Molecular mechanisms for discrete nitric oxide levels in cancer

Nitric Oxide - Biology and Chemistry

Volumn 19, Issue 2, 2008, Pages 73-76

  Ridnour, Lisa A ^a   Thomas, Douglas D ^b   Switzer, Christopher ^a   Flores Santana, Wilmarie ^a   Isenberg, Jeffrey S ^a   Ambs, Stefan ^a   Roberts, David D ^a   Wink, David A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Angiogenesis; Cancer; Nitric oxide; Nitrosative stress; Treatment

Indexed keywords

GELATINASE B; HYPOXIA INDUCIBLE FACTOR 1; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PROTEIN KINASE B; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; THROMBOSPONDIN 1;

ANGIOGENESIS; CARCINOGENESIS; CYTOTOXICITY; ENDOTHELIUM CELL; HUMAN; MALIGNANT NEOPLASTIC DISEASE; NITROSATIVE STRESS; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; REVIEW; TUMOR CELL; TUMOR GROWTH;

HUMANS; INFLAMMATION; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; NITRIC OXIDE; REACTIVE NITROGEN SPECIES;

EID: 47049128882     PISSN: 10898603     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.niox.2008.04.006     Document Type: Review

References (35)

1. Hibbs J.B.J. Synthesis of nitric oxide from l-arginine: a recently discovered pathway induced by cytokines with antitumour and antimicrobial activity. Res. Immunol. 142 (1991) 565-569
2. Stuehr D.J., and Nathan C.F. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J. Exp. Med. 169 (1989) 1543-1555
3. Hussain S.P., Trivers G.E., Hofseth L.J., He P., Shaikh I., Mechanic L.E., Doja S., Jiang W., Subleski J., Shorts L., Haines D., Laubach V.E., Wiltrout R.H., Djurickovic D., and Harris C.C. Nitric oxide, a mediator of inflammation, suppresses tumorigenesis. Cancer Res. 64 (2004) 6849-6853
4. Prueitt R.L., Boersma B.J., Howe T.M., Goodman J.E., Thomas D.D., Ying L., Pfiester C.M., Yfantis H.G., Cottrell J.R., Lee D.H., Remaley A.T., Hofseth L.J., Wink D.A., and Ambs S. Inflammation and IGF-I activate the Akt pathway in breast cancer. Int. J. Cancer 120 (2007) 796-805
5. Ekmekcioglu S., Ellerhorst J., Smid C.M., Prieto V.G., Munsell M., Buzaid A.C., and Grimm E.A. Inducible nitric oxide synthase and nitrotyrosine in human metastatic melanoma tumors correlate with poor survival. Clin. Cancer Res. 6 (2000) 4768-4775
6. Ekmekcioglu S., Ellerhorst J.A., Prieto V.G., Johnson M.M., Broemeling L.D., and Grimm E.A. Tumor iNOS predicts poor survival for stage III melanoma patients. Int. J. Cancer 119 (2006) 861-866
7. Wink D.A., and Mitchell J.B. Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide. Free Radic. Biol. Med. 25 (1998) 434-456
8. Ridnour L.A., Thomas D.D., Donzelli S., Espey M.G., Roberts D.D., Wink D.A., and Isenberg J.S. The biphasic nature of nitric oxide responses in tumor biology. Antioxid. Redox Signal 8 (2006) 1329-1337
9. Zhou J., Schmid T., and Brune B. HIF-1alpha and p53 as targets of NO in affecting cell proliferation, death and adaptation. Curr. Mol. Med. 4 (2004) 741-751
10. Thomas D.D., Espey M.G., Ridnour L.A., Hofseth L.J., Mancardi D., Harris C.C., and Wink D.A. Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide. Proc. Natl. Acad. Sci. USA 101 (2004) 8894-8899
11. Hofseth L.J., Saito S., Hussain S.P., Espey M.G., Miranda K.M., Araki Y., Jhappan C., Higashimoto Y., He P., Linke S.P., Quezado M.M., Zurer I., Rotter V., Wink D.A., Appella E., and Harris C.C. Nitric oxide-induced cellular stress and p53 activation in chronic inflammation. Proc. Natl. Acad. Sci. USA 100 (2003) 143-148
12. Wang C., Trudel L.J., Wogan G.N., and Deen W.M. Thresholds of nitric oxide-mediated toxicity in human lymphoblastoid cells. Chem. Res. Toxicol. 16 (2003) 1004-1013
13. Pervin S., Singh R., Freije W.A., and Chaudhuri G. MKP-1-induced dephosphorylation of extracellular signal-regulated kinase is essential for triggering nitric oxide-induced apoptosis in human breast cancer cell lines: implications in breast cancer. Cancer Res. 63 (2003) 8853-8860
14. Ridnour L.A., Isenberg J.S., Espey M.G., Thomas D.D., Roberts D.D., and Wink D.A. Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1. Proc. Natl. Acad. Sci. USA 102 (2005) 13147-13152
15. Wink D.A., and Mitchell J.B. The chemical biology of nitric oxide: insights into regulatory, cytotoxic and cytoprotective mechanisms of nitric oxide. Free Rad. Biol. Med. 25 (1998) 434-456
16. Connelly L., Jacobs A.T., Palacios-Callender M., Moncada S., and Hobbs A.J. Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression. J. Biol. Chem. 278 (2003) 26480-26487
17. Espey M.G., Miranda K.M., Pluta R.M., and Wink D.A. Nitrosative capacity of macrophages is dependent on nitric-oxide synthase induction signals. J. Biol. Chem. 275 (2000) 11341-11347
18. Ridnour L.A., Windhausen A.N., Isenberg J.S., Yeung N., Thomas D.D., Vitek M.P., Roberts D.D., and Wink D.A. Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways. Proc. Natl. Acad. Sci. USA (2007) 16898-16903
19. Bove P.F., Wesley U.V., Greul A.K., Hristova M., Dostmann W.R., and van der Vliet A. Nitric oxide promotes airway epithelial wound repair through enhanced activation of MMP-9. Am. J. Respir. Cell Mol. Biol. 36 (2007) 138-146
20. Duffield J.S. The inflammatory macrophage: a story of Jekyll and Hyde. Clin. Sci. (Lond.) (2003) 27-38
21. Crowther M., Brown N.J., Bishop E.T., and Lewis C.E. Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors. J. Leukoc. Biol. 70 (2001) 478-490
22. Whalen G.F. Solid tumours and wounds: transformed cells misunderstood as injured tissue?. Lancet 336 (1990) 1489-1492
23. Schwentker A., Vodovotz Y., Weller R., and Billiar T.R. Nitric oxide and wound repair: role of cytokines?. Nitric Oxide 7 (2002) 1-10
24. Li F., Sonveaux P., Rabbani Z.N., Liu S., Yan B., Huang Q., Vujaskovic Z., Dewhirst M.W., and Li C.Y. Regulation of HIF-1alpha stability through S-nitrosylation. Mol. Cell 26 (2007) 63-74
25. Pervin S., Singh R., Hernandez E., Wu G., and Chaudhuri G. Nitric oxide in physiologic concentrations targets the translational machinery to increase the proliferation of human breast cancer cells: involvement of mammalian target of rapamycin/eIF4E pathway. Cancer Res. 67 (2007) 289-299
26. Griffiths E.A., Pritchard S.A., Welch I.M., Price P.M., and West C.M. Is the hypoxia-inducible factor pathway important in gastric cancer. Eur. J. Cancer 41 (2005) 2792-2805
27. Sonoshita M., Takaku K., Sasaki N., Sugimoto Y., Ushikubi F., Narumiya S., Oshima M., and Taketo M.M. Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice. Nat. Med. 7 (2001) 1048-1051
28. + CD25 T cells via p53, IL-2, and OX40. Proc. Natl. Acad. Sci. USA 104 (2007) 15478-15483
29. Vodovotz Y., Chesler L., Chong H., Kim S.J., Simpson J.T., DeGraff W., Cox G.W., Roberts A.B., Wink D.A., and Barcellos-Hoff M.H. Regulation of transforming growth factor beta1 by nitric oxide. Cancer Res. 59 (1999) 2142-2149
30. Roberts D.D., Isenberg J.S., Ridnour L.A., and Wink D.A. Nitric oxide and its gatekeeper thrombospondin-1 in tumor angiogenesis. Clin. Cancer Res. 13 (2007) 795-798
31. Isenberg J.S., Ridnour L.A., Perruccio E.M., Espey M.G., Wink D.A., and Roberts D.D. Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner. Proc. Natl. Acad. Sci. USA 102 (2005) 13141-13146
32. Isenberg J.S., Ridnour L.A., Dimitry J., Frazier W.A., Wink D.A., and Roberts D.D. CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1. J. Biol. Chem. 281 (2006) 26069-26080
33. Isenberg J.S., Romeo M.J., Yu C., Yu C.K., Nghiem K., Monsale J., Rick M.E., Wink D.A., Frazier W.A., and Roberts D.D. Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling. Blood 111 (2008) 613-623
34. Metzen E., Zhou J., Jelkmann W., Fandrey J., and Brune B. Nitric oxide impairs normoxic degradation of hif-1{alpha} by inhibition of prolyl hydroxylases. Mol. Biol. Cell 14 (2003) 3470-3481
35. Thomas D.D., Ridnour L.A., Espey M.G., Donzelli S., Ambs S., Hussain S.P., Harris C.C., DeGraff W., Roberts D.D., Mitchell J.B., and Wink D.A. Superoxide fluxes limit nitric oxide-induced signaling. J. Biol. Chem. 281 (2006) 25984-25993