Somatic hypermutation in the heavy chain locus correlates with transcription

Immunity

Volumn 9, Issue 1, 1998, Pages 105-114

  Fukita, Yosho ^a   Jacobs, Heinz ^a,b   Rajewsky, Klaus ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; GENE LOCUS; GENE MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION;

EID: 0032127810     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80592-0     Document Type: Article

References (63)

1. H rearrangement by promoterenhancer approximation. Mol. Cell. Biol. 11, 2096-2107.
2. Aoufouchi, S., Yelamos, J., and Milstein, C. (1996). Nonsense mutations inhibit RNA splicing in acell-free system: recognition of mutant codon is independent of protein synthesis. Cell 85, 415-422.
3. Berek, C., Berger, A., and Apel, M. (1991). Maturation of the immune response in germinal centers. Cell 67, 1121-1129.
4. Betz, A.G., Milstein, C., Gonzalez-Fernandez, A., Pannell, R., Larson, T., and Neuberger, M.S. (1994). Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region. Cell 77, 239-248.
5. Betz, A.G., Neuberger, M.S., and Milstein, C. (1993). Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes, Immunol. Today 14, 405-411.
6. Cheng, J., and Maquat, L.E. (1993). Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA. Mol. Cell. Biol. 13, 1892-1902.
7. Chomczynski, P., and Sacchi, N. (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
8. Coffman, R.L. (1982). Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development. Immunol. Rev. 69, 5-23.
9. Ford, J.E., McHeyzer-Williams, M.G., and Lieber, M.R. (1994). Analysis of individual immunoglobulin lambda light chain genes amplified from single cells is inconsistent with variable region gene conversion in germinal-center B cell somatic mutation. Eur. J. Immunol. 24, 1816-1822.
10. Förster, I., Vieira, P., and Rajewsky, K. (1989). Flow cytometric analysis of cell proliferation dynamics in the B cell compartment of the mouse. Int. Immunol. 1, 321-331.
11. Gearhart, P.J., and Bogenhagen, D.F. (1983). Clusters of point mutations are found exclusively around rearranged antibody variable genes. Proc. Natl. Acad. Sci. USA 80, 3439-3443.
12. Gonzalez-Fernandez, A., Gupta, S.K., Pannell, R., Neuberger, M.S., and Milstein, C. (1994). Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions. Proc. Natl. Acad. Sci. USA 91, 12614-12618.
13. Goyenechea, B., Klix, N., Yelamos, J., Williams, G.T., Riddell, A., Neuberger, M.S., and Milstein, C. (1997). Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers. EMBO J. 16, 3987-3994.
14. Grummt, I., and Skinner, J.A. (1985). Efficient transcription of a protein-coding genef rom the RNA polymerase I promoter in transfected cells. Proc. Natl. Acad. Sci. USA 82, 722-726.
15. Gunter, K.C., Malek, T.R., and Shevach, E.M. (1984). T cell-activating properties of an anti-Thy-1 monoclonal antibody. Possible analogy to OKT3/Leu-4. J. Exp. Med. 159, 716-730.
16. Jacob, J., Kelsoe, G., Rajewsky, K., and Weiss, U. (1991). Intraclonal generation of antibody mutants in germinal centres. Nature 354, 389-392.
17. Jacobs, H., Fukita, Y., van der Horst, G.T.J., de Boer, J., Weeda, G., Essers, J., de Wind, N., Engelward, B.P., Samson, L., Verbeek, S., et al. (1998). Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice. J. Exp. Med. 187, 1735-1743.
18. Kabat, E.A., and Wu, T.T. (1991). Identical V region amino acid sequences and segments of sequences in antibodies of different specificities. Relative contributions of VH and VL genes, minigenes, and complementarity-determining regions to binding of antibody-combining sites. J. Immunol. 147, 1709-1719.
19. Keohavong, P., and Thilly, W.G. (1989). Fidelity of DNA polymerases in DNA amplification. Proc. Natl. Acad. Sci. USA 86, 9253-9257.
20. Kim, S., Davis, M., Sinn, E., Patten, P., and Hood, L. (1981). Antibody diversity: somatic hypermutation of rearranged VH genes. Cell 27, 573-581.
21. Klein, U., Küppers, R., and Rajewsky, K. (1997). Evidence for a large compartment of IgM-expressing memory B cells in humans. Blood 89, 1288-1298.
22. Kottmann, A.H., Brack, C., Eibel, H., and Kohler, G. (1992). A survey of protein-DNA interaction sites within the murine immunoglobulin heavy chain locus reveals a particularly complex pattern around the DQ52 element. Eur. J. Immunol. 22, 2113-2120.
23. Kottmann, A.H., Zevnik, B., Welte, M., Nielsen, P.J., and Kohler, G. (1994). A second promoter and enhancer element within the immunoglobulin heavy chain locus. Eur. J. Immunol. 24, 817-821.
24. Kuhn, A., Deppert, U., and Grummt, I. (1990). A 140-base-pair repetitive sequence element in the mouse rRNA gene spacer enhances transcription by RNA polymerase I in a cell-free system. Proc. Natl. Acad. Sci. USA 87, 7527-7531.
25. Kühn, R., Rajewsky, K., and Muller, W. (1991). Generation and analysis of interleukin-4 deficient mice. Science 254, 707-710.
26. Lacy, E., Roberts, S., Evans, E.P., Burtenshaw, M.D., and Costantini, F.D. (1983). A foreign beta-globin gene in transgenic mice: integration at abnormal chromosomal positions and expression in inappropriate tissues. Cell 34, 343-358.
27. Laird, P.W., Zijderveld, A., Linders, K., Rudnicki, M.A., Jaenisch, R., and Berns, A. (1991). Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 19, 4293.
28. Lebecque, S.G., and Gearhart, P.J. (1990). Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is approximately 1 kb from V(D)J gene. J. Exp. Med. 172, 1717-1727.
29. Ledbetter, J.A., and Herzenberg, L.A. (1979). Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens, Immunol. Rev. 47, 63-90.
30. Lozano, F., Maertzdorf, B., Pannell, R., and Milstein, C. (1994). Low cytoplasmic mRNA levels of immunoglobulin kappa light chain genes containing nonsense codons correlate with inefficient splicing. EMBO J. 13, 4617-4622.
31. Maquat, L.E. (1995). When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells. Rna 1, 453-465.
32. Miltenyi, S., Müller, W., Weichel, W., and Radbruch, A. (1990). High gradient magnetic cell separation with MACS. Cytometry 11, 231-238.
33. O'Brien, R.L., Brinster, R.L., and Storb, U. (1987). Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice. Nature 326, 405-409.
34. Orphanides, G., Lagrange, T., and Reinberg, D. (1996). The general transcription factors of RNA polymerase II. Genes Dev. 10, 2657-2683.
35. Peltz, S.W., He, F., Welch, E., and Jacobson, A. (1994). Nonsensemediated mRNA decay in yeast. Prog. Nucleic Acid Res. Mol. Biol. 47, 271-298.
36. Peters, A., and Storb, U. (1996). Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity 4, 57-65.
37. Rada, C., Yélamos, J., Dean, W., and Milstein, C. (1997). The 5′ hypermutation boundary of K chains is independent of local and neighbouring sequences and related to the distance from the initiation of transcription. Eur. J. Immunol. 27, 3115-3120.
38. Rajewsky, K. (1996). Clonal selection and learning in the antibody system. Nature 381, 751-758.
39. Reeder, R.H. (1990). rRNA synthesis in the nucleolus. Trends Genet. 6, 390-395.
40. Reth, M., Imanishi-Kari, T., and Rajewsky, K. (1979). Analysis of the repertoire of anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in C 57 BL/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti-idiotope antibodies. Eur. J. Immunol. 9, 1004-1013.
41. Roes, J., Huppi, K., Rajewsky, K., and Sablitzky, F. (1989). V gene rearrangement is required to fully activate the hypermutation mechanism in B cells. J. Immunol. 142, 1022-1026.
42. Roes, J., Müller, W., and Rajewsky, K. (1995). Mouse anti-mouse IgD monoclonal antibodies generated in IgD-deficient mice. J. Immunol. Methods 183, 231-237.
43. Rogerson, B.J. (1994). Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes. Mol. Immunol. 31, 83-98.
44. Rogozin, I.B., and Kolchanov, N.A. (1992). Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis. Biochim. Biophys. Acta 1171, 11-18.
45. Rose, M.L., Birbeck, M.S., Wallis, V.J., Forrester, J.A., and Davies, A.J. (1980). Peanut lectin binding properties of germinal centres of mouse lymphoid tissue. Nature 284, 364-366.
46. Rothenfluh, H.S., Taylor, L., Bothwell, A.L., Both, G.W., and Steele, E.J. (1993). Somatic hypermutation in 5′ flanking regions of heavy chain antibody variable regions. Eur. J. Immunol. 23, 2152-2159.
47. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press).
48. Schreck, R., Carey, M.F., and Grummt, I. (1989). Transcriptional enhancement by upstream activators is brought about by different molecular mechanisms for class I and II RNA polymerase genes. EMBO J. 8, 3011-3017.
49. Schwenk, F., Baron, U., and Rajewsky, K. (1995). A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res. 23, 5080-5081.
50. Sharpe, M.J., Milstein, C., Jarvis, J.M., and Neuberger, M.S. (1991). Somatic hypermutation of immunoglobulin kappa may depend on sequences 3′ of C kappa and occurs on passenger transgenes. EMBO J. 10, 2139-2145.
51. Smale, ST., and Tjian, R. (1985). Transcription of herpes simplex virus tk sequences under the control of wild-type and mutant human RNA polymerase I promoters. Mol. Cell. Biol. 5, 352-362.
52. Sonoda, E., Pewzner-Jung, Y., Schwers, S., Taki, S., Jung, S., Eilat, D., and Rajewsky, K. (1997). B cell development under the condition of allelic inclusion. Immunity 6, 225-233.
53. Springer, T., Galfre, G., Secher, D.S., and Milstein, C. (1979). Mac1: a macrophage differentiation antigen identified by monoclonal antibody. Eur. J. Immunol. 9, 301-306.
54. Taki, S., Meiering, M., and Rajewsky, K. (1993). Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus. Science 262, 1268-1271.
55. H-C mu transcription in human precursor B lymphocytes initiates in a unique region upstream of DQ52. Eur. J. Immunol. 25, 257-261.
56. Tindall, K.R., and Kunkel, T.A. (1988). Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase. Biochemistry 27, 6008-6013.
57. Tumas-Brundage, K., and Manser, T. (1997). The transcriptional promoter regulates hypermutation of the antibody heavy chain locus. J. Exp. Med. 185, 239-250.
58. Weber, J.S., Berry, J., Manser, T., and Claflin, J.L. (1991). Position of the rearranged V kappa and its 5′ flanking sequences determines the location of somatic mutations in the J kappa locus. J. Immunol. 146, 3652-3655.
59. Wood, C., and Tonegawa, S. (1983). Diversity and joining segments of mouse immunoglobulin heavy chain genes are closely linked and in the same orientation: implications for the joining mechanism. Proc. Natl. Acad. Sci. USA 80, 3030-3034.
60. Yelamos, J., Klix, N., Goyenechea, B., Lozano, F., Chui, Y.L., Gonzalez Fernandez, A., Pannell, R., Neuberger, M.S., and Milstein, C. (1995). Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. Nature 376, 225-229.
61. Zawel, L., Kumar, K.P., and Reinberg, D. (1995). Recycling of the general transcription factors during RNA polymerase II transcription. Genes Dev. 9, 1479-1490.
62. Zawel, L., and Reinberg, D. (1992). Advances in RNA polymerase II transcription. Curr. Opin. Cell Biol. 4, 488-495.
63. Zhang, G., Taneja, K.L., Singer, R.H., and Green, M.R. (1994). Localization of pre-mRNA splicing in mammalian nuclei. Nature 372, 809-812.