiani, D.F.2    Feldhahn, N.3    Gazumyan, A.4    Nussenzweig, A.5    Nussenzweig, M.C.6
  • 171
    • 84873488846 scopus 로고    scopus 로고
    • 53BP1 regulates DSB repair using Rif1 to control 5' end resection
    • Zimmermann M, Lottersberger F, Buonomo SB, Sfeir A, de Lange T. 2013. 53BP1 regulates DSB repair using Rif1 to control 5' end resection. Science 339(6120):700-704.
    • (2013) Science , vol.339 , Issue.6120 , pp. 700-704
    • Zimmermann, M.1    Lottersberger, F.2    Buonomo, S.B.3    Sfeir, A.4    de Lange, T.5
  • 172
    • 84894279992 scopus 로고    scopus 로고
    • Functional overlaps between XLF and the ATM-dependent DNA double strand break response
    • Kumar V, Alt FW, Oksenych V. 2014. Functional overlaps between XLF and the ATM-dependent DNA double strand break response. DNA Repair 16:11-22.
    • (2014) DNA Repair , vol.16 , pp. 11-22
    • Kumar, V.1    Alt, F.W.2    Oksenych, V.3
  • 173
    • 77953229115 scopus 로고    scopus 로고
    • The mechanismof double-strandDNAbreak repair by the nonhomologous DNA end-joining pathway
    • Lieber MR.2010. The mechanismof double-strandDNAbreak repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem 79:181-211.
    • (2010) Annu Rev Biochem , vol.79 , pp. 181-211
    • Lieber, M.R.1
  • 174
    • 84867386682 scopus 로고    scopus 로고
    • Classical and alternative endjoining pathways for repair of lymphocyte-specific and general DNA double-strand breaks
    • Boboila C, Alt FW, Schwer B. 2012. Classical and alternative endjoining pathways for repair of lymphocyte-specific and general DNA double-strand breaks. Adv Immunol 116:1-49.
    • (2012) Adv Immunol , vol.116 , pp. 1-49
    • Boboila, C.1    Alt, F.W.2    Schwer, B.3
  • 176
    • 78149264026 scopus 로고    scopus 로고
    • Mapping of switch recombination junctions, a tool for studying DNA repair pathways during immunoglobulin class switching
    • Stavnezer J, Bjorkman A, Du L, Cagigi A, Pan-Hammarstrom W. 2010. Mapping of switch recombination junctions, a tool for studying DNA repair pathways during immunoglobulin class switching. Adv Immunol 108:45-109.
    • (2010) Adv Immunol , vol.108 , pp. 45-109
    • Stavnezer, J.1    Bjorkman, A.2    Du, L.3    Cagigi, A.4    Pan-Hammarstrom, W.5
  • 177
    • 0027156278 scopus 로고
    • Impairment of V(D)J recombination in double-strand break repair mutants
    • Taccioli GE, Rathbun G, Oltz E, Stamato T, Jeggo PA, Alt FW. 1993. Impairment of V(D)J recombination in double-strand break repair mutants. Science 260(5105):207-210.
    • (1993) Science , vol.260 , Issue.5105 , pp. 207-210
    • Taccioli, G.E.1    Rathbun, G.2    Oltz, E.3    Stamato, T.4    Jeggo, PA.5    Alt, F.W.6
  • 178
    • 3242875642 scopus 로고    scopus 로고
    • The DNAdependent protein kinase: the director at the end
    • Meek K, Gupta S, Ramsden DA, Lees-Miller SP. 2004. The DNAdependent protein kinase: the director at the end. Immunol Rev 200:132-141.
    • (2004) Immunol Rev , vol.200 , pp. 132-141
    • Meek, K.1    Gupta, S.2    Ramsden, D.A.3    Lees-Miller, S.P.4
  • 185
    • 0036152242 scopus 로고    scopus 로고
    • Mechanism and control of classswitch recombination
    • Manis JP, Tian M, Alt FW. 2002. Mechanism and control of classswitch recombination. Trends Immunol 23(1):31-39.
    • (2002) Trends Immunol , vol.23 , Issue.1 , pp. 31-39
    • Manis, J.P.1    Tian, M.2    Alt, F.W.3
  • 186
    • 0345735841 scopus 로고    scopus 로고
    • Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions
    • Cook AJ, Oganesian L, Harumal P, Basten A, Brink R, Jolly CJ. 2003. Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions. J Immunol 171(12):6556-6564.
    • (2003) J Immunol , vol.171 , Issue.12 , pp. 6556-6564
    • Cook, A.J.1    Oganesian, L.2    Harumal, P.3    Basten, A.4    Brink, R.5    Jolly, C.J.6
  • 188
    • 33847276659 scopus 로고    scopus 로고
    • The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination
    • Kiefer K, Oshinsky J, Kim J, Nakajima PB, Bosma GC, Bosma MJ. 2007. The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination. Proc Natl Acad Sci USA 104 (8):2843-2848.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.8 , pp. 2843-2848
    • Kiefer, K.1    Oshinsky, J.2    Kim, J.3    Nakajima, P.B.4    Bosma, G.C.5    Bosma, M.J.6
  • 190
    • 41149099048 scopus 로고    scopus 로고
    • DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination
    • Franco S, Murphy MM, Li G, Borjeson T, Boboila C, Alt FW. 2008. DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination. J Exp Med 205(3):557-564.
    • (2008) J Exp Med , vol.205 , Issue.3 , pp. 557-564
    • Franco, S.1    Murphy, MM.2    Li, G.3    Borjeson, T.4    Boboila, C.5    Alt, F.W.6
  • 194
    • 0037128169 scopus 로고    scopus 로고
    • Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation
    • Nagaoka H, Muramatsu M, Yamamura N, Kinoshita K, Honjo T. 2002. Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation. J Exp Med 195(4):529-534.
    • (2002) J Exp Med , vol.195 , Issue.4 , pp. 529-534
    • Nagaoka, H.1    Muramatsu, M.2    Yamamura, N.3    Kinoshita, K.4    Honjo, T.5
  • 195
    • 63149179802 scopus 로고    scopus 로고
    • Balancing AID and DNA repair during somatic hypermutation
    • Liu M, Schatz DG. 2009. Balancing AID and DNA repair during somatic hypermutation. Trends Immunol 30(4):173-181.
    • (2009) Trends Immunol , vol.30 , Issue.4 , pp. 173-181
    • Liu, M.1    Schatz, D.G.2
  • 196
    • 0032476611 scopus 로고    scopus 로고
    • Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells
    • Klein U, Rajewsky K, Kuppers R. 1998. Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med 188 (9):1679-1689.
    • (1998) J Exp Med , vol.188 , Issue.9 , pp. 1679-1689
    • Klein, U.1    Rajewsky, K.2    Kuppers, R.3
  • 198
    • 0026786650 scopus 로고
    • High frequency of somatically mutated IgM molecules in the human adult blood B cell repertoire
    • van Es JH, Meyling FH, Logtenberg T. 1992. High frequency of somatically mutated IgM molecules in the human adult blood B cell repertoire. Eur J Immunol 22(10):2761-2764.
    • (1992) Eur J Immunol , vol.22 , Issue.10 , pp. 2761-2764
    • van Es, J.H.1    Meyling, F.H.2    Logtenberg, T.3
  • 199
    • 0037074975 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas
    • Martin A, Bardwell PD, Woo CJ, Fan M, Shulman MJ, Scharff MD. 2002. Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas. Nature 415(6873):802-806.
    • (2002) Nature , vol.415 , Issue.6873 , pp. 802-806
    • Martin, A.1    Bardwell, P.D.2    Woo, C.J.3    Fan, M.4    Shulman, M.J.5    Scharff, M.D.6
  • 200
    • 0032435650 scopus 로고    scopus 로고
    • TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line
    • Sale JE, Neuberger MS. 1998. TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line. Immunity 9(6):859-869.
    • (1998) Immunity , vol.9 , Issue.6 , pp. 859-869
    • Sale, J.E.1    Neuberger, M.S.2
  • 202
    • 0030071749 scopus 로고    scopus 로고
    • An immunoglobulin mutator that targets G
    • USA
    • Bachl J, Wabl M. 1996. An immunoglobulin mutator that targets G. C base pairs. Proc Natl Acad Sci USA 93(2):851-855.
    • (1996) C base pairs. Proc Natl Acad Sci , vol.93 , Issue.2 , pp. 851-855
    • Bachl, J.1    Wabl, M.2
  • 204
    • 0032555232 scopus 로고    scopus 로고
    • Both DNA strands of antibody genes are hypermutation targets
    • USA
    • Milstein C, Neuberger MS, Staden R. 1998. Both DNA strands of antibody genes are hypermutation targets. Proc Natl Acad Sci USA 95 (15):8791-8794.
    • (1998) Proc Natl Acad Sci , vol.95 , Issue.15 , pp. 8791-8794
    • Milstein, C.1    Neuberger, M.S.2    Staden, R.3
  • 205
    • 0029872907 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes
    • Wagner SD, Neuberger MS. 1996. Somatic hypermutation of immunoglobulin genes. Annu Rev Immunol 14:441-457.
    • (1996) Annu Rev Immunol , vol.14 , pp. 441-457
    • Wagner, S.D.1    Neuberger, M.S.2
  • 207
    • 20044379457 scopus 로고    scopus 로고
    • An update on the role of translesion synthesis DNA polymerases in Ig hypermutation
    • Diaz M, Lawrence C. 2005. An update on the role of translesion synthesis DNA polymerases in Ig hypermutation. Trends Immunol 26 (4):215-220.
    • (2005) Trends Immunol , vol.26 , Issue.4 , pp. 215-220
    • Diaz, M.1    Lawrence, C.2


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