Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 16, 2010, Pages 7461-7466

  Suzuki, Sawako ^a   Tanaka, Tomoaki ^a   Poyurovsky, Masha V ^b   Nagano, Hidekazu ^a   Mayama, Takafumi ^a   Ohkubo, Shuichi ^c   Lokshin, Maria ^b   Hosokawa, Hiroyuki ^a   Nakayama, Toshinori ^a   Suzuki, Yutaka ^d   Sugano, Sumio ^d   Sato, Eiichi ^e   Nagao, Toshitaka ^e   Yokote, Koutaro ^a   Tatsuno, Ichiro ^a   Prives, Carol ^b  

^a CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c TAIHO PHARMACEUTICAL CO LTD   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; Glutaminolysis; Glutathione antioxidant; Tumor suppression

Indexed keywords

GLUTAMINASE; GLUTAMINASE 2; GLUTAMINE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

AMINO ACID METABOLISM; ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL PROTECTION; CELL SURVIVAL; COLONY FORMATION; CONTROLLED STUDY; EMBRYO; ENERGY METABOLISM; ENZYME ACTIVITY; GENOTOXICITY; HOMEOSTASIS; HUMAN; HUMAN CELL; LIVER TUMOR; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; GLUTAMINASE; GLUTAMINE; GLUTATHIONE; HUMANS; MICE; MITOCHONDRIA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS, GENETIC; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77952227625     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1002459107     Document Type: Article

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