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Volumn 8, Issue 3, 1996, Pages 159-168

The targeting of somatic hypermutation

Author keywords

Affinity maturation; Evolution; Hypermutation; Immunoglobulins; V genes

Indexed keywords

ARTICLE; DNA SEQUENCE; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; MOUSE; MUTATION RATE; NONHUMAN; SOMATIC MUTATION;

EID: 0029992777     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.1996.0020     Document Type: Article
Times cited : (92)

References (53)
  • 1
    • 0023821895 scopus 로고
    • The dynamic nature of the antibody repertoire
    • Berek C, Milstein C (1988) The dynamic nature of the antibody repertoire. Immunol Rev 105:5-26
    • (1988) Immunol Rev , vol.105 , pp. 5-26
    • Berek, C.1    Milstein, C.2
  • 2
    • 0023161406 scopus 로고
    • Mutation drift and repertoire shift in the maturation of the immune response
    • Berek C, Milstein C (1987) Mutation drift and repertoire shift in the maturation of the immune response. Immunol Rev 96:23-41
    • (1987) Immunol Rev , vol.96 , pp. 23-41
    • Berek, C.1    Milstein, C.2
  • 3
    • 0027499308 scopus 로고
    • Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: Clustering, polarity, and specific hot spots
    • Betz AG, Rada C, Pannell R, Milstein C, Neuberger MS (1993) Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. Proc Natl Acad Sci USA 90:2385-2388
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2385-2388
    • Betz, A.G.1    Rada, C.2    Pannell, R.3    Milstein, C.4    Neuberger, M.S.5
  • 4
    • 0025900034 scopus 로고
    • Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes
    • Sharpe MJ, Milstein C, Jarvis JM, Neuberger MS (1991) Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes. EMBO J 10:2139-2145
    • (1991) EMBO J , vol.10 , pp. 2139-2145
    • Sharpe, M.J.1    Milstein, C.2    Jarvis, J.M.3    Neuberger, M.S.4
  • 5
    • 0028270307 scopus 로고
    • Elements regulating somatic hypermutation of an immunoglobulin kappa gene - Critical role for the intron enhancer matrix attachment region
    • Betz AG, Milstein C, Gonzalez-Fernandez A, Pannell R, Larson T, Neuberger MS (1994) Elements regulating somatic hypermutation of an immunoglobulin kappa gene - critical role for the intron enhancer matrix attachment region. Cell 77:239-248
    • (1994) Cell , vol.77 , pp. 239-248
    • Betz, A.G.1    Milstein, C.2    Gonzalez-Fernandez, A.3    Pannell, R.4    Larson, T.5    Neuberger, M.S.6
  • 7
    • 0027174495 scopus 로고
    • Affinity maturation leads to differential expression of multiple copies of a kappa light-chain transgene
    • Lozano F, Rada C, Jarvis JM, Milstein C (1993) Affinity maturation leads to differential expression of multiple copies of a kappa light-chain transgene. Nature 363:271-273
    • (1993) Nature , vol.363 , pp. 271-273
    • Lozano, F.1    Rada, C.2    Jarvis, J.M.3    Milstein, C.4
  • 8
    • 0028577994 scopus 로고
    • Somatic mutation of immunoglobulin lambda chains: A segment of the major intron hypermutates as much as the complementarity-determining regions
    • González-Fernández A, Gupta SK, Pannell R, Neuberger MS, Milstein C (1994) Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions. Proc Natl Acad Sci USA 91:12614-12618
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12614-12618
    • González-Fernández, A.1    Gupta, S.K.2    Pannell, R.3    Neuberger, M.S.4    Milstein, C.5
  • 10
    • 0025630537 scopus 로고
    • Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is approximately 1 kb from V(D)J gene
    • Lebecque SG, Gearhart PJ (1990) Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is approximately 1 kb from V(D)J gene. J Exp Med 172:1717-1727
    • (1990) J Exp Med , vol.172 , pp. 1717-1727
    • Lebecque, S.G.1    Gearhart, P.J.2
  • 11
    • 0023107028 scopus 로고
    • Patterns of somatic mutations in immunoglobulin variable genes
    • Golding GB, Gearhart PJ, Glickman BW (1987) Patterns of somatic mutations in immunoglobulin variable genes. Genetics 115:169-176
    • (1987) Genetics , vol.115 , pp. 169-176
    • Golding, G.B.1    Gearhart, P.J.2    Glickman, B.W.3
  • 12
    • 0025148941 scopus 로고
    • Distribution of mutations around rearranged heavy-chain antibody variable-region genes
    • 2. Both GW, Taylor L, Pollard JW, Steele EJ (1990) Distribution of mutations around rearranged heavy-chain antibody variable-region genes. Mol Cell Biol 10:5187-5196
    • (1990) Mol Cell Biol , vol.10 , pp. 5187-5196
    • Both, G.W.1    Taylor, L.2    Pollard, J.W.3    Steele, E.J.4
  • 13
    • 0025817171 scopus 로고
    • Somatic hypermutation of the JC intron is markedly reduced in unrearranged kappa and H alleles and is unevenly distributed in rearranged alleles
    • 3. Weber JS, Berry J, Litwin S, Claflin JL (1991) Somatic hypermutation of the JC intron is markedly reduced in unrearranged kappa and H alleles and is unevenly distributed in rearranged alleles. J Immunol 146:3218-3226
    • (1991) J Immunol , vol.146 , pp. 3218-3226
    • Weber, J.S.1    Berry, J.2    Litwin, S.3    Claflin, J.L.4
  • 14
    • 0020503988 scopus 로고
    • Clusters of point mutations are found exclusively around rearranged antibody variable genes
    • Gearhart PJ, Bogenhagen DF (1983) Clusters of point mutations are found exclusively around rearranged antibody variable genes. Proc Natl Acad Sci USA 80:3439-3443
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 3439-3443
    • Gearhart, P.J.1    Bogenhagen, D.F.2
  • 15
    • 0027227311 scopus 로고
    • Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes
    • Betz AG, Neuberger MS, Milstein C (1993) Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes. Immunol Today 14:405-411
    • (1993) Immunol Today , vol.14 , pp. 405-411
    • Betz, A.G.1    Neuberger, M.S.2    Milstein, C.3
  • 16
    • 0024044570 scopus 로고
    • Antibody engineering for the analysis of affinity maturation of an anti-hapten response
    • 6. Allen D, Simon T, Sablitzky F, Rajewsky K, Cumano A (1988) Antibody engineering for the analysis of affinity maturation of an anti-hapten response. EMBO J 7:1995-2001
    • (1988) EMBO J , vol.7 , pp. 1995-2001
    • Allen, D.1    Simon, T.2    Sablitzky, F.3    Rajewsky, K.4    Cumano, A.5
  • 17
    • 0027364313 scopus 로고
    • Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenes
    • González-Fernández A, Milstein C (1993) Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenes. Proc Natl Acad Sci USA 90:9862-9866
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 9862-9866
    • González-Fernández, A.1    Milstein, C.2
  • 18
    • 0342509292 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes in Xeroderma pigmentosum (XP-D) patients
    • in press
    • Wagner SD, Elvin JD, MacGregor J, Norris P, Neuberger MS (1996) Somatic hypermutation of immunoglobulin genes in Xeroderma pigmentosum (XP-D) patients. Int Immunol, in press
    • (1996) Int Immunol
    • Wagner, S.D.1    Elvin, J.D.2    MacGregor, J.3    Norris, P.4    Neuberger, M.S.5
  • 20
    • 0027932819 scopus 로고
    • Bias in somatic hypermutation of human VH genes
    • Insel RA, Varade WS (1994) Bias in somatic hypermutation of human VH genes. Int Immunol 6:1437-1443
    • (1994) Int Immunol , vol.6 , pp. 1437-1443
    • Insel, R.A.1    Varade, W.S.2
  • 21
    • 0026443954 scopus 로고
    • Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis
    • Rogozin IB, Kolchanov NA (1992) Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis. Biochim Biophys Acta 1171:11-18
    • (1992) Biochim Biophys Acta , vol.1171 , pp. 11-18
    • Rogozin, I.B.1    Kolchanov, N.A.2
  • 22
    • 0023161504 scopus 로고
    • Peculiarities of immunoglobulin gene structures as a basis for somatic mutation emergence
    • Kolchanov NA, Solovyov VV, Rogozin IB (1987) Peculiarities of immunoglobulin gene structures as a basis for somatic mutation emergence. FEBS Lett 214:87-91
    • (1987) FEBS Lett , vol.214 , pp. 87-91
    • Kolchanov, N.A.1    Solovyov, V.V.2    Rogozin, I.B.3
  • 23
    • 0025726597 scopus 로고
    • Somatic hypermutagenesis in immunoglobulin genes. I. Correlation between somatic mutations and repeats. Somatic mutation properties and clonal selection
    • Rogozin IB, Solovyov VV, Kolchanov NA (1991) Somatic hypermutagenesis in immunoglobulin genes. I. Correlation between somatic mutations and repeats. Somatic mutation properties and clonal selection. Biochim Biophys Acta 1089:175-182
    • (1991) Biochim Biophys Acta , vol.1089 , pp. 175-182
    • Rogozin, I.B.1    Solovyov, V.V.2    Kolchanov, N.A.3
  • 24
    • 0028053754 scopus 로고
    • Analysis of patterns of DNA sequence variation in flanking and coding regions of murine germ-line immunoglobulin heavy-chain variable genes: Evolutionary implications
    • Rothenfluh HS, Gibbs AJ, Blanden RV, Steele EJ (1994) Analysis of patterns of DNA sequence variation in flanking and coding regions of murine germ-line immunoglobulin heavy-chain variable genes: evolutionary implications. Proc Natl Acad Sci USA 91:12163-12167
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12163-12167
    • Rothenfluh, H.S.1    Gibbs, A.J.2    Blanden, R.V.3    Steele, E.J.4
  • 26
    • 0028794835 scopus 로고
    • Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process
    • Reynaud CA, Garcia C, Hein WR, Weill JC (1995) Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process. Cell 80:115-125
    • (1995) Cell , vol.80 , pp. 115-125
    • Reynaud, C.A.1    Garcia, C.2    Hein, W.R.3    Weill, J.C.4
  • 29
    • 0025970135 scopus 로고
    • Somatic generation of diversity in a mammalian primary lymphoid organ: The sheep ileal Peyer's patches
    • Reynaud CA, Mackay CR, Muller RG, Weill JC (1991) Somatic generation of diversity in a mammalian primary lymphoid organ: the sheep ileal Peyer's patches. Cell 64:995-1005
    • (1991) Cell , vol.64 , pp. 995-1005
    • Reynaud, C.A.1    Mackay, C.R.2    Muller, R.G.3    Weill, J.C.4
  • 30
    • 0025281166 scopus 로고
    • Ongoing diversification of a rearranged immunoglobulin light-chain gene in a bursal lymphoma cell line
    • Kim S, Humphries EH, Tjoekler L, Carlson L, Thompson CB (1990) Ongoing diversification of a rearranged immunoglobulin light-chain gene in a bursal lymphoma cell line. Mol Cell Biol 10:3224-3231
    • (1990) Mol Cell Biol , vol.10 , pp. 3224-3231
    • Kim, S.1    Humphries, E.H.2    Tjoekler, L.3    Carlson, L.4    Thompson, C.B.5
  • 31
    • 0023652339 scopus 로고
    • A hyperconversion mechanism generates the chicken light chain preimmune repertoire
    • Reynauld C-A, Anquez V, Grimal H, Weill J-C (1987) A hyperconversion mechanism generates the chicken light chain preimmune repertoire. Cell 48:379-388
    • (1987) Cell , vol.48 , pp. 379-388
    • Reynauld, C.-A.1    Anquez, V.2    Grimal, H.3    Weill, J.-C.4
  • 33
    • 0030052281 scopus 로고    scopus 로고
    • Rearrangement/ hypermutation/ gene conversion: When, where and why?
    • Weill J-C, Reynaud C-A (1996) Rearrangement/ hypermutation/ gene conversion: when, where and why? Immunol Today 17:92-96
    • (1996) Immunol Today , vol.17 , pp. 92-96
    • Weill, J.-C.1    Reynaud, C.-A.2
  • 34
    • 0028818503 scopus 로고
    • Somatic hypermutation: How many mechanisms diversify V region sequences?
    • Maizels N (1995) Somatic hypermutation: how many mechanisms diversify V region sequences? Cell 83:9-12
    • (1995) Cell , vol.83 , pp. 9-12
    • Maizels, N.1
  • 35
    • 0028962371 scopus 로고
    • A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks
    • Greenberg AS, Avila D, Hughes M, Hughes A, McKinney EC, Flajnik MF (1995) A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks. Nature 374:168-173
    • (1995) Nature , vol.374 , pp. 168-173
    • Greenberg, A.S.1    Avila, D.2    Hughes, M.3    Hughes, A.4    McKinney, E.C.5    Flajnik, M.F.6
  • 36
    • 0026470596 scopus 로고
    • What limits affinity maturation of antibodies in Xenopus - The rate of somatic mutation or the ability to select mutants?
    • Wilson M, Hsu E, Marcuz A, Courtet M, Du PL, Steinberg C (1992) What limits affinity maturation of antibodies in Xenopus - the rate of somatic mutation or the ability to select mutants? EMBO J 11:4337-4347
    • (1992) EMBO J , vol.11 , pp. 4337-4347
    • Wilson, M.1    Hsu, E.2    Marcuz, A.3    Courtet, M.4    Du, P.L.5    Steinberg, C.6
  • 37
    • 0025911840 scopus 로고
    • The ontogeny of diversification at the immunoglobulin heavy chain locus in Xenopus
    • Schwager J, Burckert N, Courtet M, Du Pasquier L (1991) The ontogeny of diversification at the immunoglobulin heavy chain locus in Xenopus. EMBO J 10:2461-2470
    • (1991) EMBO J , vol.10 , pp. 2461-2470
    • Schwager, J.1    Burckert, N.2    Courtet, M.3    Du Pasquier, L.4
  • 38
    • 0026515436 scopus 로고
    • Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell-dependent antigen
    • Weiss U, Zeobelein R, Rajewsky K (1992) Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell-dependent antigen. Eur J Immunol 22:511-517
    • (1992) Eur J Immunol , vol.22 , pp. 511-517
    • Weiss, U.1    Zeobelein, R.2    Rajewsky, K.3
  • 40
    • 0025119206 scopus 로고
    • Three-dimensional structure determination of an anti-2-phenyloxazolone antibody: The role of somatic mutation and heavy/ light chain pairing in the maturation of an immune response
    • Alzari PM, Spinelli S, Mariuzza RA, Boulot G, Poljak RJ, Jarvis JM, Milstein C (1990) Three-dimensional structure determination of an anti-2-phenyloxazolone antibody: the role of somatic mutation and heavy/ light chain pairing in the maturation of an immune response. EMBO J 9:3807-3814
    • (1990) EMBO J , vol.9 , pp. 3807-3814
    • Alzari, P.M.1    Spinelli, S.2    Mariuzza, R.A.3    Boulot, G.4    Poljak, R.J.5    Jarvis, J.M.6    Milstein, C.7
  • 42
    • 0026611978 scopus 로고
    • Sequential 1H and 15N NMR assignments and secondary structure of a recombinant anti-digoxin antibody VL domain
    • 2. Constantine KL, Goldfarb V, Wittekind M, Anthony J, Ng SC, Mueller L (1992) Sequential 1H and 15N NMR assignments and secondary structure of a recombinant anti-digoxin antibody VL domain. Biochem 31:5033-5043
    • (1992) Biochem , vol.31 , pp. 5033-5043
    • Constantine, K.L.1    Goldfarb, V.2    Wittekind, M.3    Anthony, J.4    Ng, S.C.5    Mueller, L.6
  • 43
    • 0023390930 scopus 로고
    • 5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes
    • 5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes. EMBO J 8:2267-2272
    • (1987) EMBO J , vol.8 , pp. 2267-2272
    • Kudo, A.1    Melchers, F.2
  • 44
    • 0023808491 scopus 로고
    • preB gene in humans and conservation of its structure in other mammalian species
    • preB gene in humans and conservation of its structure in other mammalian species. EMBO J 7:111-116
    • (1988) EMBO J , vol.7 , pp. 111-116
    • Bauer, S.R.1    Kudo, A.2    Melchers, F.3
  • 45
    • 0022021722 scopus 로고
    • H genes in Caiman, a phylogenetically ancient reptile: Evolutionary diversification in coding segments and variation in the structure and organization of recombination elements
    • H genes in Caiman, a phylogenetically ancient reptile: evolutionary diversification in coding segments and variation in the structure and organization of recombination elements. Proc Natl Acad Sci USA 82:844-848
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 844-848
    • Litman, G.W.1    Murphy, K.2    Berger, L.3    Litman, R.4    Hinds, K.5    Erickson, B.W.6
  • 48
    • 0025195481 scopus 로고
    • H gene families and additional patterns of sequence variation suggest a high degree of immunoglobulin gene complexity in a lower vertebrate, Xenopus laevis
    • H gene families and additional patterns of sequence variation suggest a high degree of immunoglobulin gene complexity in a lower vertebrate, Xenopus laevis. J Exp Med 171:1721-1737
    • (1990) J Exp Med , vol.171 , pp. 1721-1737
    • Haire, R.N.1    Amemiya, C.T.2    Suzuki, D.3    Litman, G.W.4
  • 49
    • 0023969950 scopus 로고
    • Immunoglobulin heavy chain variable region gene evolution: Structure and family relationships of two genes and a pseudogene in a teleost fish
    • Wilson MR, Middleton D, Warr GW (1988) Immunoglobulin heavy chain variable region gene evolution: structure and family relationships of two genes and a pseudogene in a teleost fish. Proc Natl Acad Sci USA 85:1566-1570
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 1566-1570
    • Wilson, M.R.1    Middleton, D.2    Warr, G.W.3
  • 50
    • 0025052356 scopus 로고
    • Characterization of a complete immunoglobulin heavy-chain variable region germ-line gene of rainbow trout
    • Matsunaga T, Chen T, Tormanen V (1990) Characterization of a complete immunoglobulin heavy-chain variable region germ-line gene of rainbow trout. Proc Natl Acad Sci USA 87:7767-7771
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 7767-7771
    • Matsunaga, T.1    Chen, T.2    Tormanen, V.3
  • 51
    • 0025350961 scopus 로고
    • Immunoglobulin heavy chain gene organization and complexity in the skate, Raja erinacea
    • Harding FA, Cohen N, Litman GW (1990) Immunoglobulin heavy chain gene organization and complexity in the skate, Raja erinacea. Nucl Acid Res 18:1015-1020
    • (1990) Nucl Acid Res , vol.18 , pp. 1015-1020
    • Harding, F.A.1    Cohen, N.2    Litman, G.W.3
  • 52
    • 0028676261 scopus 로고
    • Structural conservation of hypervariable regions in immunoglobulins evolution
    • Barre S, Greenberg AS, Flajnik MF, Chothia C (1994) Structural conservation of hypervariable regions in immunoglobulins evolution. Nat Struct Biol 1:915-920
    • (1994) Nat Struct Biol , vol.1 , pp. 915-920
    • Barre, S.1    Greenberg, A.S.2    Flajnik, M.F.3    Chothia, C.4


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