-
1
-
-
0036212917
-
Molecular mechanism of class switch recombination: Linkage with somatic hypermutation
-
Honjo T, Kinoshita K, Muramatsu M (2002) Molecular mechanism of class switch recombination: Linkage with somatic hypermutation. Annu Rev Immunol 20: 165-196.
-
(2002)
Annu Rev Immunol
, vol.20
, pp. 165-196
-
-
Honjo, T.1
Kinoshita, K.2
Muramatsu, M.3
-
2
-
-
34249794280
-
Evolution of the immunoglobulin heavy chain class switch recombination mechanism
-
Chaudhuri J, et al. (2007) Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Adv Immunol 94:157-214.
-
(2007)
Adv Immunol
, vol.94
, pp. 157-214
-
-
Chaudhuri, J.1
-
3
-
-
0034268780
-
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
-
Muramatsu M, et al. (2000) Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102:553-563.
-
(2000)
Cell
, vol.102
, pp. 553-563
-
-
Muramatsu, M.1
-
4
-
-
0035818990
-
AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching
-
Petersen S, et al. (2001) AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching. Nature 414:660-665.
-
(2001)
Nature
, vol.414
, pp. 660-665
-
-
Petersen, S.1
-
5
-
-
0042931069
-
The block in immunoglobulin class switch recombination caused by activation-induced cytidine deaminase deficiency occurs prior to the generation of DNA double strand breaks in switch mu region
-
Catalan N, et al. (2003) The block in immunoglobulin class switch recombination caused by activation-induced cytidine deaminase deficiency occurs prior to the generation of DNA double strand breaks in switch mu region. J Immunol 171: 2504-2509.
-
(2003)
J Immunol
, vol.171
, pp. 2504-2509
-
-
Catalan, N.1
-
6
-
-
0242473148
-
Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination
-
Schrader CE, et al. (2003) Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination. EMBO J 22:5893-5903.
-
(2003)
EMBO J
, vol.22
, pp. 5893-5903
-
-
Schrader, C.E.1
-
7
-
-
2942613670
-
AID: How does it aid antibody diversity?
-
Honjo T, Muramatsu M, Fagarasan S (2004) AID: How does it aid antibody diversity? Immunity 20:659-668.
-
(2004)
Immunity
, vol.20
, pp. 659-668
-
-
Honjo, T.1
Muramatsu, M.2
Fagarasan, S.3
-
8
-
-
0020038653
-
Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line
-
Alt FW, Rosenberg N, Casanova RJ, Thomas E, Baltimore D (1982) Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line. Nature 296:325-331.
-
(1982)
Nature
, vol.296
, pp. 325-331
-
-
Alt, F.W.1
Rosenberg, N.2
Casanova, R.J.3
Thomas, E.4
Baltimore, D.5
-
9
-
-
0025345212
-
Circular DNA is excised by immunoglobulin class switch recombination
-
Iwasato T, Shimizu A, Honjo T, Yamagishi H (1990) Circular DNA is excised by immunoglobulin class switch recombination. Cell 62:143-149.
-
(1990)
Cell
, vol.62
, pp. 143-149
-
-
Iwasato, T.1
Shimizu, A.2
Honjo, T.3
Yamagishi, H.4
-
10
-
-
0027280936
-
Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting
-
Gu H, Zou YR, Rajewsky K (1993) Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell 73:1155-1164.
-
(1993)
Cell
, vol.73
, pp. 1155-1164
-
-
Gu, H.1
Zou, Y.R.2
Rajewsky, K.3
-
11
-
-
0037162518
-
Internal IgH class switch region deletions are position-independent and enhanced by AID expression
-
Dudley DD, et al. (2002) Internal IgH class switch region deletions are position-independent and enhanced by AID expression. Proc Natl Acad Sci USA 99:9984-9989.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 9984-9989
-
-
Dudley, D.D.1
-
12
-
-
0037866984
-
H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation
-
Reina-San-Martin B, et al. (2003) H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation. J Exp Med 197:1767-1778.
-
(2003)
J Exp Med
, vol.197
, pp. 1767-1778
-
-
Reina-San-Martin, B.1
-
13
-
-
8644238314
-
ATM is required for efficient recombination between immunoglobulin switch regions
-
Reina-San-Martin B, Chen HT, Nussenzweig A, Nussenzweig MC (2004) ATM is required for efficient recombination between immunoglobulin switch regions. J Exp Med 200:1103-1110.
-
(2004)
J Exp Med
, vol.200
, pp. 1103-1110
-
-
Reina-San-Martin, B.1
Chen, H.T.2
Nussenzweig, A.3
Nussenzweig, M.C.4
-
14
-
-
34748863465
-
IgH class switching and translocations use a robust non-classical end-joining pathway
-
Yan CT, et al. (2007) IgH class switching and translocations use a robust non-classical end-joining pathway. Nature 449:478-482.
-
(2007)
Nature
, vol.449
, pp. 478-482
-
-
Yan, C.T.1
-
15
-
-
38049144085
-
Flexibility in the order of action and in the enzymology of the nuclease, polymerases, and ligase of vertebrate non-homologous DNA end joining: Relevance to cancer, aging, and the immune system
-
Lieber MR, Lu H, Gu J, Schwarz K (2008) Flexibility in the order of action and in the enzymology of the nuclease, polymerases, and ligase of vertebrate non-homologous DNA end joining: Relevance to cancer, aging, and the immune system. Cell Res 18: 125-133.
-
(2008)
Cell Res
, vol.18
, pp. 125-133
-
-
Lieber, M.R.1
Lu, H.2
Gu, J.3
Schwarz, K.4
-
16
-
-
3242887420
-
The role of the non-homologous end-joining pathway in lymphocyte development
-
Rooney S, Chaudhuri J, Alt FW (2004) The role of the non-homologous end-joining pathway in lymphocyte development. Immunol Rev 200:115-131.
-
(2004)
Immunol Rev
, vol.200
, pp. 115-131
-
-
Rooney, S.1
Chaudhuri, J.2
Alt, F.W.3
-
17
-
-
41149099048
-
DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination
-
Franco S, et al. (2008) DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination. J Exp Med 205:557-564.
-
(2008)
J Exp Med
, vol.205
, pp. 557-564
-
-
Franco, S.1
-
18
-
-
65549111779
-
Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes
-
Callén E, et al. (2009) Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Mol Cell 34:285-297.
-
(2009)
Mol Cell
, vol.34
, pp. 285-297
-
-
Callén, E.1
-
19
-
-
77649263330
-
Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4
-
in press
-
Boboila C, et al. (2009) Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. J Exp Med, in press.
-
(2009)
J Exp Med
-
-
Boboila, C.1
-
20
-
-
0029791694
-
Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways
-
Boulton SJ, Jackson SP (1996) Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways. EMBO J 15:5093-5103.
-
(1996)
EMBO J
, vol.15
, pp. 5093-5103
-
-
Boulton, S.J.1
Jackson, S.P.2
-
21
-
-
0032404178
-
Double-strand break repair in Ku86- and XRCC4-deficient cells
-
Kabotyanski EB, Gomelsky L, Han JO, Stamato TD, Roth DB (1998) Double-strand break repair in Ku86- and XRCC4-deficient cells. Nucleic Acids Res 26:5333-5342.
-
(1998)
Nucleic Acids Res
, vol.26
, pp. 5333-5342
-
-
Kabotyanski, E.B.1
Gomelsky, L.2
Han, J.O.3
Stamato, T.D.4
Roth, D.B.5
-
22
-
-
0344012187
-
Biochemical evidence for Ku-independent backup pathways of NHEJ
-
Wang H, et al. (2003) Biochemical evidence for Ku-independent backup pathways of NHEJ. Nucleic Acids Res 31:5377-5388.
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 5377-5388
-
-
Wang, H.1
-
23
-
-
2942525595
-
Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells
-
Guirouilh-Barbat J, et al. (2004) Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells. Mol Cell 14:611-623.
-
(2004)
Mol Cell
, vol.14
, pp. 611-623
-
-
Guirouilh-Barbat, J.1
-
24
-
-
38049187905
-
Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends
-
Guirouilh-Barbat J, Rass E, Plo I, Bertrand P, Lopez BS (2007) Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends. Proc Natl Acad Sci USA 104:20902-20907.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 20902-20907
-
-
Guirouilh-Barbat, J.1
Rass, E.2
Plo, I.3
Bertrand, P.4
Lopez, B.S.5
-
25
-
-
33644643189
-
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations
-
Ramiro AR, et al. (2006) Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature 440:105-109.
-
(2006)
Nature
, vol.440
, pp. 105-109
-
-
Ramiro, A.R.1
-
26
-
-
0030022218
-
Antibody class switching
-
Stavnezer J (1996) Antibody class switching. Adv Immunol 61:79-146.
-
(1996)
Adv Immunol
, vol.61
, pp. 79-146
-
-
Stavnezer, J.1
-
27
-
-
3142765336
-
Class-switch recombination: Interplay of transcription, DNA deamination and DNA repair
-
Chaudhuri J, Alt FW (2004) Class-switch recombination: Interplay of transcription, DNA deamination and DNA repair. Nat Rev Immunol 4:541-552.
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 541-552
-
-
Chaudhuri, J.1
Alt, F.W.2
-
28
-
-
67650457059
-
Mechanisms promoting translocations in editing and switching peripheral B cells
-
Wang JH, et al. (2009) Mechanisms promoting translocations in editing and switching peripheral B cells. Nature 460:231-236.
-
(2009)
Nature
, vol.460
, pp. 231-236
-
-
Wang, J.H.1
-
29
-
-
0037188898
-
Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations
-
Zhu C, et al. (2002) Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell 109:811-821.
-
(2002)
Cell
, vol.109
, pp. 811-821
-
-
Zhu, C.1
-
30
-
-
0345671747
-
Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG1-secreting B-cell blasts
-
Radbruch A, Müller W, Rajewsky K (1986) Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG1-secreting B-cell blasts. Proc Natl Acad Sci USA 83:3954-3957.
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 3954-3957
-
-
Radbruch, A.1
Müller, W.2
Rajewsky, K.3
-
31
-
-
0031841548
-
Deletion of the IgH intronic enhancer and associated matrix-attachment regions decreases, but does not abolish, class switching at the mu locus
-
Bottaro A, et al. (1998) Deletion of the IgH intronic enhancer and associated matrix-attachment regions decreases, but does not abolish, class switching at the mu locus. Int Immunol 10:799-806.
-
(1998)
Int Immunol
, vol.10
, pp. 799-806
-
-
Bottaro, A.1
-
32
-
-
33846340098
-
Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1-/- B cells
-
Reina-San-Martin B, Chen J, Nussenzweig A, Nussenzweig MC (2007) Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1-/- B cells. Eur J Immunol 37:235-239.
-
(2007)
Eur J Immunol
, vol.37
, pp. 235-239
-
-
Reina-San-Martin, B.1
Chen, J.2
Nussenzweig, A.3
Nussenzweig, M.C.4
-
33
-
-
0023020765
-
Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching
-
Yancopoulos GD, et al. (1986) Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching. EMBO J 5:3259-3266.
-
(1986)
EMBO J
, vol.5
, pp. 3259-3266
-
-
Yancopoulos, G.D.1
-
34
-
-
15244361942
-
Chromosomal translocation mechanisms at intronic Alu elements in mammalian cells
-
Elliott B, Richardson C, Jasin M (2005) Chromosomal translocation mechanisms at intronic Alu elements in mammalian cells. Mol Cell 17:885-894.
-
(2005)
Mol Cell
, vol.17
, pp. 885-894
-
-
Elliott, B.1
Richardson, C.2
Jasin, M.3
-
36
-
-
30744445418
-
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations
-
Franco S, et al. (2006) H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell 21:201-214.
-
(2006)
Mol Cell
, vol.21
, pp. 201-214
-
-
Franco, S.1
-
37
-
-
4644257592
-
AID is required for c-myc/IgH chromosome translocations in vivo
-
Ramiro AR, et al. (2004) AID is required for c-myc/IgH chromosome translocations in vivo. Cell 118:431-438.
-
(2004)
Cell
, vol.118
, pp. 431-438
-
-
Ramiro, A.R.1
-
38
-
-
13244268505
-
Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells
-
Pan-Hammarström Q, et al. (2005) Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells. J Exp Med 201: 189-194.
-
(2005)
J Exp Med
, vol.201
, pp. 189-194
-
-
Pan-Hammarström, Q.1
-
39
-
-
0034612308
-
The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations
-
Ferguson DO, et al. (2000) The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proc Natl Acad Sci USA 97:6630-6633.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 6630-6633
-
-
Ferguson, D.O.1
-
40
-
-
77649251872
-
Role of the translocation partner in protection against AID-dependent chromosomal translocations
-
Jankovic M, et al. (2009) Role of the translocation partner in protection against AID-dependent chromosomal translocations. Proc Natl Acad Sci 79:7837-7841.
-
(2009)
Proc Natl Acad Sci
, vol.79
, pp. 7837-7841
-
-
Jankovic, M.1
-
41
-
-
33846606769
-
Antibody class switching mediated by yeast endonuclease-generated DNA breaks
-
Zarrin AA, et al. (2007) Antibody class switching mediated by yeast endonuclease-generated DNA breaks. Science 315:377-381.
-
(2007)
Science
, vol.315
, pp. 377-381
-
-
Zarrin, A.A.1
-
42
-
-
59649086891
-
Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching
-
Wang JH, et al. (2008) Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching. J Exp Med 205: 3079-3090.
-
(2008)
J Exp Med
, vol.205
, pp. 3079-3090
-
-
Wang, J.H.1
-
43
-
-
5144225797
-
DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining
-
Bentley J, Diggle CP, Harnden P, Knowles MA, Kiltie AE (2004) DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining. Nucleic Acids Res 32:5249-5259.
-
(2004)
Nucleic Acids Res
, vol.32
, pp. 5249-5259
-
-
Bentley, J.1
Diggle, C.P.2
Harnden, P.3
Knowles, M.A.4
Kiltie, A.E.5
-
44
-
-
37849023839
-
Distinctive differences in DNA double-strand break repair between normal urothelial and urothelial carcinoma cells
-
Windhofer F, Krause S, Hader C, Schulz WA, Florl AR (2008) Distinctive differences in DNA double-strand break repair between normal urothelial and urothelial carcinoma cells. Mutat Res 638:56-65.
-
(2008)
Mutat Res
, vol.638
, pp. 56-65
-
-
Windhofer, F.1
Krause, S.2
Hader, C.3
Schulz, W.A.4
Florl, A.R.5
-
45
-
-
0030858967
-
Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination
-
Gu Y, Jin S, Gao Y, Weaver DT, Alt FW (1997) Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination. Proc Natl Acad Sci USA 94:8076-8081.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 8076-8081
-
-
Gu, Y.1
Jin, S.2
Gao, Y.3
Weaver, D.T.4
Alt, F.W.5
-
46
-
-
0032511976
-
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
-
Frank KM, et al. (1998) Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature 396:173-177.
-
(1998)
Nature
, vol.396
, pp. 173-177
-
-
Frank, K.M.1
-
47
-
-
0032522564
-
Ku80 is required for immunoglobulin isotype switching
-
Casellas R, et al. (1998) Ku80 is required for immunoglobulin isotype switching. EMBO J 17:2404-2411.
-
(1998)
EMBO J
, vol.17
, pp. 2404-2411
-
-
Casellas, R.1
|