Reductive carboxylation supports growth in tumour cells with defective mitochondria

Nature

Volumn 481, Issue 7381, 2012, Pages 385-388

  Mullen, Andrew R ^a   Wheaton, William W ^b,c   Jin, Eunsook S ^a,d   Chen, Pei Hsuan ^a   Sullivan, Lucas B ^b,c   Cheng, Tzuling ^a   Yang, Youfeng ^e   Linehan, W Marston ^e   Chandel, Navdeep S ^b,c   Deberardinis, Ralph J ^a,f  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

^f UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMINE; ISOCITRATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

CANCER; ENZYME ACTIVITY; INHIBITION; LIPID; METABOLISM; METABOLITE; MITOCHONDRION; MUTATION; TUMOR;

AEROBIC METABOLISM; ARTICLE; CARBOXYLATION; CELL GROWTH; CYTOSOL; HUMAN; KIDNEY CARCINOMA; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; TUMOR CELL; TUMOR GROWTH;

ACETYL COENZYME A; ANIMALS; CARCINOMA, RENAL CELL; CELL HYPOXIA; CELL LINE, TUMOR; CITRIC ACID; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX III; FUMARATE HYDRATASE; GLUCOSE; GLUTAMINE; HUMANS; ISOCITRATE DEHYDROGENASE; KIDNEY NEOPLASMS; MICE; MITOCHONDRIA; NADP; NEOPLASMS;

EID: 84855987831     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature10642     Document Type: Article

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