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Volumn 158, Issue 6, 1997, Pages 2779-2789

Analysis of the Frequency and Pattern of Somatic Mutations Within Nonproductively Rearranged Human Variable Heavy Chain Genes

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

EID: 0031569118     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (153)

References (41)
  • 1
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • Tonegawa, S. 1983. Somatic generation of antibody diversity. Nature 302:575.
    • (1983) Nature , vol.302 , pp. 575
    • Tonegawa, S.1
  • 2
    • 0028818503 scopus 로고
    • Somatic hypermutation: How many mechanisms diversify V region sequences?
    • Maizels, N. 1995. Somatic hypermutation: how many mechanisms diversify V region sequences? Cell 83:9.
    • (1995) Cell , vol.83 , pp. 9
    • Maizels, N.1
  • 3
    • 0030071749 scopus 로고    scopus 로고
    • An immunoglobulin mutator that targets G-C base pairs
    • Bachl, J., and M. Wabl. 1996. An immunoglobulin mutator that targets G-C base pairs. Proc. Natl. Acad. Sci. USA 93:851.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 851
    • Bachl, J.1    Wabl, M.2
  • 4
    • 0023161406 scopus 로고
    • Mutation drift and repertoire shift in the maturation of the immune response
    • Berek, C., and C. Milstein. 1987. Mutation drift and repertoire shift in the maturation of the immune response. Immunol. Rev. 96:23.
    • (1987) Immunol. Rev. , vol.96 , pp. 23
    • Berek, C.1    Milstein, C.2
  • 5
    • 0026331458 scopus 로고
    • Maturation of immune responses in germinal centers
    • Berek, C., A. Berger, and M. Apel. 1991. Maturation of immune responses in germinal centers. Cell 67:1121.
    • (1991) Cell , vol.67 , pp. 1121
    • Berek, C.1    Berger, A.2    Apel, M.3
  • 6
    • 0026417411 scopus 로고
    • The centre of hypermutation
    • MacLennan, I. 1991. The centre of hypermutation. Nature 354:352.
    • (1991) Nature , vol.354 , pp. 352
    • MacLennan, I.1
  • 7
    • 0028270307 scopus 로고
    • Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region
    • Betz, A. G., C. Milstein, A. Gonzalez-Fernandez, R. Pannell, T. Larsson, and M. S. Neuberger. 1994. Elements regulating somatic hypermutation of an immunoglobulin κ gene: critical role for the intron enhancer/matrix attachment region. Cell 77:239.
    • (1994) Cell , vol.77 , pp. 239
    • Betz, A.G.1    Milstein, C.2    Gonzalez-Fernandez, A.3    Pannell, R.4    Larsson, T.5    Neuberger, M.S.6
  • 8
    • 0025148941 scopus 로고
    • Distribution of mutations around rearranged heavy-chain antibody variable-region genes
    • Both, G. W., L. Taylor, J. W. Pollard, and E. J. Steele. 1990. Distribution of mutations around rearranged heavy-chain antibody variable-region genes. Mol. Cell. Biol. 10:5187.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 5187
    • Both, G.W.1    Taylor, L.2    Pollard, J.W.3    Steele, E.J.4
  • 9
    • 0030063726 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
    • Peters, A., and U. Storb. 1996. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity 4:57.
    • (1996) Immunity , vol.4 , pp. 57
    • Peters, A.1    Storb, U.2
  • 10
    • 0025881727 scopus 로고
    • Mutation in a reporter gene depends on proximity to and transcription of immunoglobulin variable transgenes
    • Umar, A., P. A. Schweitzer, N. S. Levy, J. D. Gearhart, and P. J. Gearhart. 1991. Mutation in a reporter gene depends on proximity to and transcription of immunoglobulin variable transgenes. Proc. Natl. Acad. Sci. USA 88:4902.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 4902
    • Umar, A.1    Schweitzer, P.A.2    Levy, N.S.3    Gearhart, J.D.4    Gearhart, P.J.5
  • 11
    • 0027510316 scopus 로고
    • Mutations of the chloramphenical acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer
    • Azuma, T., N. Motoyama, L. Fields, and D. Loh. 1993. Mutations of the chloramphenical acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer. Int. Immunol. 5:121.
    • (1993) Int. Immunol. , vol.5 , pp. 121
    • Azuma, T.1    Motoyama, N.2    Fields, L.3    Loh, D.4
  • 13
    • 0029996999 scopus 로고    scopus 로고
    • Characterization of the cis-acting elements required for somatic hypermutation of murine antibody V genes using conventional transgenic and transgene homologous recombination approaches
    • Tumas-Brundage, K, K. A. Vora, A. M. Giusti, and T. Manser. 1996. Characterization of the cis-acting elements required for somatic hypermutation of murine antibody V genes using conventional transgenic and transgene homologous recombination approaches. Semin. Immunol. 8:141.
    • (1996) Semin. Immunol. , vol.8 , pp. 141
    • Tumas-Brundage, K.1    Vora, K.A.2    Giusti, A.M.3    Manser, T.4
  • 16
    • 0028794835 scopus 로고
    • Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process
    • Reynaud, C. A., C. Garcia, W. R. Hein, and J. C. Weill. 1995. Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process. Cell 80:115.
    • (1995) Cell , vol.80 , pp. 115
    • Reynaud, C.A.1    Garcia, C.2    Hein, W.R.3    Weill, J.C.4
  • 17
    • 0028577994 scopus 로고
    • Somatic mutation of immunoglobulin λ chains: A segment of the major intron hypermutates as much as the complementarity-determining regions
    • Gonzalez-Fernandez, A., S. K. Gupta, R. Pannell, M. S. Neuberger, and C. Milstein. 1994. Somatic mutation of immunoglobulin λ chains: a segment of the major intron hypermutates as much as the complementarity-determining regions. Proc. Natl. Acad. Sci. USA 91:12614.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 12614
    • Gonzalez-Fernandez, A.1    Gupta, S.K.2    Pannell, R.3    Neuberger, M.S.4    Milstein, C.5
  • 18
    • 0027364313 scopus 로고
    • Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin κ light-chain transgenes
    • Gonzalez-Fernandez, A., and C. Milstein. 1993. Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin κ light-chain transgenes. Proc. Acad. Sci. USA 90:9862.
    • (1993) Proc. Acad. Sci. USA , vol.90 , pp. 9862
    • Gonzalez-Fernandez, A.1    Milstein, C.2
  • 19
    • 0025900034 scopus 로고
    • Somatic hypermutation of immunoglobulin κ may depend on sequences 3′ of Cκ and occurs on passenger transgenes
    • Sharpe, M. J., C. Milstein, J. M. Jarvis, and M. S. Neuberger. 1991. Somatic hypermutation of immunoglobulin κ may depend on sequences 3′ of Cκ and occurs on passenger transgenes. EMBO J. 10:2139.
    • (1991) EMBO J. , vol.10 , pp. 2139
    • Sharpe, M.J.1    Milstein, C.2    Jarvis, J.M.3    Neuberger, M.S.4
  • 20
    • 0027227311 scopus 로고
    • Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes
    • Betz, A. G., M. S. Neuberger, and C. Milstein. 1993. Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes. Immunol. Today 14:405.
    • (1993) Immunol. Today , vol.14 , pp. 405
    • Betz, A.G.1    Neuberger, M.S.2    Milstein, C.3
  • 23
    • 0026443954 scopus 로고
    • Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis
    • Rogozin, I. B., and N. A. Kolchanov. 1992. Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis. Biochem. Biophys. Acta 1171:11.
    • (1992) Biochem. Biophys. Acta , vol.1171 , pp. 11
    • Rogozin, I.B.1    Kolchanov, N.A.2
  • 24
    • 0026844401 scopus 로고
    • The development of B cells and the B-cell repertoire in the microenvironment of the germinal center
    • Berek, C. 1992. The development of B cells and the B-cell repertoire in the microenvironment of the germinal center. Immunol. Review 126:5.
    • (1992) Immunol. Review , vol.126 , pp. 5
    • Berek, C.1
  • 25
    • 0029063311 scopus 로고
    • Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction
    • Brezinschek, H.-P., R. I. Brezinschek, and P. E. Lipsky. 1995. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. J. Immunol. 155:190.
    • (1995) J. Immunol. , vol.155 , pp. 190
    • Brezinschek, H.-P.1    Brezinschek, R.I.2    Lipsky, P.E.3
  • 28
    • 0027305024 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells
    • Jacob, J., J. Przylepa, C. Miller, and G. Kelsoe. 1993. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells. J. Exp. Med. 178: 1293.
    • (1993) J. Exp. Med. , vol.178 , pp. 1293
    • Jacob, J.1    Przylepa, J.2    Miller, C.3    Kelsoe, G.4
  • 29
    • 0023462643 scopus 로고
    • Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse
    • Shlomchik, M. J., A. H. Aucoin, D. S. Pisetsky, and M. G. Weigert. 1987. Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. Proc. Natl. Acad. Sci. USA 84:9150.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 9150
    • Shlomchik, M.J.1    Aucoin, A.H.2    Pisetsky, D.S.3    Weigert, M.G.4
  • 30
    • 0028176654 scopus 로고
    • Heavy-chain directed B-cell maturation: Continuous clonal selection beginning at the pre-B cell stage
    • Schwartz, R. S., and B. D. Stollar. 1994. Heavy-chain directed B-cell maturation: continuous clonal selection beginning at the pre-B cell stage. Immunol. Today 15:27.
    • (1994) Immunol. Today , vol.15 , pp. 27
    • Schwartz, R.S.1    Stollar, B.D.2
  • 31
    • 0030070295 scopus 로고    scopus 로고
    • Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis
    • Schröder, A. E., A. Greiner, C. Seyfert, and C. Berek. 1996. Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis. Proc. Acad. Sci. USA 93:221.
    • (1996) Proc. Acad. Sci. USA , vol.93 , pp. 221
    • Schröder, A.E.1    Greiner, A.2    Seyfert, C.3    Berek, C.4
  • 32
    • 0027491651 scopus 로고
    • Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections
    • Küppers, R., M. Zhao, M.-L. Hansmann, and K. Rajewski. 1993. Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. EMBO J. 12:4955.
    • (1993) EMBO J. , vol.12 , pp. 4955
    • Küppers, R.1    Zhao, M.2    Hansmann, M.-L.3    Rajewski, K.4
  • 33
    • 0025630537 scopus 로고
    • Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is approximately 1kb from V(D)J gene
    • Lebecque, S. G., and P. J. Gearhart. 1990. Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is approximately 1kb from V(D)J gene. J. Exp. Med. 172:1717.
    • (1990) J. Exp. Med. , vol.172 , pp. 1717
    • Lebecque, S.G.1    Gearhart, P.J.2
  • 36
    • 0029947265 scopus 로고    scopus 로고
    • Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells
    • Smith, D. S., G. Creadon, P. K. Jena, J. P. Portanova, B. L. Kotzin, and L. J. Wysocki. 1996. Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells. J. Immunol. 156:2642.
    • (1996) J. Immunol. , vol.156 , pp. 2642
    • Smith, D.S.1    Creadon, G.2    Jena, P.K.3    Portanova, J.P.4    Kotzin, B.L.5    Wysocki, L.J.6
  • 37
    • 0025774040 scopus 로고
    • Somatic mutation in constant regions of mouse λ1 light chains
    • Motoyama, N., H. Okada, and T. Azuma. 1991. Somatic mutation in constant regions of mouse λ1 light chains. Proc. Natl. Acad. Sci. USA 88:7933.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 7933
    • Motoyama, N.1    Okada, H.2    Azuma, T.3
  • 38
    • 0027499308 scopus 로고
    • Passenger transgene reveal intrinsic specificity of the antibody hypermutation mechanism: Clustering, polarity, and specific hot spots
    • Betz, A. G., C. Rada, R. Pannell, C. Milstein, and M. S. Neuberger. 1993. Passenger transgene reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. Proc. Natl. Acad. Sci. USA 90:2385.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 2385
    • Betz, A.G.1    Rada, C.2    Pannell, R.3    Milstein, C.4    Neuberger, M.S.5
  • 39
    • 0027460052 scopus 로고
    • Molecular evolution of the human immunoglobulin e response: High incidence of shared mutations and clonal relatedness among ε VH5 transcripts from three unrelated patients with atopic dermatitis
    • Van der Stoep, N., J. van der Linden, and T. J. Logtenberg. 1992. Molecular evolution of the human immunoglobulin E response: high incidence of shared mutations and clonal relatedness among ε VH5 transcripts from three unrelated patients with atopic dermatitis. J. Exp. Med. 177:99.
    • (1992) J. Exp. Med. , vol.177 , pp. 99
    • Van Der Stoep, N.1    Van Der Linden, J.2    Logtenberg, T.J.3
  • 40
    • 0027932819 scopus 로고
    • Bias in somatic hypermutation of human VH genes
    • Insel, R. A., and W. S. Varade. 1994. Bias in somatic hypermutation of human VH genes. Int. Immunol. 6:1437.
    • (1994) Int. Immunol. , vol.6 , pp. 1437
    • Insel, R.A.1    Varade, W.S.2
  • 41
    • 0023278330 scopus 로고
    • Canonical structures for the hypervariable regions on immunoglobulins
    • Chothia, C., and A. M. Lesk. 1987. Canonical structures for the hypervariable regions on immunoglobulins. J. Mol. Biol. 196:901.
    • (1987) J. Mol. Biol. , vol.196 , pp. 901
    • Chothia, C.1    Lesk, A.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.