Activation of fatty acid synthesis during neoplastic transformation: Role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase

Experimental Cell Research

Volumn 279, Issue 1, 2002, Pages 80-90

  Yang, Yu An ^a   Han, Wan Fang ^a   Morin, Patrice J ^b   Chrest, Francis J ^b   Pizer, Ellen S ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Fatty acid synthase; Mitogen activated protein kinase; Neoplasia; Phosphatidylinositol 3 kinase; Sterol regulatory element binding proteins

Indexed keywords

CERULENIN; EPIDERMAL GROWTH FACTOR; FATTY ACID SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; STEROL REGULATORY ELEMENT BINDING PROTEIN;

ARTICLE; BINDING SITE; BREAST EPITHELIUM; CELL TRANSFORMATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; FATTY ACID METABOLISM; FATTY ACID SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPOGENESIS; MALIGNANT TRANSFORMATION; ONCOGENE H RAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0036385719     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2002.5600     Document Type: Article

References (47)

1. Wakil, S. (1989). Fatty acid synthase, a proficient multifunctional enzyme. Biochemistry 28, 4523-4530.
2. Witkowski, A., Rangan, V. S., Randhawa, Z. I., Amy, C. M., and Smith, S. (1991). Structural organization of the multifunctional animal fatty-acid synthase. Int. J. Biochem. 198, 571-579.
3. Sul, H. S., and Wang, D. (1998). Nutritional and hormonal regulation of enzymes in fat synthesis: Studies of fatty acid synthase and mitochondrial glycerol-3-phosphate acyltransferase gene transcription. Annu. Rev. Nutr. 18, 331-351.
4. Wang, D., and Sul, H. S. (1998). Insulin stimulation of the fatty acid synthase promoter is mediated by the phosphatidylinositol 3-kinase pathway: Involvement of protein kinase B/Akt. J. Biol. Chem. 273, 25420-25426.
5. Wilentz, R., Witters, L., and Pizer, E. (2000). Lipogenic enzymes fatty acid synthase and acetyl-CoA carboxylase are co-expressed with sterol regulatory element binding protein and Ki-67 in fetal tissues. Pediatr. Dev. Pathol. 3, 525-531.
6. Jackowski, S., Wang, J., and Baburina, I. (2000). Activity of the phosphatidylcholine biosynthetic pathway modulates the distribution of fatty acids into glycerolipids in proliferating cells. Biochim. Biophys. Acta 1483, 301-315.
7. Jensen, V., Ladekarl, M., Holm-Nielsen, P., Melsen, F., and Soerensen, F. (1995). The prognostic value of oncogenic antigen 519 (OA-519) expression and prolierative activity detected by antibody MIB-1 in node-negative breast cancer. J. Pathol. 176, 343-352.
8. Alo, P. L., Visca, P., Marci, A., Mangoni, A., Botti, C., and Di Tondo, U. (1996). Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients. Cancer 77, 474-482.
9. Pizer, E., Lax, S., Kuhajda, F., Pasternack, G., and Kurman, R. (1998). Fatty acid synthase expression in endometrial carcinoma: Correlation with cell proliferation and hormone receptors. Cancer 83, 528-537.
10. Rashid, A., Pizer, E. S., Moga, M., Milgraum, L. Z., Zahurak, M., Pasternack, G. R., Kuhajda, F. P., and Hamilton, S. R. (1997). Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia. Am. J. Pathol. 150, 201-208.
11. Li, J. N., Mahmoud, M. A., Han, W. F., Ripple, M., and Pizer, E. S. (2000). Sterol regulatory element binding protein-1 participates in the regulation of fatty acid synthase expression in colorectal neoplasia. Exp. Cell Res. 261, 159-165.
12. Epstein, J. I., Carmichael, M., and Partin, A. W. (1994). OA-519 (fatty acid synthase) as an independent predictor of pathologic stage in adenocarcinoma of the prostate. Urology 45, 81-86.
13. Pizer, E. S., Pflug, B. R., Bova, G. S., Han, W. F., Udan, M. S., and Nelson, J. B. (2001). Increased fatty acid synthase as a therapeutic target in androgen independent prostate cancer progression. Prostate 47, 102-110.
14. Wang, Y., Kuhajda, F. P., Li, J. N., Pizer, E. S., Han, W. F., Sokoll, L. J., and Chan, D. W. (2001). Fatty acid synthase (FAS) expression in human breast cancer cell culture supernatants and in breast cancer patients. Cancer Lett. 167, 99-104.
15. Pizer, E. S., Wood, F. D., Heine, H. S., Romantsev, F. E., Pasternack, G. R., and Kuhajda, F. P. (1996). Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer. Cancer Res. 56, 1189-1193.
16. Pizer, E. S., Jackisch, C., Wood, F. D., Pasternack, G. R., Davidson, N. E., and Kuhajda, F. P. (1996). Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells. Cancer Res. 56, 2745-2747.
17. Pizer, E. S., Thupari, J., Han, W. F., Pinn, M. L., Chrest, F. J., Frehywot, G. L., Townsend, C. A., and Kuhajda, F. P. (2000). Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. Cancer Res. 60, 213-218.
18. Kim, J. B., Sarraf, P., Wright, M., Yao, K. M., Mueller, E., Solanes, G., Lowell, B. B., and Spiegelman, B. M. (1998). Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. J. Clin. Invest. 101, 1-9.
19. Brown, M. S., and Goldstein, J. L. (1997). The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89, 331-340.
20. Magana, M. M., and Osborne, T. F. (1996). Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty-acid synthase promoter. J. Biol. Chem. 271, 32689-32694.
21. Pai, J. T., Guryev, O., Brown, M. S., and Goldstein, J. L. (1998). Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins. J. Biol. Chem. 273, 26138-26148.
22. Shimano, H., Yahagi, N., Amemiya-Kudo, M., Hasty, A. H., Osuga, J., Tamura, Y., Shionoiri, F., Iizuka, Y., Ohashi, K., Harada, K., Gotoda, T., Ishibashi, S., and Yamada, N. (1999). Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes. J. Biol. Chem. 274, 35832-35839.
23. Sabine, J. R., Abraham, S., and Chaikoff, I. L. (1967). Control of lipid metabolism in hepatomas: Insensitivity of rate of fatty acid and cholesterol synthesis by mouse hepatoma BW7756 to fasting and to feedback control. Cancer Res. 27, 793-799.
24. Swinnen, J. V., Ulrix, W., Heyns, W., and Verhoeven, G. (1997). Coordinate regulation of lipogenic gene expression by androgens: Evidence for a cascade mechanism involving sterol regulatory element binding proteins. Proc. Natl. Acad. Sci. USA 94, 12975-12980.
25. Martinez-Lacaci, I., Kannan, S., De Santis, M., Bianco, C., Kim, N., Wallace-Jones, B., Ebert, A. D., Wechselberger, C., and Salomon, D. S. (2000). RAS transformation causes sustained activation of epidermal growth factor receptor and elevation of mitogen-activated protein kinase in human mammary epithelial cells. Int. J. Cancer 88, 44-52.
26. Hamilton, M., and Wolfman, A. (1998). Oncogenic Ha-Ras-dependent mitogen-activated protein kinase activity requires signaling through the epidermal growth factor receptor. J. Biol. Chem. 273, 28155-28162.
27. Basolo, F., Elliott, J., Tait, L., Chen, X. Q., Maloney, T., Russo, I. H., Pauley, R., Momiki, S., Caamano, J., and Klein-Szanto, A. J. (1991). Transformation of human breast epithelial cells by c-Ha-ras oncogene. Mol. Carcinog. 4, 25-35.
28. Oldham, S. M., Clark, G. J., Gangarosa, L. M., Coffey, R. J. J., and Der, C. J. (1996). Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells. Proc. Natl. Acad. Sci. USA 93, 6924-6928.
29. Gioeli, D., Mandell, J. W., Petroni, G. R., Frierson, H. F., and Weber, M. J. (1999). Activation of mitogen-activated protein kinase associated with prostate cancer progression. Cancer Res. 59, 279-284.
30. Maemura, M., Iino, Y., Koibuchi, Y., Yokoe, T., and Morishita, Y. (1999). Mitogen-activated protein kinase cascade in breast cancer. Oncology 57(Suppl.), 37-44.
31. Kennedy, S. G., Wagner, A. J., Conzen, S. D., Jordan, J., Bellacosa, A., Tsichlis, P. N., and Hay, N. (1997). The PI 3-kinase/Akt signaling pathway delivers an antiapoptotic signal. Genes Dev. 11, 701-713.
32. Graff, J. R., Konicek, B. W., McNulty, A. M., Wang, Z., Houck, K., Allen, S., Paul, J. D., Hbaiu, A., Goode, R. G., Sandusky, G. E., Vessella, R. L., and Neubauer, B. L. (2000). Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression. J. Biol. Chem. 275, 24500-24505.
33. Sonoda, Y., Ozawa, T., Aldape, K. D., Deen, D. F., Berger, M. S., and Pieper, R. O. (2001). Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma. Cancer Res. 61, 6674-6678.
34. Spandidos, D. A., and Wilkie, N. M. (1984). Malignant transformation of early passage rodent cells by a single mutated human oncogene. Nature 310, 469-475.
35. Tanno, S., Tanno, S., Mitsuuchi, Y., Altomare, D. A., Xiao, G. H., and Testa, J. R. (2001). AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells. Cancer Res. 61, 589-593.
36. Roth, G., Kotzka, J., Kremer, L., Lehr, S., Lohaus, C., Meyer, H. E., Krone, W., and Muller-Wieland, D. (2000). MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro. J. Biol. Chem. 275, 33302-33307.
37. Hackel, P. O., Zwick, E., Prenzel, N., and Ullrich, A: (1999). Epidermal growth factor receptors: Critical mediators of multiple receptor pathways. Curr. Opin. Cell Biol. 11, 184-189.
38. Kim, K. S., Park, S. W., and Kim, Y. S. (1992). Regulation of fatty acid synthase at transcriptional and post-transcriptional levels in rat liver. Yonsei Med. J. 33, 199-208.
39. Oskouian, B. (2000). Overexpression of fatty acid synthase in SKBR3 breast cancer cell line is mediated via a transcriptional mechanism. Cancer Lett. 149, 43-51.
40. Schroy, P. C. R., Brown-Shimer, S., Kim, K., Johnson, K. A., Murnane, M. J., Yang, S., O'Brien, M. J., Carney, W. P., and Kupchik, H. Z. (1995). Detection of p21ras mutations in colorectal adenomas and carcinomas by enzyme-linked immunosorbent assay. Cancer 76, 201-209.
41. Kelland, L. R., Smith, V., Valenti, M., Patterson, L., Clarke, P. A., Detre, S., End, D., Howes, A. J., Dowsett, M., Workman, P., and Johnston, S. R. (2001). Preclinical antitumor activity and pharmacodynamic studies with the earnesyl protein transferase inhibitor R115777 in human breast cancer. Clin. Cancer Res. 7, 3544-3550.
42. Clark, G. J., and Der, C. J. (1995). Aberrant function of the Ras signal transduction pathway in human breast cancer. Breast Cancer Res. Treat. 35, 133-144.
43. Swinnen, J. V., Heemers, H., Deboel, L., Foufelle, F., Heyns, W., and Verhoeven, G. (2000). Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway. Oncogene 19, 5173-5181.
44. Milgraum, L. Z., Witters, L. A., Pasternack, G. R., and Kuhajda, F. P. (1997). Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma. Clin. Cancer Res. 3, 2115-2120.
45. Sul, H. S., Latasa, M. J., Moon, Y., and Kim, K. H. (2000). Regulation of the fatty acid synthase promoter by insulin. J. Nutr. 130, 315S-320S.
46. Obeid, O. A., and Emery, P. W. (1993). Lipid metabolism in cachectic tumor-bearing rats at different stages of tumor growth. Nutr. Cancer 19, 87-98.
47. Ookhtens, M., Kannan, R., Lyon, I., and Baker, N. (1984). Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor. Am. J. Physiol. 247, R146-R153.