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Volumn 205, Issue 11, 2008, Pages 2585-2594

Regulation of class switch recombination and somatic mutation by AID phosphorylation

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; ALANINE; SERINE; THREONINE; AICDA (ACTIVATION INDUCED CYTIDINE DEAMINASE); AICDA (ACTIVATION-INDUCED CYTIDINE DEAMINASE); CYTIDINE DEAMINASE; UNCLASSIFIED DRUG;

EID: 57749191326     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20081319     Document Type: Article
Times cited : (110)

References (53)
  • 2
    • 33646181086 scopus 로고    scopus 로고
    • Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus
    • Jung, D., C. Giallourakis, R. Mostoslavsky, and F.W. Alt. 2006. Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu. Rev. Immunol. 24:541-570.
    • (2006) Annu. Rev. Immunol , vol.24 , pp. 541-570
    • Jung, D.1    Giallourakis, C.2    Mostoslavsky, R.3    Alt, F.W.4
  • 3
  • 4
    • 0030006070 scopus 로고    scopus 로고
    • Clonal selection and learning in the antibody system
    • Rajewsky, K. 1996. Clonal selection and learning in the antibody system. Nature. 381:751-758.
    • (1996) Nature , vol.381 , pp. 751-758
    • Rajewsky, K.1
  • 5
    • 0008476550 scopus 로고
    • Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin
    • McKean, D., K. Huppi, M. Bell, L. Staudt, W. Gerhard, and M. Weigert. 1984. Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. Proc. Natl. Acad. Sci. USA. 81:3180-3184.
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 3180-3184
    • McKean, D.1    Huppi, K.2    Bell, M.3    Staudt, L.4    Gerhard, W.5    Weigert, M.6
  • 6
    • 12744259733 scopus 로고    scopus 로고
    • Activation- induced deaminase: Controversies and open questions
    • Barreto, V.M., A.R. Ramiro, and M.C. Nussenzweig. 2005. Activation- induced deaminase: controversies and open questions. Trends Immunol. 26:90-96.
    • (2005) Trends Immunol , vol.26 , pp. 90-96
    • Barreto, V.M.1    Ramiro, A.R.2    Nussenzweig, M.C.3
  • 8
    • 34249790004 scopus 로고    scopus 로고
    • Molecular mechanisms of antibody somatic hypermutation
    • Di Noia, J.M., and M. Neuberger. 2007. Molecular mechanisms of antibody somatic hypermutation. Annu. Rev. Biochem. 76:1-22.
    • (2007) Annu. Rev. Biochem , vol.76 , pp. 1-22
    • Di Noia, J.M.1    Neuberger, M.2
  • 9
    • 22144443194 scopus 로고    scopus 로고
    • AID to overcome the limitations of genomic information
    • Honjo, T., H. Nagaoka, R. Shinkura, and M. Muramatsu. 2005. AID to overcome the limitations of genomic information. Nat. Immunol. 6:655-661.
    • (2005) Nat. Immunol , vol.6 , pp. 655-661
    • Honjo, T.1    Nagaoka, H.2    Shinkura, R.3    Muramatsu, M.4
  • 11
    • 29444458721 scopus 로고    scopus 로고
    • Mismatch repair converts AID- instigated nicks to double-strand breaks for antibody class-switch re combination
    • Stavnezer, J., and C.E. Schrader. 2006. Mismatch repair converts AID- instigated nicks to double-strand breaks for antibody class-switch re combination. Trends Genet. 22:23-28.
    • (2006) Trends Genet , vol.22 , pp. 23-28
    • Stavnezer, J.1    Schrader, C.E.2
  • 12
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu, M., K. Kinoshita, S. Fagarasan, S. Yamada, Y. Shinkai, and T. Honjo. 2000. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell. 102:553-563.
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5    Honjo, T.6
  • 13
    • 0033603340 scopus 로고    scopus 로고
    • Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA- editing deaminase family in germinal center B cells
    • Muramatsu, M., V.S. Sankaranand, S. Anant, M. Sugai, K. Kinoshita, N.O. Davidson, and T. Honjo. 1999. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA- editing deaminase family in germinal center B cells. J. Biol. Chem. 274:18470-18476.
    • (1999) J. Biol. Chem , vol.274 , pp. 18470-18476
    • Muramatsu, M.1    Sankaranand, V.S.2    Anant, S.3    Sugai, M.4    Kinoshita, K.5    Davidson, N.O.6    Honjo, T.7
  • 15
    • 0037019315 scopus 로고    scopus 로고
    • AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
    • Petersen-Mahrt, S.K., R.S. Harris, and M.S. Neuberger. 2002. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature. 418:99-103.
    • (2002) Nature , vol.418 , pp. 99-103
    • Petersen-Mahrt, S.K.1    Harris, R.S.2    Neuberger, M.S.3
  • 16
    • 0037452080 scopus 로고    scopus 로고
    • Transcription-targeted DNA deamination by the AID antibody diversification enzyme
    • Chaudhuri, J., M. Tian, C. Khuong, K. Chua, E. Pinaud, and F.W. Alt. 2003. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature. 422:726-730.
    • (2003) Nature , vol.422 , pp. 726-730
    • Chaudhuri, J.1    Tian, M.2    Khuong, C.3    Chua, K.4    Pinaud, E.5    Alt, F.W.6
  • 17
    • 0037561998 scopus 로고    scopus 로고
    • AID mediates hypermutation by deaminating single-stranded DNA
    • Dickerson, S.K., E. Market, E. Besmer, and F.N. Papavasiliou. 2003. AID mediates hypermutation by deaminating single-stranded DNA. J. Exp. Med. 197:1291-1296.
    • (2003) J. Exp. Med , vol.197 , pp. 1291-1296
    • Dickerson, S.K.1    Market, E.2    Besmer, E.3    Papavasiliou, F.N.4
  • 18
    • 0037926476 scopus 로고    scopus 로고
    • Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
    • Pham, P., R. Bransteitter, J. Petruska, and M.F. Goodman. 2003. Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation. Nature. 424:103-107.
    • (2003) Nature , vol.424 , pp. 103-107
    • Pham, P.1    Bransteitter, R.2    Petruska, J.3    Goodman, M.F.4
  • 19
    • 0038293484 scopus 로고    scopus 로고
    • Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand
    • Ramiro, A.R., P. Stavropoulos, M. Jankovic, and M.C. Nussenzweig. 2003. Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat. Immunol. 4:452-456.
    • (2003) Nat. Immunol , vol.4 , pp. 452-456
    • Ramiro, A.R.1    Stavropoulos, P.2    Jankovic, M.3    Nussenzweig, M.C.4
  • 23
    • 2642623612 scopus 로고    scopus 로고
    • Mutation of BCL-6 gene in normal B cells by the process of somatic hypermuta- tion of Ig genes
    • Shen, H.M., A. Peters, B. Baron, X. Zhu, and U. Storb. 1998. Mutation of BCL-6 gene in normal B cells by the process of somatic hypermuta- tion of Ig genes. Science. 280:1750-1752.
    • (1998) Science , vol.280 , pp. 1750-1752
    • Shen, H.M.1    Peters, A.2    Baron, B.3    Zhu, X.4    Storb, U.5
  • 28
    • 0038515309 scopus 로고    scopus 로고
    • E-proteins directly regulate expression of activation-induced deaminase in mature B cells
    • Sayegh, C.E., M.W. Quong, Y. Agata, and C. Murre. 2003. E-proteins directly regulate expression of activation-induced deaminase in mature B cells. Nat. Immunol. 4:586-593.
    • (2003) Nat. Immunol , vol.4 , pp. 586-593
    • Sayegh, C.E.1    Quong, M.W.2    Agata, Y.3    Murre, C.4
  • 31
    • 51049110262 scopus 로고    scopus 로고
    • AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development
    • Takizawa, M., H. Tolarova, Z. Li, W. Dubois, S. Lim, E. Callen, S. Franco, M. Mosaico, L. Feigenbaum, F.W. Alt, et al. 2008. AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development. J. Exp. Med. 205:1949-1957.
    • (2008) J. Exp. Med , vol.205 , pp. 1949-1957
    • Takizawa, M.1    Tolarova, H.2    Li, Z.3    Dubois, W.4    Lim, S.5    Callen, E.6    Franco, S.7    Mosaico, M.8    Feigenbaum, L.9    Alt, F.W.10
  • 33
    • 2442474264 scopus 로고    scopus 로고
    • Somatic hypermutation is limited by CRM1- dependent nuclear export of activation-induced deaminase
    • McBride, K.M., V. Barreto, A.R. Ramiro, P. Stavropoulos, and M.C. Nussenzweig. 2004. Somatic hypermutation is limited by CRM1- dependent nuclear export of activation-induced deaminase. J. Exp. Med. 199:1235-1244.
    • (2004) J. Exp. Med , vol.199 , pp. 1235-1244
    • McBride, K.M.1    Barreto, V.2    Ramiro, A.R.3    Stavropoulos, P.4    Nussenzweig, M.C.5
  • 34
    • 1242341972 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1
    • Ito, S., H. Nagaoka, R. Shinkura, N. Begum, M. Muramatsu, M. Nakata, and T. Honjo. 2004. Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1. Proc. Natl. Acad. Sci. USA. 101:1975-1980.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 1975-1980
    • Ito, S.1    Nagaoka, H.2    Shinkura, R.3    Begum, N.4    Muramatsu, M.5    Nakata, M.6    Honjo, T.7
  • 35
    • 2942722486 scopus 로고    scopus 로고
    • Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks
    • Brar, S.S., M. Watson, and M. Diaz. 2004. Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks. J. Biol. Chem. 279:26395-26401.
    • (2004) J. Biol. Chem , vol.279 , pp. 26395-26401
    • Brar, S.S.1    Watson, M.2    Diaz, M.3
  • 38
    • 31044435055 scopus 로고    scopus 로고
    • PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells
    • Pasqualucci, L., Y. Kitaura, H. Gu, and R. Dalla-Favera. 2006. PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells. Proc. Natl. Acad. Sci. USA. 103:395-400.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 395-400
    • Pasqualucci, L.1    Kitaura, Y.2    Gu, H.3    Dalla-Favera, R.4
  • 39
    • 47749085064 scopus 로고    scopus 로고
    • Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase
    • Pham, P., M.B. Smolka, P. Calabrese, A. Landolph, K. Zhang, H. Zhou, and M.F. Goodman. 2008. Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase. J. Biol. Chem. 283: 17428-17439.
    • (2008) J. Biol. Chem , vol.283 , pp. 17428-17439
    • Pham, P.1    Smolka, M.B.2    Calabrese, P.3    Landolph, A.4    Zhang, K.5    Zhou, H.6    Goodman, M.F.7
  • 41
    • 38449084983 scopus 로고    scopus 로고
    • Role of activation-induced deaminase protein kinase A phosphoryl- ation sites in Ig gene conversion and somatic hypermutation
    • Chatterji, M., S. Unniraman, K.M. McBride, and D.G. Schatz. 2007. Role of activation-induced deaminase protein kinase A phosphoryl- ation sites in Ig gene conversion and somatic hypermutation. J. Immunol. 179:5274-5280.
    • (2007) J. Immunol , vol.179 , pp. 5274-5280
    • Chatterji, M.1    Unniraman, S.2    McBride, K.M.3    Schatz, D.G.4
  • 45
    • 0141992113 scopus 로고    scopus 로고
    • C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion
    • Barreto, V., B. Reina-San-Martin, A.R. Ramiro, K.M. McBride, and M.C. Nussenzweig. 2003. C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion. Mol. Cell. 12:501-508.
    • (2003) Mol. Cell , vol.12 , pp. 501-508
    • Barreto, V.1    Reina-San-Martin, B.2    Ramiro, A.R.3    McBride, K.M.4    Nussenzweig, M.C.5
  • 46
    • 0030845386 scopus 로고    scopus 로고
    • Rapid methods for the analysis of immunoglobulin gene hypermutation: Application to trans- genic and gene targeted mice
    • Jolly, C.J., N. Klix, and M.S. Neuberger. 1997. Rapid methods for the analysis of immunoglobulin gene hypermutation: application to trans- genic and gene targeted mice. Nucleic Acids Res. 25:1913-1919.
    • (1997) Nucleic Acids Res , vol.25 , pp. 1913-1919
    • Jolly, C.J.1    Klix, N.2    Neuberger, M.S.3
  • 47
    • 34547115451 scopus 로고    scopus 로고
    • Antigen receptor diversification and chromosome translocations
    • Jankovic, M., A. Nussenzweig, and M.C. Nussenzweig. 2007. Antigen receptor diversification and chromosome translocations. Nat. Immunol. 8:801-808.
    • (2007) Nat. Immunol , vol.8 , pp. 801-808
    • Jankovic, M.1    Nussenzweig, A.2    Nussenzweig, M.C.3
  • 48
    • 4344700569 scopus 로고    scopus 로고
    • Replication protein A interacts with AID to promote deamination of somatic hypermutation targets
    • Chaudhuri, J., C. Khuong, and F.W. Alt. 2004. Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature. 430:992-998.
    • (2004) Nature , vol.430 , pp. 992-998
    • Chaudhuri, J.1    Khuong, C.2    Alt, F.W.3
  • 49
    • 37549036739 scopus 로고    scopus 로고
    • Mechanism of R-loop formation at immunoglobulin class switch sequences
    • Roy, D., K. Yu, and M.R. Lieber. 2008. Mechanism of R-loop formation at immunoglobulin class switch sequences. Mol. Cell. Biol. 28:50-60.
    • (2008) Mol. Cell. Biol , vol.28 , pp. 50-60
    • Roy, D.1    Yu, K.2    Lieber, M.R.3
  • 50
    • 0038664358 scopus 로고    scopus 로고
    • The influence of transcriptional orientation on endogenous switch region function
    • Shinkura, R., M. Tian, M. Smith, K. Chua, Y. Fujiwara, and F.W. Alt. 2003. The influence of transcriptional orientation on endogenous switch region function. Nat. Immunol. 4:435-441.
    • (2003) Nat. Immunol , vol.4 , pp. 435-441
    • Shinkura, R.1    Tian, M.2    Smith, M.3    Chua, K.4    Fujiwara, Y.5    Alt, F.W.6
  • 51
    • 2342493308 scopus 로고    scopus 로고
    • Protein kinase C family functions in B-cell activation
    • Guo, B., T.T. Su, and D.J. Rawlings. 2004. Protein kinase C family functions in B-cell activation. Curr. Opin. Immunol. 16:367-373.
    • (2004) Curr. Opin. Immunol , vol.16 , pp. 367-373
    • Guo, B.1    Su, T.T.2    Rawlings, D.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.