-
1
-
-
0034006420
-
Endothelial nitric oxide synthase: Correlation with histologic grade, lymph node status and estrogen receptor expression in human breast cancer
-
J.H. Martin, S. Begum, O. Alalami, A. Harrison, and K.W. Scott Endothelial nitric oxide synthase: correlation with histologic grade, lymph node status and estrogen receptor expression in human breast cancer Tumour Biol. 21 2000 90 97
-
(2000)
Tumour Biol.
, vol.21
, pp. 90-97
-
-
Martin, J.H.1
Begum, S.2
Alalami, O.3
Harrison, A.4
Scott, K.W.5
-
2
-
-
0034293211
-
ENOS expression is associated with the estrogen and progesterone receptor status in invasive breast carcinoma
-
M. Vakkala, P. Paakko, and Y. Soini eNOS expression is associated with the estrogen and progesterone receptor status in invasive breast carcinoma Int. J. Oncol. 17 2000 667 671
-
(2000)
Int. J. Oncol.
, vol.17
, pp. 667-671
-
-
Vakkala, M.1
Paakko, P.2
Soini, Y.3
-
3
-
-
84892795827
-
Breast cancer statistics, 2013
-
C. DeSantis, J. Ma, L. Bryan, and A. Jemal Breast cancer statistics, 2013 CA Cancer J. Clin 64 2014 52 62
-
(2014)
CA Cancer J. Clin
, vol.64
, pp. 52-62
-
-
Desantis, C.1
Ma, J.2
Bryan, L.3
Jemal, A.4
-
4
-
-
84868019043
-
Cancer cell metabolism: One hallmark, many faces
-
J.R. Cantor, and D.M. Sabatini Cancer cell metabolism: one hallmark, many faces Cancer Discov 2 2012 881 898
-
(2012)
Cancer Discov
, vol.2
, pp. 881-898
-
-
Cantor, J.R.1
Sabatini, D.M.2
-
5
-
-
0034614637
-
The hallmarks of cancer
-
D. Hanahan, and R.A. Weinberg The hallmarks of cancer Cell 100 2000 57 70
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
6
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
7
-
-
10744221423
-
Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer
-
A. Isidoro, M. Martinez, P.L. Fernaíndez, A.D. Ortega, G. Santamaria, M. Chamorro, J.C. Reed, and J.M. Cuezva Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer Biochem. J. 378 2004 17 20
-
(2004)
Biochem. J.
, vol.378
, pp. 17-20
-
-
Isidoro, A.1
Martinez, M.2
Fernaíndez, P.L.3
Ortega, A.D.4
Santamaria, G.5
Chamorro, M.6
Reed, J.C.7
Cuezva, J.M.8
-
8
-
-
78649891511
-
Balancing biosynthesis and bioenergetics: Metabolic programs in oncogenesis
-
J.F. Barger, and D.R. Plas Balancing biosynthesis and bioenergetics: metabolic programs in oncogenesis Endocr. Relat. Cancer 17 2010 R287 R304
-
(2010)
Endocr. Relat. Cancer
, vol.17
, pp. R287-R304
-
-
Barger, J.F.1
Plas, D.R.2
-
9
-
-
84858604270
-
Metabolic reprogramming: A cancer hallmark even warburg did not anticipate
-
P.S. Ward, and C.B. Thompson Metabolic reprogramming: a cancer hallmark even warburg did not anticipate Cancer Cell 21 2012 297 308
-
(2012)
Cancer Cell
, vol.21
, pp. 297-308
-
-
Ward, P.S.1
Thompson, C.B.2
-
10
-
-
84855878565
-
P53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2
-
T. Contractor, and C.R. Harris p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2 Cancer Res. 72 2012 560 567
-
(2012)
Cancer Res.
, vol.72
, pp. 560-567
-
-
Contractor, T.1
Harris, C.R.2
-
11
-
-
84881056831
-
MYC, Metabolism, Cell Growth, and Tumorigenesis
-
C.V. Dang MYC, Metabolism, Cell Growth, and Tumorigenesis Cold Spring Harbor Perspect. Med 3 2013
-
(2013)
Cold Spring Harbor Perspect. Med
, vol.3
-
-
Dang, C.V.1
-
12
-
-
0034698178
-
Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc
-
R.C. Osthus, H. Shim, S. Kim, Q. Li, R. Reddy, M. Mukherjee, Y. Xu, D. Wonsey, L.A. Lee, and C.V. Dang Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc J. Biol. Chem. 275 2000 21797 21800
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 21797-21800
-
-
Osthus, R.C.1
Shim, H.2
Kim, S.3
Li, Q.4
Reddy, R.5
Mukherjee, M.6
Xu, Y.7
Wonsey, D.8
Lee, L.A.9
Dang, C.V.10
-
13
-
-
78649711427
-
The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
-
A.J. Levine, and A.M. Puzio-Kuter The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes Science 330 2010 1340 1344
-
(2010)
Science
, vol.330
, pp. 1340-1344
-
-
Levine, A.J.1
Puzio-Kuter, A.M.2
-
14
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
M.G. Vander Heiden, L.C. Cantley, and C.B. Thompson Understanding the Warburg effect: the metabolic requirements of cell proliferation Science 324 2009 1029 1033
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
16
-
-
79955398591
-
Otto Warburg's contributions to current concepts of cancer metabolism
-
W.H. Koppenol, P.L. Bounds, and C.V. Dang Otto Warburg's contributions to current concepts of cancer metabolism Nat. Rev. Cancer 11 2011 325 337
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 325-337
-
-
Koppenol, W.H.1
Bounds, P.L.2
Dang, C.V.3
-
19
-
-
0017153683
-
Aerobic glycolysis during lymphocyte proliferation
-
T. Wang, C. Marquardt, and J. Foker Aerobic glycolysis during lymphocyte proliferation Nature 261 1976 702 705
-
(1976)
Nature
, vol.261
, pp. 702-705
-
-
Wang, T.1
Marquardt, C.2
Foker, J.3
-
20
-
-
0014356282
-
Early effects of phytohaemagglutinin on glucose metabolism of normal human lymphocytes
-
C.J. Hedeskov Early effects of phytohaemagglutinin on glucose metabolism of normal human lymphocytes Biochem. J. 110 1968 373 380
-
(1968)
Biochem. J.
, vol.110
, pp. 373-380
-
-
Hedeskov, C.J.1
-
21
-
-
0021824122
-
Glutamine and glucose metabolism during thymocyte proliferation. Pathways of glutamine and glutamate metabolism
-
K. Brand Glutamine and glucose metabolism during thymocyte proliferation. Pathways of glutamine and glutamate metabolism Biochem. J. 228 1985 353 361
-
(1985)
Biochem. J.
, vol.228
, pp. 353-361
-
-
Brand, K.1
-
22
-
-
37449034854
-
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
-
R.J. DeBerardinis, A. Mancuso, E. Daikhin, I. Nissim, M. Yudkoff, S. Wehrli, and C.B. Thompson Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis Proc. Natl. Acad. Sci. USA 104 2007 19345 19350
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 19345-19350
-
-
Deberardinis, R.J.1
Mancuso, A.2
Daikhin, E.3
Nissim, I.4
Yudkoff, M.5
Wehrli, S.6
Thompson, C.B.7
-
24
-
-
84857716739
-
Multiple biological activities of lactic acid in cancer: Influences on tumor growth, angiogenesis and metastasis
-
S. Dhup, R.K. Dadhich, P.E. Porporato, and P. Sonveaux Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis Curr. Pharm. Des 18 2012 1319 1330
-
(2012)
Curr. Pharm. des
, vol.18
, pp. 1319-1330
-
-
Dhup, S.1
Dadhich, R.K.2
Porporato, P.E.3
Sonveaux, P.4
-
25
-
-
0036717382
-
Molecular imaging of cancer with positron emission tomography
-
S.S. Gambhir Molecular imaging of cancer with positron emission tomography Nat. Rev. Cancer 2 2002 683 693
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 683-693
-
-
Gambhir, S.S.1
-
26
-
-
12944262229
-
Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer
-
M.L. Macheda, S. Rogers, and J.D. Best Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer J. Cell. Physiol. 202 2005 654 662
-
(2005)
J. Cell. Physiol.
, vol.202
, pp. 654-662
-
-
Macheda, M.L.1
Rogers, S.2
Best, J.D.3
-
27
-
-
75149178349
-
Tumor metabolism of lactate: The influence and therapeutic potential for MCT and CD147 regulation
-
K.M. Kennedy, and M.W. Dewhirst Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation Future Oncol 6 2009 127 148
-
(2009)
Future Oncol
, vol.6
, pp. 127-148
-
-
Kennedy, K.M.1
Dewhirst, M.W.2
-
28
-
-
0036077547
-
Glucose transporters: Expression, regulation and cancer
-
R.A. Medina, and G.I. Owen Glucose transporters: expression, regulation and cancer Biol. Res. 35 2002 9 26
-
(2002)
Biol. Res.
, vol.35
, pp. 9-26
-
-
Medina, R.A.1
Owen, G.I.2
-
29
-
-
0026517325
-
Enzymes as prognostic markers and therapeutic indicators in patients with cancer
-
M.K. Schwartz Enzymes as prognostic markers and therapeutic indicators in patients with cancer Clin. Chim. Acta 206 1992 77 82
-
(1992)
Clin. Chim. Acta
, vol.206
, pp. 77-82
-
-
Schwartz, M.K.1
-
30
-
-
0031825144
-
Role for glucose transporter 1 protein in human breast cancer
-
M. Grover-McKay, S.A. Walsh, E.A. Seftor, P.A. Thomas, and M.J. Hendrix Role for glucose transporter 1 protein in human breast cancer Pathol. Oncol. Res. 4 1998 115 120
-
(1998)
Pathol. Oncol. Res.
, vol.4
, pp. 115-120
-
-
Grover-Mckay, M.1
Walsh, S.A.2
Seftor, E.A.3
Thomas, P.A.4
Hendrix, M.J.5
-
31
-
-
0038714272
-
Isozymes of mammalian hexokinase: Structure, subcellular localization and metabolic function
-
J.E. Wilson Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function J. Exp. Biol. 206 2003 2049 2057
-
(2003)
J. Exp. Biol.
, vol.206
, pp. 2049-2057
-
-
Wilson, J.E.1
-
32
-
-
33746924468
-
Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria
-
S.P. Mathupala, Y.H. Ko, P.L. Pedersen, and I.I. Hexokinase Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria Oncogene 25 2006 4777 4786
-
(2006)
Oncogene
, vol.25
, pp. 4777-4786
-
-
Mathupala, S.P.1
Ko, Y.H.2
Pedersen, P.L.3
Hexokinase, I.I.4
-
33
-
-
0022595453
-
Hexokinase receptor complex in hepatoma mitochondria: Evidence from N,N′-dicyclohexlycarbodiimide-labeling studies for the involvement of the pore-forming protein VDAC
-
R.A. Nakashima, P.S. Mangan, M. Colombini, and P.L. Pedersen Hexokinase receptor complex in hepatoma mitochondria: evidence from N,N′-dicyclohexlycarbodiimide-labeling studies for the involvement of the pore-forming protein VDAC Biochemistry 25 1986 1015 1021
-
(1986)
Biochemistry
, vol.25
, pp. 1015-1021
-
-
Nakashima, R.A.1
Mangan, P.S.2
Colombini, M.3
Pedersen, P.L.4
-
34
-
-
0042575733
-
High aerobic glycolysis of rat hepatoma cells in culture: Role of mitochondrial hexokinase
-
E. Bustamante, and P.L. Pedersen High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase Proc. Natl. Acad. Sci. USA 74 1977 3735 3739
-
(1977)
Proc. Natl. Acad. Sci. USA
, vol.74
, pp. 3735-3739
-
-
Bustamante, E.1
Pedersen, P.L.2
-
35
-
-
0024237766
-
Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP
-
K.K. Arora, and P.L. Pedersen Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP J. Biol. Chem. 263 1988 17422 17428
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 17422-17428
-
-
Arora, K.K.1
Pedersen, P.L.2
-
36
-
-
0020079964
-
Stability of hexokinase II in Vitro and in ascites tumor cells
-
I.A. Rose, and J.V.B. Warms Stability of hexokinase II in Vitro and in ascites tumor cells Arch. Biochem. Biophys. 213 1982 625 634
-
(1982)
Arch. Biochem. Biophys.
, vol.213
, pp. 625-634
-
-
Rose, I.A.1
Warms, J.V.B.2
-
37
-
-
0036510541
-
Mitochondrial binding of hexokinase II inhibits bax-induced cytochrome c release and apoptosis
-
J.G. Pastorino, N. Shulga, and J.B. Hoek Mitochondrial binding of hexokinase II inhibits bax-induced cytochrome c release and apoptosis J. Biol. Chem. 277 2002 7610 7618
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 7610-7618
-
-
Pastorino, J.G.1
Shulga, N.2
Hoek, J.B.3
-
38
-
-
0021873592
-
Alterations in the activity and isozymic profile of human phosphofructokinase during malignant transformation in vivo and in vitro: Transformation- and progression-linked discriminants of malignancy
-
S. Vora, J.P. Halper, and D.M. Knowles Alterations in the activity and isozymic profile of human phosphofructokinase during malignant transformation in vivo and in vitro: transformation- and progression-linked discriminants of malignancy Cancer Res. 45 1985 2993 3001
-
(1985)
Cancer Res.
, vol.45
, pp. 2993-3001
-
-
Vora, S.1
Halper, J.P.2
Knowles, D.M.3
-
39
-
-
84886779564
-
Differential phosphofructokinase-1 isoenzyme patterns associated with glycolytic efficiency in human breast cancer and paracancer tissues
-
G. Wang, Z. Xu, C. Wang, F. Yao, J. Li, C. Chen, and S. Sun Differential phosphofructokinase-1 isoenzyme patterns associated with glycolytic efficiency in human breast cancer and paracancer tissues Oncol. Lett 6 2013 1701 1706
-
(2013)
Oncol. Lett
, vol.6
, pp. 1701-1706
-
-
Wang, G.1
Xu, Z.2
Wang, C.3
Yao, F.4
Li, J.5
Chen, C.6
Sun, S.7
-
40
-
-
0342919888
-
Control of liver 6-phosphofructokinase by fructose 2,6-bisphosphate and other effectors
-
E. Van Schaftingen, M.F. Jett, L. Hue, and H.G. Hers Control of liver 6-phosphofructokinase by fructose 2,6-bisphosphate and other effectors Proc. Natl. Acad. Sci. USA 78 1981 3483 3486
-
(1981)
Proc. Natl. Acad. Sci. USA
, vol.78
, pp. 3483-3486
-
-
Van Schaftingen, E.1
Jett, M.F.2
Hue, L.3
Hers, H.G.4
-
41
-
-
0035146957
-
PFK-2/FBPase-2: Maker and breaker of the essential biofactor fructose-2,6-bisphosphate
-
D.A. Okar, A.J. Lange, A. Manzano, A. Navarro-Sabate, L. Riera, and R. Bartrons PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2,6-bisphosphate Trends Biochem. Sci. 26 2001 30 35
-
(2001)
Trends Biochem. Sci.
, vol.26
, pp. 30-35
-
-
Okar, D.A.1
Lange, A.J.2
Manzano, A.3
Navarro-Sabate, A.4
Riera, L.5
Bartrons, R.6
-
42
-
-
0037108709
-
High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers
-
T. Atsumi, J. Chesney, C. Metz, L. Leng, S. Donnelly, Z. Makita, R. Mitchell, and R. Bucala High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers Cancer Res. 62 2002 5881 5887
-
(2002)
Cancer Res.
, vol.62
, pp. 5881-5887
-
-
Atsumi, T.1
Chesney, J.2
Metz, C.3
Leng, L.4
Donnelly, S.5
Makita, Z.6
Mitchell, R.7
Bucala, R.8
-
43
-
-
33746037631
-
PFKFB3 gene silencing decreases glycolysis, induces cell-cycle delay and inhibits anchorage-independent growth in HeLa cells
-
M.N. Calvo, R. Bartrons, E. Castano, J.C. Perales, A. Navarro-Sabate, and A. Manzano PFKFB3 gene silencing decreases glycolysis, induces cell-cycle delay and inhibits anchorage-independent growth in HeLa cells FEBS Lett. 580 2006 3308 3314
-
(2006)
FEBS Lett.
, vol.580
, pp. 3308-3314
-
-
Calvo, M.N.1
Bartrons, R.2
Castano, E.3
Perales, J.C.4
Navarro-Sabate, A.5
Manzano, A.6
-
44
-
-
38349183620
-
Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth
-
B. Clem, S. Telang, A. Clem, A. Yalcin, J. Meier, A. Simmons, M.A. Rasku, S. Arumugam, W.L. Dean, J. Eaton, A. Lane, J.O. Trent, and J. Chesney Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth Mol. Cancer Ther. 7 2008 110 120
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 110-120
-
-
Clem, B.1
Telang, S.2
Clem, A.3
Yalcin, A.4
Meier, J.5
Simmons, A.6
Rasku, M.A.7
Arumugam, S.8
Dean, W.L.9
Eaton, J.10
Lane, A.11
Trent, J.O.12
Chesney, J.13
-
45
-
-
84882239565
-
Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer
-
B.F. Clem, J. O'Neal, G. Tapolsky, A.L. Clem, Y. Imbert-Fernandez, D.A. Kerr, A.C. Klarer, R. Redman, D.M. Miller, J.O. Trent, S. Telang, and J. Chesney Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer Mol. Cancer Ther. 12 2013 1461 1470
-
(2013)
Mol. Cancer Ther.
, vol.12
, pp. 1461-1470
-
-
Clem, B.F.1
O'Neal, J.2
Tapolsky, G.3
Clem, A.L.4
Imbert-Fernandez, Y.5
Kerr, D.A.6
Klarer, A.C.7
Redman, R.8
Miller, D.M.9
Trent, J.O.10
Telang, S.11
Chesney, J.12
-
47
-
-
40749163248
-
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
H.R. Christofk, M.G. Vander Heiden, M.H. Harris, A. Ramanathan, R.E. Gerszten, R. Wei, M.D. Fleming, S.L. Schreiber, and L.C. Cantley The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth Nature 452 2008 230 233
-
(2008)
Nature
, vol.452
, pp. 230-233
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Harris, M.H.3
Ramanathan, A.4
Gerszten, R.E.5
Wei, R.6
Fleming, M.D.7
Schreiber, S.L.8
Cantley, L.C.9
-
48
-
-
84872174405
-
M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth
-
M. Cortes-Cros, C. Hemmerlin, S. Ferretti, J. Zhang, J.S. Gounarides, H. Yin, A. Muller, A. Haberkorn, P. Chene, W.R. Sellers, and F. Hofmann M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth Proc. Natl. Acad. Sci. USA 110 2013 489 494
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 489-494
-
-
Cortes-Cros, M.1
Hemmerlin, C.2
Ferretti, S.3
Zhang, J.4
Gounarides, J.S.5
Yin, H.6
Muller, A.7
Haberkorn, A.8
Chene, P.9
Sellers, W.R.10
Hofmann, F.11
-
49
-
-
84885589840
-
PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells
-
W.J. Israelsen, T.L. Dayton, S.M. Davidson, B.P. Fiske, A.M. Hosios, G. Bellinger, J. Li, Y. Yu, M. Sasaki, J.W. Horner, L.N. Burga, J. Xie, M.J. Jurczak, R.A. DePinho, C.B. Clish, T. Jacks, R.G. Kibbey, G.M. Wulf, D. Di Vizio, G.B. Mills, L.C. Cantley, and M.G. Vander Heiden PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells Cell 155 2013 397 409
-
(2013)
Cell
, vol.155
, pp. 397-409
-
-
Israelsen, W.J.1
Dayton, T.L.2
Davidson, S.M.3
Fiske, B.P.4
Hosios, A.M.5
Bellinger, G.6
Li, J.7
Yu, Y.8
Sasaki, M.9
Horner, J.W.10
Burga, L.N.11
Xie, J.12
Jurczak, M.J.13
Depinho, R.A.14
Clish, C.B.15
Jacks, T.16
Kibbey, R.G.17
Wulf, G.M.18
Di Vizio, D.19
Mills, G.B.20
Cantley, L.C.21
Vander Heiden, M.G.22
more..
-
50
-
-
82755166890
-
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses
-
D. Anastasiou, G. Poulogiannis, J.M. Asara, M.B. Boxer, J.k. Jiang, M. Shen, G. Bellinger, A.T. Sasaki, J.W. Locasale, D.S. Auld, C.J. Thomas, M.G. Vander Heiden, and L.C. Cantley Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses Science 334 2011 1278 1283
-
(2011)
Science
, vol.334
, pp. 1278-1283
-
-
Anastasiou, D.1
Poulogiannis, G.2
Asara, J.M.3
Boxer, M.B.4
Jiang, J.K.5
Shen, M.6
Bellinger, G.7
Sasaki, A.T.8
Locasale, J.W.9
Auld, D.S.10
Thomas, C.J.11
Vander Heiden, M.G.12
Cantley, L.C.13
-
51
-
-
33847755430
-
Adaptation of energy metabolism in breast cancer brain metastases
-
E.I. Chen, J. Hewel, J.S. Krueger, C. Tiraby, M.R. Weber, A. Kralli, K. Becker, J.R. Yates, and B. Felding-Habermann Adaptation of energy metabolism in breast cancer brain metastases Cancer Res. 67 2007 1472 1486
-
(2007)
Cancer Res.
, vol.67
, pp. 1472-1486
-
-
Chen, E.I.1
Hewel, J.2
Krueger, J.S.3
Tiraby, C.4
Weber, M.R.5
Kralli, A.6
Becker, K.7
Yates, J.R.8
Felding-Habermann, B.9
-
52
-
-
69949101473
-
Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
-
Z.T. Schafer, A.R. Grassian, L. Song, Z. Jiang, Z. Gerhart-Hines, H.Y. Irie, S. Gao, P. Puigserver, and J.S. Brugge Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment Nature 461 2009 109 113
-
(2009)
Nature
, vol.461
, pp. 109-113
-
-
Schafer, Z.T.1
Grassian, A.R.2
Song, L.3
Jiang, Z.4
Gerhart-Hines, Z.5
Irie, H.Y.6
Gao, S.7
Puigserver, P.8
Brugge, J.S.9
-
53
-
-
0034282419
-
Cells overexpressing fructose-2,6-bisphosphatase showed enhanced pentose phosphate pathway flux and resistance to oxidative stress
-
J. Boada, T. Roig, X. Perez, A. Gamez, R. Bartrons, M. Cascante, and J. Bermudez Cells overexpressing fructose-2,6-bisphosphatase showed enhanced pentose phosphate pathway flux and resistance to oxidative stress FEBS Lett. 480 2000 261 264
-
(2000)
FEBS Lett.
, vol.480
, pp. 261-264
-
-
Boada, J.1
Roig, T.2
Perez, X.3
Gamez, A.4
Bartrons, R.5
Cascante, M.6
Bermudez, J.7
-
54
-
-
0030706079
-
Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma
-
L.Z. Milgraum, L.A. Witters, G.R. Pasternack, and F.P. Kuhajda Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma Clin. Cancer Res. 3 1997 2115 2120
-
(1997)
Clin. Cancer Res.
, vol.3
, pp. 2115-2120
-
-
Milgraum, L.Z.1
Witters, L.A.2
Pasternack, G.R.3
Kuhajda, F.P.4
-
55
-
-
30544433533
-
ATP citrate lyase is an important component of cell growth and transformation
-
D.E. Bauer, G. Hatzivassiliou, F. Zhao, C. Andreadis, and C.B. Thompson ATP citrate lyase is an important component of cell growth and transformation Oncogene 24 2005 6314 6322
-
(2005)
Oncogene
, vol.24
, pp. 6314-6322
-
-
Bauer, D.E.1
Hatzivassiliou, G.2
Zhao, F.3
Andreadis, C.4
Thompson, C.B.5
-
56
-
-
0027145124
-
Glutamine and cancer
-
W.W. Souba Glutamine and cancer Ann. Surg. 218 1993 715 728
-
(1993)
Ann. Surg.
, vol.218
, pp. 715-728
-
-
Souba, W.W.1
-
57
-
-
0034856827
-
Glutamine and cancer
-
M.A. Medina Glutamine and cancer J. Nutr. 131 2001 2539S 2542S
-
(2001)
J. Nutr.
, vol.131
, pp. 2539S-2542S
-
-
Medina, M.A.1
-
58
-
-
70149093912
-
Recurring mutations found by sequencing an acute myeloid leukemia genome
-
E.R. Mardis, L. Ding, D.J. Dooling, D.E. Larson, M.D. McLellan, K. Chen, D.C. Koboldt, R.S. Fulton, K.D. Delehaunty, S.D. McGrath, L.A. Fulton, D.P. Locke, V.J. Magrini, R.M. Abbott, T.L. Vickery, J.S. Reed, J.S. Robinson, T. Wylie, S.M. Smith, L. Carmichael, J.M. Eldred, C.C. Harris, J. Walker, J.B. Peck, F. Du, A.F. Dukes, G.E. Sanderson, A.M. Brummett, E. Clark, J.F. McMichael, R.J. Meyer, J.K. Schindler, C.S. Pohl, J.W. Wallis, X. Shi, L. Lin, H. Schmidt, Y. Tang, C. Haipek, M.E. Wiechert, J.V. Ivy, J. Kalicki, G. Elliott, R.E. Ries, J.E. Payton, P. Westervelt, M.H. Tomasson, M.A. Watson, J. Baty, S. Heath, W.D. Shannon, R. Nagarajan, D.C. Link, M.J. Walter, T.A. Graubert, J.F. DiPersio, R.K. Wilson, and T.J. Ley Recurring mutations found by sequencing an acute myeloid leukemia genome N. Engl. J. Med. 361 2009 1058 1066
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 1058-1066
-
-
Mardis, E.R.1
Ding, L.2
Dooling, D.J.3
Larson, D.E.4
McLellan, M.D.5
Chen, K.6
Koboldt, D.C.7
Fulton, R.S.8
Delehaunty, K.D.9
McGrath, S.D.10
Fulton, L.A.11
Locke, D.P.12
Magrini, V.J.13
Abbott, R.M.14
Vickery, T.L.15
Reed, J.S.16
Robinson, J.S.17
Wylie, T.18
Smith, S.M.19
Carmichael, L.20
Eldred, J.M.21
Harris, C.C.22
Walker, J.23
Peck, J.B.24
Du, F.25
Dukes, A.F.26
Sanderson, G.E.27
Brummett, A.M.28
Clark, E.29
McMichael, J.F.30
Meyer, R.J.31
Schindler, J.K.32
Pohl, C.S.33
Wallis, J.W.34
Shi, X.35
Lin, L.36
Schmidt, H.37
Tang, Y.38
Haipek, C.39
Wiechert, M.E.40
Ivy, J.V.41
Kalicki, J.42
Elliott, G.43
Ries, R.E.44
Payton, J.E.45
Westervelt, P.46
Tomasson, M.H.47
Watson, M.A.48
Baty, J.49
Heath, S.50
Shannon, W.D.51
Nagarajan, R.52
Link, D.C.53
Walter, M.J.54
Graubert, T.A.55
Dipersio, J.F.56
Wilson, R.K.57
Ley, T.J.58
more..
-
59
-
-
60849115270
-
IDH1 and IDH2 Mutations in Gliomas
-
H. Yan, D.W. Parsons, G. Jin, R. McLendon, B.A. Rasheed, W. Yuan, I. Kos, I. Batinic-Haberle, S. Jones, G.J. Riggins, H. Friedman, A. Friedman, D. Reardon, J. Herndon, K.W. Kinzler, V.E. Velculescu, B. Vogelstein, and D.D. Bigner IDH1 and IDH2 Mutations in Gliomas N. Engl. J. Med. 360 2009 765 773
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 765-773
-
-
Yan, H.1
Parsons, D.W.2
Jin, G.3
McLendon, R.4
Rasheed, B.A.5
Yuan, W.6
Kos, I.7
Batinic-Haberle, I.8
Jones, S.9
Riggins, G.J.10
Friedman, H.11
Friedman, A.12
Reardon, D.13
Herndon, J.14
Kinzler, K.W.15
Velculescu, V.E.16
Vogelstein, B.17
Bigner, D.D.18
-
60
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
L. Dang, D.W. White, S. Gross, B.D. Bennett, M.A. Bittinger, E.M. Driggers, V.R. Fantin, H.G. Jang, S. Jin, M.C. Keenan, K.M. Marks, R.M. Prins, P.S. Ward, K.E. Yen, L.M. Liau, J.D. Rabinowitz, L.C. Cantley, C.B. Thompson, M.G. Vander Heiden, and S.M. Su Cancer-associated IDH1 mutations produce 2-hydroxyglutarate Nature 462 2009 739 744
-
(2009)
Nature
, vol.462
, pp. 739-744
-
-
Dang, L.1
White, D.W.2
Gross, S.3
Bennett, B.D.4
Bittinger, M.A.5
Driggers, E.M.6
Fantin, V.R.7
Jang, H.G.8
Jin, S.9
Keenan, M.C.10
Marks, K.M.11
Prins, R.M.12
Ward, P.S.13
Yen, K.E.14
Liau, L.M.15
Rabinowitz, J.D.16
Cantley, L.C.17
Thompson, C.B.18
Vander Heiden, M.G.19
Su, S.M.20
more..
-
61
-
-
66149146320
-
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
-
M. Tahiliani, K.P. Koh, Y. Shen, W.A. Pastor, H. Bandukwala, Y. Brudno, S. Agarwal, L.M. Iyer, D.R. Liu, L. Aravind, and A. Rao Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1 Science 324 2009 930 935
-
(2009)
Science
, vol.324
, pp. 930-935
-
-
Tahiliani, M.1
Koh, K.P.2
Shen, Y.3
Pastor, W.A.4
Bandukwala, H.5
Brudno, Y.6
Agarwal, S.7
Iyer, L.M.8
Liu, D.R.9
Aravind, L.10
Rao, A.11
-
62
-
-
78651463452
-
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
-
W. Xu, H. Yang, Y. Liu, Y. Yang, P. Wang, S.H. Kim, S. Ito, C. Yang, P. Wang, M.T. Xiao, L.x. Liu, W.q. Jiang, J. Liu, J.y. Zhang, B. Wang, S. Frye, Y. Zhang, Y.h. Xu, Q.y. Lei, K.L. Guan, S.m. Zhao, and Y. Xiong Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases Cancer Cell 19 2011 17 30
-
(2011)
Cancer Cell
, vol.19
, pp. 17-30
-
-
Xu, W.1
Yang, H.2
Liu, Y.3
Yang, Y.4
Wang, P.5
Kim, S.H.6
Ito, S.7
Yang, C.8
Wang, P.9
Xiao, M.T.10
Liu, L.X.11
Jiang, W.Q.12
Liu, J.13
Zhang, J.Y.14
Wang, B.15
Frye, S.16
Zhang, Y.17
Xu, Y.H.18
Lei, Q.Y.19
Guan, K.L.20
Zhao, S.M.21
Xiong, Y.22
more..
-
63
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
M.E. Figueroa, O. bdel-Wahab, C. Lu, P.S. Ward, J. Patel, A. Shih, Y. Li, N. Bhagwat, A. Vasanthakumar, H.F. Fernandez, M.S. Tallman, Z. Sun, K. Wolniak, J.K. Peeters, W. Liu, S.E. Choe, V.R. Fantin, E. Paietta, B. Lowenberg, J.D. Licht, L.A. Godley, R. Delwel, P.J.M. Valk, C.B. Thompson, R.L. Levine, and A. Melnick Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation Cancer Cell 18 2010 553 567
-
(2010)
Cancer Cell
, vol.18
, pp. 553-567
-
-
Figueroa, M.E.1
Bdel-Wahab, O.2
Lu, C.3
Ward, P.S.4
Patel, J.5
Shih, A.6
Li, Y.7
Bhagwat, N.8
Vasanthakumar, A.9
Fernandez, H.F.10
Tallman, M.S.11
Sun, Z.12
Wolniak, K.13
Peeters, J.K.14
Liu, W.15
Choe, S.E.16
Fantin, V.R.17
Paietta, E.18
Lowenberg, B.19
Licht, J.D.20
Godley, L.A.21
Delwel, R.22
Valk, P.J.M.23
Thompson, C.B.24
Levine, R.L.25
Melnick, A.26
more..
-
64
-
-
79952366279
-
Metabolism unhinged: IDH mutations in cancer
-
J.R. Prensner, and A.M. Chinnaiyan Metabolism unhinged: IDH mutations in cancer Nat. Med 17 2011 291 293
-
(2011)
Nat. Med
, vol.17
, pp. 291-293
-
-
Prensner, J.R.1
Chinnaiyan, A.M.2
-
65
-
-
84855987831
-
Reductive carboxylation supports growth in tumour cells with defective mitochondria
-
A.R. Mullen, W.W. Wheaton, E.S. Jin, P.H. Chen, L.B. Sullivan, T. Cheng, Y. Yang, W.M. Linehan, N.S. Chandel, and R.J. DeBerardinis Reductive carboxylation supports growth in tumour cells with defective mitochondria Nature 481 2012 385 388
-
(2012)
Nature
, vol.481
, pp. 385-388
-
-
Mullen, A.R.1
Wheaton, W.W.2
Jin, E.S.3
Chen, P.H.4
Sullivan, L.B.5
Cheng, T.6
Yang, Y.7
Linehan, W.M.8
Chandel, N.S.9
Deberardinis, R.J.10
-
66
-
-
83755178091
-
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of alpha-ketoglutarate to citrate to support cell growth and viability
-
D.R. Wise, P.S. Ward, J.E. Shay, J.R. Cross, J.J. Gruber, U.M. Sachdeva, J.M. Platt, R.G. DeMatteo, M.C. Simon, and C.B. Thompson Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of alpha-ketoglutarate to citrate to support cell growth and viability Proc. Natl. Acad. Sci. USA 108 2011 19611 19616
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 19611-19616
-
-
Wise, D.R.1
Ward, P.S.2
Shay, J.E.3
Cross, J.R.4
Gruber, J.J.5
Sachdeva, U.M.6
Platt, J.M.7
Dematteo, R.G.8
Simon, M.C.9
Thompson, C.B.10
-
67
-
-
84902343371
-
Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects
-
A.R. Mullen, Z. Hu, X. Shi, L. Jiang, L.K. Boroughs, Z. Kovacs, R. Boriack, D. Rakheja, L.B. Sullivan, W.M. Linehan, N.S. Chandel, and R.J. DeBerardinis Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects Cell Rep 7 2014 1679 1690
-
(2014)
Cell Rep
, vol.7
, pp. 1679-1690
-
-
Mullen, A.R.1
Hu, Z.2
Shi, X.3
Jiang, L.4
Boroughs, L.K.5
Kovacs, Z.6
Boriack, R.7
Rakheja, D.8
Sullivan, L.B.9
Linehan, W.M.10
Chandel, N.S.11
Deberardinis, R.J.12
-
68
-
-
0142227019
-
Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
-
J. Luo, B.D. Manning, and L.C. Cantley Targeting the PI3K-Akt pathway in human cancer: rationale and promise Cancer Cell 4 2003 257 262
-
(2003)
Cancer Cell
, vol.4
, pp. 257-262
-
-
Luo, J.1
Manning, B.D.2
Cantley, L.C.3
-
69
-
-
33745307617
-
Ras, PI(3)K and mTOR signalling controls tumour cell growth
-
R.J. Shaw, and L.C. Cantley Ras, PI(3)K and mTOR signalling controls tumour cell growth Nature 441 2006 424 430
-
(2006)
Nature
, vol.441
, pp. 424-430
-
-
Shaw, R.J.1
Cantley, L.C.2
-
70
-
-
51849111556
-
PI3K pathway alterations in cancer: Variations on a theme
-
T.L. Yuan, and L.C. Cantley PI3K pathway alterations in cancer: variations on a theme Oncogene 27 2008 5497 5510
-
(2008)
Oncogene
, vol.27
, pp. 5497-5510
-
-
Yuan, T.L.1
Cantley, L.C.2
-
71
-
-
2542561169
-
Akt stimulates aerobic glycolysis in cancer cells
-
R.L. Elstrom, D.E. Bauer, M. Buzzai, R. Karnauskas, M.H. Harris, D.R. Plas, H. Zhuang, R.M. Cinalli, A. Alavi, C.M. Rudin, and C.B. Thompson Akt stimulates aerobic glycolysis in cancer cells Cancer Res. 64 2004 3892 3899
-
(2004)
Cancer Res.
, vol.64
, pp. 3892-3899
-
-
Elstrom, R.L.1
Bauer, D.E.2
Buzzai, M.3
Karnauskas, R.4
Harris, M.H.5
Plas, D.R.6
Zhuang, H.7
Cinalli, R.M.8
Alavi, A.9
Rudin, C.M.10
Thompson, C.B.11
-
72
-
-
0030748651
-
Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades
-
J. Deprez, D. Vertommen, D.R. Alessi, L. Hue, and M.H. Rider Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades J. Biol. Chem. 272 1997 17269 17275
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 17269-17275
-
-
Deprez, J.1
Vertommen, D.2
Alessi, D.R.3
Hue, L.4
Rider, M.H.5
-
73
-
-
0034983918
-
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
-
K. Gottlob, N. Majewski, S. Kennedy, E. Kandel, R.B. Robey, and N. Hay Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase Genes Dev. 15 2001 1406 1418
-
(2001)
Genes Dev.
, vol.15
, pp. 1406-1418
-
-
Gottlob, K.1
Majewski, N.2
Kennedy, S.3
Kandel, E.4
Robey, R.B.5
Hay, N.6
-
74
-
-
0035012605
-
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
-
E. Laughner, P. Taghavi, K. Chiles, P.C. Mahon, and G.L. Semenza HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression Mol. Cell. Biol. 21 2001 3995 4004
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3995-4004
-
-
Laughner, E.1
Taghavi, P.2
Chiles, K.3
Mahon, P.C.4
Semenza, G.L.5
-
75
-
-
0034002793
-
Fatty-acid synthase and human cancer: New perspectives on its role in tumor biology
-
F.P. Kuhajda Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology Nutrition 16 2000 202 208
-
(2000)
Nutrition
, vol.16
, pp. 202-208
-
-
Kuhajda, F.P.1
-
76
-
-
34748912615
-
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
-
J.A. Menendez, and R. Lupu Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis Nat. Rev. Cancer 7 2007 763 777
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 763-777
-
-
Menendez, J.A.1
Lupu, R.2
-
77
-
-
34548814981
-
Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells
-
S. Yoon, M.Y. Lee, S.W. Park, J.S. Moon, Y.K. Koh, Y.H. Ahn, B.W. Park, and K.S. Kim Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells J. Biol. Chem. 282 2007 26122 26131
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 26122-26131
-
-
Yoon, S.1
Lee, M.Y.2
Park, S.W.3
Moon, J.S.4
Koh, Y.K.5
Ahn, Y.H.6
Park, B.W.7
Kim, K.S.8
-
78
-
-
0036469122
-
Role of the phosphatidylinositol 3-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells
-
T. Van de Sande, E. De Schrijver, W. Heyns, G. Verhoeven, and J.V. Swinnen Role of the phosphatidylinositol 3-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells Cancer Res. 62 2002 642 646
-
(2002)
Cancer Res.
, vol.62
, pp. 642-646
-
-
Van De Sande, T.1
De Schrijver, E.2
Heyns, W.3
Verhoeven, G.4
Swinnen, J.V.5
-
79
-
-
0036385719
-
Activation of fatty acid synthesis during neoplastic transformation: Role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase
-
Y.A. Yang, W.F. Han, P.J. Morin, F.J. Chrest, and E.S. Pizer Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase Exp. Cell Res. 279 2002 80 90
-
(2002)
Exp. Cell Res.
, vol.279
, pp. 80-90
-
-
Yang, Y.A.1
Han, W.F.2
Morin, P.J.3
Chrest, F.J.4
Pizer, E.S.5
-
80
-
-
33747807398
-
Targeting fatty acid synthase in breast and endometrial cancer: An alternative to selective estrogen receptor modulators?
-
R. Lupu, and J.A. Menendez Targeting fatty acid synthase in breast and endometrial cancer: an alternative to selective estrogen receptor modulators? Endocrinology 147 2006 4056 4066
-
(2006)
Endocrinology
, vol.147
, pp. 4056-4066
-
-
Lupu, R.1
Menendez, J.A.2
-
81
-
-
0037072780
-
The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes
-
D.C. Berwick, I. Hers, K.J. Heesom, S.K. Moule, and J.M. Tavar+¬ The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes J. Biol. Chem. 277 2002 33895 33900
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 33895-33900
-
-
Berwick, D.C.1
Hers, I.2
Heesom, K.J.3
Moule, S.K.4
Tavar, J.M.5
-
82
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
H. Zhong, A.M. De Marzo, E. Laughner, M. Lim, D.A. Hilton, D. Zagzag, P. Buechler, W.B. Isaacs, G.L. Semenza, and J.W. Simons Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases Cancer Res. 59 1999 5830 5835
-
(1999)
Cancer Res.
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
Lim, M.4
Hilton, D.A.5
Zagzag, D.6
Buechler, P.7
Isaacs, W.B.8
Semenza, G.L.9
Simons, J.W.10
-
83
-
-
76049100577
-
HIF-1: Upstream and downstream of cancer metabolism
-
G.L. Semenza HIF-1: upstream and downstream of cancer metabolism Curr. Opin. Genet. Dev 20 2010 51 56
-
(2010)
Curr. Opin. Genet. Dev
, vol.20
, pp. 51-56
-
-
Semenza, G.L.1
-
84
-
-
0035834409
-
A Conserved family of prolyl-4-hydroxylases that modify HIF
-
R.K. Bruick, and S.L. McKnight A Conserved family of prolyl-4-hydroxylases that modify HIF Science 294 2001 1337 1340
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
85
-
-
43649093915
-
Oxygen sensing by metazoans: The central role of the hif hydroxylase pathway
-
J. Kaelin, and P.J. Ratcliffe Oxygen sensing by metazoans: the central role of the hif hydroxylase pathway Mol. Cell 30 2008 393 402
-
(2008)
Mol. Cell
, vol.30
, pp. 393-402
-
-
Kaelin, J.1
Ratcliffe, P.J.2
-
86
-
-
0028068606
-
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
-
G.L. Semenza, P.H. Roth, H.M. Fang, and G.L. Wang Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1 J. Biol. Chem. 269 1994 23757 23763
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 23757-23763
-
-
Semenza, G.L.1
Roth, P.H.2
Fang, H.M.3
Wang, G.L.4
-
87
-
-
63449103705
-
Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis
-
X. Xia, M.E. Lemieux, W. Li, J.S. Carroll, M. Brown, X.S. Liu, and A.L. Kung Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis Proc. Natl. Acad. Sci. USA 106 2009 4260 4265
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 4260-4265
-
-
Xia, X.1
Lemieux, M.E.2
Li, W.3
Carroll, J.S.4
Brown, M.5
Liu, X.S.6
Kung, A.L.7
-
88
-
-
67650531089
-
Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts
-
D.R. Mole, C. Blancher, R.R. Copley, P.J. Pollard, J.M. Gleadle, J. Ragoussis, and P.J. Ratcliffe Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts J. Biol. Chem. 284 2009 16767 16775
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 16767-16775
-
-
Mole, D.R.1
Blancher, C.2
Copley, R.R.3
Pollard, P.J.4
Gleadle, J.M.5
Ragoussis, J.6
Ratcliffe, P.J.7
-
89
-
-
18644366801
-
Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors
-
I.F. Robey, A.D. Lien, S.J. Welsh, B. Baggett, and R.J. Gillies Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors Neoplasia 7 2005 324 330
-
(2005)
Neoplasia
, vol.7
, pp. 324-330
-
-
Robey, I.F.1
Lien, A.D.2
Welsh, S.J.3
Baggett, B.4
Gillies, R.J.5
-
90
-
-
33646917296
-
The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism
-
M.S. Ullah, A.J. Davies, and A.P. Halestrap The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism J. Biol. Chem. 281 2006 9030 9037
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 9030-9037
-
-
Ullah, M.S.1
Davies, A.J.2
Halestrap, A.P.3
-
91
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
-
J.w. Kim, I. Tchernyshyov, G.L. Semenza, and C.V. Dang HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia Cell Metab. 3 2006 177 185
-
(2006)
Cell Metab.
, vol.3
, pp. 177-185
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
92
-
-
19944433653
-
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIFalpha prolyl hydroxylase
-
M.A. Selak, S.M. Armour, E.D. MacKenzie, H. Boulahbel, D.G. Watson, K.D. Mansfield, Y. Pan, M.C. Simon, C.B. Thompson, and E. Gottlieb Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIFalpha prolyl hydroxylase Cancer Cell 7 2005 77 85
-
(2005)
Cancer Cell
, vol.7
, pp. 77-85
-
-
Selak, M.A.1
Armour, S.M.2
Mackenzie, E.D.3
Boulahbel, H.4
Watson, D.G.5
Mansfield, K.D.6
Pan, Y.7
Simon, M.C.8
Thompson, C.B.9
Gottlieb, E.10
-
93
-
-
23644448721
-
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer. El role of fumarate in regulation of HIF stability
-
J.S. Isaacs, Y.J. Jung, D.R. Mole, S. Lee, C. Torres-Cabala, Y.L. Chung, M. Merino, J. Trepel, B. Zbar, J. Toro, P.J. Ratcliffe, W.M. Linehan, and L. Neckers HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer. el role of fumarate in regulation of HIF stability Cancer Cell 8 2005 143 153
-
(2005)
Cancer Cell
, vol.8
, pp. 143-153
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mole, D.R.3
Lee, S.4
Torres-Cabala, C.5
Chung, Y.L.6
Merino, M.7
Trepel, J.8
Zbar, B.9
Toro, J.10
Ratcliffe, P.J.11
Linehan, W.M.12
Neckers, L.13
-
94
-
-
84880439188
-
The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling
-
L.B. Sullivan, E. Martinez-Garcia, H. Nguyen, A.R. Mullen, E. Dufour, S. Sudarshan, J.D. Licht, R.J. DeBerardinis, and N.S. Chandel The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling Mol. Cell 51 2013 236 248
-
(2013)
Mol. Cell
, vol.51
, pp. 236-248
-
-
Sullivan, L.B.1
Martinez-Garcia, E.2
Nguyen, H.3
Mullen, A.R.4
Dufour, E.5
Sudarshan, S.6
Licht, J.D.7
Deberardinis, R.J.8
Chandel, N.S.9
-
95
-
-
64849098267
-
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha
-
S. Zhao, Y. Lin, W. Xu, W. Jiang, Z. Zha, P. Wang, W. Yu, Z. Li, L. Gong, Y. Peng, J. Ding, Q. Lei, K.L. Guan, and Y. Xiong Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha Science 324 2009 261 265
-
(2009)
Science
, vol.324
, pp. 261-265
-
-
Zhao, S.1
Lin, Y.2
Xu, W.3
Jiang, W.4
Zha, Z.5
Wang, P.6
Yu, W.7
Li, Z.8
Gong, L.9
Peng, Y.10
Ding, J.11
Lei, Q.12
Guan, K.L.13
Xiong, Y.14
-
96
-
-
67651204610
-
Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species
-
S. Sudarshan, C. Sourbier, H.S. Kong, K. Block, V.A.V. Romero, Y. Yang, C. Galindo, M. Mollapour, B. Scroggins, N. Goode, M.J. Lee, C.W. Gourlay, J. Trepel, W.M. Linehan, and L. Neckers Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species Mol. Cell. Biol. 29 2009 4080 4090
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 4080-4090
-
-
Sudarshan, S.1
Sourbier, C.2
Kong, H.S.3
Block, K.4
Romero, V.A.V.5
Yang, Y.6
Galindo, C.7
Mollapour, M.8
Scroggins, B.9
Goode, N.10
Lee, M.J.11
Gourlay, C.W.12
Trepel, J.13
Linehan, W.M.14
Neckers, L.15
-
97
-
-
59449106196
-
Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in head and neck squamous cell carcinoma
-
W. Sun, S. Zhou, S.S. Chang, T. McFate, A. Verma, and J.A. Califano Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in head and neck squamous cell carcinoma Clin. Cancer Res. 15 2009 476 484
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 476-484
-
-
Sun, W.1
Zhou, S.2
Chang, S.S.3
McFate, T.4
Verma, A.5
Califano, J.A.6
-
98
-
-
34250751339
-
Nitric oxide and superoxide: Interference with hypoxic signaling
-
B. Brune, and J. Zhou Nitric oxide and superoxide: Interference with hypoxic signaling Cardiovasc. Res. 75 2007 275 282
-
(2007)
Cardiovasc. Res.
, vol.75
, pp. 275-282
-
-
Brune, B.1
Zhou, J.2
-
100
-
-
75149150660
-
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
-
C.J. David, M. Chen, M. Assanah, P. Canoll, and J.L. Manley HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer Nature 463 2010 364 368
-
(2010)
Nature
, vol.463
, pp. 364-368
-
-
David, C.J.1
Chen, M.2
Assanah, M.3
Canoll, P.4
Manley, J.L.5
-
101
-
-
57749088701
-
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
-
D.R. Wise, R.J. DeBerardinis, A. Mancuso, N. Sayed, X.Y. Zhang, H.K. Pfeiffer, I. Nissim, E. Daikhin, M. Yudkoff, S.B. McMahon, and C.B. Thompson Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction Proc. Natl. Acad. Sci. USA 105 2008 18782 18787
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 18782-18787
-
-
Wise, D.R.1
Deberardinis, R.J.2
Mancuso, A.3
Sayed, N.4
Zhang, X.Y.5
Pfeiffer, H.K.6
Nissim, I.7
Daikhin, E.8
Yudkoff, M.9
McMahon, S.B.10
Thompson, C.B.11
-
102
-
-
34247614521
-
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
-
H. Zhang, P. Gao, R. Fukuda, G. Kumar, B. Krishnamachary, K.I. Zeller, C. Dang, and G.L. Semenza HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity Cancer Cell 11 2007 407 420
-
(2007)
Cancer Cell
, vol.11
, pp. 407-420
-
-
Zhang, H.1
Gao, P.2
Fukuda, R.3
Kumar, G.4
Krishnamachary, B.5
Zeller, K.I.6
Dang, C.7
Semenza, G.L.8
-
103
-
-
46349099384
-
Global identification of Myc target genes reveals its direct role in mitochondrial biogenesis and its E-Box usage in vivo.
-
J. Kim, J.h. Lee, and V.R. Iyer Global identification of Myc target genes reveals its direct role in mitochondrial biogenesis and its E-Box usage in vivo. PLoS One e1798 2008
-
(2008)
PLoS One
, pp. e1798
-
-
Kim, J.1
Lee, J.H.2
Iyer, V.R.3
-
104
-
-
21744442902
-
Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis
-
F. Li, Y. Wang, K.I. Zeller, J.J. Potter, D.R. Wonsey, K.A. O'Donnell, J.w. Kim, J.T. Yustein, L.A. Lee, and C.V. Dang Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis Mol. Cell. Biol. 25 2005 6225 6234
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 6225-6234
-
-
Li, F.1
Wang, Y.2
Zeller, K.I.3
Potter, J.J.4
Wonsey, D.R.5
O'Donnell, K.A.6
Kim, J.W.7
Yustein, J.T.8
Lee, L.A.9
Dang, C.V.10
-
105
-
-
84887430076
-
Metabolic regulation by p53 family members (abstract)
-
C. Berkers, O. Maddocks, E. Cheung, I. Mor, and K. Vousden Metabolic regulation by p53 family members (abstract) Cell Metab. 18 2013 617 633
-
(2013)
Cell Metab.
, vol.18
, pp. 617-633
-
-
Berkers, C.1
Maddocks, O.2
Cheung, E.3
Mor, I.4
Vousden, K.5
-
106
-
-
1942506067
-
The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression
-
F. Schwartzenberg-Bar-Yoseph, M. Armoni, and E. Karnieli The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression Cancer Res. 64 2004 2627 2633
-
(2004)
Cancer Res.
, vol.64
, pp. 2627-2633
-
-
Schwartzenberg-Bar-Yoseph, F.1
Armoni, M.2
Karnieli, E.3
-
107
-
-
11244347171
-
Glycolytic enzymes can modulate cellular life span
-
H. Kondoh, M.E. Lleonart, J. Gil, J. Wang, P. Degan, G. Peters, D. Martinez, A. Carnero, and D. Beach Glycolytic enzymes can modulate cellular life span Cancer Res. 65 2005 177 185
-
(2005)
Cancer Res.
, vol.65
, pp. 177-185
-
-
Kondoh, H.1
Lleonart, M.E.2
Gil, J.3
Wang, J.4
Degan, P.5
Peters, G.6
Martinez, D.7
Carnero, A.8
Beach, D.9
-
108
-
-
33745918951
-
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
-
K. Bensaad, A. Tsuruta, M.A. Selak, M.N.C. Vidal, K. Nakano, R. Bartrons, E. Gottlieb, and K.H. Vousden TIGAR, a p53-inducible regulator of glycolysis and apoptosis Cell 126 2006 107 120
-
(2006)
Cell
, vol.126
, pp. 107-120
-
-
Bensaad, K.1
Tsuruta, A.2
Selak, M.A.3
Vidal, M.N.C.4
Nakano, K.5
Bartrons, R.6
Gottlieb, E.7
Vousden, K.H.8
-
109
-
-
59449084996
-
Structural and biochemical studies of TIGAR (TP53-induced glycolysis and apoptosis regulator)
-
H. Li, and G. Jogl Structural and biochemical studies of TIGAR (TP53-induced glycolysis and apoptosis regulator) J. Biol. Chem. 284 2009 1748 1754
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 1748-1754
-
-
Li, H.1
Jogl, G.2
-
110
-
-
33745149291
-
P53 regulates mitochondrial respiration
-
S. Matoba, J.G. Kang, W.D. Patino, A. Wragg, M. Boehm, O. Gavrilova, P.J. Hurley, F. Bunz, and P.M. Hwang p53 regulates mitochondrial respiration Science 312 2006 1650 1653
-
(2006)
Science
, vol.312
, pp. 1650-1653
-
-
Matoba, S.1
Kang, J.G.2
Patino, W.D.3
Wragg, A.4
Boehm, M.5
Gavrilova, O.6
Hurley, P.J.7
Bunz, F.8
Hwang, P.M.9
-
111
-
-
77952227625
-
Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species
-
S. Suzuki, T. Tanaka, M.V. Poyurovsky, H. Nagano, T. Mayama, S. Ohkubo, M. Lokshin, H. Hosokawa, T. Nakayama, Y. Suzuki, S. Sugano, E. Sato, T. Nagao, K. Yokote, I. Tatsuno, and C. Prives Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species Proc. Natl. Acad. Sci. USA 107 2010 7461 7466
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 7461-7466
-
-
Suzuki, S.1
Tanaka, T.2
Poyurovsky, M.V.3
Nagano, H.4
Mayama, T.5
Ohkubo, S.6
Lokshin, M.7
Hosokawa, H.8
Nakayama, T.9
Suzuki, Y.10
Sugano, S.11
Sato, E.12
Nagao, T.13
Yokote, K.14
Tatsuno, I.15
Prives, C.16
-
112
-
-
27944487902
-
Logic of the yeast metabolic cycle: Temporal compartmentalization of cellular processes
-
B.P. Tu, A. Kudlicki, M. Rowicka, and S.L. McKnight Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes Science 310 2005 1152 1158
-
(2005)
Science
, vol.310
, pp. 1152-1158
-
-
Tu, B.P.1
Kudlicki, A.2
Rowicka, M.3
McKnight, S.L.4
-
113
-
-
0038491561
-
P53 activation in adipocytes of obese mice
-
N. Yahagi, H. Shimano, T. Matsuzaka, Y. Najima, M. Sekiya, Y. Nakagawa, T. Ide, S. Tomita, H. Okazaki, Y. Tamura, Y. Iizuka, K. Ohashi, T. Gotoda, R. Nagai, S. Kimura, S. Ishibashi, J.i. Osuga, and N. Yamada p53 activation in adipocytes of obese mice J. Biol. Chem. 2003
-
(2003)
J. Biol. Chem.
-
-
Yahagi, N.1
Shimano, H.2
Matsuzaka, T.3
Najima, Y.4
Sekiya, M.5
Nakagawa, Y.6
Ide, T.7
Tomita, S.8
Okazaki, H.9
Tamura, Y.10
Iizuka, Y.11
Ohashi, K.12
Gotoda, T.13
Nagai, R.14
Kimura, S.15
Ishibashi, S.16
Osuga, J.I.17
Yamada, N.18
-
114
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
R.A. Gatenby, and R.J. Gillies Why do cancers have high aerobic glycolysis? Nat. Rev. Cancer 4 2004 891 899
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
117
-
-
0027282347
-
EPR characterization of molecular targets for NO in mammalian cells and organelles
-
Y. Henry, M. Lepoivre, J.C. Drapier, C. Ducrocq, J.L. Boucher, and A. Guissani EPR characterization of molecular targets for NO in mammalian cells and organelles FASEB J. 7 1993 1124 1134
-
(1993)
FASEB J.
, vol.7
, pp. 1124-1134
-
-
Henry, Y.1
Lepoivre, M.2
Drapier, J.C.3
Ducrocq, C.4
Boucher, J.L.5
Guissani, A.6
-
119
-
-
0029792562
-
Nitric oxide-cyclic GMP signal transduction system
-
A.J. Hobbs, and L.J. Ignarro Nitric oxide-cyclic GMP signal transduction system Methods Enzymol. 269 1996 134 148
-
(1996)
Methods Enzymol.
, vol.269
, pp. 134-148
-
-
Hobbs, A.J.1
Ignarro, L.J.2
-
120
-
-
24944438175
-
Tonic and acute nitric oxide signaling through soluble guanylate cyclase is mediated by nonheme nitric oxide, ATP, and GTP
-
S.P.L. Cary, J.A. Winger, and M.A. Marletta Tonic and acute nitric oxide signaling through soluble guanylate cyclase is mediated by nonheme nitric oxide, ATP, and GTP Proc. Natl. Acad. Sci. USA 102 2005 13064 13069
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 13064-13069
-
-
Cary, S.P.L.1
Winger, J.A.2
Marletta, M.A.3
-
121
-
-
28044464985
-
Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases
-
M.W. Cleeter, J.M. Cooper, V.M. Darley-Usmar, S. Moncada, and A.H. Schapira Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases FEBS Lett. 345 1994 50 54
-
(1994)
FEBS Lett.
, vol.345
, pp. 50-54
-
-
Cleeter, M.W.1
Cooper, J.M.2
Darley-Usmar, V.M.3
Moncada, S.4
Schapira, A.H.5
-
122
-
-
0029805172
-
Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and the ugly
-
J.S. Beckman, and W.H. Koppenol Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly Am. J. Physiol. 271 1996 C1424 C1437
-
(1996)
Am. J. Physiol.
, vol.271
, pp. C1424-C1437
-
-
Beckman, J.S.1
Koppenol, W.H.2
-
123
-
-
84884169659
-
Peroxynitrite a stealthy biological oxidant
-
R. Radi Peroxynitrite a stealthy biological oxidant J. Biol. Chem 288 2013 26464 26472
-
(2013)
J. Biol. Chem
, vol.288
, pp. 26464-26472
-
-
Radi, R.1
-
124
-
-
21444449754
-
Fatty acid transduction of nitric oxide signaling: Nitrolinoleic acid is a hydrophobically-stabilized nitric oxide donor
-
F.J. Schopfer, P.R.S. Baker, G. Giles, P. Chumley, C. Batthyany, J. Crawford, R.P. Patel, N. Hogg, B.P. Branchaud, J.R. Lancaster Jr, and B.A. Freeman Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid is a hydrophobically-stabilized nitric oxide donor J. Biol. Chem 280 2005 19289 19297
-
(2005)
J. Biol. Chem
, vol.280
, pp. 19289-19297
-
-
Schopfer, F.J.1
Baker, P.R.S.2
Giles, G.3
Chumley, P.4
Batthyany, C.5
Crawford, J.6
Patel, R.P.7
Hogg, N.8
Branchaud, B.P.9
Lancaster, Jr.J.R.10
Freeman, B.A.11
-
125
-
-
0002489906
-
Kinetics of nitric oxide reaction in liquid and gas phase
-
M. Feelisch, J.S. Stamler, Wiley & Sons
-
D.A. Wink, J.S. Beckman, and P.C. Ford Kinetics of nitric oxide reaction in liquid and gas phase M. Feelisch, J.S. Stamler, Methods in nitric oxide research 1996 Wiley & Sons 29 37
-
(1996)
Methods in Nitric Oxide Research
, pp. 29-37
-
-
Wink, D.A.1
Beckman, J.S.2
Ford, P.C.3
-
126
-
-
0029558489
-
Kinetics of nitric oxide autoxidation in aqueous solution in the absence and presence of various reductants. The nature of the oxidizing intermediates
-
S. Goldstein, and G. Czapski Kinetics of nitric oxide autoxidation in aqueous solution in the absence and presence of various reductants. The nature of the oxidizing intermediates J. Am. Chem. Soc. 117 1995 12078 12084
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 12078-12084
-
-
Goldstein, S.1
Czapski, G.2
-
128
-
-
13444282230
-
Protein S-nitrosylation: Purview and parameters
-
D.T. Hess, A. Matsumoto, S.O. Kim, H.E. Marshall, and J.S. Stamler Protein S-nitrosylation: purview and parameters Nat. Rev. Mol. Cell. Biol. 6 2005 150 166
-
(2005)
Nat. Rev. Mol. Cell. Biol.
, vol.6
, pp. 150-166
-
-
Hess, D.T.1
Matsumoto, A.2
Kim, S.O.3
Marshall, H.E.4
Stamler, J.S.5
-
130
-
-
84886951613
-
Site specific identification of endogenous S-nitrosocysteine proteomes
-
P.T. Doulias, M. Tenopoulou, K. Raju, L.A. Spruce, S.H. Seeholzer, and H. Ischiropoulos Site specific identification of endogenous S-nitrosocysteine proteomes J. Proteomics 92 2013 195 203
-
(2013)
J. Proteomics
, vol.92
, pp. 195-203
-
-
Doulias, P.T.1
Tenopoulou, M.2
Raju, K.3
Spruce, L.A.4
Seeholzer, S.H.5
Ischiropoulos, H.6
-
131
-
-
47049115757
-
Nitric oxide, N[omega]-hydroxy-l-arginine and breast cancer
-
S. Pervin, R. Singh, and G. Chaudhuri Nitric oxide, N[omega]-hydroxy-l-arginine and breast cancer Nitric Oxide 19 2008 103 106
-
(2008)
Nitric Oxide
, vol.19
, pp. 103-106
-
-
Pervin, S.1
Singh, R.2
Chaudhuri, G.3
-
132
-
-
47049128882
-
Molecular mechanisms for discrete nitric oxide levels in cancer
-
L.A. Ridnour, D.D. Thomas, C. Switzer, W. Flores-Santana, J.S. Isenberg, S. Ambs, D.D. Roberts, and D.A. Wink Molecular mechanisms for discrete nitric oxide levels in cancer Nitric Oxide 19 2008 73 76
-
(2008)
Nitric Oxide
, vol.19
, pp. 73-76
-
-
Ridnour, L.A.1
Thomas, D.D.2
Switzer, C.3
Flores-Santana, W.4
Isenberg, J.S.5
Ambs, S.6
Roberts, D.D.7
Wink, D.A.8
-
133
-
-
45049084732
-
The chemical biology of nitric oxide: Implications in cellular signaling
-
D.D. Thomas, L.A. Ridnour, J.S. Isenberg, W. Flores-Santana, C.H. Switzer, S. Donzelli, P. Hussain, C. Vecoli, N. Paolocci, S. Ambs, C.A. Colton, C.C. Harris, D.D. Roberts, and D.A. Wink The chemical biology of nitric oxide: implications in cellular signaling Free Radic. Biol. Med. 45 2008 18 31
-
(2008)
Free Radic. Biol. Med.
, vol.45
, pp. 18-31
-
-
Thomas, D.D.1
Ridnour, L.A.2
Isenberg, J.S.3
Flores-Santana, W.4
Switzer, C.H.5
Donzelli, S.6
Hussain, P.7
Vecoli, C.8
Paolocci, N.9
Ambs, S.10
Colton, C.A.11
Harris, C.C.12
Roberts, D.D.13
Wink, D.A.14
-
134
-
-
33746813720
-
The biphasic nature of nitric oxide responses in tumor biology
-
L.A. Ridnour, D.D. Thomas, S. Donzelli, M.G. Espey, D.D. Roberts, D.A. Wink, and J.S. Isenberg The biphasic nature of nitric oxide responses in tumor biology Antioxid. Redox Signal. 8 2006 1329 1337
-
(2006)
Antioxid. Redox Signal.
, vol.8
, pp. 1329-1337
-
-
Ridnour, L.A.1
Thomas, D.D.2
Donzelli, S.3
Espey, M.G.4
Roberts, D.D.5
Wink, D.A.6
Isenberg, J.S.7
-
136
-
-
2942665472
-
Hypoxic inducible factor 1a, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide
-
D.D. Thomas, M.G. Espey, L.A. Ridnour, L.J. Hofseth, D. Mancardi, C.C. Harris, and D.A. Wink Hypoxic inducible factor 1a, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide Proc. Natl. Acad. Sci. USA 101 2004 8894 8899
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 8894-8899
-
-
Thomas, D.D.1
Espey, M.G.2
Ridnour, L.A.3
Hofseth, L.J.4
Mancardi, D.5
Harris, C.C.6
Wink, D.A.7
-
137
-
-
33846416533
-
Nitric oxide in physiologic concentrations targets the translational machinery to increase the proliferation of human breast cancer cells: Involvement of mammalian target of rapamycin/eIF4E pathway
-
S. Pervin, R. Singh, E. Hernandez, G. Wu, and G. Chaudhuri Nitric oxide in physiologic concentrations targets the translational machinery to increase the proliferation of human breast cancer cells: involvement of mammalian target of rapamycin/eIF4E pathway Cancer Res. 67 2007 289 299
-
(2007)
Cancer Res.
, vol.67
, pp. 289-299
-
-
Pervin, S.1
Singh, R.2
Hernandez, E.3
Wu, G.4
Chaudhuri, G.5
-
138
-
-
0042093606
-
Nitric oxide-mediated promotion of mammary tumour cell migration requires sequential activation of nitric oxide synthase, guanylate cyclase and mitogen-activated protein kinase
-
L.C. Jadeski, C. Chakraborty, and P.K. Lala Nitric oxide-mediated promotion of mammary tumour cell migration requires sequential activation of nitric oxide synthase, guanylate cyclase and mitogen-activated protein kinase Int. J. Cancer 106 2003 496 504
-
(2003)
Int. J. Cancer
, vol.106
, pp. 496-504
-
-
Jadeski, L.C.1
Chakraborty, C.2
Lala, P.K.3
-
140
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
G.L. Semenza Targeting HIF-1 for cancer therapy Nat. Rev. Cancer 3 2003 721 732
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
141
-
-
84866042262
-
Nitric oxide synthase and breast cancer: Role of TIMP-1 in NO-mediated Akt activation
-
e44081 2012
-
L.A. Ridnour, K.M. Barasch, A.N. Windhausen, T.H. Dorsey, M.M. Lizardo, H.G. Yfantis, D.H. Lee, C.H. Switzer, R.Y. Cheng, J.L. Heinecke, E. Brueggemann, H.B. Hines, C. Khanna, S.A. Glynn, S. Ambs, and D.A. Wink Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation PLoS. One 7 2012 e44081 2012
-
(2012)
PLoS. One
, vol.7
-
-
Ridnour, L.A.1
Barasch, K.M.2
Windhausen, A.N.3
Dorsey, T.H.4
Lizardo, M.M.5
Yfantis, H.G.6
Lee, D.H.7
Switzer, C.H.8
Cheng, R.Y.9
Heinecke, J.L.10
Brueggemann, E.11
Hines, H.B.12
Khanna, C.13
Glynn, S.A.14
Ambs, S.15
Wink, D.A.16
-
142
-
-
84866022996
-
Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer
-
C. Switzer, R. Cheng, L. Ridnour, S. Glynn, S. Ambs, and D. Wink Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer Breast Cancer Res. 14 2012 R125
-
(2012)
Breast Cancer Res.
, vol.14
, pp. R125
-
-
Switzer, C.1
Cheng, R.2
Ridnour, L.3
Glynn, S.4
Ambs, S.5
Wink, D.6
-
143
-
-
84866497973
-
S-Nitrosylation of EGFR and Src activates an oncogenic signaling network in human basal-like breast cancer
-
C.H. Switzer, S.A. Glynn, R.Y.S. Cheng, L.A. Ridnour, J.E. Green, S. Ambs, and D.A. Wink S-Nitrosylation of EGFR and Src activates an oncogenic signaling network in human basal-like breast cancer Mol. Cancer Res. 10 2012 1203 1215
-
(2012)
Mol. Cancer Res.
, vol.10
, pp. 1203-1215
-
-
Switzer, C.H.1
Glynn, S.A.2
Cheng, R.Y.S.3
Ridnour, L.A.4
Green, J.E.5
Ambs, S.6
Wink, D.A.7
-
145
-
-
1242321336
-
The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations
-
L.A. Ridnour, D.D. Thomas, D. Mancardi, M.G. Espey, K.M. Miranda, N. Paolocci, M. Feelisch, J. Fukuto, and D.A. Wink The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations Biol. Chem. 385 2004 1 10
-
(2004)
Biol. Chem.
, vol.385
, pp. 1-10
-
-
Ridnour, L.A.1
Thomas, D.D.2
Mancardi, D.3
Espey, M.G.4
Miranda, K.M.5
Paolocci, N.6
Feelisch, M.7
Fukuto, J.8
Wink, D.A.9
-
146
-
-
0346059592
-
MKP-1-induced dephosphorylation of extracellular signal-regulated kinase is essential for triggering nitric oxide-induced apoptosis in human breast cancer cell lines: Implications in breast cancer
-
S. Pervin, R. Singh, W.A. Freije, and G. Chaudhuri MKP-1-induced dephosphorylation of extracellular signal-regulated kinase is essential for triggering nitric oxide-induced apoptosis in human breast cancer cell lines: implications in breast cancer Cancer Res. 63 2003 8853 8860
-
(2003)
Cancer Res.
, vol.63
, pp. 8853-8860
-
-
Pervin, S.1
Singh, R.2
Freije, W.A.3
Chaudhuri, G.4
-
147
-
-
0024584020
-
Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells
-
D.J. Stuehr, and C.F. Nathan Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells J. Exp. Med. 169 1989 1543 1555
-
(1989)
J. Exp. Med.
, vol.169
, pp. 1543-1555
-
-
Stuehr, D.J.1
Nathan, C.F.2
-
148
-
-
70349509861
-
Nitric oxide induces cell death by regulating anti-apoptotic BCL-2 family members
-
e7059 2009
-
C.M. Snyder, E.H. Shroff, J. Liu, and N.S. Chandel Nitric oxide induces cell death by regulating anti-apoptotic BCL-2 family members PLoS One 4 2009 e7059 2009
-
(2009)
PLoS One
, vol.4
-
-
Snyder, C.M.1
Shroff, E.H.2
Liu, J.3
Chandel, N.S.4
-
149
-
-
0027980511
-
Quenching of the tyrosyl free radical of ribonucleotide reductase by nitric oxide. Relationship to cytostasis induced in tumor cells by cytotoxic macrophages
-
M. Lepoivre, J.M. Flaman, P. Bobe, G. Lemaire, and Y. Henry Quenching of the tyrosyl free radical of ribonucleotide reductase by nitric oxide. Relationship to cytostasis induced in tumor cells by cytotoxic macrophages J. Biol. Chem. 269 1994 21891 21897
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 21891-21897
-
-
Lepoivre, M.1
Flaman, J.M.2
Bobe, P.3
Lemaire, G.4
Henry, Y.5
-
150
-
-
0031845632
-
The multifaced roles of nitric oxide in cancer
-
D.A. Wink, Y. Vodovotz, J. Laval, F. Laval, M.W. Dewhirst, and J.B. Mitchell The multifaced roles of nitric oxide in cancer Carcinogenesis 19 1998 711 721
-
(1998)
Carcinogenesis
, vol.19
, pp. 711-721
-
-
Wink, D.A.1
Vodovotz, Y.2
Laval, J.3
Laval, F.4
Dewhirst, M.W.5
Mitchell, J.B.6
-
151
-
-
33748746776
-
Superoxide fluxes limit nitric oxide-induced signaling
-
D.D. Thomas, L.A. Ridnour, M.G. Espey, S. Donzelli, S. Ambs, S.P. Hussain, C.C. Harris, W. DeGraff, D.D. Roberts, J.B. Mitchell, and D.A. Wink Superoxide fluxes limit nitric oxide-induced signaling J. Biol. Chem. 281 2006 25984 25993
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 25984-25993
-
-
Thomas, D.D.1
Ridnour, L.A.2
Espey, M.G.3
Donzelli, S.4
Ambs, S.5
Hussain, S.P.6
Harris, C.C.7
Degraff, W.8
Roberts, D.D.9
Mitchell, J.B.10
Wink, D.A.11
-
152
-
-
77953384917
-
Redox regulation in cancer: A double-edged sword with therapeutic potential
-
A. Acharya, I. Das, D. Chandhok, and T. Saha Redox regulation in cancer: a double-edged sword with therapeutic potential Oxid. Med. Cell Longev 3 2010 23 34
-
(2010)
Oxid. Med. Cell Longev
, vol.3
, pp. 23-34
-
-
Acharya, A.1
Das, I.2
Chandhok, D.3
Saha, T.4
-
153
-
-
14044250858
-
The intimate relation between nitric oxide and superoxide in apoptosis and cell survival
-
B. Brune The intimate relation between nitric oxide and superoxide in apoptosis and cell survival Antioxid. Redox Signal. 7 2005 497 507
-
(2005)
Antioxid. Redox Signal.
, vol.7
, pp. 497-507
-
-
Brune, B.1
-
154
-
-
39749113294
-
The interaction of superoxide with nitric oxide destabilizes hypoxia-inducible factor-1a
-
B. Herr, J. Zhou, S. Drsoe, and B. Brnne The interaction of superoxide with nitric oxide destabilizes hypoxia-inducible factor-1a Cell. Mol. Life Sci. 64 2007 3295 3305
-
(2007)
Cell. Mol. Life Sci.
, vol.64
, pp. 3295-3305
-
-
Herr, B.1
Zhou, J.2
Drsoe, S.3
Brnne, B.4
-
155
-
-
84923262417
-
Nitric oxide effect on naphthoquinone toxicity in endothelial cells: Role of bioenergetic dysfunction and PARP activation
-
K.A. Broniowska, A.R. Diers, J.A. Corbett, and N. Hogg Nitric oxide effect on naphthoquinone toxicity in endothelial cells: role of bioenergetic dysfunction and PARP activation Biochemistry 2013
-
(2013)
Biochemistry
-
-
Broniowska, K.A.1
Diers, A.R.2
Corbett, J.A.3
Hogg, N.4
-
156
-
-
65949116548
-
5.2 Nitric oxide in regulation of mitochondrial function, respiration, and glycolysis
-
A. Lajtha, G. Gibson, G. Dienel, Springer US
-
J.P. Bolanos, and A. Almeida 5.2 Nitric oxide in regulation of mitochondrial function, respiration, and glycolysis A. Lajtha, G. Gibson, G. Dienel, Handbook of neurochemistry and molecular neurobiology 2007 Springer US 487 517
-
(2007)
Handbook of Neurochemistry and Molecular Neurobiology
, pp. 487-517
-
-
Bolanos, J.P.1
Almeida, A.2
-
157
-
-
33746941255
-
Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates
-
W.S. Jobgen, S.K. Fried, W.J. Fu, C.J. Meininger, and G. Wu Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates J. Nutr. Biochem. 17 2006 571 588
-
(2006)
J. Nutr. Biochem.
, vol.17
, pp. 571-588
-
-
Jobgen, W.S.1
Fried, S.K.2
Fu, W.J.3
Meininger, C.J.4
Wu, G.5
-
158
-
-
33745039466
-
Nitric oxide, cell bioenergetics and neurodegeneration
-
S. Moncada, and J.P. Bolanos Nitric oxide, cell bioenergetics and neurodegeneration J. Neurochem. 97 2006 1676 1689
-
(2006)
J. Neurochem.
, vol.97
, pp. 1676-1689
-
-
Moncada, S.1
Bolanos, J.P.2
-
159
-
-
0032947296
-
Nitric oxide and mitochondrial respiration
-
G.C. Brown Nitric oxide and mitochondrial respiration Biochim. Biophys. Acta Bioenerg 1411 1999 351 369
-
(1999)
Biochim. Biophys. Acta Bioenerg
, vol.1411
, pp. 351-369
-
-
Brown, G.C.1
-
160
-
-
34250700076
-
Nitric oxide and mitochondrial respiration in the heart
-
G.C. Brown, and V. Borutaite Nitric oxide and mitochondrial respiration in the heart Cardiovasc. Res. 75 2007 283 290
-
(2007)
Cardiovasc. Res.
, vol.75
, pp. 283-290
-
-
Brown, G.C.1
Borutaite, V.2
-
161
-
-
77950815689
-
Nitration of specific tyrosines in FoF1 ATP synthase and activity loss in aging
-
V. Haynes, N.J. Traaseth, S. Elfering, Y. Fujisawa, and C. Giulivi Nitration of specific tyrosines in FoF1 ATP synthase and activity loss in aging Am. J. Physiol. Endocrinol. Metab. 298 2010 E978 E987
-
(2010)
Am. J. Physiol. Endocrinol. Metab.
, vol.298
, pp. E978-E987
-
-
Haynes, V.1
Traaseth, N.J.2
Elfering, S.3
Fujisawa, Y.4
Giulivi, C.5
-
162
-
-
0035834101
-
Proteomic method identifies proteins nitrated in vivo during inflammatory challenge
-
K.S. Aulak, M. Miyagi, L. Yan, K.A. West, D. Massillon, J.W. Crabb, and D.J. Stuehr Proteomic method identifies proteins nitrated in vivo during inflammatory challenge Proc. Natl. Acad. Sci. USA 98 2001 12056 12061
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 12056-12061
-
-
Aulak, K.S.1
Miyagi, M.2
Yan, L.3
West, K.A.4
Massillon, D.5
Crabb, J.W.6
Stuehr, D.J.7
-
163
-
-
55549123029
-
Protein tyrosine nitration of the flavin subunit is associated with oxidative modification of mitochondrial complex ii in the post-ischemic myocardium
-
C.L. Chen, J. Chen, S. Rawale, S. Varadharaj, P.P.T. Kaumaya, J.L. Zweier, and Y.R. Chen Protein tyrosine nitration of the flavin subunit is associated with oxidative modification of mitochondrial complex ii in the post-ischemic myocardium J. Biol. Chem. 283 2008 27991 28003
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 27991-28003
-
-
Chen, C.L.1
Chen, J.2
Rawale, S.3
Varadharaj, S.4
Kaumaya, P.P.T.5
Zweier, J.L.6
Chen, Y.R.7
-
164
-
-
84864601291
-
Selective vulnerability of synaptic signaling and metabolism to nitrosative stress
-
A.A. Mongin, P. Dohare, and D. Jourd'heuil Selective vulnerability of synaptic signaling and metabolism to nitrosative stress Antioxid. Redox Signal. 17 2012 992 1012
-
(2012)
Antioxid. Redox Signal.
, vol.17
, pp. 992-1012
-
-
Mongin, A.A.1
Dohare, P.2
Jourd'Heuil, D.3
-
165
-
-
59549106445
-
Proteomic analysis of protein tyrosine nitration after ischemia reperfusion injury: Mitochondria as the major target
-
B. Liu, A.K. Tewari, L. Zhang, K.B. Green-Church, J.L. Zweier, Y.R. Chen, and G. He Proteomic analysis of protein tyrosine nitration after ischemia reperfusion injury: mitochondria as the major target Biochim. Biophys. Acta Proteins Proteomics 1794 2009 476 485
-
(2009)
Biochim. Biophys. Acta Proteins Proteomics
, vol.1794
, pp. 476-485
-
-
Liu, B.1
Tewari, A.K.2
Zhang, L.3
Green-Church, K.B.4
Zweier, J.L.5
Chen, Y.R.6
He, G.7
-
166
-
-
0029161636
-
Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase
-
G.C. Brown Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase FEBS Lett. 369 1995 136 139
-
(1995)
FEBS Lett.
, vol.369
, pp. 136-139
-
-
Brown, G.C.1
-
168
-
-
0028134892
-
Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase
-
G.C. Brown, and C.E. Cooper Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase FEBS Lett. 356 1994 295 298
-
(1994)
FEBS Lett.
, vol.356
, pp. 295-298
-
-
Brown, G.C.1
Cooper, C.E.2
-
169
-
-
0033573981
-
On the mechanism by which vascular endothelial cells regulate their oxygen consumption
-
E. Clementi, G.C. Brown, N. Foxwell, and S. Moncada On the mechanism by which vascular endothelial cells regulate their oxygen consumption Proc. Natl. Acad. Sci. USA 96 1999 1559 1562
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 1559-1562
-
-
Clementi, E.1
Brown, G.C.2
Foxwell, N.3
Moncada, S.4
-
170
-
-
0027945838
-
Nitric oxide potently and reversibly deenergizes mitochondria at low oxygen tension
-
M. Schweizer, and C. Richter Nitric oxide potently and reversibly deenergizes mitochondria at low oxygen tension Biochem. Biophys. Res. Commun. 204 1994 169 175
-
(1994)
Biochem. Biophys. Res. Commun.
, vol.204
, pp. 169-175
-
-
Schweizer, M.1
Richter, C.2
-
171
-
-
31444433077
-
Nitric oxide inhibition of respiration involves both competitive (heme) and noncompetitive (copper) binding to cytochrome c oxidase
-
M.G. Mason, P. Nicholls, M.T. Wilson, and C.E. Cooper Nitric oxide inhibition of respiration involves both competitive (heme) and noncompetitive (copper) binding to cytochrome c oxidase Proc. Natl. Acad. Sci. USA 103 2006 708 713
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 708-713
-
-
Mason, M.G.1
Nicholls, P.2
Wilson, M.T.3
Cooper, C.E.4
-
172
-
-
2442664117
-
Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase
-
M. Palacios-Callender, M. Quintero, V.S. Hollis, R.J. Springett, and S. Moncada Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase Proc. Natl. Acad. Sci. USA 101 2004 7630 7635
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 7630-7635
-
-
Palacios-Callender, M.1
Quintero, M.2
Hollis, V.S.3
Springett, R.J.4
Moncada, S.5
-
173
-
-
0041856216
-
Control of mitochondrial respiration by NO. Effects of low oxygen and respiratory state
-
P.S. Brookes, D.W. Kraus, S. Shiva, J.E. Doeller, M.C. Barone, R.P. Patel, J.R. Lancaster Jr, and V. Darley-Usmar Control of mitochondrial respiration by NO. Effects of low oxygen and respiratory state J. Biol. Chem. 278 2003 31603 31609
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 31603-31609
-
-
Brookes, P.S.1
Kraus, D.W.2
Shiva, S.3
Doeller, J.E.4
Barone, M.C.5
Patel, R.P.6
Lancaster, Jr.J.R.7
Darley-Usmar, V.8
-
174
-
-
0347622940
-
Competitive, reversible, physiological? Inhibition of mitochondrial cytochrome oxidase by nitric oxide
-
C. Cooper Competitive, reversible, physiological? Inhibition of mitochondrial cytochrome oxidase by nitric oxide IUBMB Life 55 2003 591 597
-
(2003)
IUBMB Life
, vol.55
, pp. 591-597
-
-
Cooper, C.1
-
175
-
-
15444372431
-
Nitric oxide-induced persistent inhibition and nitrosylation of active site cysteine residues of mitochondrial cytochrome-c oxidase in lung endothelial cells
-
J. Zhang, B. Jin, L. Li, E.R. Block, and J.M. Patel Nitric oxide-induced persistent inhibition and nitrosylation of active site cysteine residues of mitochondrial cytochrome-c oxidase in lung endothelial cells Am. J. Physiol. Cell Physiol 288 2005 C840 C849
-
(2005)
Am. J. Physiol. Cell Physiol
, vol.288
, pp. C840-C849
-
-
Zhang, J.1
Jin, B.2
Li, L.3
Block, E.R.4
Patel, J.M.5
-
176
-
-
77249126523
-
Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species
-
B.P. Dranka, B.G. Hill, and V.M. Darley-Usmar Mitochondrial reserve capacity in endothelial cells: the impact of nitric oxide and reactive oxygen species Free Radic. Biol. Med. 48 2010 905 914
-
(2010)
Free Radic. Biol. Med.
, vol.48
, pp. 905-914
-
-
Dranka, B.P.1
Hill, B.G.2
Darley-Usmar, V.M.3
-
177
-
-
0346458616
-
Chronic exposure to nitric oxide alters the free iron pool in endothelial cells: Role of mitochondrial respiratory complexes and heat shock proteins
-
A. Ramachandran, E. Ceaser, and V.M. Darley-Usmar Chronic exposure to nitric oxide alters the free iron pool in endothelial cells: role of mitochondrial respiratory complexes and heat shock proteins Proc. Natl. Acad. Sci. USA 101 2004 384 389
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 384-389
-
-
Ramachandran, A.1
Ceaser, E.2
Darley-Usmar, V.M.3
-
178
-
-
33644992047
-
Direct evidence for S-nitrosation of mitochondrial complex i
-
L.S. Burwell, S.M. Nadtochiy, A.J. Tompkins, S. Young, and P.S. Brookes Direct evidence for S-nitrosation of mitochondrial complex I Biochem. J. 394 2006 627 634
-
(2006)
Biochem. J.
, vol.394
, pp. 627-634
-
-
Burwell, L.S.1
Nadtochiy, S.M.2
Tompkins, A.J.3
Young, S.4
Brookes, P.S.5
-
179
-
-
0032560572
-
Persistant inhibition of cell respiration by nitric oxide: Crucial role of S-nitrosylation of mitochondrial complex i and protective action of glutathione
-
E. Clementi, G.C. Brown, M. Feelisch, and S. Moncada Persistant inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione Proc. Natl. Acad. Sci. USA 95 1998 7631 7636
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 7631-7636
-
-
Clementi, E.1
Brown, G.C.2
Feelisch, M.3
Moncada, S.4
-
180
-
-
0036169830
-
Selective nitration of mitochondrial complex i by peroxynitrite: Involvement in mitochondria dysfunction and cell death of dopaminergic SH-SY5Y cells
-
T. Yamamoto, W. Maruyama, Y. Kato, H. Yi, M. Shamoto-Nagai, M. Tanaka, Y. Sato, and M. Naoi Selective nitration of mitochondrial complex I by peroxynitrite: involvement in mitochondria dysfunction and cell death of dopaminergic SH-SY5Y cells J. Neural Transm. 109 2002 1 13
-
(2002)
J. Neural Transm.
, vol.109
, pp. 1-13
-
-
Yamamoto, T.1
Maruyama, W.2
Kato, Y.3
Yi, H.4
Shamoto-Nagai, M.5
Tanaka, M.6
Sato, Y.7
Naoi, M.8
-
181
-
-
0035477926
-
Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formation
-
N.A. Riobo, E. Clementi, M. Melani, A. Boveris, E. Cadenas, S. Moncada, and J.J. Poderoso Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formation Biochem. J. 359 2001 139 145
-
(2001)
Biochem. J.
, vol.359
, pp. 139-145
-
-
Riobo, N.A.1
Clementi, E.2
Melani, M.3
Boveris, A.4
Cadenas, E.5
Moncada, S.6
Poderoso, J.J.7
-
182
-
-
12344335535
-
Hypoxia accelerates nitric oxide-dependent inhibition of mitochondrial complex i in activated macrophages
-
M.T. Frost, Q. Wang, S. Moncada, and M. Singer Hypoxia accelerates nitric oxide-dependent inhibition of mitochondrial complex I in activated macrophages Am. J. Physiol. Regul. Integr. Comp. Physiol 288 2005 R394 R400
-
(2005)
Am. J. Physiol. Regul. Integr. Comp. Physiol
, vol.288
, pp. R394-R400
-
-
Frost, M.T.1
Wang, Q.2
Moncada, S.3
Singer, M.4
-
183
-
-
0030200037
-
The effects of nitric oxide on electron transport complexes
-
R. Welter, L. Yu, and C.A. Yu The effects of nitric oxide on electron transport complexes Arch. Biochem. Biophys. 331 1996 9 14
-
(1996)
Arch. Biochem. Biophys.
, vol.331
, pp. 9-14
-
-
Welter, R.1
Yu, L.2
Yu, C.A.3
-
184
-
-
0029986691
-
Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles
-
J.J. Poderoso, M.C. Carreras, C. Lisdero, N. Riobo, F. Schopfer, and A. Boveris Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles Arch. Biochem. Biophys. 328 1996 85 92
-
(1996)
Arch. Biochem. Biophys.
, vol.328
, pp. 85-92
-
-
Poderoso, J.J.1
Carreras, M.C.2
Lisdero, C.3
Riobo, N.4
Schopfer, F.5
Boveris, A.6
-
185
-
-
67649757115
-
A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury
-
T.A. Prime, F.H. Blaikie, C. Evans, S.M. Nadtochiy, A.M. James, C.C. Dahm, D.A. Vitturi, R.P. Patel, C.R. Hiley, I. Abakumova, R. Requejo, E.T. Chouchani, T.R. Hurd, J.F. Garvey, C.T. Taylor, P.S. Brookes, R.A. Smith, and M.P. Murphy A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury Proc. Natl. Acad. Sci. USA 106 2009 10764 10769
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 10764-10769
-
-
Prime, T.A.1
Blaikie, F.H.2
Evans, C.3
Nadtochiy, S.M.4
James, A.M.5
Dahm, C.C.6
Vitturi, D.A.7
Patel, R.P.8
Hiley, C.R.9
Abakumova, I.10
Requejo, R.11
Chouchani, E.T.12
Hurd, T.R.13
Garvey, J.F.14
Taylor, C.T.15
Brookes, P.S.16
Smith, R.A.17
Murphy, M.P.18
-
186
-
-
34548412578
-
Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer
-
S. Shiva, M.N. Sack, J.J. Greer, M. Duranski, L.A. Ringwood, L. Burwell, X. Wang, P.H. Macarthur, A. Shoja, N. Raghavachari, J.W. Calvert, P.S. Brookes, D.J. Lefer, and M.T. Gladwin Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer J. Exp. Med. 2007
-
(2007)
J. Exp. Med.
-
-
Shiva, S.1
Sack, M.N.2
Greer, J.J.3
Duranski, M.4
Ringwood, L.A.5
Burwell, L.6
Wang, X.7
Macarthur, P.H.8
Shoja, A.9
Raghavachari, N.10
Calvert, J.W.11
Brookes, P.S.12
Lefer, D.J.13
Gladwin, M.T.14
-
188
-
-
0022461970
-
Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible
-
J.C. Drapier, and J.B. Hibbs Jr. Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible J. Clin. Invest. 78 1986 790 797
-
(1986)
J. Clin. Invest.
, vol.78
, pp. 790-797
-
-
Drapier, J.C.1
Hibbs, Jr.J.B.2
-
189
-
-
0028090219
-
Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide
-
L. Castro, M. Rodriguez, and R. Radi Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide J. Biol. Chem. 269 1994 29409 29415
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 29409-29415
-
-
Castro, L.1
Rodriguez, M.2
Radi, R.3
-
190
-
-
33847658682
-
Mitochondrial aconitase reaction with nitric oxide, S-nitrosoglutathione, and peroxynitrite: Mechanisms and relative contributions to aconitase inactivation
-
V. Tortora, C. Quijano, B. Freeman, R. Radi, and L. Castro Mitochondrial aconitase reaction with nitric oxide, S-nitrosoglutathione, and peroxynitrite: mechanisms and relative contributions to aconitase inactivation Free Radic. Biol. Med. 42 2007 1075 1088
-
(2007)
Free Radic. Biol. Med.
, vol.42
, pp. 1075-1088
-
-
Tortora, V.1
Quijano, C.2
Freeman, B.3
Radi, R.4
Castro, L.5
-
191
-
-
24644469955
-
Sites and mechanisms of aconitase inactivation by peroxynitrite: Modulation by citrate and glutathione
-
D. Han, R. Canali, J. Garcia, R. Aguilera, T.K. Gallaher, and E. Cadenas Sites and mechanisms of aconitase inactivation by peroxynitrite: modulation by citrate and glutathione Biochemistry 44 2005 11986 11996
-
(2005)
Biochemistry
, vol.44
, pp. 11986-11996
-
-
Han, D.1
Canali, R.2
Garcia, J.3
Aguilera, R.4
Gallaher, T.K.5
Cadenas, E.6
-
193
-
-
77955492720
-
Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): Implications for the regulation of mitochondrial function by reversible S-nitrosation
-
E.T. Chouchani, T.R. Hurd, S.M. Nadtochiy, P.S. Brookes, I.M. Fearnley, K.S. Lilley, R.A. Smith, and M.P. Murphy Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation Biochem. J. 430 2010 49 59
-
(2010)
Biochem. J.
, vol.430
, pp. 49-59
-
-
Chouchani, E.T.1
Hurd, T.R.2
Nadtochiy, S.M.3
Brookes, P.S.4
Fearnley, I.M.5
Lilley, K.S.6
Smith, R.A.7
Murphy, M.P.8
-
194
-
-
0036803015
-
Inactivation of NADP+-dependent isocitrate dehydrogenase by nitric oxide
-
E.S. Yang, C. Richter, J.S. Chun, T.L. Huh, S.S. Kang, and J.W. Park Inactivation of NADP+-dependent isocitrate dehydrogenase by nitric oxide Free Radic. Biol. Med. 33 2002 927 937
-
(2002)
Free Radic. Biol. Med.
, vol.33
, pp. 927-937
-
-
Yang, E.S.1
Richter, C.2
Chun, J.S.3
Huh, T.L.4
Kang, S.S.5
Park, J.W.6
-
195
-
-
79955973551
-
Inactivation and reactivation of the mitochondrial alpha-ketoglutarate dehydrogenase complex
-
Q. Shi, H. Xu, H. Yu, N. Zhang, Y. Ye, A.G. Estevez, H. Deng, and G.E. Gibson Inactivation and reactivation of the mitochondrial alpha-ketoglutarate dehydrogenase complex J. Biol. Chem. 286 2011 17640 17648
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 17640-17648
-
-
Shi, Q.1
Xu, H.2
Yu, H.3
Zhang, N.4
Ye, Y.5
Estevez, A.G.6
Deng, H.7
Gibson, G.E.8
-
197
-
-
0038494557
-
Nitric oxide signaling regulates mitochondrial number and function
-
E. Bossy-Wetzel, and S.A. Lipton Nitric oxide signaling regulates mitochondrial number and function Cell Death Differ. 10 2003 757 760
-
(2003)
Cell Death Differ.
, vol.10
, pp. 757-760
-
-
Bossy-Wetzel, E.1
Lipton, S.A.2
-
198
-
-
26844558334
-
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
-
E. Nisoli, C. Tonello, A. Cardile, V. Cozzi, R. Bracale, L. Tedesco, S. Falcone, A. Valerio, O. Cantoni, E. Clementi, S. Moncada, and M.O. Carruba Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS Science 310 2005 314 317
-
(2005)
Science
, vol.310
, pp. 314-317
-
-
Nisoli, E.1
Tonello, C.2
Cardile, A.3
Cozzi, V.4
Bracale, R.5
Tedesco, L.6
Falcone, S.7
Valerio, A.8
Cantoni, O.9
Clementi, E.10
Moncada, S.11
Carruba, M.O.12
-
199
-
-
0347579845
-
Mitochondrial biogenesis in mammals: The role of endogenous nitric oxide
-
E. Nisoli, E. Clementi, C. Paolucci, V. Cozzi, C. Tonello, C. Sciorati, R. Bracale, A. Valerio, M. Francolini, S. Moncada, and M.O. Carruba Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide Science 299 2003 896 899
-
(2003)
Science
, vol.299
, pp. 896-899
-
-
Nisoli, E.1
Clementi, E.2
Paolucci, C.3
Cozzi, V.4
Tonello, C.5
Sciorati, C.6
Bracale, R.7
Valerio, A.8
Francolini, M.9
Moncada, S.10
Carruba, M.O.11
-
200
-
-
26644471251
-
Nitric oxide and mitochondrial biogenesis: A key to long-term regulation of cellular metabolism
-
E. Clementi, and E. Nisoli Nitric oxide and mitochondrial biogenesis: a key to long-term regulation of cellular metabolism Comp. Biochem. Physiol. A Mol. Integr. Physiol 142 2005 102 110
-
(2005)
Comp. Biochem. Physiol. A Mol. Integr. Physiol
, vol.142
, pp. 102-110
-
-
Clementi, E.1
Nisoli, E.2
-
201
-
-
77956722579
-
Nitric oxide and AMPK cooperatively regulate PGC-1a in skeletal muscle cells
-
V.A. Lira, D.L. Brown, A.K. Lira, A.N. Kavazis, Q.A. Soltow, E.H. Zeanah, and D.S. Criswell Nitric oxide and AMPK cooperatively regulate PGC-1a in skeletal muscle cells J. Physiol. 588 2010 3551 3566
-
(2010)
J. Physiol.
, vol.588
, pp. 3551-3566
-
-
Lira, V.A.1
Brown, D.L.2
Lira, A.K.3
Kavazis, A.N.4
Soltow, Q.A.5
Zeanah, E.H.6
Criswell, D.S.7
-
202
-
-
77949615815
-
Central role of nitric oxide synthase in AICAR and caffeine-induced mitochondrial biogenesis in L6 myocytes
-
G.K. McConell, G.P.Y. Ng, M. Phillips, Z. Ruan, S.L. Macaulay, and G.D. Wadley Central role of nitric oxide synthase in AICAR and caffeine-induced mitochondrial biogenesis in L6 myocytes J. Appl. Physiol. 108 2010 589 595
-
(2010)
J. Appl. Physiol.
, vol.108
, pp. 589-595
-
-
McConell, G.K.1
Ng, G.P.Y.2
Phillips, M.3
Ruan, Z.4
Macaulay, S.L.5
Wadley, G.D.6
-
203
-
-
34547545892
-
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha
-
S. Jager, C. Handschin, J. Pierre, and B.M. Spiegelman AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha Proc. Natl. Acad. Sci. USA 104 2007 12017 12022
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 12017-12022
-
-
Jager, S.1
Handschin, C.2
Pierre, J.3
Spiegelman, B.M.4
-
204
-
-
67650882500
-
AMPKalpha1 regulates the antioxidant status of vascular endothelial cells
-
S.L. Colombo, and S. Moncada AMPKalpha1 regulates the antioxidant status of vascular endothelial cells Biochem. J. 421 2009 163 169
-
(2009)
Biochem. J.
, vol.421
, pp. 163-169
-
-
Colombo, S.L.1
Moncada, S.2
-
205
-
-
31544473721
-
Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1alpha in cancer: Role of free radical formation
-
M. Quintero, P.A. Brennan, G.J. Thomas, and S. Moncada Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1alpha in cancer: role of free radical formation Cancer Res. 66 2006 770 774
-
(2006)
Cancer Res.
, vol.66
, pp. 770-774
-
-
Quintero, M.1
Brennan, P.A.2
Thomas, G.J.3
Moncada, S.4
-
206
-
-
6344292389
-
Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo: Role of mitochondrial reactive nitrogen species
-
M.H. Zou, S.S. Kirkpatrick, B.J. Davis, J.S. Nelson, W.G. Wiles, U. Schlattner, D. Neumann, M. Brownlee, M.B. Freeman, and M.H. Goldman Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo: role of mitochondrial reactive nitrogen species J. Biol. Chem. 279 2004 43940 43951
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 43940-43951
-
-
Zou, M.H.1
Kirkpatrick, S.S.2
Davis, B.J.3
Nelson, J.S.4
Wiles, W.G.5
Schlattner, U.6
Neumann, D.7
Brownlee, M.8
Freeman, M.B.9
Goldman, M.H.10
-
207
-
-
0141706665
-
Activation of 5′-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells: Role of peroxynitrite
-
M.H. Zou, X.Y. Hou, C.M. Shi, S. Kirkpatick, F. Liu, M.H. Goldman, and R.A. Cohen Activation of 5′-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells: role of peroxynitrite J. Biol. Chem. 278 2003 34003 34010
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 34003-34010
-
-
Zou, M.H.1
Hou, X.Y.2
Shi, C.M.3
Kirkpatick, S.4
Liu, F.5
Goldman, M.H.6
Cohen, R.A.7
-
208
-
-
10944237677
-
Inhibition of mitochondrial respiration by nitric oxide rapidly stimulates cytoprotective GLUT3-mediated glucose uptake through 5′-AMP-activated protein kinase
-
P. Cidad, A. Almeida, and J.P. Bolanos Inhibition of mitochondrial respiration by nitric oxide rapidly stimulates cytoprotective GLUT3-mediated glucose uptake through 5′-AMP-activated protein kinase Biochem. J. 384 2004 629 636
-
(2004)
Biochem. J.
, vol.384
, pp. 629-636
-
-
Cidad, P.1
Almeida, A.2
Bolanos, J.P.3
-
209
-
-
1342310736
-
Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway
-
A. Almeida, S. Moncada, and J.P. Bolanos Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway Nat. Cell Biol. 6 2004 45 51
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 45-51
-
-
Almeida, A.1
Moncada, S.2
Bolanos, J.P.3
-
210
-
-
0347383733
-
Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells
-
L. Bergandi, F. Silvagno, I. Russo, C. Riganti, G. Anfossi, E. Aldieri, D. Ghigo, M. Trovati, and A. Bosia Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells Arterioscler. Thromb. Vasc. Biol. 23 2003 2215 2221
-
(2003)
Arterioscler. Thromb. Vasc. Biol.
, vol.23
, pp. 2215-2221
-
-
Bergandi, L.1
Silvagno, F.2
Russo, I.3
Riganti, C.4
Anfossi, G.5
Aldieri, E.6
Ghigo, D.7
Trovati, M.8
Bosia, A.9
-
211
-
-
55349084429
-
Potential role of nitric oxide in contraction-stimulated glucose uptake and mitochondrial biogenesis in skeletal muscle
-
G.K. McConell, and G.D. Wadley Potential role of nitric oxide in contraction-stimulated glucose uptake and mitochondrial biogenesis in skeletal muscle Clin. Exp. Pharmacol. Physiol. 35 2008 1488 1492
-
(2008)
Clin. Exp. Pharmacol. Physiol.
, vol.35
, pp. 1488-1492
-
-
McConell, G.K.1
Wadley, G.D.2
-
212
-
-
0348134741
-
Redistribution of intracellular oxygen in hypoxia by nitric oxide: Effect on HIF1alpha
-
T. Hagen, C.T. Taylor, F. Lam, and S. Moncada Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha Science 302 2003 1975 1978
-
(2003)
Science
, vol.302
, pp. 1975-1978
-
-
Hagen, T.1
Taylor, C.T.2
Lam, F.3
Moncada, S.4
-
213
-
-
0035864361
-
Accumulation of HIF-1alpha under the influence of nitric oxide
-
K.B. Sandau, J. Fandrey, and B. Brune Accumulation of HIF-1alpha under the influence of nitric oxide Blood 97 2001 1009 1015
-
(2001)
Blood
, vol.97
, pp. 1009-1015
-
-
Sandau, K.B.1
Fandrey, J.2
Brune, B.3
-
214
-
-
84867503958
-
Nitric oxide produced endogenously is responsible for hypoxia-induced HIF-1alpha stabilization in colon carcinoma cells
-
R. Chowdhury, L.C. Godoy, A. Thiantanawat, L.J. Trudel, W.M. Deen, and G.N. Wogan Nitric oxide produced endogenously is responsible for hypoxia-induced HIF-1alpha stabilization in colon carcinoma cells Chem. Res. Toxicol. 25 2012 2194 2202
-
(2012)
Chem. Res. Toxicol.
, vol.25
, pp. 2194-2202
-
-
Chowdhury, R.1
Godoy, L.C.2
Thiantanawat, A.3
Trudel, L.J.4
Deen, W.M.5
Wogan, G.N.6
-
215
-
-
34047272690
-
Regulation of HIF-1alpha stability through S-nitrosylation
-
F. Li, P. Sonveaux, Z.N. Rabbani, S. Liu, B. Yan, Q. Huang, Z. Vujaskovic, M. Dewhirst, and C.Y. Li Regulation of HIF-1alpha stability through S-nitrosylation Mol. Cell 26 2007 63 74
-
(2007)
Mol. Cell
, vol.26
, pp. 63-74
-
-
Li, F.1
Sonveaux, P.2
Rabbani, Z.N.3
Liu, S.4
Yan, B.5
Huang, Q.6
Vujaskovic, Z.7
Dewhirst, M.8
Li, C.Y.9
-
216
-
-
84863707285
-
Endothelial cell-derived nitric oxide enhances aerobic glycolysis in astrocytes via HIF-1alpha-mediated target gene activation
-
B. Brix, J.R. Mesters, L. Pellerin, and O. Johren Endothelial cell-derived nitric oxide enhances aerobic glycolysis in astrocytes via HIF-1alpha-mediated target gene activation J. Neurosci. 32 2012 9727 9735
-
(2012)
J. Neurosci.
, vol.32
, pp. 9727-9735
-
-
Brix, B.1
Mesters, J.R.2
Pellerin, L.3
Johren, O.4
-
217
-
-
0033515479
-
Nitric oxide-induced S-glutathionylation and inactivation of glyceraldehyde-3-phosphate dehydrogenase
-
S. Mohr, H. Hallak, A. de Boitte, E.G. Lapetina, and B. Brüne Nitric oxide-induced S-glutathionylation and inactivation of glyceraldehyde-3-phosphate dehydrogenase J. Biol. Chem. 274 1999 9427 9430
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 9427-9430
-
-
Mohr, S.1
Hallak, H.2
De Boitte, A.3
Lapetina, E.G.4
Brüne, B.5
-
218
-
-
77958046248
-
Differential mechanisms of inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by S-nitrosothiols and NO in cellular and cell-free conditions
-
K.A. Broniowska, and N. Hogg Differential mechanisms of inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by S-nitrosothiols and NO in cellular and cell-free conditions Am. J. Physiol. Heart Circ. Physiol 299 2010 H1212 H1219
-
(2010)
Am. J. Physiol. Heart Circ. Physiol
, vol.299
, pp. H1212-H1219
-
-
Broniowska, K.A.1
Hogg, N.2
-
219
-
-
0037300717
-
Modifications of glyceraldehyde-3-phosphate dehydrogenase induced by increasing concentrations of peroxynitrite: Early recognition by 20S proteasome
-
D.P. Buchczyk, T. Grune, H. Sies, and L.O. Klotz Modifications of glyceraldehyde-3-phosphate dehydrogenase induced by increasing concentrations of peroxynitrite: early recognition by 20S proteasome Biol. Chem. 384 2003 237 241
-
(2003)
Biol. Chem.
, vol.384
, pp. 237-241
-
-
Buchczyk, D.P.1
Grune, T.2
Sies, H.3
Klotz, L.O.4
-
220
-
-
0032535514
-
Glyceraldehyde-3-phosphate dehydrogenase inactivation by peroxynitrite
-
J.M. Souza, and R. Radi Glyceraldehyde-3-phosphate dehydrogenase inactivation by peroxynitrite Arch. Biochem. Biophys. 360 1998 187 194
-
(1998)
Arch. Biochem. Biophys.
, vol.360
, pp. 187-194
-
-
Souza, J.M.1
Radi, R.2
-
221
-
-
77956195960
-
Protein tyrosine nitration of aldolase in mast cells: A plausible pathway in nitric oxide-mediated regulation of mast cell function
-
Y. Sekar, T.C. Moon, C.M. Slupsky, and A.D. Befus Protein tyrosine nitration of aldolase in mast cells: a plausible pathway in nitric oxide-mediated regulation of mast cell function J. Immunol. 185 2010 578 587
-
(2010)
J. Immunol.
, vol.185
, pp. 578-587
-
-
Sekar, Y.1
Moon, T.C.2
Slupsky, C.M.3
Befus, A.D.4
-
222
-
-
3042852404
-
Tyrosine nitration impairs mammalian aldolase A activity
-
T. Koeck, B. Levison, S.L. Hazen, J.W. Crabb, D.J. Stuehr, and K.S. Aulak Tyrosine nitration impairs mammalian aldolase A activity Mol. Cell. Proteomics 3 2004 548 557
-
(2004)
Mol. Cell. Proteomics
, vol.3
, pp. 548-557
-
-
Koeck, T.1
Levison, B.2
Hazen, S.L.3
Crabb, J.W.4
Stuehr, D.J.5
Aulak, K.S.6
-
223
-
-
0034083406
-
Inducible nitric oxide synthase expression, apoptosis, and angiogenesis in in situ and invasive breast carcinomas
-
M. Vakkala, K. Kahlos, E. Lakari, P. Paakko, V. Kinnula, and Y. Soini Inducible nitric oxide synthase expression, apoptosis, and angiogenesis in in situ and invasive breast carcinomas Clin. Cancer Res. 6 2000 2408 2416
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 2408-2416
-
-
Vakkala, M.1
Kahlos, K.2
Lakari, E.3
Paakko, P.4
Kinnula, V.5
Soini, Y.6
-
224
-
-
0029079394
-
Roles of nitric oxide in tumor growth
-
D.C. Jenkins, I.G. Charles, L.L. Thomsen, D.W. Moss, L.S. Holmes, S.A. Baylis, P. Rhodes, K. Westmore, P.C. Emson, and S. Moncada Roles of nitric oxide in tumor growth Proc. Natl. Acad. Sci. USA 92 1995 4392 4396
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 4392-4396
-
-
Jenkins, D.C.1
Charles, I.G.2
Thomsen, L.L.3
Moss, D.W.4
Holmes, L.S.5
Baylis, S.A.6
Rhodes, P.7
Westmore, K.8
Emson, P.C.9
Moncada, S.10
-
225
-
-
19944434036
-
The role of early expression of inducible nitric oxide synthase in human breast cancer
-
S. Loibl, A. Buck, C. Strank, G. von Minckwitz, M. Roller, H.P. Sinn, V. Schini-Kerth, C. Solbach, K. Strebhardt, and M. Kaufmann The role of early expression of inducible nitric oxide synthase in human breast cancer Eur. J. Cancer 41 2005 265 271
-
(2005)
Eur. J. Cancer
, vol.41
, pp. 265-271
-
-
Loibl, S.1
Buck, A.2
Strank, C.3
Von Minckwitz, G.4
Roller, M.5
Sinn, H.P.6
Schini-Kerth, V.7
Solbach, C.8
Strebhardt, K.9
Kaufmann, M.10
-
226
-
-
23744465234
-
Significance of inducible nitric oxide synthase expression in benign and malignant breast epithelium: An immunohistochemical study of 151 cases
-
A. Bulut, E. Erden, S. Sak, H. Doruk, N. Kursun, and D. Dincol Significance of inducible nitric oxide synthase expression in benign and malignant breast epithelium: an immunohistochemical study of 151 cases Virchows Arch. 447 2005 24 30
-
(2005)
Virchows Arch.
, vol.447
, pp. 24-30
-
-
Bulut, A.1
Erden, E.2
Sak, S.3
Doruk, H.4
Kursun, N.5
Dincol, D.6
-
227
-
-
0029024521
-
Nitric oxide synthase activity in human breast cancer
-
L.L. Thomsen, D.W. Miles, L. Happerfield, L.G. Bobrow, R.G.; RG Knowles, and S. Moncada Nitric oxide synthase activity in human breast cancer Br. J. Cancer 72 1995 41 44
-
(1995)
Br. J. Cancer
, vol.72
, pp. 41-44
-
-
Thomsen, L.L.1
Miles, D.W.2
Happerfield, L.3
Bobrow, L.G.4
Knowles, R.G.5
Moncada, S.6
-
228
-
-
78049426509
-
Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients
-
S.A. Glynn, B.J. Boersma, T.H. Dorsey, M. Yi, H.G. Yfantis, L.A. Ridnour, D.N. Martin, C.H. Switzer, R.S. Hudson, D.A. Wink, D.H. Lee, R.M. Stephens, and S. Ambs Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients J. Clin. Invest. 120 2010 3843 3854
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 3843-3854
-
-
Glynn, S.A.1
Boersma, B.J.2
Dorsey, T.H.3
Yi, M.4
Yfantis, H.G.5
Ridnour, L.A.6
Martin, D.N.7
Switzer, C.H.8
Hudson, R.S.9
Wink, D.A.10
Lee, D.H.11
Stephens, R.M.12
Ambs, S.13
-
229
-
-
80054794980
-
Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer
-
C.H. Switzer, S.A. Glynn, L.A. Ridnour, R.Y.S. Cheng, M.P. Vitek, S. Ambs, and D.A. Wink Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer Trends Pharmacol. Sci. 32 2011 644 651
-
(2011)
Trends Pharmacol. Sci.
, vol.32
, pp. 644-651
-
-
Switzer, C.H.1
Glynn, S.A.2
Ridnour, L.A.3
Cheng, R.Y.S.4
Vitek, M.P.5
Ambs, S.6
Wink, D.A.7
-
230
-
-
34548317034
-
Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer
-
R.A. Gatenby, K. Smallbone, P.K. Maini, F. Rose, J. Averill, R.B. Nagle, L. Worrall, and R.J. Gillies Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer Br. J. Cancer 97 2007 646 653
-
(2007)
Br. J. Cancer
, vol.97
, pp. 646-653
-
-
Gatenby, R.A.1
Smallbone, K.2
Maini, P.K.3
Rose, F.4
Averill, J.5
Nagle, R.B.6
Worrall, L.7
Gillies, R.J.8
-
231
-
-
27944502154
-
Breast carcinomas fulfill the Warburg hypothesis and provide metabolic markers of cancer prognosis
-
A. Isidoro, E. Casado, A. Redondo, P. Acebo, E. Espinosa, A.M. Alonso, P. Cejas, D. Hardisson, J.A. Fresno Vara, C. Belda-Iniesta, M. Gonzaílez-Baron, and J.M. Cuezva Breast carcinomas fulfill the Warburg hypothesis and provide metabolic markers of cancer prognosis Carcinogenesis 26 2005 2095 2104
-
(2005)
Carcinogenesis
, vol.26
, pp. 2095-2104
-
-
Isidoro, A.1
Casado, E.2
Redondo, A.3
Acebo, P.4
Espinosa, E.5
Alonso, A.M.6
Cejas, P.7
Hardisson, D.8
Fresno Vara, J.A.9
Belda-Iniesta, C.10
Gonzaílez-Baron, M.11
Cuezva, J.M.12
-
232
-
-
84867527044
-
Metabolic associations of reduced proliferation and oxidative stress in advanced breast cancer
-
L. Jerby, L. Wolf, C. Denkert, G.Y. Stein, M. Hilvo, M. Oresic, T. Geiger, and E. Ruppin Metabolic associations of reduced proliferation and oxidative stress in advanced breast cancer Cancer Res. 72 2012 5712 5720
-
(2012)
Cancer Res.
, vol.72
, pp. 5712-5720
-
-
Jerby, L.1
Wolf, L.2
Denkert, C.3
Stein, G.Y.4
Hilvo, M.5
Oresic, M.6
Geiger, T.7
Ruppin, E.8
-
233
-
-
84869208957
-
An integrated genomic screen identifies ldhb as an essential gene for triple-negative breast cancer
-
M.L. McCleland, A.S. Adler, Y. Shang, T. Hunsaker, T. Truong, D. Peterson, E. Torres, L. Li, B. Haley, J.P. Stephan, M. Belvin, G. Hatzivassiliou, E.M. Blackwood, L. Corson, M. Evangelista, J. Zha, and R. Firestein An integrated genomic screen identifies ldhb as an essential gene for triple-negative breast cancer Cancer Res. 72 2012 5812 5823
-
(2012)
Cancer Res.
, vol.72
, pp. 5812-5823
-
-
McCleland, M.L.1
Adler, A.S.2
Shang, Y.3
Hunsaker, T.4
Truong, T.5
Peterson, D.6
Torres, E.7
Li, L.8
Haley, B.9
Stephan, J.P.10
Belvin, M.11
Hatzivassiliou, G.12
Blackwood, E.M.13
Corson, L.14
Evangelista, M.15
Zha, J.16
Firestein, R.17
-
234
-
-
84903764168
-
Nitric oxide is a positive regulator of the Warburg effect in ovarian cancer cells
-
e1302 2014
-
C.A. Caneba, L. Yang, J. Baddour, R. Curtis, J. Win, S. Hartig, J. Marini, and D. Nagrath Nitric oxide is a positive regulator of the Warburg effect in ovarian cancer cells Cell Death. Dis 5 2014 e1302 2014
-
(2014)
Cell Death. Dis
, vol.5
-
-
Caneba, C.A.1
Yang, L.2
Baddour, J.3
Curtis, R.4
Win, J.5
Hartig, S.6
Marini, J.7
Nagrath, D.8
|