-
1
-
-
1842333581
-
Transcriptionally active DNA region that rearranges frequently in murine lymphoid tumors
-
Adams JM, Gerondakis S, Webb E, Mitchell J, Bernard O, Cory S. 1982. Transcriptionally active DNA region that rearranges frequently in murine lymphoid tumors. Proc Natl Acad Sci 79: 6966-6970.
-
(1982)
Proc Natl Acad Sci
, vol.79
, pp. 6966-6970
-
-
Adams, J.M.1
Gerondakis, S.2
Webb, E.3
Mitchell, J.4
Bernard, O.5
Cory, S.6
-
2
-
-
11344268432
-
Efficient release from promoter-proximal stall sites requires transcript cleavage factor TFIIS
-
Adelman K, Marr MT, Werner J, Saunders A, Ni Z, Andrulis ED, Lis JT. 2005. Efficient release from promoter-proximal stall sites requires transcript cleavage factor TFIIS. Mol Cell 17: 103-112.
-
(2005)
Mol Cell
, vol.17
, pp. 103-112
-
-
Adelman, K.1
Marr, M.T.2
Werner, J.3
Saunders, A.4
Ni, Z.5
Andrulis, E.D.6
Lis, J.T.7
-
3
-
-
34548036949
-
Germinal-center organization and cellular dynamics
-
Allen CD, Okada T, Cyster JG. 2007a. Germinal-center organization and cellular dynamics. Immunity 27: 190-202.
-
(2007)
Immunity
, vol.27
, pp. 190-202
-
-
Allen, C.D.1
Okada, T.2
Cyster, J.G.3
-
4
-
-
33846635838
-
Imaging of germinal center selection events during affinity maturation
-
Allen CD, Okada T, Tang HL, Cyster JG. 2007b. Imaging of germinal center selection events during affinity maturation. Science 315: 528-531.
-
(2007)
Science
, vol.315
, pp. 528-531
-
-
Allen, C.D.1
Okada, T.2
Tang, H.L.3
Cyster, J.G.4
-
5
-
-
45149088174
-
Proteasomal degradation restricts the nuclear lifespan of AID
-
Aoufouchi S, Faili A, Zober C, D'Orlando O, Weller S, Weill JC, Reynaud CA. 2008. Proteasomal degradation restricts the nuclear lifespan of AID. J Exp Med 205: 1357-1368.
-
(2008)
J Exp Med
, vol.205
, pp. 1357-1368
-
-
Aoufouchi, S.1
Faili, A.2
Zober, C.3
D'Orlando, O.4
Weller, S.5
Weill, J.C.6
Reynaud, C.A.7
-
6
-
-
28544438261
-
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation
-
Basu U, Chaudhuri J, Alpert C, Dutt S, Ranganath S, Li G, Schrum JP, Manis JP, Alt FW. 2005. The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature 438: 508-511.
-
(2005)
Nature
, vol.438
, pp. 508-511
-
-
Basu, U.1
Chaudhuri, J.2
Alpert, C.3
Dutt, S.4
Ranganath, S.5
Li, G.6
Schrum, J.P.7
Manis, J.P.8
Alt, F.W.9
-
7
-
-
53949103770
-
Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase
-
Basu U, Wang Y, Alt FW. 2008. Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase. Mol Cell 32: 285-291.
-
(2008)
Mol Cell
, vol.32
, pp. 285-291
-
-
Basu, U.1
Wang, Y.2
Alt, F.W.3
-
8
-
-
79551681406
-
The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates
-
Basu U, Meng FL, Keim C, Grinstein V, Pefanis E, Eccleston J, Zhang T, Myers D, Wasserman CR, Wesemann DR, et al. 2011. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell 144: 353-363.
-
(2011)
Cell
, vol.144
, pp. 353-363
-
-
Basu, U.1
Meng, F.L.2
Keim, C.3
Grinstein, V.4
Pefanis, E.5
Eccleston, J.6
Zhang, T.7
Myers, D.8
Wasserman, C.R.9
Wesemann, D.R.10
-
9
-
-
0032100706
-
Affinity dependence of the B cell response to antigen: A threshold, a ceiling, and the importance of off-rate
-
Batista FD, Neuberger MS. 1998. Affinity dependence of the B cell response to antigen: A threshold, a ceiling, and the importance of off-rate. Immunity 8: 751-759.
-
(1998)
Immunity
, vol.8
, pp. 751-759
-
-
Batista, F.D.1
Neuberger, M.S.2
-
10
-
-
84866564544
-
The histone chaperone SPT6 is required for AID target determination through H3K4me3 regulation
-
Begum NA, Stanlie A, Nakata M, Akiyama H, Honjo T. 2012. The histone chaperone SPT6 is required for AID target determination through H3K4me3 regulation. J Biol Chem 287: 32415-32429.
-
(2012)
J Biol Chem
, vol.287
, pp. 32415-32429
-
-
Begum, N.A.1
Stanlie, A.2
Nakata, M.3
Akiyama, H.4
Honjo, T.5
-
11
-
-
77149176004
-
Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4
-
Boboila C, Yan C, Wesemann DR, Jankovic M, Wang JH, Manis J, Nussenzweig A, Nussenzweig M, Alt FW. 2010. Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. J Exp Med 207: 417-427.
-
(2010)
J Exp Med
, vol.207
, pp. 417-427
-
-
Boboila, C.1
Yan, C.2
Wesemann, D.R.3
Jankovic, M.4
Wang, J.H.5
Manis, J.6
Nussenzweig, A.7
Nussenzweig, M.8
Alt, F.W.9
-
12
-
-
84867386682
-
Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks
-
Boboila C, Alt FW, Schwer B. 2012. Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks. Adv Immunol 116: 1-49.
-
(2012)
Adv Immunol
, vol.116
, pp. 1-49
-
-
Boboila, C.1
Alt, F.W.2
Schwer, B.3
-
13
-
-
0027952630
-
S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process
-
Bottaro A, Lansford R, Xu L, Zhang J, Rothman P, Alt FW. 1994. S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process. EMBO J 13: 665-674.
-
(1994)
EMBO J
, vol.13
, pp. 665-674
-
-
Bottaro, A.1
Lansford, R.2
Xu, L.3
Zhang, J.4
Rothman, P.5
Alt, F.W.6
-
14
-
-
0037388165
-
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
-
Bransteitter R, Pham P, Scharff MD, Goodman MF. 2003. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc Natl Acad Sci 100: 4102-4107.
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 4102-4107
-
-
Bransteitter, R.1
Pham, P.2
Scharff, M.D.3
Goodman, M.F.4
-
15
-
-
10944223445
-
Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase
-
Bransteitter R, Pham P, Calabrese P, Goodman MF. 2004. Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase. J Biol Chem 279: 51612-51621.
-
(2004)
J Biol Chem
, vol.279
, pp. 51612-51621
-
-
Bransteitter, R.1
Pham, P.2
Calabrese, P.3
Goodman, M.F.4
-
16
-
-
38449084983
-
Role of activation-induced deaminase protein kinase A phosphorylation sites in Ig gene conversion and somatic hypermutation
-
Chatterji M, Unniraman S, McBride KM, Schatz DG. 2007. Role of activation-induced deaminase protein kinase A phosphorylation sites in Ig gene conversion and somatic hypermutation. J Immunol 179: 5274-5280.
-
(2007)
J Immunol
, vol.179
, pp. 5274-5280
-
-
Chatterji, M.1
Unniraman, S.2
McBride, K.M.3
Schatz, D.G.4
-
17
-
-
3142765336
-
Class-switch recombination: Interplay of transcription, DNA deamination and DNA repair
-
Chaudhuri J, Alt FW. 2004. Class-switch recombination: Interplay of transcription, DNA deamination and DNA repair. Nat Rev Immunol 4: 541-552.
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 541-552
-
-
Chaudhuri, J.1
Alt, F.W.2
-
18
-
-
0037452080
-
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
-
Chaudhuri J, Tian M, Khuong C, Chua K, Pinaud E, Alt FW. 2003. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature 422: 726-730.
-
(2003)
Nature
, vol.422
, pp. 726-730
-
-
Chaudhuri, J.1
Tian, M.2
Khuong, C.3
Chua, K.4
Pinaud, E.5
Alt, F.W.6
-
19
-
-
4344700569
-
Replication protein A interacts with AID to promote deamination of somatic hypermutation targets
-
Chaudhuri J, Khuong C, Alt FW. 2004. Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature 430: 992-998.
-
(2004)
Nature
, vol.430
, pp. 992-998
-
-
Chaudhuri, J.1
Khuong, C.2
Alt, F.W.3
-
20
-
-
34249794280
-
Evolution of the immunoglobulin heavy chain class switch recombination mechanism
-
Chaudhuri J, Basu U, Zarrin A, Yan C, Franco S, Perlot T, Vuong B, Wang J, Phan RT, Datta A, et al. 2007. Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Adv Immunol 94: 157-214.
-
(2007)
Adv Immunol
, vol.94
, pp. 157-214
-
-
Chaudhuri, J.1
Basu, U.2
Zarrin, A.3
Yan, C.4
Franco, S.5
Perlot, T.6
Vuong, B.7
Wang, J.8
Phan, R.T.9
Datta, A.10
-
21
-
-
0018135592
-
Distribution of horseradish peroxidase (HRP)-anti-HRP immune complexes in mouse spleen with special reference to follicular dendritic cells
-
Chen LL, Frank AM, Adams JC, Steinman RM. 1978. Distribution of horseradish peroxidase (HRP)-anti-HRP immune complexes in mouse spleen with special reference to follicular dendritic cells. J Cell Biol 79: 184-199.
-
(1978)
J Cell Biol
, vol.79
, pp. 184-199
-
-
Chen, L.L.1
Frank, A.M.2
Adams, J.C.3
Steinman, R.M.4
-
22
-
-
80053558376
-
Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells
-
Chiarle R, Zhang Y, Frock RL, Lewis SM, Molinie B, Ho YJ, Myers DR, Choi VW, Compagno M, Malkin DJ, et al. 2011. Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell 147: 107-119.
-
(2011)
Cell
, vol.147
, pp. 107-119
-
-
Chiarle, R.1
Zhang, Y.2
Frock, R.L.3
Lewis, S.M.4
Molinie, B.5
Ho, Y.J.6
Myers, D.R.7
Choi, V.W.8
Compagno, M.9
Malkin, D.J.10
-
25
-
-
49349112190
-
Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1
-
Conticello SG, Ganesh K, Xue K, Lu M, Rada C, Neuberger MS. 2008. Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1. Mol Cell 31: 474-484.
-
(2008)
Mol Cell
, vol.31
, pp. 474-484
-
-
Conticello, S.G.1
Ganesh, K.2
Xue, K.3
Lu, M.4
Rada, C.5
Neuberger, M.S.6
-
27
-
-
0029598833
-
RNA:DNA complex formation upon transcription of immunoglobulin switch regions: Implications for the mechanism and regulation of class switch recombination
-
Daniels GA, Lieber MR. 1995. RNA:DNA complex formation upon transcription of immunoglobulin switch regions: Implications for the mechanism and regulation of class switch recombination. Nucleic Acids Res 23: 5006-5011.
-
(1995)
Nucleic Acids Res
, vol.23
, pp. 5006-5011
-
-
Daniels, G.A.1
Lieber, M.R.2
-
28
-
-
0032757402
-
Switching to IgG3, IgG2b, and IgA is division linked and independent, revealing a stochastic framework for describing differentiation
-
Deenick EK, Hasbold J, Hodgkin PD. 1999. Switching to IgG3, IgG2b, and IgA is division linked and independent, revealing a stochastic framework for describing differentiation. J Immunol 163: 4707-4714.
-
(1999)
J Immunol
, vol.163
, pp. 4707-4714
-
-
Deenick, E.K.1
Hasbold, J.2
Hodgkin, P.D.3
-
29
-
-
0030831199
-
The complexity of signaling pathways activated by the BCR
-
DeFranco AL. 1997. The complexity of signaling pathways activated by the BCR. Curr Opin Immunol 9: 296-308.
-
(1997)
Curr Opin Immunol
, vol.9
, pp. 296-308
-
-
Defranco, A.L.1
-
30
-
-
53349129731
-
miR-181b negatively regulates activation-induced cytidine deaminase in B cells
-
de Yebenes VG, Belver L, Pisano DG, Gonzalez S, Villasante A, Croce C, He L, Ramiro AR. 2008. miR-181b negatively regulates activation-induced cytidine deaminase in B cells. J Exp Med 205: 2199-2206.
-
(2008)
J Exp Med
, vol.205
, pp. 2199-2206
-
-
de Yebenes, V.G.1
Belver, L.2
Pisano, D.G.3
Gonzalez, S.4
Villasante, A.5
Croce, C.6
He, L.7
-
31
-
-
0037026482
-
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase
-
Di Noia J, Neuberger MS. 2002. Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature 419: 43-48.
-
(2002)
Nature
, vol.419
, pp. 43-48
-
-
Di Noia, J.1
Neuberger, M.S.2
-
33
-
-
43049173617
-
MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation
-
Dorsett Y, McBride KM, Jankovic M, Gazumyan A, Thai TH, Robbiani DF, Di Virgilio M, Reina San-Martin B, Heidkamp G, Schwickert TA, et al. 2008. MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity 28: 630-638.
-
(2008)
Immunity
, vol.28
, pp. 630-638
-
-
Dorsett, Y.1
McBride, K.M.2
Jankovic, M.3
Gazumyan, A.4
Thai, T.H.5
Robbiani, D.F.6
Di Virgilio, M.7
Reina, S.B.8
Heidkamp, G.9
Schwickert, T.A.10
-
34
-
-
0019179349
-
An immunoglobulin deletion mutant with implications for the heavy-chain switch and RNA splicing
-
Dunnick W, Rabbitts TH, Milstein C. 1980. An immunoglobulin deletion mutant with implications for the heavy-chain switch and RNA splicing. Nature 286: 669-675.
-
(1980)
Nature
, vol.286
, pp. 669-675
-
-
Dunnick, W.1
Rabbitts, T.H.2
Milstein, C.3
-
36
-
-
0024385049
-
Rapid induction of transcription of unrearranged Sg1 switch regions in activated murine B cells by interleukin 4
-
Esser C, Radbruch A. 1989. Rapid induction of transcription of unrearranged Sg1 switch regions in activated murine B cells by interleukin 4. EMBO J 8: 483-488.
-
(1989)
EMBO J
, vol.8
, pp. 483-488
-
-
Esser, C.1
Radbruch, A.2
-
37
-
-
1642499721
-
DNA polymerase h is involved in hypermutation occurring during immunoglobulin class switch recombination
-
Faili A, Aoufouchi S, Weller S, Vuillier F, Stary A, Sarasin A, Reynaud CA, Weill JC. 2004. DNA polymerase h is involved in hypermutation occurring during immunoglobulin class switch recombination. J Exp Med 199: 265-270.
-
(2004)
J Exp Med
, vol.199
, pp. 265-270
-
-
Faili, A.1
Aoufouchi, S.2
Weller, S.3
Vuillier, F.4
Stary, A.5
Sarasin, A.6
Reynaud, C.A.7
Weill, J.C.8
-
38
-
-
30744445418
-
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations
-
Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, et al. 2006. H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell 21: 201-214.
-
(2006)
Mol Cell
, vol.21
, pp. 201-214
-
-
Franco, S.1
Gostissa, M.2
Zha, S.3
Lombard, D.B.4
Murphy, M.M.5
Zarrin, A.A.6
Yan, C.7
Tepsuporn, S.8
Morales, J.C.9
Adams, M.M.10
-
39
-
-
4444258534
-
Chromatin architecture of the human genome: Gene-rich domains are enriched in open chromatin fibers
-
Gilbert N, Boyle S, Fiegler H, Woodfine K, Carter NP, Bickmore WA. 2004. Chromatin architecture of the human genome: Gene-rich domains are enriched in open chromatin fibers. Cell 118: 555-566.
-
(2004)
Cell
, vol.118
, pp. 555-566
-
-
Gilbert, N.1
Boyle, S.2
Fiegler, H.3
Woodfine, K.4
Carter, N.P.5
Bickmore, W.A.6
-
41
-
-
84863105929
-
AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells
-
Gramlich HS, Reisbig T, Schatz DG. 2012. AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells. PLoS ONE 7: e39601.
-
(2012)
PLoS ONE
, vol.7
-
-
Gramlich, H.S.1
Reisbig, T.2
Schatz, D.G.3
-
42
-
-
0027280936
-
Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting
-
Gu H, Zou YR, Rajewsky K. 1993. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell 73: 1155-1164.
-
(1993)
Cell
, vol.73
, pp. 1155-1164
-
-
Gu, H.1
Zou, Y.R.2
Rajewsky, K.3
-
43
-
-
36549036731
-
APE1-and APE2-dependent DNA breaks in immunoglobulin class switch recombination
-
Guikema JE, Linehan EK, Tsuchimoto D, Nakabeppu Y, Strauss PR, Stavnezer J, Schrader CE. 2007. APE1-and APE2-dependent DNA breaks in immunoglobulin class switch recombination. J Exp Med 204: 3017-3026.
-
(2007)
J Exp Med
, vol.204
, pp. 3017-3026
-
-
Guikema, J.E.1
Linehan, E.K.2
Tsuchimoto, D.3
Nakabeppu, Y.4
Strauss, P.R.5
Stavnezer, J.6
Schrader, C.E.7
-
44
-
-
79955009382
-
Sense transcription through the S region is essential for immunoglobulin class switch recombination
-
Haddad D, Oruc Z, Puget N, Laviolette-Malirat N, Philippe M, Carrion C, Le Bert M, Khamlichi AA. 2011. Sense transcription through the S region is essential for immunoglobulin class switch recombination. EMBO J 30: 1608-1620.
-
(2011)
EMBO J
, vol.30
, pp. 1608-1620
-
-
Haddad, D.1
Oruc, Z.2
Puget, N.3
Laviolette-Malirat, N.4
Philippe, M.5
Carrion, C.6
Le Bert, M.7
Khamlichi, A.A.8
-
45
-
-
0036303482
-
Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III
-
Hadi MZ, Ginalski K, Nguyen LH, Wilson DM. 2002. Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III. J Mol Biol 316: 853-866.
-
(2002)
J Mol Biol
, vol.316
, pp. 853-866
-
-
Hadi, M.Z.1
Ginalski, K.2
Nguyen, L.H.3
Wilson, D.M.4
-
46
-
-
84859474968
-
DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes
-
Hakim O, Resch W, Yamane A, Klein I, Kieffer-Kwon KR, Jankovic M, Oliveira T, Bothmer A, Voss TC, Ansarah-Sobrinho C, et al. 2012. DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes. Nature 484: 69-74.
-
(2012)
Nature
, vol.484
, pp. 69-74
-
-
Hakim, O.1
Resch, W.2
Yamane, A.3
Klein, I.4
Kieffer-Kwon, K.R.5
Jankovic, M.6
Oliveira, T.7
Bothmer, A.8
Voss, T.C.9
Ansarah-Sobrinho, C.10
-
47
-
-
77956417669
-
Cutting edge: CTNNBL1 is dispensable for Ig class switch recombination
-
Han L, Masani S, Yu K. 2010. Cutting edge: CTNNBL1 is dispensable for Ig class switch recombination. J Immunol 185: 1379-1381.
-
(2010)
J Immunol
, vol.185
, pp. 1379-1381
-
-
Han, L.1
Masani, S.2
Yu, K.3
-
48
-
-
79960990878
-
Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination
-
Han L, Masani S, Yu K. 2011. Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination. Proc Natl Acad Sci 108: 11584-11589.
-
(2011)
Proc Natl Acad Sci
, vol.108
, pp. 11584-11589
-
-
Han, L.1
Masani, S.2
Yu, K.3
-
50
-
-
0031905273
-
Cell division number regulates IgG1 and IgE switching of B cells following stimulation by CD40 ligand and IL-4
-
Hasbold J, Lyons AB, Kehry MR, Hodgkin PD. 1998. Cell division number regulates IgG1 and IgE switching of B cells following stimulation by CD40 ligand and IL-4. Eur J Immunol 28: 1040-1051.
-
(1998)
Eur J Immunol
, vol.28
, pp. 1040-1051
-
-
Hasbold, J.1
Lyons, A.B.2
Kehry, M.R.3
Hodgkin, P.D.4
-
51
-
-
77955921194
-
Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination
-
Hasham MG, Donghia NM, Coffey E, Maynard J, Snow KJ, Ames J, Wilpan RY, He Y, King BL, Mills KD. 2010. Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination. Nat Immunol 11: 820-826.
-
(2010)
Nat Immunol
, vol.11
, pp. 820-826
-
-
Hasham, M.G.1
Donghia, N.M.2
Coffey, E.3
Maynard, J.4
Snow, K.J.5
Ames, J.6
Wilpan, R.Y.7
He, Y.8
King, B.L.9
Mills, K.D.10
-
52
-
-
34248585765
-
Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns
-
Hauser AE, Junt T, Mempel TR, Sneddon MW, Kleinstein SH, Henrickson SE, von Andrian UH, Shlomchik MJ, Haberman AM. 2007. Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns. Immunity 26: 655-667.
-
(2007)
Immunity
, vol.26
, pp. 655-667
-
-
Hauser, A.E.1
Junt, T.2
Mempel, T.R.3
Sneddon, M.W.4
Kleinstein, S.H.5
Henrickson, S.E.6
von Andrian, U.H.7
Shlomchik, M.J.8
Haberman, A.M.9
-
53
-
-
0032416146
-
Processing of switch transcripts is required for targeting of antibody class switch recombination
-
Hein K, Lorenz MG, Siebenkotten G, Petry K, Christine R, Radbruch A. 1998. Processing of switch transcripts is required for targeting of antibody class switch recombination. J Exp Med 188: 2369-2374.
-
(1998)
J Exp Med
, vol.188
, pp. 2369-2374
-
-
Hein, K.1
Lorenz, M.G.2
Siebenkotten, G.3
Petry, K.4
Christine, R.5
Radbruch, A.6
-
54
-
-
0030037519
-
B cell differentiation and isotype switching is related to division cycle number
-
Hodgkin PD, Lee JH, Lyons AB. 1996. B cell differentiation and isotype switching is related to division cycle number. J Exp Med 184: 277-281.
-
(1996)
J Exp Med
, vol.184
, pp. 277-281
-
-
Hodgkin, P.D.1
Lee, J.H.2
Lyons, A.B.3
-
55
-
-
0008411148
-
Organization of immunoglobulin heavy chain genes and allelic deletion model
-
Honjo T, Kataoka T. 1978. Organization of immunoglobulin heavy chain genes and allelic deletion model. Proc Natl Acad Sci 75: 2140-2144.
-
(1978)
Proc Natl Acad Sci
, vol.75
, pp. 2140-2144
-
-
Honjo, T.1
Kataoka, T.2
-
56
-
-
0031202137
-
Telomerase is up-regulated in human germinal center B cells in vivo and can be re-expressed in memory B cells activated in vitro
-
Hu BT, Lee SC, Marin E, Ryan DH, Insel RA. 1997. Telomerase is up-regulated in human germinal center B cells in vivo and can be re-expressed in memory B cells activated in vitro. J Immunol 159: 1068-1071.
-
(1997)
J Immunol
, vol.159
, pp. 1068-1071
-
-
Hu, B.T.1
Lee, S.C.2
Marin, E.3
Ryan, D.H.4
Insel, R.A.5
-
57
-
-
28244492832
-
B cells productively engage soluble antigen-pulsed dendritic cells: Visualization of live-cell dynamics of B cell-dendritic cell interactions
-
Huang NN, Han SB, Hwang IY, Kehrl JH. 2005. B cells productively engage soluble antigen-pulsed dendritic cells: Visualization of live-cell dynamics of B cell-dendritic cell interactions. J Immunol 175: 7125-7134.
-
(2005)
J Immunol
, vol.175
, pp. 7125-7134
-
-
Huang, N.N.1
Han, S.B.2
Hwang, I.Y.3
Kehrl, J.H.4
-
58
-
-
34248157719
-
APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks
-
Iles N, Rulten S, El-Khamisy SF, Caldecott KW. 2007. APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. Mol Cell Biol 27: 3793-3803.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 3793-3803
-
-
Iles, N.1
Rulten, S.2
El-Khamisy, S.F.3
Caldecott, K.W.4
-
59
-
-
0025345212
-
Circular DNA is excised by immunoglobulin class switch recombination
-
Iwasato T, Shimizu A, Honjo T, Yamagishi H. 1990. Circular DNA is excised by immunoglobulin class switch recombination. Cell 62: 143-149.
-
(1990)
Cell
, vol.62
, pp. 143-149
-
-
Iwasato, T.1
Shimizu, A.2
Honjo, T.3
Yamagishi, H.4
-
60
-
-
0026060620
-
Intraclonal generation of antibody mutants in germinal centres
-
Jacob J, Kelsoe G, Rajewsky K, Weiss U. 1991. Intraclonal generation of antibody mutants in germinal centres. Nature 354: 389-392.
-
(1991)
Nature
, vol.354
, pp. 389-392
-
-
Jacob, J.1
Kelsoe, G.2
Rajewsky, K.3
Weiss, U.4
-
61
-
-
0027417869
-
Shutdown of class switch recombination by deletion of a switch region control element
-
Jung S, Rajewsky K, Radbruch A. 1993. Shutdown of class switch recombination by deletion of a switch region control element. Science 259: 984-987.
-
(1993)
Science
, vol.259
, pp. 984-987
-
-
Jung, S.1
Rajewsky, K.2
Radbruch, A.3
-
62
-
-
1842319924
-
Rearrangement of immunoglobulin g 1-chain gene and mechanism for heavy-chain class switch
-
Kataoka T, Kawakami T, Takahashi N, Honjo T. 1980. Rearrangement of immunoglobulin g 1-chain gene and mechanism for heavy-chain class switch. Proc Natl Acad Sci 77: 919-923.
-
(1980)
Proc Natl Acad Sci
, vol.77
, pp. 919-923
-
-
Kataoka, T.1
Kawakami, T.2
Takahashi, N.3
Honjo, T.4
-
63
-
-
0019460884
-
Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes
-
Kataoka T, Miyata T, Honjo T. 1981. Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes. Cell 23: 357-368.
-
(1981)
Cell
, vol.23
, pp. 357-368
-
-
Kataoka, T.1
Miyata, T.2
Honjo, T.3
-
64
-
-
0032428658
-
Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions
-
Kinoshita K, Tashiro J, Tomita S, Lee CG, Honjo T. 1998. Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions. Immunity 9: 849-858.
-
(1998)
Immunity
, vol.9
, pp. 849-858
-
-
Kinoshita, K.1
Tashiro, J.2
Tomita, S.3
Lee, C.G.4
Honjo, T.5
-
65
-
-
37549015263
-
Germinal centres: Role in B-cell physiology and malignancy
-
Klein U, Dalla-Favera R. 2008. Germinal centres: Role in B-cell physiology and malignancy. Nat Rev Immunol 8: 22-33.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 22-33
-
-
Klein, U.1
Dalla-Favera, R.2
-
66
-
-
0344953578
-
Transcriptional analysis of the B cell germinal center reaction
-
Klein U, Tu Y, Stolovitzky GA, Keller JL, Haddad J Jr, Miljkovic V, Cattoretti G, Califano A, Dalla-Favera R. 2003. Transcriptional analysis of the B cell germinal center reaction. Proc Natl Acad Sci 100: 2639-2644.
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 2639-2644
-
-
Klein, U.1
Tu, Y.2
Stolovitzky, G.A.3
Keller, J.L.4
Haddad Jr., J.5
Miljkovic, V.6
Cattoretti, G.7
Califano, A.8
Dalla-Favera, R.9
-
67
-
-
80053502216
-
Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes
-
Klein IA, Resch W, Jankovic M, Oliveira T, Yamane A, Nakahashi H, Di Virgilio M, Bothmer A, Nussenzweig A, Robbiani DF, et al. 2011. Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes. Cell 147: 95-106.
-
(2011)
Cell
, vol.147
, pp. 95-106
-
-
Klein, I.A.1
Resch, W.2
Jankovic, M.3
Oliveira, T.4
Yamane, A.5
Nakahashi, H.6
Di Virgilio, M.7
Bothmer, A.8
Nussenzweig, A.9
Robbiani, D.F.10
-
68
-
-
27644532332
-
Specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) expressed by marginal zone macrophages is essential for defense against pulmonary Streptococcus pneumoniae infection
-
Koppel EA, Wieland CW, van den Berg VC, Litjens M, Florquin S, van Kooyk Y, van der Poll T, Geijtenbeek TB. 2005. Specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) expressed by marginal zone macrophages is essential for defense against pulmonary Streptococcus pneumoniae infection. Eur J Immunol 35: 2962-2969.
-
(2005)
Eur J Immunol
, vol.35
, pp. 2962-2969
-
-
Koppel, E.A.1
Wieland, C.W.2
Van den Berg, V.C.3
Litjens, M.4
Florquin, S.5
van Kooyk, Y.6
Van der Poll, T.7
Geijtenbeek, T.B.8
-
69
-
-
0025630537
-
Boundaries of somatic mutation in rearranged immunoglobulin genes: 59 boundary is near the promoter, and 39 boundary is approximately 1 kb from V(D)J gene
-
Lebecque SG, Gearhart PJ. 1990. Boundaries of somatic mutation in rearranged immunoglobulin genes: 59 boundary is near the promoter, and 39 boundary is approximately 1 kb from V(D)J gene. J Exp Med 172: 1717-1727.
-
(1990)
J Exp Med
, vol.172
, pp. 1717-1727
-
-
Lebecque, S.G.1
Gearhart, P.J.2
-
70
-
-
0021071480
-
Translocations among antibody genes in human cancer
-
Leder P, Battey J, Lenoir G, Moulding C, Murphy W, Potter H, Stewart T, Taub R. 1983. Translocations among antibody genes in human cancer. Science 222: 765-771.
-
(1983)
Science
, vol.222
, pp. 765-771
-
-
Leder, P.1
Battey, J.2
Lenoir, G.3
Moulding, C.4
Murphy, W.5
Potter, H.6
Stewart, T.7
Taub, R.8
-
71
-
-
70349873824
-
Comprehensive mapping of long-range interactions reveals folding principles of the human genome
-
Lieberman-Aiden E, van Berkum NL, Williams L, Imakaev M, Ragoczy T, Telling A, Amit I, Lajoie BR, Sabo PJ, Dorschner MO, et al. 2009. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science 326: 289-293.
-
(2009)
Science
, vol.326
, pp. 289-293
-
-
Lieberman-Aiden, E.1
van Berkum, N.L.2
Williams, L.3
Imakaev, M.4
Ragoczy, T.5
Telling, A.6
Amit, I.7
Lajoie, B.R.8
Sabo, P.J.9
Dorschner, M.O.10
-
72
-
-
71249101060
-
Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer
-
Lin C, Yang L, Tanasa B, Hutt K, Ju BG, Ohgi K, Zhang J, Rose DW, Fu XD, Glass CK, et al. 2009. Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell 139: 1069-1083.
-
(2009)
Cell
, vol.139
, pp. 1069-1083
-
-
Lin, C.1
Yang, L.2
Tanasa, B.3
Hutt, K.4
Ju, B.G.5
Ohgi, K.6
Zhang, J.7
Rose, D.W.8
Fu, X.D.9
Glass, C.K.10
-
73
-
-
63149179802
-
Balancing AID and DNA repair during somatic hypermutation
-
Liu M, Schatz DG. 2009. Balancing AID and DNA repair during somatic hypermutation. Trends Immunol 30: 173-181.
-
(2009)
Trends Immunol
, vol.30
, pp. 173-181
-
-
Liu, M.1
Schatz, D.G.2
-
74
-
-
39149099085
-
Two levels of protection for the B cell genome during somatic hypermutation
-
Liu M, Duke JL, Richter DJ, Vinuesa CG, Goodnow CC, Kleinstein SH, Schatz DG. 2008. Two levels of protection for the B cell genome during somatic hypermutation. Nature 451: 841-845.
-
(2008)
Nature
, vol.451
, pp. 841-845
-
-
Liu, M.1
Duke, J.L.2
Richter, D.J.3
Vinuesa, C.G.4
Goodnow, C.C.5
Kleinstein, S.H.6
Schatz, D.G.7
-
75
-
-
0028968667
-
Switch transcripts in immunoglobulin class switching
-
Lorenz M, Jung S, Radbruch A. 1995. Switch transcripts in immunoglobulin class switching. Science 267: 1825-1828.
-
(1995)
Science
, vol.267
, pp. 1825-1828
-
-
Lorenz, M.1
Jung, S.2
Radbruch, A.3
-
76
-
-
25444475799
-
Repair of double-strand DNA breaks by the human nonhomologous DNA end joining pathway: The iterative processing model
-
Ma Y, Lu H, Schwarz K, Lieber MR. 2005. Repair of double-strand DNA breaks by the human nonhomologous DNA end joining pathway: The iterative processing model. Cell Cycle 4: 1193-1200.
-
(2005)
Cell Cycle
, vol.4
, pp. 1193-1200
-
-
Ma, Y.1
Lu, H.2
Schwarz, K.3
Lieber, M.R.4
-
78
-
-
78650307766
-
Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions
-
Maul RW, Saribasak H, Martomo SA, McClure RL, Yang W, Vaisman A, Gramlich HS, Schatz DG, Woodgate R, Wilson DM 3rd, et al. 2011. Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions. Nat Immunol 12: 70-76.
-
(2011)
Nat Immunol
, vol.12
, pp. 70-76
-
-
Maul, R.W.1
Saribasak, H.2
Martomo, S.A.3
McClure, R.L.4
Yang, W.5
Vaisman, A.6
Gramlich, H.S.7
Schatz, D.G.8
Woodgate, R.9
Wilson III, D.M.10
-
79
-
-
33745048221
-
Regulation of hyper-mutation by activation-induced cytidine deaminase phosphorylation
-
McBride KM, Gazumyan A, Woo EM, Barreto VM, Robbiani DF, Chait BT, Nussenzweig MC. 2006. Regulation of hyper-mutation by activation-induced cytidine deaminase phosphorylation. Proc Natl Acad Sci 103: 8798-8803.
-
(2006)
Proc Natl Acad Sci
, vol.103
, pp. 8798-8803
-
-
McBride, K.M.1
Gazumyan, A.2
Woo, E.M.3
Barreto, V.M.4
Robbiani, D.F.5
Chait, B.T.6
Nussenzweig, M.C.7
-
80
-
-
57749191326
-
Regulation of class switch recombination and somatic mutation by AID phosphorylation
-
McBride KM, Gazumyan A, Woo EM, Schwickert TA, Chait BT, Nussenzweig MC. 2008. Regulation of class switch recombination and somatic mutation by AID phosphorylation. J Exp Med 205: 2585-2594.
-
(2008)
J Exp Med
, vol.205
, pp. 2585-2594
-
-
McBride, K.M.1
Gazumyan, A.2
Woo, E.M.3
Schwickert, T.A.4
Chait, B.T.5
Nussenzweig, M.C.6
-
81
-
-
0033603340
-
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
-
Muramatsu M, Sankaranand VS, Anant S, Sugai M, Kinoshita K, Davidson NO, Honjo T. 1999. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J Biol Chem 274: 18470-18476.
-
(1999)
J Biol Chem
, vol.274
, pp. 18470-18476
-
-
Muramatsu, M.1
Sankaranand, V.S.2
Anant, S.3
Sugai, M.4
Kinoshita, K.5
Davidson, N.O.6
Honjo, T.7
-
82
-
-
0034268780
-
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
-
Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T. 2000. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102: 553-563.
-
(2000)
Cell
, vol.102
, pp. 553-563
-
-
Muramatsu, M.1
Kinoshita, K.2
Fagarasan, S.3
Yamada, S.4
Shinkai, Y.5
Honjo, T.6
-
83
-
-
13444259474
-
Somatic hypermutation at A.T pairs: Polymerase error versus dUTP incorporation
-
Neuberger MS, Di Noia JM, Beale RC, Williams GT, Yang Z, Rada C. 2005. Somatic hypermutation at A.T pairs: Polymerase error versus dUTP incorporation. Nat Rev Immunol 5: 171-178.
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 171-178
-
-
Neuberger, M.S.1
Di Noia, J.M.2
Beale, R.C.3
Williams, G.T.4
Yang, Z.5
Rada, C.6
-
84
-
-
78751608734
-
The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA
-
Nowak U, Matthews AJ, Zheng S, Chaudhuri J. 2011. The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA. Nat Immunol 12: 160-166.
-
(2011)
Nat Immunol
, vol.12
, pp. 160-166
-
-
Nowak, U.1
Matthews, A.J.2
Zheng, S.3
Chaudhuri, J.4
-
85
-
-
84865180284
-
Activation induced deaminase: How much and where?
-
Orthwein A, Di Noia JM. 2012. Activation induced deaminase: How much and where? Semin Immunol 24: 246-254.
-
(2012)
Semin Immunol
, vol.24
, pp. 246-254
-
-
Orthwein, A.1
Di Noia, J.M.2
-
86
-
-
34548210885
-
Myc dynamically and preferentially relocates to a transcription factory occupied by Igh
-
Osborne CS, Chakalova L, Mitchell JA, Horton A, Wood AL, Bolland DJ, Corcoran AE, Fraser P. 2007. Myc dynamically and preferentially relocates to a transcription factory occupied by Igh. PLoS Biol 5: e192.
-
(2007)
PLoS Biol
, vol.5
-
-
Osborne, C.S.1
Chakalova, L.2
Mitchell, J.A.3
Horton, A.4
Wood, A.L.5
Bolland, D.J.6
Corcoran, A.E.7
Fraser, P.8
-
87
-
-
13244268505
-
Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells
-
Pan-Hammarstrom Q, Jones AM, Lahdesmaki A, Zhou W, Gatti RA, Hammarstrom L, Gennery AR, Ehrenstein MR. 2005. Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells. J Exp Med 201: 189-194.
-
(2005)
J Exp Med
, vol.201
, pp. 189-194
-
-
Pan-Hammarstrom, Q.1
Jones, A.M.2
Lahdesmaki, A.3
Zhou, W.4
Gatti, R.A.5
Hammarstrom, L.6
Gennery, A.R.7
Ehrenstein, M.R.8
-
88
-
-
31044435055
-
PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells
-
Pasqualucci L, Kitaura Y, Gu H, Dalla-Favera R. 2006. PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells. Proc Natl Acad Sci 103: 395-400.
-
(2006)
Proc Natl Acad Sci
, vol.103
, pp. 395-400
-
-
Pasqualucci, L.1
Kitaura, Y.2
Gu, H.3
Dalla-Favera, R.4
-
89
-
-
37549068541
-
AID is required for germinal centerderived lymphomagenesis
-
Pasqualucci L, Bhagat G, Jankovic M, Compagno M, Smith P, Muramatsu M, Honjo T, Morse HC 3rd, Nussenzweig MC, Dalla-Favera R. 2008. AID is required for germinal centerderived lymphomagenesis. Nat Genet 40: 108-112.
-
(2008)
Nat Genet
, vol.40
, pp. 108-112
-
-
Pasqualucci, L.1
Bhagat, G.2
Jankovic, M.3
Compagno, M.4
Smith, P.5
Muramatsu, M.6
Honjo, T.7
Morse III, H.C.8
Nussenzweig, M.C.9
Dalla-Favera, R.10
-
90
-
-
77957239251
-
Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5
-
Pavri R, Gazumyan A, Jankovic M, Di Virgilio M, Klein I, Ansarah-Sobrinho C, Resch W, Yamane A, Reina San-Martin B, Barreto V, et al. 2010. Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. Cell 143: 122-133.
-
(2010)
Cell
, vol.143
, pp. 122-133
-
-
Pavri, R.1
Gazumyan, A.2
Jankovic, M.3
Di Virgilio, M.4
Klein, I.5
Ansarah-Sobrinho, C.6
Resch, W.7
Yamane, A.8
Reina San-Martin, B.9
Barreto, V.10
-
91
-
-
41649094641
-
Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions
-
Perlot T, Li G, Alt FW. 2008. Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions. Proc Natl Acad Sci 105: 3843-3848.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 3843-3848
-
-
Perlot, T.1
Li, G.2
Alt, F.W.3
-
92
-
-
0030063726
-
Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
-
Peters A, Storb U. 1996. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity 4: 57-65.
-
(1996)
Immunity
, vol.4
, pp. 57-65
-
-
Peters, A.1
Storb, U.2
-
93
-
-
0037019315
-
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
-
Petersen-Mahrt SK, Harris RS, Neuberger MS. 2002. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature 418: 99-103.
-
(2002)
Nature
, vol.418
, pp. 99-103
-
-
Petersen-Mahrt, S.K.1
Harris, R.S.2
Neuberger, M.S.3
-
94
-
-
0032101611
-
Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein
-
Phung QH, Winter DB, Cranston A, Tarone RE, Bohr VA, Fishel R, Gearhart PJ. 1998. Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein. J Exp Med 187: 1745-1751.
-
(1998)
J Exp Med
, vol.187
, pp. 1745-1751
-
-
Phung, Q.H.1
Winter, D.B.2
Cranston, A.3
Tarone, R.E.4
Bohr, V.A.5
Fishel, R.6
Gearhart, P.J.7
-
95
-
-
0035881820
-
The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially
-
Rada C, Milstein C. 2001. The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially. EMBO J 20: 4570-4576.
-
(2001)
EMBO J
, vol.20
, pp. 4570-4576
-
-
Rada, C.1
Milstein, C.2
-
96
-
-
0037108463
-
Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
-
Rada C, Williams GT, Nilsen H, Barnes DE, Lindahl T, Neuberger MS. 2002. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr Biol 12: 1748-1755.
-
(2002)
Curr Biol
, vol.12
, pp. 1748-1755
-
-
Rada, C.1
Williams, G.T.2
Nilsen, H.3
Barnes, D.E.4
Lindahl, T.5
Neuberger, M.S.6
-
97
-
-
67449161835
-
Immunoglobulin switch mu sequence causes RNA polymerase II accumulation and reduces dA hypermutation
-
Rajagopal D, Maul RW, Ghosh A, Chakraborty T, Khamlichi AA, Sen R, Gearhart PJ. 2009. Immunoglobulin switch mu sequence causes RNA polymerase II accumulation and reduces dA hypermutation. J Exp Med 206: 1237-1244.
-
(2009)
J Exp Med
, vol.206
, pp. 1237-1244
-
-
Rajagopal, D.1
Maul, R.W.2
Ghosh, A.3
Chakraborty, T.4
Khamlichi, A.A.5
Sen, R.6
Gearhart, P.J.7
-
98
-
-
0038293484
-
Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand
-
Ramiro AR, Stavropoulos P, Jankovic M, Nussenzweig MC. 2003. Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat Immunol 4: 452-456.
-
(2003)
Nat Immunol
, vol.4
, pp. 452-456
-
-
Ramiro, A.R.1
Stavropoulos, P.2
Jankovic, M.3
Nussenzweig, M.C.4
-
99
-
-
4644257592
-
AID is required for c-myc/IgH chromosome translocations in vivo
-
Ramiro AR, Jankovic M, Eisenreich T, Difilippantonio S, Chen-Kiang S, Muramatsu M, Honjo T, Nussenzweig A, Nussenzweig MC. 2004. AID is required for c-myc/IgH chromosome translocations in vivo. Cell 118: 431-438.
-
(2004)
Cell
, vol.118
, pp. 431-438
-
-
Ramiro, A.R.1
Jankovic, M.2
Eisenreich, T.3
Difilippantonio, S.4
Chen-Kiang, S.5
Muramatsu, M.6
Honjo, T.7
Nussenzweig, A.8
Nussenzweig, M.C.9
-
100
-
-
33644643189
-
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations
-
Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, et al. 2006. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature 440: 105-109.
-
(2006)
Nature
, vol.440
, pp. 105-109
-
-
Ramiro, A.R.1
Jankovic, M.2
Callen, E.3
Difilippantonio, S.4
Chen, H.T.5
McBride, K.M.6
Eisenreich, T.R.7
Chen, J.8
Dickins, R.A.9
Lowe, S.W.10
-
101
-
-
0024980981
-
Antigen receptor tail clue
-
Reth M. 1989. Antigen receptor tail clue. Nature 338: 383-384.
-
(1989)
Nature
, vol.338
, pp. 383-384
-
-
Reth, M.1
-
102
-
-
0034264851
-
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2)
-
Revy P, Muto T, Levy Y, Geissmann F, Plebani A, Sanal O, Catalan N, Forveille M, Dufourcq-Labelouse R, Gennery A, et al. 2000. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2). Cell 102: 565-575.
-
(2000)
Cell
, vol.102
, pp. 565-575
-
-
Revy, P.1
Muto, T.2
Levy, Y.3
Geissmann, F.4
Plebani, A.5
Sanal, O.6
Catalan, N.7
Forveille, M.8
Dufourcq-Labelouse, R.9
Gennery, A.10
-
103
-
-
84866870443
-
Close proximity to Igh is a contributing factor to AID-mediated translocations
-
Rocha PP, Micsinai M, Kim JR, Hewitt SL, Souza PP, Trimarchi T, Strino F, Parisi F, Kluger Y, Skok JA. 2012. Close proximity to Igh is a contributing factor to AID-mediated translocations. Mol Cell 47: 873-885.
-
(2012)
Mol Cell
, vol.47
, pp. 873-885
-
-
Rocha, P.P.1
Micsinai, M.2
Kim, J.R.3
Hewitt, S.L.4
Souza, P.P.5
Trimarchi, T.6
Strino, F.7
Parisi, F.8
Kluger, Y.9
Skok, J.A.10
-
104
-
-
0021209335
-
Antigen Presentation By Hapten-specific B Lymphocytes. I. Role of Surface Immunoglobulin Receptors
-
Rock KL, Benacerraf B, Abbas AK. 1984. Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors. J Exp Med 160: 1102-1113.
-
(1984)
J Exp Med
, vol.160
, pp. 1102-1113
-
-
Rock, K.L.1
Benacerraf, B.2
Abbas, A.K.3
-
105
-
-
1542619234
-
Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process
-
Rogozin IB, Diaz M. 2004. Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process. J Immunol 172: 3382-3384.
-
(2004)
J Immunol
, vol.172
, pp. 3382-3384
-
-
Rogozin, I.B.1
Diaz, M.2
-
106
-
-
0035379581
-
Somatic mutation hotspots correlate with DNA polymerase h error spectrum
-
Rogozin IB, Pavlov YI, Bebenek K, Matsuda T, Kunkel TA. 2001. Somatic mutation hotspots correlate with DNA polymerase h error spectrum. Nat Immunol 2: 530-536.
-
(2001)
Nat Immunol
, vol.2
, pp. 530-536
-
-
Rogozin, I.B.1
Pavlov, Y.I.2
Bebenek, K.3
Matsuda, T.4
Kunkel, T.A.5
-
107
-
-
0038054340
-
Spatial proximity of translocation-prone gene loci in human lymphomas
-
Roix JJ, McQueen PG, Munson PJ, Parada LA, Misteli T. 2003. Spatial proximity of translocation-prone gene loci in human lymphomas. Nat Genet 34: 287-291.
-
(2003)
Nat Genet
, vol.34
, pp. 287-291
-
-
Roix, J.J.1
McQueen, P.G.2
Munson, P.J.3
Parada, L.A.4
Misteli, T.5
-
108
-
-
37549036739
-
Mechanism of R-loop formation at immunoglobulin class switch sequences
-
Roy D, Yu K, Lieber MR. 2008. Mechanism of R-loop formation at immunoglobulin class switch sequences. Mol Cell Biol 28: 50-60.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 50-60
-
-
Roy, D.1
Yu, K.2
Lieber, M.R.3
-
109
-
-
79952266545
-
AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants
-
Ruiz JF, Gomez-Gonzalez B, Aguilera A. 2011. AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants. PLoS Genet 7: e1002009.
-
(2011)
PLoS Genet
, vol.7
-
-
Ruiz, J.F.1
Gomez-Gonzalez, B.2
Aguilera, A.3
-
110
-
-
70349483915
-
Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes
-
Sabouri Z, Okazaki IM, Shinkura R, Begum N, Nagaoka H, Tsuchimoto D, Nakabeppu Y, Honjo T. 2009. Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes. Int Immunol 21: 947-955.
-
(2009)
Int Immunol
, vol.21
, pp. 947-955
-
-
Sabouri, Z.1
Okazaki, I.M.2
Shinkura, R.3
Begum, N.4
Nagaoka, H.5
Tsuchimoto, D.6
Nakabeppu, Y.7
Honjo, T.8
-
111
-
-
33847206141
-
In vivo imaging of germinal centres reveals a dynamic open structure
-
Schwickert TA, Lindquist RL, Shakhar G, Livshits G, Skokos D, Kosco-Vilbois MH, Dustin ML, Nussenzweig MC. 2007. In vivo imaging of germinal centres reveals a dynamic open structure. Nature 446: 83-87.
-
(2007)
Nature
, vol.446
, pp. 83-87
-
-
Schwickert, T.A.1
Lindquist, R.L.2
Shakhar, G.3
Livshits, G.4
Skokos, D.5
Kosco-Vilbois, M.H.6
Dustin, M.L.7
Nussenzweig, M.C.8
-
113
-
-
0020059958
-
Organization of the constant-region gene family of the mouse immunoglobulin heavy chain
-
Shimizu A, Takahashi N, Yaoita Y, Honjo T. 1982. Organization of the constant-region gene family of the mouse immunoglobulin heavy chain. Cell 28: 499-506.
-
(1982)
Cell
, vol.28
, pp. 499-506
-
-
Shimizu, A.1
Takahashi, N.2
Yaoita, Y.3
Honjo, T.4
-
114
-
-
0038664358
-
The influence of transcriptional orientation on endogenous switch region function
-
Shinkura R, Tian M, Smith M, Chua K, Fujiwara Y, Alt FW. 2003. The influence of transcriptional orientation on endogenous switch region function. Nat Immunol 4: 435-441.
-
(2003)
Nat Immunol
, vol.4
, pp. 435-441
-
-
Shinkura, R.1
Tian, M.2
Smith, M.3
Chua, K.4
Fujiwara, Y.5
Alt, F.W.6
-
115
-
-
29444458721
-
Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination
-
Stavnezer J, Schrader CE. 2006. Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination. Trends Genet 22: 23-28.
-
(2006)
Trends Genet
, vol.22
, pp. 23-28
-
-
Stavnezer, J.1
Schrader, C.E.2
-
116
-
-
0021963170
-
Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes
-
Stavnezer J, Sirlin S, Abbott J. 1985. Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes. J Exp Med 161: 577-601.
-
(1985)
J Exp Med
, vol.161
, pp. 577-601
-
-
Stavnezer, J.1
Sirlin, S.2
Abbott, J.3
-
117
-
-
0031443534
-
Somatic hypermutation of immunoglobulin genes is linked to transcription
-
Storb U, Peters A, Klotz E, Kim N, Shen HM, Kage K, Rogerson B, Martin TE. 1998. Somatic hypermutation of immunoglobulin genes is linked to transcription. Curr Top Microbiol Immunol 229: 11-19.
-
(1998)
Curr Top Microbiol Immunol
, vol.229
, pp. 11-19
-
-
Storb, U.1
Peters, A.2
Klotz, E.3
Kim, N.4
Shen, H.M.5
Kage, K.6
Rogerson, B.7
Martin, T.E.8
-
118
-
-
67650482967
-
Visualizing B cell capture of cognate antigen from follicular dendritic cells
-
Suzuki K, Grigorova I, Phan TG, Kelly LM, Cyster JG. 2009. Visualizing B cell capture of cognate antigen from follicular dendritic cells. J Exp Med 206: 1485-1493.
-
(2009)
J Exp Med
, vol.206
, pp. 1485-1493
-
-
Suzuki, K.1
Grigorova, I.2
Phan, T.G.3
Kelly, L.M.4
Cyster, J.G.5
-
119
-
-
0041381361
-
AID mutant analyses indicate requirement for class-switch-specific cofactors
-
Ta VT, Nagaoka H, Catalan N, Durandy A, Fischer A, Imai K, Nonoyama S, Tashiro J, Ikegawa M, Ito S, et al. 2003. AID mutant analyses indicate requirement for class-switch-specific cofactors. Nat Immunol 4: 843-848.
-
(2003)
Nat Immunol
, vol.4
, pp. 843-848
-
-
Ta, V.T.1
Nagaoka, H.2
Catalan, N.3
Durandy, A.4
Fischer, A.5
Imai, K.6
Nonoyama, S.7
Tashiro, J.8
Ikegawa, M.9
Ito, S.10
-
120
-
-
0035067615
-
Palindromic but not G-rich sequences are targets of class switch recombination
-
Tashiro J, Kinoshita K, Honjo T. 2001. Palindromic but not G-rich sequences are targets of class switch recombination. Int Immunol 13: 495-505.
-
(2001)
Int Immunol
, vol.13
, pp. 495-505
-
-
Tashiro, J.1
Kinoshita, K.2
Honjo, T.3
-
121
-
-
0001292985
-
Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells
-
Taub R, Kirsch I, Morton C, Lenoir G, Swan D, Tronick S, Aaronson S, Leder P. 1982. Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc Natl Acad Sci 79: 7837-7841.
-
(1982)
Proc Natl Acad Sci
, vol.79
, pp. 7837-7841
-
-
Taub, R.1
Kirsch, I.2
Morton, C.3
Lenoir, G.4
Swan, D.5
Tronick, S.6
Aaronson, S.7
Leder, P.8
-
122
-
-
43049178852
-
MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase
-
Teng G, Hakimpour P, Landgraf P, Rice A, Tuschl T, Casellas R, Papavasiliou FN. 2008. MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase. Immunity 28: 621-629.
-
(2008)
Immunity
, vol.28
, pp. 621-629
-
-
Teng, G.1
Hakimpour, P.2
Landgraf, P.3
Rice, A.4
Tuschl, T.5
Casellas, R.6
Papavasiliou, F.N.7
-
123
-
-
0031041632
-
The transcriptional promoter regulates hypermutation of the antibody heavy chain locus
-
Tumas-Brundage K, Manser T. 1997. The transcriptional promoter regulates hypermutation of the antibody heavy chain locus. J Exp Med 185: 239-250.
-
(1997)
J Exp Med
, vol.185
, pp. 239-250
-
-
Tumas-Brundage, K.1
Manser, T.2
-
124
-
-
34548526067
-
Strand-biased spreading of mutations during somatic hypermutation
-
Unniraman S, Schatz DG. 2007. Strand-biased spreading of mutations during somatic hypermutation. Science 317: 1227-1230.
-
(2007)
Science
, vol.317
, pp. 1227-1230
-
-
Unniraman, S.1
Schatz, D.G.2
-
126
-
-
78149477766
-
Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter
-
Victora GD, Schwickert TA, Fooksman DR, Kamphorst AO, Meyer-Hermann M, Dustin ML, Nussenzweig MC. 2010. Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell 143: 592-605.
-
(2010)
Cell
, vol.143
, pp. 592-605
-
-
Victora, G.D.1
Schwickert, T.A.2
Fooksman, D.R.3
Kamphorst, A.O.4
Meyer-Hermann, M.5
Dustin, M.L.6
Nussenzweig, M.C.7
-
127
-
-
84865166153
-
Combinatorial mechanisms regulating AID-dependent DNA deamination: Interacting proteins and post-translational modifications
-
Vuong BQ, Chaudhuri J. 2012. Combinatorial mechanisms regulating AID-dependent DNA deamination: Interacting proteins and post-translational modifications. Semin Immunol 24: 264-272.
-
(2012)
Semin Immunol
, vol.24
, pp. 264-272
-
-
Vuong, B.Q.1
Chaudhuri, J.2
-
128
-
-
0014943022
-
Variability in the l light chain sequences of mouse antibody
-
Weigert MG, Cesari IM, Yonkovich SJ, Cohn M. 1970. Variability in the l light chain sequences of mouse antibody. Nature 228: 1045-1047.
-
(1970)
Nature
, vol.228
, pp. 1045-1047
-
-
Weigert, M.G.1
Cesari, I.M.2
Yonkovich, S.J.3
Cohn, M.4
-
129
-
-
0034614916
-
Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern
-
Wiesendanger M, Kneitz B, Edelmann W, Scharff MD. 2000. Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern. J Exp Med 191: 579-584.
-
(2000)
J Exp Med
, vol.191
, pp. 579-584
-
-
Wiesendanger, M.1
Kneitz, B.2
Edelmann, W.3
Scharff, M.D.4
-
130
-
-
14244250387
-
MSH2-MSH6 stimulates DNA polymerase h, suggesting a role for A:T mutations in antibody genes
-
Wilson TM, Vaisman A, Martomo SA, Sullivan P, Lan L, Hanaoka F, Yasui A, Woodgate R, Gearhart PJ. 2005. MSH2-MSH6 stimulates DNA polymerase h, suggesting a role for A:T mutations in antibody genes. J Exp Med 201: 637-645.
-
(2005)
J Exp Med
, vol.201
, pp. 637-645
-
-
Wilson, T.M.1
Vaisman, A.2
Martomo, S.A.3
Sullivan, P.4
Lan, L.5
Hanaoka, F.6
Yasui, A.7
Woodgate, R.8
Gearhart, P.J.9
-
131
-
-
0029829265
-
The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice
-
Xanthoudakis S, Smeyne RJ, Wallace JD, Curran T. 1996. The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice. Proc Natl Acad Sci 93: 8919-8923.
-
(1996)
Proc Natl Acad Sci
, vol.93
, pp. 8919-8923
-
-
Xanthoudakis, S.1
Smeyne, R.J.2
Wallace, J.D.3
Curran, T.4
-
132
-
-
84862865669
-
Immunoglobulin class-switch DNA recombination: Induction, targeting and beyond
-
Xu Z, Zan H, Pone EJ, Mai T, Casali P. 2012. Immunoglobulin class-switch DNA recombination: Induction, targeting and beyond. Nat Rev Immunol 12: 517-531.
-
(2012)
Nat Rev Immunol
, vol.12
, pp. 517-531
-
-
Xu, Z.1
Zan, H.2
Pone, E.J.3
Mai, T.4
Casali, P.5
-
134
-
-
34748863465
-
IgH class switching and translocations use a robust non-classical end-joining pathway
-
Yan CT, Boboila C, Souza EK, Franco S, Hickernell TR, Murphy M, Gumaste S, Geyer M, Zarrin AA, Manis JP, et al. 2007. IgH class switching and translocations use a robust non-classical end-joining pathway. Nature 449: 478-482.
-
(2007)
Nature
, vol.449
, pp. 478-482
-
-
Yan, C.T.1
Boboila, C.2
Souza, E.K.3
Franco, S.4
Hickernell, T.R.5
Murphy, M.6
Gumaste, S.7
Geyer, M.8
Zarrin, A.A.9
Manis, J.P.10
-
135
-
-
33845901812
-
Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences
-
Yang SY, Fugmann SD, Schatz DG. 2006. Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences. J Exp Med 203: 2919-2928.
-
(2006)
J Exp Med
, vol.203
, pp. 2919-2928
-
-
Yang, S.Y.1
Fugmann, S.D.2
Schatz, D.G.3
-
136
-
-
0037650190
-
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
-
Yu K, Chedin F, Hsieh CL, Wilson TE, Lieber MR. 2003. R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat Immunol 4: 442-451.
-
(2003)
Nat Immunol
, vol.4
, pp. 442-451
-
-
Yu, K.1
Chedin, F.2
Hsieh, C.L.3
Wilson, T.E.4
Lieber, M.R.5
-
137
-
-
0027273019
-
A selective defect in IgG2b switching as a result of targeted mutation of the Ig 2b promoter and exon
-
Zhang J, Bottaro A, Li S, Stewart V, Alt FW. 1993. A selective defect in IgG2b switching as a result of targeted mutation of the Ig 2b promoter and exon. EMBO J 12: 3529-3537.
-
(1993)
EMBO J
, vol.12
, pp. 3529-3537
-
-
Zhang, J.1
Bottaro, A.2
Li, S.3
Stewart, V.4
Alt, F.W.5
-
138
-
-
84862778059
-
Spatial organization of the mouse genome and its role in recurrent chromosomal translocations
-
Zhang Y, McCord RP, Ho YJ, Lajoie BR, Hildebrand DG, Simon AC, Becker MS, Alt FW, Dekker J. 2012. Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Cell 148: 908-921.
-
(2012)
Cell
, vol.148
, pp. 908-921
-
-
Zhang, Y.1
McCord, R.P.2
Ho, Y.J.3
Lajoie, B.R.4
Hildebrand, D.G.5
Simon, A.C.6
Becker, M.S.7
Alt, F.W.8
Dekker, J.9
|