Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α

Science

Volumn 324, Issue 5924, 2009, Pages 261-265

  Zhao, Shimin ^a,b   Lin, Yan ^a   Xu, Wei ^a,b   Jiang, Wenqing ^a,b   Zhai, Zhengyu ^a   Wang, Pu ^a,b   Yu, Wei ^a,b   Li, Zhiqiang ^c   Gong, Lingling ^c   Peng, Yingjie ^d   Ding, Jianping ^d   Lei, Qunying ^a   Guan, Kun Liang ^a,e   Xiong, Yue ^a,b,f  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c WUHAN UNIVERSITY   (China)

^d INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; GLUCOSE TRANSPORTER 1; HETERODIMER; HYPOXIA INDUCIBLE FACTOR 1ALPHA; ISOCITRATE DEHYDROGENASE (NADP); MESSENGER RNA; PHOSPHOGLYCERATE KINASE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; SHORT HAIRPIN RNA; VASCULOTROPIN;

BRAIN; CATALYSIS; ENZYME ACTIVITY; GENE EXPRESSION; INHIBITION; MUTATION; PUBLIC HEALTH; TUMOR;

AMINO ACID SUBSTITUTION; ARTICLE; CARCINOGENESIS; CATALYSIS; CELL CULTURE; CELL STRAIN HEK293; ENZYME ACTIVITY; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GENE TARGETING; GLIOBLASTOMA; GLIOMA; HELA CELL; HUMAN; HUMAN GENOME; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

ADOLESCENT; ADULT; AGED; ASTROCYTOMA; BIOCATALYSIS; BRAIN NEOPLASMS; CELL LINE; CHILD; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; GLIOBLASTOMA; GLIOMA; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; ISOCITRATE DEHYDROGENASE; KETOGLUTARIC ACIDS; MALE; MIDDLE AGED; MUTANT PROTEINS; OLIGODENDROGLIOMA; OXALATES; PROTEIN MULTIMERIZATION;

EID: 64849098267     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1170944     Document Type: Article

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13. We thank members of the Fudan Molecular and Cell Biology Laboratory for valuable input; Y. Liu, X. Liu, and H. Zhu for assistance with histology; Z. Bao, L. Yang, Q. Shi, and G. Zhao for clinical samples; and S. Jackson for reading the manuscript. This work is supported by the 985 program from the Chinese Ministry of Education, State Key Development Programs of China