Why does somatic hypermutation by AID require transcription of its target genes?

Advances in Immunology

Volumn 122, Issue , 2014, Pages 253-277

  Storb, Ursula ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

AID; AID targets; Hotspots; Negative supercoils; SHM of non Ig genes; Single stranded DNA; Somatic hypermutation model; Transcription

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3G; RNA; RNA POLYMERASE; RNA POLYMERASE II; SINGLE STRANDED DNA;

ARTICLE; CARBOXY TERMINAL SEQUENCE; DNA REPLICATION; DNA STRAND; ENZYME MECHANISM; EXCISION REPAIR; GENE CONVERSION; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; RNA DEGRADATION; RNA PROCESSING; RNA SEQUENCE; SOMATIC HYPERMUTATION; TRANSCRIPTION TERMINATION;

AID; AID TARGETS; HOTSPOTS; NEGATIVE SUPERCOILS; SHM OF NON-IG GENES; SINGLE-STRANDED DNA; SOMATIC HYPERMUTATION MODEL; TRANSCRIPTION;

ANIMALS; B-LYMPHOCYTE SUBSETS; CYTIDINE DEAMINASE; GENE TARGETING; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; LYMPHOCYTE ACTIVATION; MICE; MUTATION; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; TRANSCRIPTIONAL ACTIVATION;

EID: 84893404966     PISSN: 00652776     EISSN: 15578445     Source Type: Book Series    
DOI: 10.1016/B978-0-12-800267-4.00007-9     Document Type: Chapter

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