Genetic analysis reveals an intrinsic property of the germinal center B cells to generate A:T mutations

DNA Repair

Volumn 7, Issue 8, 2008, Pages 1392-1398

  Ouchida, Rika ^a   Ukai, Akiko ^a   Mori, Hiromi ^a   Kawamura, Kiyoko ^b   Dollé, Martijn E T ^c   Tagawa, Masatoshi ^b   Sakamoto, Akemi ^d   Tokuhisa, Takeshi ^d   Yokosuka, Tadashi ^a   Saito, Takashi ^a   Yokoi, Masayuki ^e   Hanaoka, Fumio ^e   Vijg, Jan ^f   Wang, Ji Yang ^a  

^a RIKEN YOKOHAMA INSTITUTE   (Japan)

^b CHIBA CANCER CENTER   (Japan)

^c NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^d CHIBA UNIVERSITY   (Japan)

^e OSAKA UNIVERSITY   (Japan)

^f BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

Author keywords

Activation induced cytidine deaminase; DNA polymerase ; Genome mutation; Germinal center B cells; Mismatch repair

Indexed keywords

CYTIDINE DEAMINASE; CYTOSINE; DNA DIRECTED DNA POLYMERASE ETA; URACIL;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; GENE MUTATION; GERMINAL CENTER; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; MISMATCH REPAIR; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

ADENINE; ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; DNA PRIMERS; MICE; POINT MUTATION; THYMINE; TRANSCRIPTION, GENETIC;

EID: 46649119260     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2008.04.014     Document Type: Article

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