New insights into the enigma of immunoglobulin D

Immunological Reviews

Volumn 237, Issue 1, 2010, Pages 160-179

  Chen, Kang ^a   Cerutti, Andrea ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b HOSPITAL DEL MAR   (Spain)

Author keywords

antimicrobial peptide; autoinflammatory syndromes; basophil; class switch recombination; IgD

Indexed keywords

ANTIINFECTIVE AGENT; IMMUNOGLOBULIN D; IMMUNOGLOBULIN M; VIRULENCE FACTOR;

ALLERGIC DISEASE; ALTERNATIVE RNA SPLICING; AUTOIMMUNITY; B LYMPHOCYTE; BONE MARROW CELL; GENE REARRANGEMENT; HUMAN; IMMUNITY; IMMUNOSURVEILLANCE; INFECTION; INFLAMMATION; MAMMAL; MUCOSA; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; TISSUE INJURY;

AMINO ACID SEQUENCE; ANIMALS; B-LYMPHOCYTES; HUMANS; IMMUNOGLOBULIN D; IMMUNOGLOBULIN G; IMMUNOGLOBULIN ISOTYPES; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT;

EID: 77955910064     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.1600-065X.2010.00929.x     Document Type: Review

References (220)

1. Rowe DS, Fahey JL. A new class of human immunoglobulins. I. A unique myeloma protein. J Exp Med 1965 121:171 184.
2. Rowe DS, Fahey JL. A new class of human immunoglobulins. II. Normal serum IgD. J Exp Med 1965 121:185 199.
3. Black CA. A brief history of the discovery of the immunoglobulins and the origin of the modern immunoglobulin nomenclature. Immunol Cell Biol 1997 75:65 68.
4. Finkelman FD, van Boxel JA, Asofsky R, Paul WE. Cell membrane IgD: demonstration of IgD on human lymphocytes by enzyme-catalyzed iodination and comparison with cell surface Ig of mouse, guinea pig, and rabbit. J Immunol 1976 116:1173 1181.
5. Martin LN, Leslie GA, Hindes R. Lymphocyte surface IgD and IgM in non-human primates. Int Arch Allergy Appl Immunol 1976 51:320 329.
6. Ruddick JH, Leslie GA. Structure and biologic functions of human IgD. XI. Identification and ontogeny of a rat lymphocyte immunoglobulin having antigenic cross-reactivity with human IgD. J Immunol 1977 118:1025 1031.
7. Finkelman FD, Woods VL, Berning A, Scher I. Demonstration of mouse serum IgD. J Immunol 1979 123:1253 1259.
8. Chen CL, Lehmeyer JE, Cooper MD. Evidence for an IgD homologue on chicken lymphocytes. J Immunol 1982 129:2580 2585.
9. Preud'homme JL, Petit I, Barra A, Morel F, Lecron JC, Lelievre E. Structural and functional properties of membrane and secreted IgD. Mol Immunol 2000 37:871 887.
10. Stavnezer J, Guikema JE, Schrader CE. Mechanism and regulation of class switch recombination. Annu Rev Immunol 2008 26:261 292.
11. Hordvik I, Thevarajan J, Samdal I, Bastani N, Krossoy B. Molecular cloning and phylogenetic analysis of the Atlantic salmon immunoglobulin D gene. Scand J Immunol 1999 50:202 210.
12. Ohta Y, Flajnik M. IgD, like IgM, is a primordial immunoglobulin class perpetuated in most jawed vertebrates. Proc Natl Acad Sci USA 2006 103:10723 10728.
13. Gambon-Deza F, Espinel CS. IgD in the reptile leopard gecko. Mol Immunol 2008 45:3470 3476.
14. Wei Z, et al. Expression of IgM, IgD, and IgY in a reptile, Anolis carolinensis. J Immunol 2009 183:3858 3864.
15. Wilson M, Bengten E, Miller NW, Clem LW, Du Pasquier L, Warr GW. A novel chimeric Ig heavy chain from a teleost fish shares similarities to IgD. Proc Natl Acad Sci USA 1997 94:4593 4597.
16. Saha NR, Suetake H, Kikuchi K, Suzuki Y. Fugu immunoglobulin D: a highly unusual gene with unprecedented duplications in its constant region. Immunogenetics 2004 56:438 447.
17. Choi DH, Jang HN, Ha DM, Kim JW, Oh CH, Choi SH. Cloning and expression of partial Japanese flounder (Paralichthys olivaceus) IgD. J Biochem Mol Biol 2007 40:459 466.
18. Zhao Y, et al. Identification of IgF, a hinge-region-containing Ig class, and IgD in Xenopus tropicalis. Proc Natl Acad Sci USA 2006 103:12087 12092.
19. Hirono I, Nam BH, Enomoto J, Uchino K, Aoki T. Cloning and characterisation of a cDNA encoding Japanese flounder Paralichthys olivaceus IgD. Fish Shellfish Immunol 2003 15:63 70.
20. Zhao Y, et al. Artiodactyl IgD: the missing link. J Immunol 2002 169:4408 4416.
21. Bengten E, et al. The IgH locus of the channel catfish, Ictalurus punctatus, contains multiple constant region gene sequences: different genes encode heavy chains of membrane and secreted IgD. J Immunol 2002 169:2488 2497.
22. Stenvik J, Schroder MB, Olsen K, Zapata A, Jorgensen TO. Expression of immunoglobulin heavy chain transcripts (VH-families, IgM, and IgD) in head kidney and spleen of the Atlantic cod (Gadus morhua L.). Dev Comp Immunol 2001 25:291 302.
23. Greenberg AS, Hughes AL, Guo J, Avila D, McKinney EC, Flajnik MF. A novel "chimeric" antibody class in cartilaginous fish: IgM may not be the primordial immunoglobulin. Eur J Immunol 1996 26:1123 1129.
24. Bengten E, Clem LW, Miller NW, Warr GW, Wilson M. Channel catfish immunoglobulins: repertoire and expression. Dev Comp Immunol 2006 30:77 92.
25. Xu Z, Wang GL, Nie P. IgM, IgD and IgY and their expression pattern in the Chinese soft-shelled turtle Pelodiscus sinensis. Mol Immunol 2009 46:2124 2132.
26. Zhao Y, Hammarstrom L. Cloning of the complete rat immunoglobulin delta gene: evolutionary implications. Immunology 2003 108:288 295.
27. Zhao Y, Kacskovics I, Rabbani H, Hammarstrom L. Physical mapping of the bovine immunoglobulin heavy chain constant region gene locus. J Biol Chem 2003 278:35024 35032.
28. Allansmith M, McClellan BH, Butterworth M, Maloney JR. The development of immunoglobulin levels in man. J Pediatr 1968 72:276 290.
29. Buckley CE 3rd., Dorsey FC. Serum immunoglobulin levels throughout the life-span of healthy man. Ann Intern Med 1971 75:673 682.
30. Buckley RH, Dees SC, O'Fallon WM. Serum immunoglobulins. I. Levels in normal children and in uncomplicated childhood allergy. Pediatrics 1968 41:600 611.
31. Buckley RH, Younger JB, Brumley GW. Evaluation of serum immunoglobulin concentrations in the perinatal period by use of a standardized method of measurement. J Pediatr 1969 75:1143 1148.
32. Kalff MW. Quantitative determination of serum immunoglobulin levels by single radial immunodiffusion. Clin Biochem 1970 3:91 104.
33. Ritchie RF, Palomaki GE, Neveux LM, Navolotskaia O, Ledue TB, Craig WY. Reference distributions for immunoglobulins A, G, and M: a practical, simple, and clinically relevant approach in a large cohort. J Clin Lab Anal 1998 12:363 370.
34. del Carmen Candia-Plata M, Garcia J, Guzman R, Porath J, Vazquez-Moreno L. Isolation of human serum immunoglobulins with a new salt-promoted adsorbent. J Chromatogr A 2006 1118:211 217.
35. Stulik J, Kovarova H, Tichy M, Urban P. Electrophoretic analysis of microheterogeneity of paraproteins in a patient with IgD myeloma. Neoplasma 1995 42:105 108.
36. Vitetta ES, Uhr JW. Cell surface immunoglobulin. XIX. Susceptibility of IgD and IgM on murine splenocytes to cleavage by papain. J Immunol 1976 117:1579 1583.
37. Mellis SJ, Baenziger JU. Structures of the O-glycosidically linked oligosaccharides of human IgD. J Biol Chem 1983 258:11557 11563.
38. Tissot JD, et al. Clonal imbalances of serum immunoglobulins after allogeneic bone marrow transplantation: an analysis by high-resolution two-dimensional gel electrophoresis. Bone Marrow Transplant 1992 10:347 353.
39. Brandtzaeg P, Surjan L Jr., Berdal P. Immunoglobulin-producing cells in clinically normal, hyperplastic and inflamed human palatine tonsils. Acta Otolaryngol Suppl 1979 360:211 215.
40. Bahna SL, Heiner DC, Myhre BA. Changes in serum IgD in cigarette smokers. Clin Exp Immunol 1983 51:624 630.
41. Dunnette SL, Gleich GJ, Miller RD, Kyle RA. Measurement of IgD by a double antibody radioimmunoassay: demonstration of an apparent trimodal distribution of IgD levels in normal human sera. J Immunol 1977 119:1727 1731.
42. Litwin SD, Zehr BD, Insel RA. Selective concentration of IgD class-specific antibodies in human milk. Clin Exp Immunol 1990 80:263 267.
43. Brandtzaeg P, Gjeruldsen ST, Korsrud F, Baklien K, Berdal P, Ek J. The human secretory immune system shows striking heterogeneity with regard to involvement of J chain-positive IgD immunocytes. J Immunol 1979 122:503 510.
44. Surjan L Jr., Brandtzaeg P, Berdal P. Immunoglobulin systems of human tonsils. II. Patients with chronic tonsillitis or tonsillar hyperplasia: quantification of Ig-producing cells, tonsillar morphometry and serum Ig concentrations. Clin Exp Immunol 1978 31:382 390. (Pubitemid 8335611)
45. Korsrud FR, Brandtzaeg P. Quantitative immunohistochemistry of immunoglobulin- and J-chain-producing cells in human parotid and submandibular salivary glands. Immunology 1980 39:129 140.
46. Cederqvist LL, Ewool LC, Bonsnes RW, Litwin SD. Detectability and pattern of immunoglobulins in normal amniotic fluid throughout gestation. Am J Obstet Gynecol 1978 130:220 224.
47. Brandtzaeg P, Korsrud FR. Significance of different J chain profiles in human tissues: generation of IgA and IgM with binding site for secretory component is related to the J chain expressing capacity of the total local immunocyte population, including IgG and IgD producing cells, and depends on the clinical state of the tissue. Clin Exp Immunol 1984 58:709 718.
48. Brandtzaeg P, et al. Production and secretion of immunoglobulins in the gastrointestinal tract. Ann Allergy 1987 59:21 39.
49. Bjerke K, Brandtzaeg P, Rognum TO. Distribution of immunoglobulin producing cells is different in normal human appendix and colon mucosa. Gut 1986 27:667 674.
50. Plebani A, et al. IgM and IgD concentrations in the serum and secretions of children with selective IgA deficiency. Clin Exp Immunol 1983 53:689 696.
51. Korsrud FR, Brandtzaeg P. Immunohistochemical evaluation of J-chain expression by intra- and extra-follicular immunoglobulin-producing human tonsillar cells. Scand J Immunol 1981 13:271 280.
52. Brandtzaeg P. Overview of the mucosal immune system. Curr Top Microbiol Immunol 1989 146:13 25.
53. Chen K, et al. Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils. Nat Immunol 2009 10:889 898.
54. Liu YJ, et al. Normal human IgD+IgM- germinal center B cells can express up to 80 mutations in the variable region of their IgD transcripts. Immunity 1996 4:603 613.
55. Arpin C, et al. The normal counterpart of IgD myeloma cells in germinal center displays extensively mutated IgVH gene, Cmu-Cdelta switch, and lambda light chain expression. J Exp Med 1998 187:1169 1178.
56. Johansen FE, Baekkevold ES, Carlsen HS, Farstad IN, Soler D, Brandtzaeg P. Regional induction of adhesion molecules and chemokine receptors explains disparate homing of human B cells to systemic and mucosal effector sites: dispersion from tonsils. Blood 2005 106:593 600.
57. Brandtzaeg P, Nilssen DE. Mucosal aspects of primary B cell deficiency and gastrointestinal infections. Curr Opin Gastroenterol 1995 11:532 540.
58. Brandtzaeg P. The role of humoral mucosal immunity in the induction and maintenance of chronic airway infections. Am J Respir Crit Care Med 1995 151:2081 2086 discussion 2086-2087.
59. Brandtzaeg P, Carlsen HS, Farstad IN. The human mucosal B-cell system. In:Mestecky J, Lamm ME, Strober W, Bienenstock J, McGhee JR, Mayer L eds. Mucosal Immunology. Amsterdam:Elsevier Academic Press, 2005:617 654.
60. Cederqvist LL, Ewool LC, Litwin SD. IgD and the fetal immune response. Scand J Immunol 1977 6:821 825.
61. Salimonu LS, Ladipo OA, Adeniran SO, Osukoya BO. Serum immunoglobulin levels in normal, premature and postmature newborns and their mothers. Int J Gynaecol Obstet 1978 16:119 123.
62. Zegers BJ, van der Giessen M, Reerink-Brongers EE, Stoop JW. The serum IgG subclass levels in healthy infants of 13-62 weeks of age. Clin Chim Acta 1980 101:265 269.
63. Avrech OM, Samra Z, Lazarovich Z, Caspi E, Jacobovich A, Sompolinsky D. Efficacy of the placental barrier for immunoglobulins: correlations between maternal, paternal and fetal immunoglobulin levels. Int Arch Allergy Immunol 1994 103:160 165.
64. Salonen EM, Hovi T, Meurman O, Vesikari T, Vaheri A. Kinetics of specific IgA, IgD, IgE, IgG, and IgM antibody responses in rubella. J Med Virol 1985 16:1 9.
65. Rogentine GN Jr., Rowe DS, Bradley J, Waldmann TA, Fahey JL. Metabolism of human immunoglobulin D (IgD). J Clin Invest 1966 45:1467 1478.
66. Rudders RA, Andersen J. IgD-Fc receptors on normal and neoplastic human B lymphocytes. Clin Exp Immunol 1982 50:579 586. (Pubitemid 13249343)
67. Swenson CD, Thorbecke GJ. The effect of aging on IgD receptor expression by T cells and its functional implications. Immunol Rev 1997 160:145 157.
68. Swenson CD, et al. Human T cell IgD receptors react with O-glycans on both human IgD and IgA1. Eur J Immunol 1998 28:2366 2372.
69. Tamma SM, Coico RF. IgD-receptor (IgD-R) cross-linking partially protects murine T cells from dexamethasone-induced apoptosis. J Leukoc Biol 2003 73:764 770.
70. Lakshmi Tamma SM, Wu Y, Toporovsky I, Lima V, Coico RF. IgD receptor-mediated signal transduction in T cells. Cell Immunol 2001 207:110 117.
71. Wu Y, Lakshmi Tamma SM, Lima V, Coico R. Facilitated antigen presentation by B cells expressing IgD when responding T cells express IgD-receptors. Cell Immunol 1999 192:194 202.
72. Sechet B, Meseri-Delwail A, Arock M, Wijdenes J, Lecron JC, Sarrouilhe D. Immunoglobulin D enhances interleukin-6 release from the KU812 human prebasophil cell line. Gen Physiol Biophys 2003 22:255 263.
73. Berretty PJ, Cormane RH. Immunofluorescence studies on eosinophilic granulocytes. Br J Dermatol 1979 101:309 314.
74. Walsh GM, Kay AB. Binding of immunoglobulin classes and subclasses to human neutrophils and eosinophils. Clin Exp Immunol 1986 63:466 472.
75. Lawrence DA, Weigle WO, Spiegelberg HL. Immunoglobulins cytophilic for human lymphocytes, monocytes, and neutrophils. J Clin Invest 1975 55:368 376.
76. Hunyadi J, Hamerlinck F, Cormane RH. Immunoglobulin and complement bearing polymorphonuclear leukocytes in allergic contact dermatitis and psoriasis vulgaris. Br J Dermatol 1976 94:417 422.
77. Dikeacou TC, van Joost T, Cormane RH. The recruitment of inflammatory cells using the skin-window technique. Arch Dermatol Res 1979 265:1 7.
78. Drenth JP, Goertz J, Daha MR, van der Meer JW. Immunoglobulin D enhances the release of tumor necrosis factor-alpha, and interleukin-1 beta as well as interleukin-1 receptor antagonist from human mononuclear cells. Immunology 1996 88:355 362.
79. Sjoberg O. Presence of receptors for IgD on human T and non-T lymphocytes. Scand J Immunol 1980 11:377 382. (Pubitemid 10098954)
80. Fine JM, Rivat C, Lambin P, Ropartz C. Monoclonal IgD. A comparative study of 60 sera with IgD "M" component. Biomedicine 1974 211:119 125.
81. Pernis B, Governa M, Rowe DS. Light chain types in plasma cells that produce IgD. Immunology 1969 16:685 689.
82. Hobbs JR, Corbett AA. Younger age of presentation and extraosseous tumour in IgD myelomatosis. Br Med J 1969 1:412 414.
83. Jancelewicz Z, Takatsuki K, Sugai S, Pruzanski W. IgD multiple myeloma. Review of 133 cases. Arch Intern Med 1975 135:87 93.
84. Fibbe WE, Jansen J. Prognostic factors in IgD myeloma: a study of 21 cases. Scand J Haematol 1984 33:471 475.
85. Shimamoto Y, Anami Y, Yamaguchi M. A new risk grouping for IgD myeloma based on analysis of 165 Japanese patients. Eur J Haematol 1991 47:262 267.
86. Blade J, Lust JA, Kyle RA. Immunoglobulin D multiple myeloma: presenting features, response to therapy, and survival in a series of 53 cases. J Clin Oncol 1994 12:2398 2404.
87. Arpin C, et al. Human peripheral B cell development. sIgM-IgD+CD38+ hypermutated germinal center centroblasts preferentially express Ig lambda light chain and have undergone mu-to-delta switch. Ann N Y Acad Sci 1997 815:193 198.
88. Litwin SD, Zehr BD. In vitro studies on human IgD. II. IgD-secreting cells preferentially elaborate IgD, lambda molecules. Eur J Immunol 1987 17:491 495.
89. Litwin SD, Zehr BD. Membrane IgD-positive B cells of "low-IgD serum phenotype" individuals fail to secrete IgD and fail to shift to preferential lambda light-chain expression in vitro. J Clin Immunol 1987 7:114 120.
90. Litwin SD, Zehr BD. In vitro studies on human IgD. III. Immunologic features of individuals with high sera IgD and spontaneous IgD biosynthesis. Clin Immunol Immunopathol 1988 47:75 83.
91. Nemazee D, Gavin A, Hoebe K, Beutler B. Immunology: Toll-like receptors and antibody responses. Nature 2006 441:E4. discussion E4.
92. Zouali M. Receptor editing and receptor revision in rheumatic autoimmune diseases. Trends Immunol 2008 29:103 109.
93. van der Burg M, Bende RJ, Aarts WM, Langerak AW, van Dongen JJ, van Noesel CJ. Biased Iglambda expression in hypermutated IgD multiple myelomas does not result from receptor revision. Leukemia 2002 16:1358 1361.
94. Derudder E, et al. Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals. Nat Immunol 2009 10:647 654.
95. Bengten E, Wilson M, Miller N, Clem LW, Pilstrom L, Warr GW. Immunoglobulin isotypes: structure, function, and genetics. Curr Top Microbiol Immunol 2000 248:189 219.
96. Miller NW, Rycyzyn MA, Wilson MR, Warr GW, Naftel JP, Clem LW. Development and characterization of channel catfish long term B cell lines. J Immunol 1994 152:2180 2189.
97. Kerr WG, Hendershot LM, Burrows PD. Regulation of IgM and IgD expression in human B-lineage cells. J Immunol 1991 146:3314 3321.
98. Weiss EA, Michael A, Yuan D. Role of transcriptional termination in the regulation of mu mRNA expression in B lymphocytes. J Immunol 1989 143:1046 1052.
99. Yuan D. Regulation of immunoglobulin D synthesis in murine neonatal B lymphocytes. Mol Cell Biol 1986 6:1015 1022.
100. Kim M, Qiu P, Abuodeh R, Chen J, Yuan D. Differential regulation of transcription termination occurring at two different sites on the micro-delta gene complex. Int Immunol 1999 11:813 824.
101. Yuan D, Witte PL, Tan J, Hawley J, Dang T. Regulation of IgM and IgD heavy chain gene expression: effect of abrogation of intergenic transcriptional termination. J Immunol 1996 157:2073 2081.
102. Peterson ML, Perry RP. The regulated production of mu m and mu s mRNA is dependent on the relative efficiencies of mu s poly(A) site usage and the c mu 4-to-M1 splice. Mol Cell Biol 1989 9:726 738.
103. Takagaki Y, Seipelt RL, Peterson ML, Manley JL. The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation. Cell 1996 87:941 952.
104. Kluin PM, et al. IgD class switching: identification of a novel recombination site in neoplastic and normal B cells. Eur J Immunol 1995 25:3504 3508.
105. White MB, Word CJ, Humphries CG, Blattner FR, Tucker PW. Immunoglobulin D switching can occur through homologous recombination in human B cells. Mol Cell Biol 1990 10:3690 3699.
106. Seifert M, Steimle-Grauer SA, Goossens T, Hansmann ML, Brauninger A, Kuppers R. A model for the development of human IgD-only B cells: genotypic analyses suggest their generation in superantigen driven immune responses. Mol Immunol 2009 46:630 639.
107. Lin LC, Putnam FW. Primary structure of the Fc region of human immunoglobulin D: implications for evolutionary origin and biological function. Proc Natl Acad Sci USA 1981 78:504 508.
108. Mellis SJ, Baenziger JU. Structures of the oligosaccharides present at the three asparagine-linked glycosylation sites of human IgD. J Biol Chem 1983 258:11546 11556.
109. Amin AR, et al. The immunoaugmenting properties of murine IgD reside in its C delta 1 and C delta 3 regions: potential role for IgD-associated glycans. Int Immunol 1993 5:607 614.
110. Gala FA, Morrison SL. The role of constant region carbohydrate in the assembly and secretion of human IgD and IgA1. J Biol Chem 2002 277:29005 29011.
111. Baenziger J, Kornfeld S. Structure of the carbohydrate units of IgA1 immunoglobulin. I. Composition, glycopeptide isolation, and structure of the asparagine-linked oligosaccharide units. J Biol Chem 1974 249:7260 7269.
112. Baenziger J, Kornfeld S. Structure of the carbohydrate units of IgA1 immunoglobulin. II. Structure of the O-glycosidically linked oligosaccharide units. J Biol Chem 1974 249:7270 7281.
113. Takahashi N, Tetaert D, Debuire B, Lin LC, Putnam FW. Complete amino acid sequence of the delta heavy chain of human immunoglobulin D. Proc Natl Acad Sci USA 1982 79:2850 2854. (Pubitemid 12032330)
114. Smith AC, de Wolff JF, Molyneux K, Feehally J, Barratt J. O-glycosylation of serum IgD in IgA nephropathy. J Am Soc Nephrol 2006 17:1192 1199.
115. Spiegelberg HL. The structure and biology of human IgD. Immunol Rev 1977 37:3 24.
116. Griffiths RW, Gleich GJ. Proteolytic degradation of IgD and its relation to molecular conformation. J Biol Chem 1972 247:4543 4548.
117. Goyert SM, Hugli TE, Spiegelberg HL. Sites of "spontaneous" degradation of IgD. J Immunol 1977 118:2138 2144.
118. Lin LC, Putnam FW. Structural studies of human IgD: isolation by a two-step purification procedure and characterization by chemical and enzymatic fragmentation. Proc Natl Acad Sci USA 1979 76:6572 6576.
119. Sun Z, Almogren A, Furtado PB, Chowdhury B, Kerr MA, Perkins SJ. Semi-extended solution structure of human myeloma immunoglobulin D determined by constrained X-ray scattering. J Mol Biol 2005 353:155 173.
120. Loset GA, Roux KH, Zhu P, Michaelsen TE, Sandlie I. Differential segmental flexibility and reach dictate the antigen binding mode of chimeric IgD and IgM: implications for the function of the B cell receptor. J Immunol 2004 172:2925 2934.
121. Van Boxel JA, Paul WE, Terry WD, Green I. Communications. IgD-bearing human lymphocytes. J Immunol 1972 109:648 651.
122. Rowe DS, Hug K, Faulk WP, McCormick JN, Gerber H. IgD on the surface of peripheral blood lymphocytes of the human newborn. Nat New Biol 1973 242:155 157.
123. Rowe DS, Hug K, Forni L, Pernis B. Immunoglobulin D as a lymphocyte receptor. J Exp Med 1973 138:965 972.
124. Abney ER, Parkhouse RM. Candidate for immunoglobulin D present on murine B lymphocytes. Nature 1974 252:600 602.
125. Melcher U, Vitetta ES, McWilliams M, Lamm ME, Phillips-Quagliata JM, Uhr JW. Cell surface immunoglobulin. X. Identification of an IgD-like molecule on the surface of murine splenocytes. J Exp Med 1974 140:1427 1431.
126. Kim KM, Reth M. The B cell antigen receptor of class IgD induces a stronger and more prolonged protein tyrosine phosphorylation than that of class IgM. J Exp Med 1995 181:1005 1014.
127. Kim KM, Reth M. Function of B-cell antigen receptor of different classes. Immunol Lett 1995 44:81 85.
128. Kim KM, Reth M. Signaling difference between class IgM and IgD antigen receptors. Ann N Y Acad Sci 1995 766:81 88.
129. Carsetti R, Kohler G, Lamers MC. Transitional B cells are the target of negative selection in the B cell compartment. J Exp Med 1995 181:2129 2140.
130. Ales-Martinez JE, Warner GL, Scott DW. Immunoglobulins D and M mediate signals that are qualitatively different in B cells with an immature phenotype. Proc Natl Acad Sci USA 1988 85:6919 6923.
131. Peckham D, Andersen-Nissen E, Finkelman FD, Stunz LL, Ashman RF. Difference in apoptosis induction between surface IgD and IgM. Int Immunol 2001 13:285 295.
132. Geisberger R, Crameri R, Achatz G. Models of signal transduction through the B-cell antigen receptor. Immunology 2003 110:401 410.
133. Heltemes LM, Manser T. Level of B cell antigen receptor surface expression influences both positive and negative selection of B cells during primary development. J Immunol 2002 169:1283 1292.
134. Iglesias A, Lamers M, Kohler G. Expression of immunoglobulin delta chain causes allelic exclusion in transgenic mice. Nature 1987 330:482 484.
135. Lutz C, et al. IgD can largely substitute for loss of IgM function in B cells. Nature 1998 393:797 801.
136. Nitschke L, Kosco MH, Kohler G, Lamers MC. Immunoglobulin D-deficient mice can mount normal immune responses to thymus-independent and -dependent antigens. Proc Natl Acad Sci USA 1993 90:1887 1891.
137. Roes J, Rajewsky K. Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells. J Exp Med 1993 177:45 55.
138. Geisberger R, Lamers M, Achatz G. The riddle of the dual expression of IgM and IgD. Immunology 2006 118:429 437.
139. Yuan D, Dang T, Bibi R. Inappropriate expression of IgD from a transgene inhibits the function of antigen-specific memory B cells. Cell Immunol 2001 211:61 70.
140. Glynne R, Akkaraju S, Healy JI, Rayner J, Goodnow CC, Mack DH. How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis. Nature 2000 403:672 676.
141. Cohen P, Ziff M, Vitetta ES. Characterization of a B cell defect in the NZB mouse manifested by an increased ratio of surface IgM to IgD. J Immunol 1978 121:973 977.
142. Duty JA, et al. Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors. J Exp Med 2009 206:139 151.
143. Wienands J, Reth M. Glycosyl-phosphatidylinositol linkage as a mechanism for cell-surface expression of immunoglobulin D. Nature 1992 356:246 248.
144. Chaturvedi A, Siddiqui Z, Bayiroglu F, Rao KV. A GPI-linked isoform of the IgD receptor regulates resting B cell activation. Nat Immunol 2002 3:951 957.
145. Koelsch K, et al. Mature B cells class switched to IgD are autoreactive in healthy individuals. J Clin Invest 2007 117:1558 1565.
146. Luster MI, Armen RC, Hallum JV, Leslie GA. Measles virus-specific IgD antibodies in patients with subacute sclerosing panencephalitis. Proc Natl Acad Sci USA 1976 73:1297 1299.
147. Heiner DC, Rose B. A study of antibody responses by radioimmunodiffusion with demonstration of gamma D antigen-binding activity in four sera. J Immunol 1970 104:691 697.
148. Jefferis R, Mathews JB. Studies of human IgD myeloma proteins. Proteolytic digestion patterns. Immunochemistry 1977 14:171 178.
149. Sewell HF, Chambers L, Maxwell V, Matthews JB, Jefferis R. The natural antibody response to E. coli includes antibodies of the IgD class. Clin Exp Immunol 1978 31:104 110.
150. Swierczynska Z, Wozniczko-Orlowska G, Maldyk H. An IgD myeloma protein with anti-streptolysin O activity. Immunochemistry 1976 13:379 382.
151. Forsgren A, et al. Isolation and characterization of a novel IgD-binding protein from Moraxella catarrhalis. J Immunol 2001 167:2112 2120.
152. Ronander E, Brant M, Janson H, Sheldon J, Forsgren A, Riesbeck K. Identification of a novel Haemophilus influenzae protein important for adhesion to epithelial cells. Microbes Infect 2008 10:87 96.
153. Vladutiu AO. Immunoglobulin D: properties, measurement, and clinical relevance. Clin Diagn Lab Immunol 2000 7:131 140.
154. Listi F, et al. A study of serum immunoglobulin levels in elderly persons that provides new insights into B cell immunosenescence. Ann N Y Acad Sci 2006 1089:487 495.
155. Kiyotaki C, Shimizu A, Watanabe S, Yamamura Y. Superoxide production from human polymorphonuclear leucocytes stimulated with immunoglobulins of different classes and fragments of IgG bound to polystyrene dishes. Immunology 1978 35:613 618.
156. Wilson BJ, Kocvara H. A simple rapid method for layering blood on Ficoll-Isopaque gradients. J Immunol Methods 1975 9:67 68.
157. Boyum A. Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyte aggregating agents. Scand J Clin Lab Invest Suppl 1968 97:31 50.
158. Xu YP, et al. The relationship of allergic asthma and basophil surface IgD. Shanghai J Immunol 1986 6:164 165.
159. Peng Z, Fisher R, Adkinson NF Jr. Total serum IgD is increased in atopic subjects. Allergy 1991 46:436 444.
160. Conrad DH, Ben-Sasson SZ, Le Gros G, Finkelman FD, Paul WE. Infection with Nippostrongylus brasiliensis or injection of anti-IgD antibodies markedly enhances Fc-receptor-mediated interleukin 4 production by non-B, non-T cells. J Exp Med 1990 171:1497 1508.
161. Dvorak AM, Seder RA, Paul WE, Kissell-Rainville S, Plaut M, Galli SJ. Ultrastructural characteristics of Fc epsilon R-positive basophils in the spleen and bone marrow of mice immunized with goat anti-mouse IgD antibody. Lab Invest 1993 68:708 715.
162. Seder RA, et al. Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils. Proc Natl Acad Sci USA 1991 88:2835 2839.
163. Finkelman FD, Snapper CM, Mountz JD, Katona IM. Polyclonal activation of the murine immune system by a goat antibody to mouse IgD. IX. Induction of a polyclonal IgE response. J Immunol 1987 138:2826 2830.
164. Vladutiu AO, Netto D. Is quantitation of serum IgD clinically useful? Clin Chem 1982 28:1409 1410.
165. Litzman J, Ward AM, Wild G, Znojil V, Morgan G. Serum IgD levels in children under investigation for and with defined immunodeficiency. Int Arch Allergy Immunol 1997 114:54 58.
166. Mizuma H, et al. Serum IgD elevation is an early marker of B cell activation during infection with the human immunodeficiency viruses. Clin Exp Immunol 1987 68:5 14.
167. Mizuma H, Litwin S, Zolla-Pazner S. B-cell activation in HIV infection: relationship of spontaneous immunoglobulin secretion to various immunological parameters. Clin Exp Immunol 1988 71:410 416.
168. Chess Q, Daniels J, North E, Macris NT. Serum immunoglobulin elevations in the acquired immunodeficiency syndrome (AIDS): IgG, IgA, IgM, and IgD. Diagn Immunol 1984 2:148 153.
169. Papadopoulos NM, Frieri M. The presence of immunoglobulin D in endocrine disorders and diseases of immunoregulation, including the acquired immunodeficiency syndrome. Clin Immunol Immunopathol 1984 32:248 252.
170. Rowe DS, Crabbe PA, Turner MW. Immunoglobulin D in serum, body fluids and lymphoid tissues. Clin Exp Immunol 1968 3:477 490.
171. Sirisinha S, Charupatana C, Ramasoota T. Serum immunoglobulins in leprosy patients with different spectra of clinical manifestations. Proc Soc Exp Biol Med 1972 140:1062 1068.
172. Buckley CE, Trayer HR. Serum IgD concentrations in sarcoidosis and tuberculosis. Clin Exp Immunol 1972 10:257 265.
173. Kikindjanin V. IgD values in children suffering from acute, recurrent and chronic respiratory diseases. Allerg Immunol (Leipz) 1981 27:203 206.
174. Rostenberg I, Penaloza R. Serum IgG and IgD and levels in some infectious and noninfectious diseases. Clin Chim Acta 1978 85:319 321.
175. Colwell EJ, Bernier GM, Fife EH Jr. Serum immunoglobulin D and malaria antibodies in South Vietnamese residents. Trans R Soc Trop Med Hyg 1971 65:310 314.
176. Forsgren A, Grubb AO. Many bacterial species bind human IgD. J Immunol 1979 122:1468 1472.
177. Buckley RH, Fiscus SA. Serum IgD and IgE concentrations in immunodeficiency diseases. J Clin Invest 1975 55:157 165.
178. Roman S. Two different techniques for serum IgD determination, comparative study: some pathological circumstances capable of increasing IgD levels. Rev Roum Biochim 1982 19:141 149.
179. Epstein J, Xiao HQ, He XY. Markers of multiple hematopoietic-cell lineages in multiple myeloma. N Engl J Med 1990 322:664 668. (Pubitemid 20089533)
180. Kubagawa H, Vogler LB, Capra JD, Conrad ME, Lawton AR, Cooper MD. Studies on the clonal origin of multiple myeloma. Use of individually specific (idiotype) antibodies to trace the oncogenic event to its earliest point of expression in B-cell differentiation. J Exp Med 1979 150:792 807.
181. Stevenson FK, Sahota SS. B cell maturation in relation to multiple myeloma. Pathol Biol (Paris) 1999 47:89 97.
182. Jensen GS, Mant MJ, Belch AJ, Berenson JR, Ruether BA, Pilarski LM. Selective expression of CD45 isoforms defines CALLA+ monoclonal B-lineage cells in peripheral blood from myeloma patients as late stage B cells. Blood 1991 78:711 719.
183. Sahota SS, Leo R, Hamblin TJ, Stevenson FK. Ig VH gene mutational patterns indicate different tumor cell status in human myeloma and monoclonal gammopathy of undetermined significance. Blood 1996 87:746 755.
184. MacLennan ICM, Chan EYT. The origin of bone marrow plasma cells. In:Obrams GI, Potter M eds. Epidemiology and Biology of Multiple Myeloma. Berlin:Springer-Verlag, 1991:129 135.
185. Valenzuela R, Govindarajan S, Tubbs R, Deodhar S, Bukowski R. IgD myeloma. Report of a case with unusual clinical and immunologic features. Am J Clin Pathol 1979 72:246 250.
186. Moore KW, et al. Expression of IgD may use both DNA rearrangement and RNA splicing mechanisms. Proc Natl Acad Sci USA 1981 78:1800 1804.
187. Golomb HM, Davis S, Wilson C, Vardiman J. Surface immunoglobulins on hairy cells of 55 patients with hairy cell leukemia. Am J Hematol 1982 12:397 401.
188. Fu SM, Winchester RJ, Rai KR, Kunkel HG. Hairy cell leukemia: proliferation of a cell with phagocytic and B-lymphocyte properties. Scand J Immunol 1974 3:847 851.
189. Rubin AD, Douglas SD, Chessin LN, Glade PR, Dameshek W. Chronic reticulolymphocytic leukemia. Reclassification of "leukemic reticuloendotheliosis" through functional characterization of the circulating mononuclear cells. Am J Med 1969 47:149 162.
190. Najam FI, Giasuddin AS, Shembesh AH. Immunoglobulin isotypes in childhood asthma. Indian J Pediatr 1999 66:337 344.
191. Zhang M, Niehus J, Brunnee T, Kleine-Tebbe J, O'Connor A, Kunkel G. Measurement of allergen-specific IgD and correlation with allergen-specific IgE. Scand J Immunol 1994 40:502 508.
192. Kohler PF, Farr RS. Quantitative comparison of immunoglobulins in atopic (reaginic) and nonatopic (nonreaginic) individuals: higher gamma-D levels in atopic sera. J Allergy 1967 39:311 322.
193. Luster MI, Leslie GA, Bardana EJ Jr. Structure and biological functions of human IgD. VI. Serum IgD in patients with allergic bronchopulmonary aspergillosis. Int Arch Allergy Appl Immunol 1976 50:212 219.
194. Salpietro DC, Masaracchio A, Turiaco A, Di Bella MR, Toscano V, Merlino MV. Serum IgD levels in children with atopic asthma. A longitudinal study. Minerva Pediatr 2001 53:1 5.
195. Spector SL. The role of allergy in sinusitis in adults. J Allergy Clin Immunol 1992 90:518 520.
196. Gleich GJ, Stankievic RR. Measurement of penicilloyl antibodies by radioimmunoprecipitation. Immunochemistry 1969 6:85 99.
197. Bringel H, Vela C, Urena V, Gurbindo D, Garcia R, Lahoz C. IgD antibodies: in vitro blocking activity of IgE mediated reactions. Clin Allergy 1982 12:37 46.
198. Schmidt K, Mueller-Eckhard C. Antinuclear autoantibodies of IgD class: an analysis of 82 patients. Z Immun Exp Klin Immunol 1973 145:385 391.
199. Lertora JJ, Gomez-Perez FJ, Leslie GA. Structure and biological functions of human IgD. V. Insulin antibodies of the IgD class in sera from some diabetic patients. Int Arch Allergy Appl Immunol 1975 49:597 606.
200. Leslie GA, Martin LN. Structure and function of serum and membrane immunoglobulin D (IgD). Contemp Top Mol Immunol 1978 7:1 49.
201. Onodera S, Shibata A, Miura AB, Suzuki A, Sakamoto S. Quantitative determination of serum immunoglobulin D in gammopathy. Tohoku J Exp Med 1968 95:145 151.
202. Gleich GJ, Bieger RC, Stankievic R. Antigen combining activity associated with immunoglobulin D. Science 1969 165:606.
203. Ritchie RF. Two new antinuclear antibodies: their relationship to the homogeneous immunofluorescent pattern. Arthritis Rheum 1968 11:37 43.
204. Hassfeld W, et al. Demonstration of a new antinuclear antibody (anti-RA33) that is highly specific for rheumatoid arthritis. Arthritis Rheum 1989 32:1515 1520.
205. Sehgal S, Sharma BK. Antinuclear antibody activity of IgD immunoglobulins. Indian J Med Res 1986 83:610 613.
206. Wiik A, Permin H. The prevalence and possible significance of IgD granulocyte-specific antinuclear antibodies in neutropenic and non-neutropenic cases of rheumatoid arthritis. Acta Pathol Microbiol Scand C 1978 86:19 22.
207. Kantor GL, Van Herle AJ, Barnett EV. Auto-antibodies of the IgD class. Clin Exp Immunol 1970 6:951 962.
208. Pope RM, Keightley R, McDuffy S. Circulating autoantibodies to IgD in rheumatic diseases. J Immunol 1982 128:1860 1863.
209. Menoret A, Chandawarkar RY, Srivastava PK. Natural autoantibodies against heat-shock proteins hsp70 and gp96: implications for immunotherapy using heat-shock proteins. Immunology 2000 101:364 370.
210. Simon A, van der Meer JW. Pathogenesis of familial periodic fever syndromes or hereditary autoinflammatory syndromes. Am J Physiol Regul Integr Comp Physiol 2007 292:R86 R98.
211. Drenth JP, Haagsma CJ, van der Meer JW. Hyperimmunoglobulinemia D and periodic fever syndrome. The clinical spectrum in a series of 50 patients. International Hyper-IgD Study Group. Medicine (Baltimore) 1994 73:133 144.
212. Drenth JP, Boom BW, Toonstra J, Van der Meer JW. Cutaneous manifestations and histologic findings in the hyperimmunoglobulinemia D syndrome. International Hyper IgD Study Group. Arch Dermatol 1994 130:59 65.
213. Drenth JP, van der Meer JW. Hereditary periodic fever. N Engl J Med 2001 345:1748 1757.
214. Simon A, et al. Mevalonate kinase deficiency: evidence for a phenotypic continuum. Neurology 2004 62:994 997.
215. Drenth JP, et al. Mutations in the gene encoding mevalonate kinase cause hyper-IgD and periodic fever syndrome. International Hyper-IgD Study Group. Nat Genet 1999 22:178 181.
216. Biardi L, et al. Mevalonate kinase is predominantly localized in peroxisomes and is defective in patients with peroxisome deficiency disorders. J Biol Chem 1994 269:1197 1205.
217. Houten SM, Frenkel J, Waterham HR. Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation. Cell Mol Life Sci 2003 60:1118 1134.
218. Bodar EJ, Drenth JP, van der Meer JW, Simon A. Dysregulation of innate immunity: hereditary periodic fever syndromes. Br J Haematol 2009 144:279 302.
219. Rigante D, et al. First report of macrophage activation syndrome in hyperimmunoglobulinemia D with periodic fever syndrome. Arthritis Rheum 2007 56:658 661.
220. Hager EJ, et al. Deletion of a single mevalonate kinase (Mvk) allele yields a murine model of hyper-IgD syndrome. J Inherit Metab Dis 2007 30:888 895.