Induction of somatic mutation in a human β cell line in vitro

Immunity

Volumn 6, Issue 1, 1997, Pages 35-46

  Denépoux, Stéphane ^a   Razanajaona, Diane ^a   Blanchard, Dominique ^a   Meffre, Geneviève ^a   Capra, J Donald ^b   Banchereau, Jacques ^a   Lebecque, Serge ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN M;

ARTICLE; B LYMPHOCYTE; BURKITT LYMPHOMA; CELL LINE; DNA SEQUENCE; GERMINAL CENTER; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; PRIORITY JOURNAL; SOMATIC MUTATION;

EID: 0343417077     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80240-X     Document Type: Article

References (59)

1. Azuma, T., Motoyama, N., Fields, L.E., and Loh, D.Y. (1993). Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer. Int. Immunol. 5, 121-130.
2. Berek, C., Berger, A., and Apel, M. (1991). Maturation of the immune response in germinal centers. Cell 67, 1121-1129.
3. Betz, A.G., Milstein, C., Gonzalez Fernandez, A., Pannell, R., Larson, T., and Neuberger, M.S. (1994). Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region. Cell 77, 239-248.
4. Betz, A.G., Neuberger, M.S., and Milstein, C. (1993). Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes. Immunol. Today 14, 405-411.
5. Blanchard, D., Gaillard, C., Hermann, P., and Banchereau, J. (1994). Role of CD40 antigen and interleukin-2 in T cell-dependent human B lymphocyte growth. Eur. J. Immunol. 24, 330-335.
6. Chang, B., and Casali, P. (1994). The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement. Immunol. Today 15, 367-373.
7. Chapman, C.J., Mockridge, C.I., Rowe, M., Rickinson, A.B., and Stevenson, F.K. (1995). Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity. Blood 85, 2176-2181.
8. Cohen, J.H., Revillard, J.P., Magaud, J.P., Lenoir, G., Vuillaume, M., Manel, A.M., Vincent, C., and Bryon, P.A. (1987). B-cell maturation stages of Burkitt's lymphoma cell lines according to Epstein-Barr virus status and type of chromosome translocation. J. Natl. Cancer Inst. 78, 235-242.
9. Decker, D.J., Linton, P.J., Zaharevitz, S., Biery, M., Gingeras, T.R., and Klinman, N.R. (1995). Defining subsets of naive and memory B cells based on the ability of their progeny to somatically mutate in vitro. Immunity 2, 195-203.
10. Galibert, L., van Dooren, J., Durand, I., Rousset, F., Jefferis, R., Banchereau, J., and Lebecque, S. (1995). Anti-CD40 plus interleukin-4-activated human naive B cell lines express unmutated immunoglobulin genes with intraclonal heavy chain isotype variability. Eur. J. Immunol. 25, 733-737.
11. Golding, G.B., Gearhart, P.J., and Glickman, B.W. (1987). Patterns of somatic mutations in immunoglobulin variable genes. Genetics 115, 169-176.
12. Gray, D. (1993). Immunological memory. Annu. Rev. Immunol. 11, 49-77.
13. Green, N.S., Rabinowitz, J.L., Zhu, M., Kobrin, B.J. and Scharft, M.D. (1995). Immunoglobulin variable region hypermutation in hybrids derived from a pre-B-and a myeloma cell line. Proc. Natl. Acad. Sci. USA 92, 6304-6308.
14. Grouard, G., Durand, I., Filgueira, L., Banchereau, J., and Liu, Y.J. (1996). Dendritic cells capable of stimulating T cells in germinal centers. Nature 384, 364-367.
15. Han, S., Hathcock, K., Zheng, B., Kepler, T.B., Hodes, R., and Kelsoe, G. (1995). Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. J. Immunol. 155, 556-567.
16. Hermann, P., Blanchard, D., de Saint Vis, B., Fossiez, F., Gaillard, C., Vanbervliet, B., Briere, F., Banchereau, J., and Galizzi, J.P. (1993). Expression of a 32-kDa ligand for the CD40 antigen on activated human T lymphocytes. Eur. J. Immunol. 23, 961-964.
17. Jacob, J., Kelsoe, G., Rajewsky, K., and Weiss, U. (1991). Intraclonal generation of antibody mutants in germinal centres. Nature 354, 389-392.
18. Kallberg, E., Gray, D., and Leanderson, T. (1993). Analysis of somatic mutation activity in multiple V kappa genes involved in the response to 2-phenyl-5-oxazolone. Int. Immunol. 5, 573-581.
19. Kallberg, E., Jainandunsing, S., Gray, D., and Leanderson, T. (1996). Somatic mutation of immunoglobulin V genes in vitro. Science 271, 1285-1288.
20. Kelly, P.J., Pascual, V., Capra, J.D., and Lipsky, P.E. (1992). Anti-CD3-stimulated T cells induce the production of multiple Ig H chain isotypes by individual human peripheral B lymphocytes. J. Immunol. 148, 1294-1301.
21. Kelsoe, G. (1995). In situ studies of the germinal center reaction. Adv. Immunol. 60, 267-288.
22. Kepler, T.B., and Perelson, A.S. (1993). Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation. Immunol. Today 14, 412-415.
23. Klein, U., Klein, G., Ehlin Henriksson, B., Rajewsky, K., and Kuppers, R. (1995). Burkitt's lymphoma is a malignancy of mature B cells expressing somatically mutated V region genes. Mol. Med.1, 495-505.
24. Kuppers, R., Zhao, M., Hansmann, M.L., and Rajewsky, K. (1993). Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. EMBO J. 12, 4955-4967.
25. Lebecque, S.G., and Gearhart, P.J. (1990). Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is approximately 1 kb from V(D)J gene. J. Exp. Med. 172, 1717-1727.
26. Liu, Y.J., and Banchereau, J., (1996) The paths and molecular controls of peripheral B-cell development. The Immunologist 4/2, 55-66.
27. Liu, Y.J., Grouard, G., de Bouteiller, O., and Banchereau, J. (1996). Follicular dendritic cells and germinal centers. Int. Rev. Cytol. 166, 139-179.
28. Liu, Y.J., de Bouteiller, O., Arpin, C., Durand, I., and Banchereau, J. (1994). Five human mature B cell subsets. Adv. Exp. Med. Biol. 355, 289-296.
29. Liu, Y.J., Joshua, D.E., Williams, G.T., Smith, C.A., Gordon, J., and MacLennan, I.C. (1989). Mechanism of antigen-driven selection in germinal centres. Nature 342, 929-931.
30. MacLennan, I.C. (1994a). Germinal centers. Annu. Rev. Immunol. 12, 117-139.
31. MacLennan, I.C. (1994b). Somatic mutation. From the dark zone to the light. Curr. Biol. 4, 70-72.
32. MacLennan, I.C., and Gray, D. (1986). Antigen-driven selection of virgin and memory B cells. Immunol. Rev. 91, 61-85.
33. Manser, T. (1987). Mitogen-driven B cell proliferation and differentiation are not accompanied by hypermutation of immunoglobulin variable region genes. J. Immunol. 139, 234-238.
34. Marks, J.D., Tristem, M., Karpas, A., and Winter, G. (1991). Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family-specific oligonucleotide probes. Eur. J. Immunol. 21, 985-991.
35. McHeyzer Williams, M.G., McLean, M.J., Lalor, P.A., and Nossal, G.J. (1993). Antigen-driven B cell differentiation in vivo. J. Exp. Med. 178, 295-307.
36. H genes. J. Exp. Med. 181, 1319-1331.
37. Miller, R.A., Maloney, D.G., Warnke, R., and Levy, R. (1982). Treatment of B-cell lymphoma with monoclonal anti-idiotype antibody. N. Engl. J. Med. 306, 517-522.
38. Moller, P., Henne, C., Leithauser, F., Eichelmann, A., Schmidt, A., Bruderlein, S., Dhein, J., and Krammer, P.H. (1993). Coregulation of the APO-1 antigen with intercellular adhesion molecule-1 (CD54) in tonsillar B cells and coordinate expression in follicular center B cells and in follicle center and mediastinal B-cell lymphomas. Blood 81, 2067-2075.
39. Neuberger, M.S., and Milstein, C. (1995). Somatic hypermutation. Curr. Opin. Immunol. 7, 248-254.
40. Parronchi, P., Macchia, D., Piccinni, M.P., Biswas, P., Simonelli, C., Maggi, E., Ricci, M., Ansari, A.A., and Romagnani, S. (1991). Allergen-and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production. Proc. Natl. Acad. Sci. USA 88, 4538-4542.
41. Pascual, V., Liu, Y.J., Magalski, A., de Bouteiller, O., Banchereau, J., and Capra, J.D. (1994). Analysis of somatic mutation in five B cell subsets of human tonsil. J. Exp. Med. 180, 329-339.
42. Peters, A., and Storb, U. (1996). Somatic hyper-mutation of immunoglobulin genes is linked to transcription initiation. Immunity 4, 57-65.
43. Pulendran, B., Kannourakis, G., Nouri, S., Smith, K.G., and Nossal, G.J. (1995a). Soluble antigen can cause enhanced apoptosis of germinal-centre B cells. Nature 375, 331-334.
44. Pulendran, B., Smith, K.G., and Nossal, G.J. (1995b). Soluble antigen can impede affinity maturation and the germinal center reaction but enhance extrafollicular immunoglobulin production. J. Immunol. 155, 1141-1150.
45. Rizzo, L.V., DeKruyff, R.H., and Umetsu, D.T. (1992). Generation of B cell memory and affinity maturation. Induction with Th1 and Th2 T cell clones. J. Immunol. 148, 3733-3739.
46. Sablitzky, F., Wildner, G., and Rajewsky, K. (1985). Somatic mutation and clonal expansion of B cells in an antigen-driven immune response. EMBO J.4, 345-350.
47. H gene families display remarkably little polymorphism. EMBO J. 8, 3741-3748.
48. Schattner, E.J., Mascarenhas, J., Bishop, J., Yoo, D.H., Chadburn, A., Crow, M.K., and Friedman, S.M. (1996). CD4+ T-cell induction of Fas-mediated apoptosis in Burkitt's lymphoma B cells. Blood 88, 1375-1382.
49. Shokat, K.M., and Goodnow, C.C. (1995). Antigen-induced B-cell death and elimination during germinal-centre immune responses. Nature 375, 334-338.
50. Smith, D.S., Creadon, G., Jena, P.K., Portanova, J.P., Kotzin, B.L., and Wysocki, L.J. (1996). Di-and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells. J. Immunol. 156, 2642-2652.
51. H4 gene family. Location of individual gene segments. J. Immunol. 150, 2858-2868.
52. Wabl, M.R., Jack, H.M., von Borstel, R.C., and Steinberg, C.M. (1989). Scope of action of the immunoglobulin mutator system. Genome 31, 118-121.
53. Wagner, S.D., Milstein, C., and Neuberger, M.S. (1995). Codon bias targets mutation. Nature 376, 732.
54. Wagner, S.D., and Neuberger, M.S. (1996). Somatic Hypermutation of Immunoglobulin Genes. Annu. Rev. Immunol. 14, 441-458.
55. Wu, H., Pelkonen, E., Knuutila, S., and Kaartinen, M. (1995). A human follicular lymphoma B cell line hypermutates its functional immunoglobulin genes in vitro. Eur. J. Immunol. 25, 3263-3269.
56. Wysocki, L.J., Creadon, G., Lehmann, K.R., and Cambier, J.C. (1992). B-cell proliferation initiated by la cross-linking and sustained by interleukins leads to class switching but not somatic mutation in vitro. Immunology 75, 116-121.
57. Yelamos, J., Klix, N., Goyenechea, B., Lozano, F., Chui, Y.L., Gonzalez Fernandez, A., Pannell, R., Neuberger, M.S., and Milstein, C. (1995). Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. Nature 376, 225-229.
58. Zhu, M., Rabinowitz, J.L., Green, N.S., Kobrin, B.J., and Scharff, M.D. (1995). A well-differentiated B-cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene. Proc. Natl. Acad. Sci. USA 92, 2810-2814.
59. Ziegner, M., Steinhauser, G., and Berek, C. (1994). Development of antibody diversity in single germinal centers: selective expansion of high-affinity variants. Eur. J. Immunol. 24, 2393-2400.