Replication protein A interacts with AID to promote deamination of somatic hypermutation targets

Nature

Volumn 430, Issue 7003, 2004, Pages 992-998

  Chaudhuri, Jayanta ^a   Khuong, Chan ^a   Alt, Frederick W ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINATION; CATALYSIS; CELLS; DNA; GENES;

ACTIVATION-INDUCED DEAMINASE CATALYSIS (AID); SOMATIC HYPERMUTATION (SHM);

PROTEINS;

ACTIVATION INDUCED CYTIDINE DEAMINASE; CYTIDINE DEAMINASE; IMMUNOGLOBULIN; PROTEIN A; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

BIOLOGY;

ARTICLE; B LYMPHOCYTE ACTIVATION; CHEMICAL MODIFICATION; COMPLEX FORMATION; DEAMINATION; DNA REPAIR; DNA REPLICATION; EXON; GENE TARGETING; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR STABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; SOMATIC HYPERMUTATION; TRANSCRIPTION INITIATION;

AMINATION; ANIMALS; B-LYMPHOCYTES; CYTIDINE DEAMINASE; DNA; DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE DELETION; HUMANS; MICE; PROTEIN BINDING; REPLICATION PROTEIN A; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; SUBSTRATE SPECIFICITY; TRANSCRIPTION, GENETIC;

EID: 4344700569     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02821     Document Type: Article

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