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Volumn 27, Issue 1, 2013, Pages 1-17

Regulation of AID, the B-cell genome mutator

Author keywords

Activation induced deaminase; DNA repair; Somatic mutations; Transcription

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; DNA; RNA; RNA POLYMERASE II;

EID: 84872287592     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.200014.112     Document Type: Article
Times cited : (110)

References (138)
  • 1
    • 1842333581 scopus 로고
    • Transcriptionally active DNA region that rearranges frequently in murine lymphoid tumors
    • Adams JM, Gerondakis S, Webb E, Mitchell J, Bernard O, Cory S. 1982. Transcriptionally active DNA region that rearranges frequently in murine lymphoid tumors. Proc Natl Acad Sci 79: 6966-6970.
    • (1982) Proc Natl Acad Sci , vol.79 , pp. 6966-6970
    • Adams, J.M.1    Gerondakis, S.2    Webb, E.3    Mitchell, J.4    Bernard, O.5    Cory, S.6
  • 2
    • 11344268432 scopus 로고    scopus 로고
    • Efficient release from promoter-proximal stall sites requires transcript cleavage factor TFIIS
    • Adelman K, Marr MT, Werner J, Saunders A, Ni Z, Andrulis ED, Lis JT. 2005. Efficient release from promoter-proximal stall sites requires transcript cleavage factor TFIIS. Mol Cell 17: 103-112.
    • (2005) Mol Cell , vol.17 , pp. 103-112
    • Adelman, K.1    Marr, M.T.2    Werner, J.3    Saunders, A.4    Ni, Z.5    Andrulis, E.D.6    Lis, J.T.7
  • 3
    • 34548036949 scopus 로고    scopus 로고
    • Germinal-center organization and cellular dynamics
    • Allen CD, Okada T, Cyster JG. 2007a. Germinal-center organization and cellular dynamics. Immunity 27: 190-202.
    • (2007) Immunity , vol.27 , pp. 190-202
    • Allen, C.D.1    Okada, T.2    Cyster, J.G.3
  • 4
    • 33846635838 scopus 로고    scopus 로고
    • Imaging of germinal center selection events during affinity maturation
    • Allen CD, Okada T, Tang HL, Cyster JG. 2007b. Imaging of germinal center selection events during affinity maturation. Science 315: 528-531.
    • (2007) Science , vol.315 , pp. 528-531
    • Allen, C.D.1    Okada, T.2    Tang, H.L.3    Cyster, J.G.4
  • 7
    • 53949103770 scopus 로고    scopus 로고
    • Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase
    • Basu U, Wang Y, Alt FW. 2008. Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase. Mol Cell 32: 285-291.
    • (2008) Mol Cell , vol.32 , pp. 285-291
    • Basu, U.1    Wang, Y.2    Alt, F.W.3
  • 9
    • 0032100706 scopus 로고    scopus 로고
    • Affinity dependence of the B cell response to antigen: A threshold, a ceiling, and the importance of off-rate
    • Batista FD, Neuberger MS. 1998. Affinity dependence of the B cell response to antigen: A threshold, a ceiling, and the importance of off-rate. Immunity 8: 751-759.
    • (1998) Immunity , vol.8 , pp. 751-759
    • Batista, F.D.1    Neuberger, M.S.2
  • 10
    • 84866564544 scopus 로고    scopus 로고
    • The histone chaperone SPT6 is required for AID target determination through H3K4me3 regulation
    • Begum NA, Stanlie A, Nakata M, Akiyama H, Honjo T. 2012. The histone chaperone SPT6 is required for AID target determination through H3K4me3 regulation. J Biol Chem 287: 32415-32429.
    • (2012) J Biol Chem , vol.287 , pp. 32415-32429
    • Begum, N.A.1    Stanlie, A.2    Nakata, M.3    Akiyama, H.4    Honjo, T.5
  • 12
    • 84867386682 scopus 로고    scopus 로고
    • Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks
    • Boboila C, Alt FW, Schwer B. 2012. Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks. Adv Immunol 116: 1-49.
    • (2012) Adv Immunol , vol.116 , pp. 1-49
    • Boboila, C.1    Alt, F.W.2    Schwer, B.3
  • 13
    • 0027952630 scopus 로고
    • S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process
    • Bottaro A, Lansford R, Xu L, Zhang J, Rothman P, Alt FW. 1994. S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process. EMBO J 13: 665-674.
    • (1994) EMBO J , vol.13 , pp. 665-674
    • Bottaro, A.1    Lansford, R.2    Xu, L.3    Zhang, J.4    Rothman, P.5    Alt, F.W.6
  • 14
    • 0037388165 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
    • Bransteitter R, Pham P, Scharff MD, Goodman MF. 2003. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc Natl Acad Sci 100: 4102-4107.
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 4102-4107
    • Bransteitter, R.1    Pham, P.2    Scharff, M.D.3    Goodman, M.F.4
  • 15
    • 10944223445 scopus 로고    scopus 로고
    • Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase
    • Bransteitter R, Pham P, Calabrese P, Goodman MF. 2004. Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase. J Biol Chem 279: 51612-51621.
    • (2004) J Biol Chem , vol.279 , pp. 51612-51621
    • Bransteitter, R.1    Pham, P.2    Calabrese, P.3    Goodman, M.F.4
  • 16
    • 38449084983 scopus 로고    scopus 로고
    • Role of activation-induced deaminase protein kinase A phosphorylation sites in Ig gene conversion and somatic hypermutation
    • Chatterji M, Unniraman S, McBride KM, Schatz DG. 2007. Role of activation-induced deaminase protein kinase A phosphorylation sites in Ig gene conversion and somatic hypermutation. J Immunol 179: 5274-5280.
    • (2007) J Immunol , vol.179 , pp. 5274-5280
    • Chatterji, M.1    Unniraman, S.2    McBride, K.M.3    Schatz, D.G.4
  • 17
    • 3142765336 scopus 로고    scopus 로고
    • Class-switch recombination: Interplay of transcription, DNA deamination and DNA repair
    • Chaudhuri J, Alt FW. 2004. Class-switch recombination: Interplay of transcription, DNA deamination and DNA repair. Nat Rev Immunol 4: 541-552.
    • (2004) Nat Rev Immunol , vol.4 , pp. 541-552
    • Chaudhuri, J.1    Alt, F.W.2
  • 18
    • 0037452080 scopus 로고    scopus 로고
    • Transcription-targeted DNA deamination by the AID antibody diversification enzyme
    • Chaudhuri J, Tian M, Khuong C, Chua K, Pinaud E, Alt FW. 2003. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature 422: 726-730.
    • (2003) Nature , vol.422 , pp. 726-730
    • Chaudhuri, J.1    Tian, M.2    Khuong, C.3    Chua, K.4    Pinaud, E.5    Alt, F.W.6
  • 19
    • 4344700569 scopus 로고    scopus 로고
    • Replication protein A interacts with AID to promote deamination of somatic hypermutation targets
    • Chaudhuri J, Khuong C, Alt FW. 2004. Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature 430: 992-998.
    • (2004) Nature , vol.430 , pp. 992-998
    • Chaudhuri, J.1    Khuong, C.2    Alt, F.W.3
  • 21
    • 0018135592 scopus 로고
    • Distribution of horseradish peroxidase (HRP)-anti-HRP immune complexes in mouse spleen with special reference to follicular dendritic cells
    • Chen LL, Frank AM, Adams JC, Steinman RM. 1978. Distribution of horseradish peroxidase (HRP)-anti-HRP immune complexes in mouse spleen with special reference to follicular dendritic cells. J Cell Biol 79: 184-199.
    • (1978) J Cell Biol , vol.79 , pp. 184-199
    • Chen, L.L.1    Frank, A.M.2    Adams, J.C.3    Steinman, R.M.4
  • 25
    • 49349112190 scopus 로고    scopus 로고
    • Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1
    • Conticello SG, Ganesh K, Xue K, Lu M, Rada C, Neuberger MS. 2008. Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1. Mol Cell 31: 474-484.
    • (2008) Mol Cell , vol.31 , pp. 474-484
    • Conticello, S.G.1    Ganesh, K.2    Xue, K.3    Lu, M.4    Rada, C.5    Neuberger, M.S.6
  • 27
    • 0029598833 scopus 로고
    • RNA:DNA complex formation upon transcription of immunoglobulin switch regions: Implications for the mechanism and regulation of class switch recombination
    • Daniels GA, Lieber MR. 1995. RNA:DNA complex formation upon transcription of immunoglobulin switch regions: Implications for the mechanism and regulation of class switch recombination. Nucleic Acids Res 23: 5006-5011.
    • (1995) Nucleic Acids Res , vol.23 , pp. 5006-5011
    • Daniels, G.A.1    Lieber, M.R.2
  • 28
    • 0032757402 scopus 로고    scopus 로고
    • Switching to IgG3, IgG2b, and IgA is division linked and independent, revealing a stochastic framework for describing differentiation
    • Deenick EK, Hasbold J, Hodgkin PD. 1999. Switching to IgG3, IgG2b, and IgA is division linked and independent, revealing a stochastic framework for describing differentiation. J Immunol 163: 4707-4714.
    • (1999) J Immunol , vol.163 , pp. 4707-4714
    • Deenick, E.K.1    Hasbold, J.2    Hodgkin, P.D.3
  • 29
    • 0030831199 scopus 로고    scopus 로고
    • The complexity of signaling pathways activated by the BCR
    • DeFranco AL. 1997. The complexity of signaling pathways activated by the BCR. Curr Opin Immunol 9: 296-308.
    • (1997) Curr Opin Immunol , vol.9 , pp. 296-308
    • Defranco, A.L.1
  • 31
    • 0037026482 scopus 로고    scopus 로고
    • Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase
    • Di Noia J, Neuberger MS. 2002. Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature 419: 43-48.
    • (2002) Nature , vol.419 , pp. 43-48
    • Di Noia, J.1    Neuberger, M.S.2
  • 32
    • 0037561998 scopus 로고    scopus 로고
    • AID mediates hypermutation by deaminating single stranded DNA
    • Dickerson SK, Market E, Besmer E, Papavasiliou FN. 2003. AID mediates hypermutation by deaminating single stranded DNA. J Exp Med 197: 1291-1296.
    • (2003) J Exp Med , vol.197 , pp. 1291-1296
    • Dickerson, S.K.1    Market, E.2    Besmer, E.3    Papavasiliou, F.N.4
  • 34
    • 0019179349 scopus 로고
    • An immunoglobulin deletion mutant with implications for the heavy-chain switch and RNA splicing
    • Dunnick W, Rabbitts TH, Milstein C. 1980. An immunoglobulin deletion mutant with implications for the heavy-chain switch and RNA splicing. Nature 286: 669-675.
    • (1980) Nature , vol.286 , pp. 669-675
    • Dunnick, W.1    Rabbitts, T.H.2    Milstein, C.3
  • 36
    • 0024385049 scopus 로고
    • Rapid induction of transcription of unrearranged Sg1 switch regions in activated murine B cells by interleukin 4
    • Esser C, Radbruch A. 1989. Rapid induction of transcription of unrearranged Sg1 switch regions in activated murine B cells by interleukin 4. EMBO J 8: 483-488.
    • (1989) EMBO J , vol.8 , pp. 483-488
    • Esser, C.1    Radbruch, A.2
  • 39
    • 4444258534 scopus 로고    scopus 로고
    • Chromatin architecture of the human genome: Gene-rich domains are enriched in open chromatin fibers
    • Gilbert N, Boyle S, Fiegler H, Woodfine K, Carter NP, Bickmore WA. 2004. Chromatin architecture of the human genome: Gene-rich domains are enriched in open chromatin fibers. Cell 118: 555-566.
    • (2004) Cell , vol.118 , pp. 555-566
    • Gilbert, N.1    Boyle, S.2    Fiegler, H.3    Woodfine, K.4    Carter, N.P.5    Bickmore, W.A.6
  • 41
    • 84863105929 scopus 로고    scopus 로고
    • AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells
    • Gramlich HS, Reisbig T, Schatz DG. 2012. AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells. PLoS ONE 7: e39601.
    • (2012) PLoS ONE , vol.7
    • Gramlich, H.S.1    Reisbig, T.2    Schatz, D.G.3
  • 42
    • 0027280936 scopus 로고
    • Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting
    • Gu H, Zou YR, Rajewsky K. 1993. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell 73: 1155-1164.
    • (1993) Cell , vol.73 , pp. 1155-1164
    • Gu, H.1    Zou, Y.R.2    Rajewsky, K.3
  • 45
    • 0036303482 scopus 로고    scopus 로고
    • Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III
    • Hadi MZ, Ginalski K, Nguyen LH, Wilson DM. 2002. Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III. J Mol Biol 316: 853-866.
    • (2002) J Mol Biol , vol.316 , pp. 853-866
    • Hadi, M.Z.1    Ginalski, K.2    Nguyen, L.H.3    Wilson, D.M.4
  • 47
    • 77956417669 scopus 로고    scopus 로고
    • Cutting edge: CTNNBL1 is dispensable for Ig class switch recombination
    • Han L, Masani S, Yu K. 2010. Cutting edge: CTNNBL1 is dispensable for Ig class switch recombination. J Immunol 185: 1379-1381.
    • (2010) J Immunol , vol.185 , pp. 1379-1381
    • Han, L.1    Masani, S.2    Yu, K.3
  • 48
    • 79960990878 scopus 로고    scopus 로고
    • Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination
    • Han L, Masani S, Yu K. 2011. Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination. Proc Natl Acad Sci 108: 11584-11589.
    • (2011) Proc Natl Acad Sci , vol.108 , pp. 11584-11589
    • Han, L.1    Masani, S.2    Yu, K.3
  • 49
    • 77952295580 scopus 로고    scopus 로고
    • Early events in B cell activation
    • Harwood NE, Batista FD. 2010. Early events in B cell activation. Annu Rev Immunol 28: 185-210.
    • (2010) Annu Rev Immunol , vol.28 , pp. 185-210
    • Harwood, N.E.1    Batista, F.D.2
  • 50
    • 0031905273 scopus 로고    scopus 로고
    • Cell division number regulates IgG1 and IgE switching of B cells following stimulation by CD40 ligand and IL-4
    • Hasbold J, Lyons AB, Kehry MR, Hodgkin PD. 1998. Cell division number regulates IgG1 and IgE switching of B cells following stimulation by CD40 ligand and IL-4. Eur J Immunol 28: 1040-1051.
    • (1998) Eur J Immunol , vol.28 , pp. 1040-1051
    • Hasbold, J.1    Lyons, A.B.2    Kehry, M.R.3    Hodgkin, P.D.4
  • 53
    • 0032416146 scopus 로고    scopus 로고
    • Processing of switch transcripts is required for targeting of antibody class switch recombination
    • Hein K, Lorenz MG, Siebenkotten G, Petry K, Christine R, Radbruch A. 1998. Processing of switch transcripts is required for targeting of antibody class switch recombination. J Exp Med 188: 2369-2374.
    • (1998) J Exp Med , vol.188 , pp. 2369-2374
    • Hein, K.1    Lorenz, M.G.2    Siebenkotten, G.3    Petry, K.4    Christine, R.5    Radbruch, A.6
  • 54
    • 0030037519 scopus 로고    scopus 로고
    • B cell differentiation and isotype switching is related to division cycle number
    • Hodgkin PD, Lee JH, Lyons AB. 1996. B cell differentiation and isotype switching is related to division cycle number. J Exp Med 184: 277-281.
    • (1996) J Exp Med , vol.184 , pp. 277-281
    • Hodgkin, P.D.1    Lee, J.H.2    Lyons, A.B.3
  • 55
    • 0008411148 scopus 로고
    • Organization of immunoglobulin heavy chain genes and allelic deletion model
    • Honjo T, Kataoka T. 1978. Organization of immunoglobulin heavy chain genes and allelic deletion model. Proc Natl Acad Sci 75: 2140-2144.
    • (1978) Proc Natl Acad Sci , vol.75 , pp. 2140-2144
    • Honjo, T.1    Kataoka, T.2
  • 56
    • 0031202137 scopus 로고    scopus 로고
    • Telomerase is up-regulated in human germinal center B cells in vivo and can be re-expressed in memory B cells activated in vitro
    • Hu BT, Lee SC, Marin E, Ryan DH, Insel RA. 1997. Telomerase is up-regulated in human germinal center B cells in vivo and can be re-expressed in memory B cells activated in vitro. J Immunol 159: 1068-1071.
    • (1997) J Immunol , vol.159 , pp. 1068-1071
    • Hu, B.T.1    Lee, S.C.2    Marin, E.3    Ryan, D.H.4    Insel, R.A.5
  • 57
    • 28244492832 scopus 로고    scopus 로고
    • B cells productively engage soluble antigen-pulsed dendritic cells: Visualization of live-cell dynamics of B cell-dendritic cell interactions
    • Huang NN, Han SB, Hwang IY, Kehrl JH. 2005. B cells productively engage soluble antigen-pulsed dendritic cells: Visualization of live-cell dynamics of B cell-dendritic cell interactions. J Immunol 175: 7125-7134.
    • (2005) J Immunol , vol.175 , pp. 7125-7134
    • Huang, N.N.1    Han, S.B.2    Hwang, I.Y.3    Kehrl, J.H.4
  • 58
    • 34248157719 scopus 로고    scopus 로고
    • APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks
    • Iles N, Rulten S, El-Khamisy SF, Caldecott KW. 2007. APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. Mol Cell Biol 27: 3793-3803.
    • (2007) Mol Cell Biol , vol.27 , pp. 3793-3803
    • Iles, N.1    Rulten, S.2    El-Khamisy, S.F.3    Caldecott, K.W.4
  • 59
    • 0025345212 scopus 로고
    • Circular DNA is excised by immunoglobulin class switch recombination
    • Iwasato T, Shimizu A, Honjo T, Yamagishi H. 1990. Circular DNA is excised by immunoglobulin class switch recombination. Cell 62: 143-149.
    • (1990) Cell , vol.62 , pp. 143-149
    • Iwasato, T.1    Shimizu, A.2    Honjo, T.3    Yamagishi, H.4
  • 60
    • 0026060620 scopus 로고
    • Intraclonal generation of antibody mutants in germinal centres
    • Jacob J, Kelsoe G, Rajewsky K, Weiss U. 1991. Intraclonal generation of antibody mutants in germinal centres. Nature 354: 389-392.
    • (1991) Nature , vol.354 , pp. 389-392
    • Jacob, J.1    Kelsoe, G.2    Rajewsky, K.3    Weiss, U.4
  • 61
    • 0027417869 scopus 로고
    • Shutdown of class switch recombination by deletion of a switch region control element
    • Jung S, Rajewsky K, Radbruch A. 1993. Shutdown of class switch recombination by deletion of a switch region control element. Science 259: 984-987.
    • (1993) Science , vol.259 , pp. 984-987
    • Jung, S.1    Rajewsky, K.2    Radbruch, A.3
  • 62
    • 1842319924 scopus 로고
    • Rearrangement of immunoglobulin g 1-chain gene and mechanism for heavy-chain class switch
    • Kataoka T, Kawakami T, Takahashi N, Honjo T. 1980. Rearrangement of immunoglobulin g 1-chain gene and mechanism for heavy-chain class switch. Proc Natl Acad Sci 77: 919-923.
    • (1980) Proc Natl Acad Sci , vol.77 , pp. 919-923
    • Kataoka, T.1    Kawakami, T.2    Takahashi, N.3    Honjo, T.4
  • 63
    • 0019460884 scopus 로고
    • Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes
    • Kataoka T, Miyata T, Honjo T. 1981. Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes. Cell 23: 357-368.
    • (1981) Cell , vol.23 , pp. 357-368
    • Kataoka, T.1    Miyata, T.2    Honjo, T.3
  • 64
    • 0032428658 scopus 로고    scopus 로고
    • Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions
    • Kinoshita K, Tashiro J, Tomita S, Lee CG, Honjo T. 1998. Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions. Immunity 9: 849-858.
    • (1998) Immunity , vol.9 , pp. 849-858
    • Kinoshita, K.1    Tashiro, J.2    Tomita, S.3    Lee, C.G.4    Honjo, T.5
  • 65
    • 37549015263 scopus 로고    scopus 로고
    • Germinal centres: Role in B-cell physiology and malignancy
    • Klein U, Dalla-Favera R. 2008. Germinal centres: Role in B-cell physiology and malignancy. Nat Rev Immunol 8: 22-33.
    • (2008) Nat Rev Immunol , vol.8 , pp. 22-33
    • Klein, U.1    Dalla-Favera, R.2
  • 68
    • 27644532332 scopus 로고    scopus 로고
    • Specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) expressed by marginal zone macrophages is essential for defense against pulmonary Streptococcus pneumoniae infection
    • Koppel EA, Wieland CW, van den Berg VC, Litjens M, Florquin S, van Kooyk Y, van der Poll T, Geijtenbeek TB. 2005. Specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) expressed by marginal zone macrophages is essential for defense against pulmonary Streptococcus pneumoniae infection. Eur J Immunol 35: 2962-2969.
    • (2005) Eur J Immunol , vol.35 , pp. 2962-2969
    • Koppel, E.A.1    Wieland, C.W.2    Van den Berg, V.C.3    Litjens, M.4    Florquin, S.5    van Kooyk, Y.6    Van der Poll, T.7    Geijtenbeek, T.B.8
  • 69
    • 0025630537 scopus 로고
    • Boundaries of somatic mutation in rearranged immunoglobulin genes: 59 boundary is near the promoter, and 39 boundary is approximately 1 kb from V(D)J gene
    • Lebecque SG, Gearhart PJ. 1990. Boundaries of somatic mutation in rearranged immunoglobulin genes: 59 boundary is near the promoter, and 39 boundary is approximately 1 kb from V(D)J gene. J Exp Med 172: 1717-1727.
    • (1990) J Exp Med , vol.172 , pp. 1717-1727
    • Lebecque, S.G.1    Gearhart, P.J.2
  • 72
    • 71249101060 scopus 로고    scopus 로고
    • Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer
    • Lin C, Yang L, Tanasa B, Hutt K, Ju BG, Ohgi K, Zhang J, Rose DW, Fu XD, Glass CK, et al. 2009. Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell 139: 1069-1083.
    • (2009) Cell , vol.139 , pp. 1069-1083
    • Lin, C.1    Yang, L.2    Tanasa, B.3    Hutt, K.4    Ju, B.G.5    Ohgi, K.6    Zhang, J.7    Rose, D.W.8    Fu, X.D.9    Glass, C.K.10
  • 73
    • 63149179802 scopus 로고    scopus 로고
    • Balancing AID and DNA repair during somatic hypermutation
    • Liu M, Schatz DG. 2009. Balancing AID and DNA repair during somatic hypermutation. Trends Immunol 30: 173-181.
    • (2009) Trends Immunol , vol.30 , pp. 173-181
    • Liu, M.1    Schatz, D.G.2
  • 75
    • 0028968667 scopus 로고
    • Switch transcripts in immunoglobulin class switching
    • Lorenz M, Jung S, Radbruch A. 1995. Switch transcripts in immunoglobulin class switching. Science 267: 1825-1828.
    • (1995) Science , vol.267 , pp. 1825-1828
    • Lorenz, M.1    Jung, S.2    Radbruch, A.3
  • 76
    • 25444475799 scopus 로고    scopus 로고
    • Repair of double-strand DNA breaks by the human nonhomologous DNA end joining pathway: The iterative processing model
    • Ma Y, Lu H, Schwarz K, Lieber MR. 2005. Repair of double-strand DNA breaks by the human nonhomologous DNA end joining pathway: The iterative processing model. Cell Cycle 4: 1193-1200.
    • (2005) Cell Cycle , vol.4 , pp. 1193-1200
    • Ma, Y.1    Lu, H.2    Schwarz, K.3    Lieber, M.R.4
  • 81
    • 0033603340 scopus 로고    scopus 로고
    • Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
    • Muramatsu M, Sankaranand VS, Anant S, Sugai M, Kinoshita K, Davidson NO, Honjo T. 1999. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J Biol Chem 274: 18470-18476.
    • (1999) J Biol Chem , vol.274 , pp. 18470-18476
    • Muramatsu, M.1    Sankaranand, V.S.2    Anant, S.3    Sugai, M.4    Kinoshita, K.5    Davidson, N.O.6    Honjo, T.7
  • 82
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T. 2000. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102: 553-563.
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5    Honjo, T.6
  • 84
    • 78751608734 scopus 로고    scopus 로고
    • The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA
    • Nowak U, Matthews AJ, Zheng S, Chaudhuri J. 2011. The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA. Nat Immunol 12: 160-166.
    • (2011) Nat Immunol , vol.12 , pp. 160-166
    • Nowak, U.1    Matthews, A.J.2    Zheng, S.3    Chaudhuri, J.4
  • 85
    • 84865180284 scopus 로고    scopus 로고
    • Activation induced deaminase: How much and where?
    • Orthwein A, Di Noia JM. 2012. Activation induced deaminase: How much and where? Semin Immunol 24: 246-254.
    • (2012) Semin Immunol , vol.24 , pp. 246-254
    • Orthwein, A.1    Di Noia, J.M.2
  • 88
    • 31044435055 scopus 로고    scopus 로고
    • PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells
    • Pasqualucci L, Kitaura Y, Gu H, Dalla-Favera R. 2006. PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells. Proc Natl Acad Sci 103: 395-400.
    • (2006) Proc Natl Acad Sci , vol.103 , pp. 395-400
    • Pasqualucci, L.1    Kitaura, Y.2    Gu, H.3    Dalla-Favera, R.4
  • 91
    • 41649094641 scopus 로고    scopus 로고
    • Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions
    • Perlot T, Li G, Alt FW. 2008. Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions. Proc Natl Acad Sci 105: 3843-3848.
    • (2008) Proc Natl Acad Sci , vol.105 , pp. 3843-3848
    • Perlot, T.1    Li, G.2    Alt, F.W.3
  • 92
    • 0030063726 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
    • Peters A, Storb U. 1996. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity 4: 57-65.
    • (1996) Immunity , vol.4 , pp. 57-65
    • Peters, A.1    Storb, U.2
  • 93
    • 0037019315 scopus 로고    scopus 로고
    • AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
    • Petersen-Mahrt SK, Harris RS, Neuberger MS. 2002. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature 418: 99-103.
    • (2002) Nature , vol.418 , pp. 99-103
    • Petersen-Mahrt, S.K.1    Harris, R.S.2    Neuberger, M.S.3
  • 94
    • 0032101611 scopus 로고    scopus 로고
    • Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein
    • Phung QH, Winter DB, Cranston A, Tarone RE, Bohr VA, Fishel R, Gearhart PJ. 1998. Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein. J Exp Med 187: 1745-1751.
    • (1998) J Exp Med , vol.187 , pp. 1745-1751
    • Phung, Q.H.1    Winter, D.B.2    Cranston, A.3    Tarone, R.E.4    Bohr, V.A.5    Fishel, R.6    Gearhart, P.J.7
  • 95
    • 0035881820 scopus 로고    scopus 로고
    • The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially
    • Rada C, Milstein C. 2001. The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially. EMBO J 20: 4570-4576.
    • (2001) EMBO J , vol.20 , pp. 4570-4576
    • Rada, C.1    Milstein, C.2
  • 96
    • 0037108463 scopus 로고    scopus 로고
    • Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
    • Rada C, Williams GT, Nilsen H, Barnes DE, Lindahl T, Neuberger MS. 2002. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr Biol 12: 1748-1755.
    • (2002) Curr Biol , vol.12 , pp. 1748-1755
    • Rada, C.1    Williams, G.T.2    Nilsen, H.3    Barnes, D.E.4    Lindahl, T.5    Neuberger, M.S.6
  • 97
  • 98
    • 0038293484 scopus 로고    scopus 로고
    • Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand
    • Ramiro AR, Stavropoulos P, Jankovic M, Nussenzweig MC. 2003. Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat Immunol 4: 452-456.
    • (2003) Nat Immunol , vol.4 , pp. 452-456
    • Ramiro, A.R.1    Stavropoulos, P.2    Jankovic, M.3    Nussenzweig, M.C.4
  • 101
    • 0024980981 scopus 로고
    • Antigen receptor tail clue
    • Reth M. 1989. Antigen receptor tail clue. Nature 338: 383-384.
    • (1989) Nature , vol.338 , pp. 383-384
    • Reth, M.1
  • 104
    • 0021209335 scopus 로고
    • Antigen Presentation By Hapten-specific B Lymphocytes. I. Role of Surface Immunoglobulin Receptors
    • Rock KL, Benacerraf B, Abbas AK. 1984. Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors. J Exp Med 160: 1102-1113.
    • (1984) J Exp Med , vol.160 , pp. 1102-1113
    • Rock, K.L.1    Benacerraf, B.2    Abbas, A.K.3
  • 105
    • 1542619234 scopus 로고    scopus 로고
    • Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process
    • Rogozin IB, Diaz M. 2004. Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process. J Immunol 172: 3382-3384.
    • (2004) J Immunol , vol.172 , pp. 3382-3384
    • Rogozin, I.B.1    Diaz, M.2
  • 106
  • 107
    • 0038054340 scopus 로고    scopus 로고
    • Spatial proximity of translocation-prone gene loci in human lymphomas
    • Roix JJ, McQueen PG, Munson PJ, Parada LA, Misteli T. 2003. Spatial proximity of translocation-prone gene loci in human lymphomas. Nat Genet 34: 287-291.
    • (2003) Nat Genet , vol.34 , pp. 287-291
    • Roix, J.J.1    McQueen, P.G.2    Munson, P.J.3    Parada, L.A.4    Misteli, T.5
  • 108
    • 37549036739 scopus 로고    scopus 로고
    • Mechanism of R-loop formation at immunoglobulin class switch sequences
    • Roy D, Yu K, Lieber MR. 2008. Mechanism of R-loop formation at immunoglobulin class switch sequences. Mol Cell Biol 28: 50-60.
    • (2008) Mol Cell Biol , vol.28 , pp. 50-60
    • Roy, D.1    Yu, K.2    Lieber, M.R.3
  • 109
    • 79952266545 scopus 로고    scopus 로고
    • AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants
    • Ruiz JF, Gomez-Gonzalez B, Aguilera A. 2011. AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants. PLoS Genet 7: e1002009.
    • (2011) PLoS Genet , vol.7
    • Ruiz, J.F.1    Gomez-Gonzalez, B.2    Aguilera, A.3
  • 110
  • 113
    • 0020059958 scopus 로고
    • Organization of the constant-region gene family of the mouse immunoglobulin heavy chain
    • Shimizu A, Takahashi N, Yaoita Y, Honjo T. 1982. Organization of the constant-region gene family of the mouse immunoglobulin heavy chain. Cell 28: 499-506.
    • (1982) Cell , vol.28 , pp. 499-506
    • Shimizu, A.1    Takahashi, N.2    Yaoita, Y.3    Honjo, T.4
  • 114
    • 0038664358 scopus 로고    scopus 로고
    • The influence of transcriptional orientation on endogenous switch region function
    • Shinkura R, Tian M, Smith M, Chua K, Fujiwara Y, Alt FW. 2003. The influence of transcriptional orientation on endogenous switch region function. Nat Immunol 4: 435-441.
    • (2003) Nat Immunol , vol.4 , pp. 435-441
    • Shinkura, R.1    Tian, M.2    Smith, M.3    Chua, K.4    Fujiwara, Y.5    Alt, F.W.6
  • 115
    • 29444458721 scopus 로고    scopus 로고
    • Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination
    • Stavnezer J, Schrader CE. 2006. Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination. Trends Genet 22: 23-28.
    • (2006) Trends Genet , vol.22 , pp. 23-28
    • Stavnezer, J.1    Schrader, C.E.2
  • 116
    • 0021963170 scopus 로고
    • Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes
    • Stavnezer J, Sirlin S, Abbott J. 1985. Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes. J Exp Med 161: 577-601.
    • (1985) J Exp Med , vol.161 , pp. 577-601
    • Stavnezer, J.1    Sirlin, S.2    Abbott, J.3
  • 118
    • 67650482967 scopus 로고    scopus 로고
    • Visualizing B cell capture of cognate antigen from follicular dendritic cells
    • Suzuki K, Grigorova I, Phan TG, Kelly LM, Cyster JG. 2009. Visualizing B cell capture of cognate antigen from follicular dendritic cells. J Exp Med 206: 1485-1493.
    • (2009) J Exp Med , vol.206 , pp. 1485-1493
    • Suzuki, K.1    Grigorova, I.2    Phan, T.G.3    Kelly, L.M.4    Cyster, J.G.5
  • 120
    • 0035067615 scopus 로고    scopus 로고
    • Palindromic but not G-rich sequences are targets of class switch recombination
    • Tashiro J, Kinoshita K, Honjo T. 2001. Palindromic but not G-rich sequences are targets of class switch recombination. Int Immunol 13: 495-505.
    • (2001) Int Immunol , vol.13 , pp. 495-505
    • Tashiro, J.1    Kinoshita, K.2    Honjo, T.3
  • 121
    • 0001292985 scopus 로고
    • Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells
    • Taub R, Kirsch I, Morton C, Lenoir G, Swan D, Tronick S, Aaronson S, Leder P. 1982. Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc Natl Acad Sci 79: 7837-7841.
    • (1982) Proc Natl Acad Sci , vol.79 , pp. 7837-7841
    • Taub, R.1    Kirsch, I.2    Morton, C.3    Lenoir, G.4    Swan, D.5    Tronick, S.6    Aaronson, S.7    Leder, P.8
  • 123
    • 0031041632 scopus 로고    scopus 로고
    • The transcriptional promoter regulates hypermutation of the antibody heavy chain locus
    • Tumas-Brundage K, Manser T. 1997. The transcriptional promoter regulates hypermutation of the antibody heavy chain locus. J Exp Med 185: 239-250.
    • (1997) J Exp Med , vol.185 , pp. 239-250
    • Tumas-Brundage, K.1    Manser, T.2
  • 124
    • 34548526067 scopus 로고    scopus 로고
    • Strand-biased spreading of mutations during somatic hypermutation
    • Unniraman S, Schatz DG. 2007. Strand-biased spreading of mutations during somatic hypermutation. Science 317: 1227-1230.
    • (2007) Science , vol.317 , pp. 1227-1230
    • Unniraman, S.1    Schatz, D.G.2
  • 127
    • 84865166153 scopus 로고    scopus 로고
    • Combinatorial mechanisms regulating AID-dependent DNA deamination: Interacting proteins and post-translational modifications
    • Vuong BQ, Chaudhuri J. 2012. Combinatorial mechanisms regulating AID-dependent DNA deamination: Interacting proteins and post-translational modifications. Semin Immunol 24: 264-272.
    • (2012) Semin Immunol , vol.24 , pp. 264-272
    • Vuong, B.Q.1    Chaudhuri, J.2
  • 128
    • 0014943022 scopus 로고
    • Variability in the l light chain sequences of mouse antibody
    • Weigert MG, Cesari IM, Yonkovich SJ, Cohn M. 1970. Variability in the l light chain sequences of mouse antibody. Nature 228: 1045-1047.
    • (1970) Nature , vol.228 , pp. 1045-1047
    • Weigert, M.G.1    Cesari, I.M.2    Yonkovich, S.J.3    Cohn, M.4
  • 129
    • 0034614916 scopus 로고    scopus 로고
    • Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern
    • Wiesendanger M, Kneitz B, Edelmann W, Scharff MD. 2000. Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern. J Exp Med 191: 579-584.
    • (2000) J Exp Med , vol.191 , pp. 579-584
    • Wiesendanger, M.1    Kneitz, B.2    Edelmann, W.3    Scharff, M.D.4
  • 131
    • 0029829265 scopus 로고    scopus 로고
    • The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice
    • Xanthoudakis S, Smeyne RJ, Wallace JD, Curran T. 1996. The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice. Proc Natl Acad Sci 93: 8919-8923.
    • (1996) Proc Natl Acad Sci , vol.93 , pp. 8919-8923
    • Xanthoudakis, S.1    Smeyne, R.J.2    Wallace, J.D.3    Curran, T.4
  • 132
    • 84862865669 scopus 로고    scopus 로고
    • Immunoglobulin class-switch DNA recombination: Induction, targeting and beyond
    • Xu Z, Zan H, Pone EJ, Mai T, Casali P. 2012. Immunoglobulin class-switch DNA recombination: Induction, targeting and beyond. Nat Rev Immunol 12: 517-531.
    • (2012) Nat Rev Immunol , vol.12 , pp. 517-531
    • Xu, Z.1    Zan, H.2    Pone, E.J.3    Mai, T.4    Casali, P.5
  • 135
    • 33845901812 scopus 로고    scopus 로고
    • Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences
    • Yang SY, Fugmann SD, Schatz DG. 2006. Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences. J Exp Med 203: 2919-2928.
    • (2006) J Exp Med , vol.203 , pp. 2919-2928
    • Yang, S.Y.1    Fugmann, S.D.2    Schatz, D.G.3
  • 136
    • 0037650190 scopus 로고    scopus 로고
    • R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
    • Yu K, Chedin F, Hsieh CL, Wilson TE, Lieber MR. 2003. R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat Immunol 4: 442-451.
    • (2003) Nat Immunol , vol.4 , pp. 442-451
    • Yu, K.1    Chedin, F.2    Hsieh, C.L.3    Wilson, T.E.4    Lieber, M.R.5
  • 137
    • 0027273019 scopus 로고
    • A selective defect in IgG2b switching as a result of targeted mutation of the Ig 2b promoter and exon
    • Zhang J, Bottaro A, Li S, Stewart V, Alt FW. 1993. A selective defect in IgG2b switching as a result of targeted mutation of the Ig 2b promoter and exon. EMBO J 12: 3529-3537.
    • (1993) EMBO J , vol.12 , pp. 3529-3537
    • Zhang, J.1    Bottaro, A.2    Li, S.3    Stewart, V.4    Alt, F.W.5


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