Molecular mechanisms of antibody somatic hypermutation

Annual Review of Biochemistry

Volumn 76, Issue , 2007, Pages 1-22

  Di Noia, Javier M ^a   Neuberger, Michael S ^b  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Activation induced deaminase; Class switch recombination; Immunoglobulin gene diversification; Uracil excision

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; ALANINE; ANTIBODY; CYCLIC AMP DEPENDENT PROTEIN KINASE; DEAMINASE; DEOXYCYTIDINE; DNA; IMMUNOGLOBULIN; POLYNUCLEOTIDE DEAMINASE; PROTEIN MSH2; PROTEIN MSH6; UNCLASSIFIED DRUG; URACIL; URACIL DNA GLYCOSIDASE; URACIL EXCISION ENZYME; AICDA (ACTIVATION INDUCED CYTIDINE DEAMINASE); AICDA (ACTIVATION-INDUCED CYTIDINE DEAMINASE); CYTIDINE DEAMINASE; DNA BINDING PROTEIN; G T MISMATCH BINDING PROTEIN; G-T MISMATCH-BINDING PROTEIN;

AMINO ACID SUBSTITUTION; ANTIBODY AFFINITY; B LYMPHOCYTE; BINDING SITE; CATALYSIS; CELLULAR DISTRIBUTION; CHEMICAL ANALYSIS; CHROMOSOME PAIRING; DEAMINATION; DNA REPLICATION; EXCISION REPAIR; GENE CONVERSION; GENE MUTATION; GENE REARRANGEMENT; GENE TARGETING; GENE TRANSLOCATION; GENETIC LINKAGE; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HISTORICAL PERIOD; HOMOLOGOUS RECOMBINATION; HUMAN; IMMUNE RESPONSE; IMMUNOGLOBULIN VARIABLE REGION; MISMATCH REPAIR; MOLECULAR GENETICS; MOLECULAR RECOGNITION; MUTAGENESIS; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC HYPERMUTATION; TUMOR CELL; ANIMAL; DNA DAMAGE; DNA REPAIR; GENETICS; IMMUNOGLOBULIN GENE; METABOLISM; MUTATION;

ANIMALS; ANTIBODIES; CYTIDINE DEAMINASE; DNA; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; MUTATION; MUTS HOMOLOG 2 PROTEIN; RECOMBINATION, GENETIC; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; TRANSCRIPTION, GENETIC; URACIL;

EID: 34249790004     PISSN: 00664154     EISSN: 00664154     Source Type: Book Series    
DOI: 10.1146/annurev.biochem.76.061705.090740     Document Type: Review

References (142)

1. Tonegawa S. 1983. Nature 302:575-81
2. Reynaud CA, Bertocci B, Dahan A, Weill JC. 1994. Adv. Immunol. 57:353-78
3. MaizelsN. 2005. Annu. Rev. Genet. 39:23-46
4. Burnet FM. 1957. Aust.J. Sci. 20:67-69
5. LederbergJ. 1959. Science 129:1649-53
6. Hilschmann N, Craig LC. 1965. Proc. Natl. Acad. Sci. USA 53:1403-9
7. MilsteinC. 1966. Biochem.J. 101:352-68
8. Putnam FW, Titani K, Whitley EJ. 1966. Proc. R. Soc. London Ser. B 166:124-37
9. 9.Brenner S, Milstein C. 1966. Nature 211:242-43
10. Antibodies. 1967. Cold Spring Harbor Symp. Quant. Biol. 32:(Whole volume)
11. Weigert MG, Cesari IM, Yonkovich SJ, Cohn M. 1970. Nature 228:1045-47
12. Bernard O, HozumiN, Tonegawa S. 1978. Cell 15:1133-44
13. O'Brien RL, Brinster RL, Storb U. 1987. Nature 326:405-9
14. Milstein C, Neuberger MS. 1996. Adv. Protein Chem. 49:451-85
15. RajewskyK. 1996. Nature 381:751-58
16. 1998. Immunol. Rev. 162:(Whole volume)
17. Neuberger MS, Milstein C. 1995. Curr. Opin. Immunol. 7:248-54
18. Chaudhuri J, Alt FW. 2004. Nat. Rev. Immunol. 4:541-52
19. Reynaud CA, Mackay CR, Muller RG, Weill JC. 1991. Cell 64:995-1005
20. Hinds-Frey KR, Nishikata H, Litman RT, Litman GW. 1993. J. Exp. Med. 178:815-24
21. Conticello SG, Thomas CJ, Petersen-Mahrt SK, Neuberger MS. 2005. Mol. Biol. Evol. 22:367-77
22. Fugmann SD, Messier C, Novack LA, Cameron RA, Rast JP. 2006. Proc. Natl. Acad. Sci. USA 103:3728-33
23. Golding GB, Gearhart PJ, Glickman BW. 1987. Genetics 115:169-76
24. Milstein C, NeubergerMS, Staden R. 1998. Proc. Natl. Acad. Sci. USA 95:8791-94
25. Sharpe MJ, Milstein C,Jarvis.JM, Neuberger MS. 1991. EMBOJ. 10:2139-45
26. Rogozin IB, KolchanovNA. 1992. Biochim. Biophys. Acta 1171:11-18
27. Betz AG, Rada C, Pannell R, Milstein C, Neuberger MS. 1993. Proc. Natl. Acad. Sci. USA 90:2385-88
28. Wagner SD, Milstein C, Neuberger MS. 1995. Nature 376:732
29. Jolly CJ, Wagner SD, Rada C, KlixN, Milstein C, Neuberger MS. 1996. Semin. Immunol. 8:159-68
30. Kepler TB. 1997. Mol. Biol. Evol. 14:637-43
31. Phung QH, Winter DB, Cranston A, Tarone RE, Bohr VA, et al. 1998. J. Exp. Med. 187:1745-51
32. Frey S, Bertocci B, Delbos F, Quint L, Weill JC, Reynaud CA. 1998. Immunity 9:127-34
33. Rada C, Ehrenstein MR, NeubergerMS, Milstein C. 1998. Immunity 9:135-41
34. BachlJ, WablM. 1996. Proc. Natl. Acad. Sci. USA 93:851-55
35. Denepoux S, Razanajaona D, Blanchard D, Meffre G, Capra JD, et al. 1997. Immunity 6:35-46
36. SaleJE, Neuberger MS. 1998. Immunity 9:859-69
37. Wilson M, Hsu E, Marcuz A, Courtet M, Du Pasquier L, Steinberg C. 1992. EMBO J. 11:4337-47
38. Neuberger MS, Harris RS, Di Noia J, Petersen-Mahrt SK 2003. Trends Biochem. Sci. 28:305-12
39. Muramatsu M, Sankaranand VS, Anant S, Sugai M, Kinoshita K, et al. 1999. J. Biol. Chem. 274:18470-76
40. Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T. 2000. Cell 102:553-63
41. Revy P, Muto T, Levy Y, Geissmann F, Plebani A, et al. 2000. Cell 102:565-75
42. Arakawa H, HauschildJ, Buerstedde JM. 2002. Science 295:1301-6
43. Harris RS, SaleJE, Petersen-Mahrt SK, Neuberger MS. 2002. Curr. Biol. 12:435-38
44. Martin A, Bardwell PD, Woo CJ, Fan M, Shulman MJ, Scharff MD. 2002. Nature 415:802-6
45. Okazaki IM, Kinoshita K, MuramatsuM, Yoshikawa K, Honjo T. 2002. Nature 416:340-45
46. Blanc V, Davidson NO. 2003. J. Biol. Chem. 278:1395-98
47. Petersen-Mahrt SK, Harris RS, Neuberger MS. 2002. Nature 418:99-103
48. Ehrenstein MR, Neuberger MS. 1999. EMBO J. 18:3484-90
49. Neuberger MS, Lanoue A, Ehrenstein MR, Batista FD, Sale JE, Williams GT. 1999. Cold Spring Harbor Symp. Quant. Biol. 64:211-16
50. MaizelsN. 1995. Cell83:9-12
51. Weill JC, Reynaud CA. 1996. Immunol. Today 17:92-97
52. SaleJE, Calandrini DM, Takata M, Takeda S, Neuberger MS. 2001. Nature 412:921-26
53. Arakawa H, Saribasak H, Buerstedde JM. 2004. PLoS Biol. 2:E179
54. Bransteitter R, Pham P, Scharff MD, Goodman MF. 2003. Proc. Natl. Acad. Sci. USA 100:4102-7
55. Chaudhuri J, Tian M, Khuong C, Chua K, Pinaud E, Alt FW. 2003. Nature 422:726-30
56. Dickerson SK, Market E, Besmer E, Papavasiliou FN. 2003. J. Exp. Med. 197:1291-96
57. Pham P, Bransteitter R, Petruska J, Goodman MF. 2003. Nature 424:103-7
58. Ramiro AR, Stavropoulos P, Jankovic M, Nussenzweig MC. 2003. Nat. Immunol. 4:452-56
59. Sohail A, Klapacz J, Samaranayake M, Ullah A, Bhagwat AS. 2003. Nucleic Acids Res. 31:2990-94
60. Beale RC, Petersen-Mahrt SK, Watt IN, Harris RS, Rada C, Neuberger MS. 2004. J. Mol. Biol. 337:585-96
61. Di Noia J, Neuberger MS. 2002. Nature 419:43-48
62. Di Noia. JM, Neuberger MS. 2004. Eur. J. Immunol. 34:504-8
63. ImaiK, SlupphaugG, Lee WI, Revy P, Nonoyama S, et al. 2003. Nat. Immunol. 4:1023-28
64. Rada C, Di Noia. JM, Neuberger MS. 2004. Mol. Cell 16:163-71
65. Rada C, Jarvis.JM, Milstein C. 2002. Proc. Natl. Acad. Sci. USA 99:7003-8
66. Saribasak H, Saribasak NN, Ipek FM, Ellwart JW, Arakawa H, Buerstedde JM. 2006. J. Immunol. 176:365-71
67. Wiesendanger M, Kneitz B, Edelmann W, Scharff MD. 2000. J. Exp. Med. 191:579-84
68. Wilson TM, Vaisman A, Martomo SA, Sullivan P, Lan L, et al. 2005. J. Exp. Med. 201:637-45
69. Jarmuz A, Chester A, Bayliss J, Gisbourne J, Dunham I, et al. 2002. Genomics 79:285-96
70. Petersen-Mahrt SK, Neuberger MS. 2003. J. Biol. Chem. 278:19583-86
71. Harris RS, Petersen-Mahrt SK, Neuberger MS. 2002. Mol. Cell 10:1247-53
72. Fugmann SD, Rush JS, Schatz DG. 2004. Eur. J. Immunol. 34:844-49
73. Krause K, Marcu KB, Greeve J. 2006. Mol. Immunol. 43:295-307
74. Ta VT, NagaokaH, CatalanN, Durandy A, Fischer A, et al. 2003. Nat. Immunol. 4:843-48
75. Zai MJ, Kierzek AM. 2003. Nat. Immunol. 4:1153
76. Xie K, Sowden MP, Dance GS, Torelli AT, Smith HC, Wedekind JE. 2004. Proc. Natl. Acad. Sci. USA 101:8114-19
77. HuthoffH,MalimMH. 2005. Virology 334:147-53
78. Wang J, Shinkura R, Muramatsu M, Nagaoka H, Kinoshita K, Honjo T. 2006. J. Biol. Chem. 281:19115-23
79. Yang G, Obiakor H, Sinha RK, Newman BA, Hood BL, et al. 2005. Proc. Natl. Acad. Sci. USA 102:17083-88
80. Ito S, Nagaoka H, Shinkura R, Begum N, Muramatsu M, et al. 2004. Proc. Natl. Acad. Sci. USA 101:1975-80
81. McBride KM, Barreto V, Ramiro AR, Stavropoulos P, Nussenzweig MC. 2004. J. Exp. Med. 199:1235-44
82. Brar SS, Watson M, Diaz M. 2004. J. Biol. Chem. 2 79:2 6 3 95-401
83. Barreto V, Reina-San-Martin B, Ramiro AR, McBride KM, Nussenzweig MC. 2003. Mol. Cell 12:501-8
84. Shinkura R, Ito S, Begum NA, Nagaoka H, Muramatsu M, et al. 2004. Nat. Immunol. 5:707-12
85. MacDuff DA, NeubergerMS, Harris RS. 2006. Mol. Immunol. 43:1099-108
86. Wu X, Geraldes P, Platt JL, Cascalho M. 2005. J. Immunol. 174:934-41
87. Chaudhuri J, Khuong C, Alt FW. 2004. Nature 430:992-98
88. Basu U, Chaudhuri J, Alpert C, Dutt S, Ranganath S, et al. 2005. Nature 438:508-11
89. McBride KM, Gazumyan A, Woo EM, Barreto VM, Robbiani DF, et al. 2006. Proc. Natl. Acad. Sci. USA 103:8798-803
90. PasqualucciL, KitauraY,GuH, Dalla-Favera R.2006.Proc. Natl. Acad. Sci. USA 103:395-400
91. Odegard VH, Schatz DG. 2006. Nat. Rev. Immunol. 6:573-83
92. Besmer E, Market E, Papavasiliou FN. 2006. Mol. Cell. Biol. 26:4378-85
93. Nambu Y, Sugai M, Gonda H, Lee CG, Katakai T, et al. 2003. Science 302:2137-40
94. Xue K, Rada C, Neuberger MS. 2006. J. Exp. Med. 203:2085-94
95. Shen HM, Storb U. 2004. Proc. Natl. Acad. Sci. USA 101:12997-3002
96. Okazaki IM, Hiai H, Kakazu N, Yamada S, Muramatsu M, et al. 2003. J. Exp. Med. 197:1173-81
97. ParsaJY, Basit W, Wang CL, GommermanJL, Carlyle JR, Martin A. 2006. Mol. Immunol.44:567-75
98. Wang CL, Harper RA, Wabl M. 2004. Proc. Natl. Acad. Sci. USA 101:7352-56
99. Martin A, Scharff MD. 2002. Proc. Natl. Acad. Sci. USA 99:12304-8
100. Michael N, Shen HM, Longerich S, Kim N, Longacre A, Storb U. 2003. Immunity 19:235-42
101. Kotani A, Okazaki IM, Muramatsu M, Kinoshita K, Begum NA, et al. 2005. Proc. Natl. Acad. Sci. USA 102:4506-11
102. Schoetz U, Cervelli M, Wang YD, Fiedler P, BuersteddeJM. 2006. J. Immunol. 177:395-400
103. Conlon TM, Meyer KB. 2006. Eur. J. Immunol. 36:139-48
104. de Yebenes VG, Ramiro AR. 2006. Trends Mol. Med. 12:432-39
105. Krokan HE, Drablos F, Slupphaug G. 2002. Oncogene 21:8935-48
106. Rada C, Williams GT, Nilsen H, Barnes DE, Lindahl T, Neuberger MS. 2002. Curr. Biol. 12:1748-55
107. Bardwell PD, Martin A, Wong E, Li Z, Edelmann W, Scharff MD. 2003. J. Immunol. 170:1620-24
108. Di Noia. JM, Rada C, Neuberger MS. 2006. EMBO J. 25:585-95
109. Otterlei M, Warbrick E, Nagelhus TA, Haug T, Slupphaug G, et al. 1999. EMBO J. 18:3834-44
110. Bertocci B, Quint L, Delbos F, Garcia C, Reynaud CA, Weill JC. 1998. Immunity 9:257-65
111. Li Z, Scherer SJ, Ronai D, Iglesias-Ussel MD, PeledJU, et al. 2004. J. Exp. Med. 200:47-59
112. Martomo SA, Yang WW, Gearhart PJ. 2004. J. Exp. Med. 200:61-68
113. Prakash S, Johnson RE, Prakash L. 2005. Annu. Rev. Biochem. 74:317-53
114. SekiM, Gearhart PJ, Wood RD. 2005. EMBO Rep. 6:1143-48
115. NelsonJR, Lawrence CW, Hinkle DC. 1996. Nature 382:729-31
116. Ross AL, SaleJE. 2006. Mol. Immunol. 43:1587-94
117. Jansen JG, Langerak P, Tsaalbi-Shtylik A, van den Berk P, Jacobs H, de Wind N. 2006. J. Exp. Med. 203:319-23
118. Diaz M, Verkoczy LK, FlajnikMF, Klinman NR. 2001. J. Immunol. 167:327-35
119. Zan H, Komori A, Li Z, Cerutti A, Schaffer A, et al. 2001. Immunity14:643-53
120. Masuda K, Ouchida R, Hikida M, Nakayama M, Ohara O, et al. 2006. DNA Repair. 5:1384-91
121. Masuda K, Ouchida R, Takeuchi A, Saito T, Koseki H, et al. 2005. Proc. Natl. Acad. Sci.USA 102:13986-91
122. Zan H, Shima N, Xu Z, Al-Qahtani A, Evinger Iii AJ, et al. 2005. EMBO J. 24:3757-69
123. Faili A, Aoufouchi S, Flatter E, Gueranger Q, Reynaud CA, Weill JC. 2002. Nature 419:944-47
124. Martomo SA, Yang WW, Vaisman A, Maas A, Yokoi M, et al. 2006. DNA Repair 5:392-98
125. Bardwell PD, Woo CJ, Wei K, Li Z, Martin A, et al. 2004. Nat. Immunol. 5:224-29
126. Delbos F, De Smet A, Faili A, Aoufouchi S, Weill JC, Reynaud CA. 2005. J. Exp. Med. 201:1191-96
127. Martomo SA, Yang WW, Wersto RP, Ohkumo T, Kondo Y, et al. 2005. Proc. Natl. Acad. Sci. USA 102:8656-61
128. Zeng X, Winter DB, Kasmer C, Kraemer KH, Lehmann AR, Gearhart PJ. 2001. Nat. Immunol. 2:537-41
129. Ehrenstein MR, Rada C, Jones AM, Milstein C, Neuberger MS. 2001. Proc. Natl. Acad. Sci. USA 98:14553-58
130. Wu X, Tsai CY, Patam MB, Zan H, Chen JP, et al. 2006. J. Immunol. 176:5426-37
131. Li Z, PeledJU, Zhao C, Svetlanov A, Ronai D, et al. 2006. DNA Repair 5:675-82
132. Kim N, Bozek G, LoJC, Storb U. 1999. J. Exp. Med. 190:21-30
133. Phung QH, Winter DB, Alrefai R, Gearhart PJ. 1999. J. Immunol. 162:3121-24
134. Kong Q, Maizels N. 1999. Mol. Immunol. 36:83-91
135. Kunkel TA, Erie DA. 2005. Annu. Rev. Biochem. 74:681-710
136. Pavlov YI, Rogozin IB, Galkin AP, Aksenova AY, Hanaoka F, et al. 2002. Proc. Natl. Acad. Sci. USA 99:9954-59
137. Rogozin IB, Pavlov YI, Bebenek K, Matsuda T, Kunkel TA. 2001. Nat. Immunol. 2:530-36
138. Neuberger MS, Di Noia.JM, Beale RC, Williams GT, Yang Z, Rada C. 2005. Nat. Rev. Immunol. 5:171-78
139. Larson ED, Cummings WJ, Bednarski DW, Maizels N. 2005. Mol. Cell 20:367-75
140. Yabuki M, Fujii MM, Maizels N. 2005. Nat. Immunol. 6:730-36
141. Harris RS, Liddament MT. 2004. Nat. Rev. Immunol. 4:868-77
142. Poole A, Penny D, Sjoberg BM. 2001. Nat. Rev. Mol. Cell Biol. 2:147-51