-
1
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
0036463384
-
The fabric of cancer cell biology: Weaving together the strands
-
Klausner RD. The fabric of cancer cell biology: weaving together the strands. Cancer Cell 2002;1:3-10.
-
(2002)
Cancer Cell
, vol.1
, pp. 3-10
-
-
Klausner, R.D.1
-
3
-
-
2942536487
-
Invasion and metastasis in pancreatic cancer
-
Keleg S, Buchler P, Ludwig R, Buchler MW, Friess H. Invasion and metastasis in pancreatic cancer. Mol Cancer 2003;2:14.
-
(2003)
Mol Cancer
, vol.2
, pp. 14
-
-
Keleg, S.1
Buchler, P.2
Ludwig, R.3
Buchler, M.W.4
Friess, H.5
-
4
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O. On the origin of cancer cells. Science (Wash. DC) 1956;123:309-14.
-
(1956)
Science (Wash. DC)
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
6
-
-
0037079003
-
Rules for making human tumor cells
-
Hahn WC, Weinberg RA. Rules for making human tumor cells. N Engl J Med 2002;347:1593-603.
-
(2002)
N Engl J Med
, vol.347
, pp. 1593-1603
-
-
Hahn, W.C.1
Weinberg, R.A.2
-
7
-
-
0023786047
-
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
-
Vaux DL, Cory S, Adams JM. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature (Lond.) 1988;335:440-2.
-
(1988)
Nature (Lond.)
, vol.335
, pp. 440-442
-
-
Vaux, D.L.1
Cory, S.2
Adams, J.M.3
-
8
-
-
0031053586
-
Regulation of neuronal survival by the serine-threonine protein kinase Akt
-
Dudek H, Datta SR, Franke TF, et al. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science (Wash. DC) 1997;275:661-5.
-
(1997)
Science (Wash. DC)
, vol.275
, pp. 661-665
-
-
Dudek, H.1
Datta, S.R.2
Franke, T.F.3
-
9
-
-
0037421968
-
Bcl-x(L) and Akt cooperate to promote leukemogenesis in vivo
-
Kamauskas R, Niu Q, Talapatra S, et al. Bcl-x(L) and Akt cooperate to promote leukemogenesis in vivo. Oncogene 2003;22:688-98.
-
(2003)
Oncogene
, vol.22
, pp. 688-698
-
-
Kamauskas, R.1
Niu, Q.2
Talapatra, S.3
-
10
-
-
0030860466
-
Transforming activity and mitosis-related expression of the AKT2 oncogene: Evidence suggesting a link between cell cycle regulation and oncogenesis
-
Cheng JQ, Altomare DA, Klein MA, et al. Transforming activity and mitosis-related expression of the AKT2 oncogene: evidence suggesting a link between cell cycle regulation and oncogenesis. Oncogene 1997;14:2793-801.
-
(1997)
Oncogene
, vol.14
, pp. 2793-2801
-
-
Cheng, J.Q.1
Altomare, D.A.2
Klein, M.A.3
-
11
-
-
0141863388
-
Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival
-
Rathmell JC, Fox CJ, Plas DR, Hammerman PS, Cinalli RM, Thompson CB. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol Cell Biol 2003;23:7315-28.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7315-7328
-
-
Rathmell, J.C.1
Fox, C.J.2
Plas, D.R.3
Hammerman, P.S.4
Cinalli, R.M.5
Thompson, C.B.6
-
12
-
-
0041975825
-
Activated Akt promotes increased resting T-cell size, CD28-independent T-cell growth, and development of autoimmunity and lymphoma
-
Rathmell JC, Elstrom RL, Cinalli RM, Thompson CB. Activated Akt promotes increased resting T-cell size, CD28-independent T-cell growth, and development of autoimmunity and lymphoma. Eur J Immunol 2003;33:2223-32.
-
(2003)
Eur J Immunol
, vol.33
, pp. 2223-2232
-
-
Rathmell, J.C.1
Elstrom, R.L.2
Cinalli, R.M.3
Thompson, C.B.4
-
13
-
-
0035853833
-
Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology
-
Plas DR, Talapatra S, Edinger AL, Rathmell JC, Thompson CB. Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. J Biol Chem 2001;276:12041-8.
-
(2001)
J Biol Chem
, vol.276
, pp. 12041-12048
-
-
Plas, D.R.1
Talapatra, S.2
Edinger, A.L.3
Rathmell, J.C.4
Thompson, C.B.5
-
14
-
-
0034983918
-
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
-
Gottlob K, Majewski N, Kennedy S, Kandel E, Robey RB, Hay N. Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev 2001;15:1406-18.
-
(2001)
Genes Dev
, vol.15
, pp. 1406-1418
-
-
Gottlob, K.1
Majewski, N.2
Kennedy, S.3
Kandel, E.4
Robey, R.B.5
Hay, N.6
-
15
-
-
0001582482
-
Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: Amplification of AKT1 in a primary human gastric adenocarcinoma
-
Staal SP. Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci USA 1987;84:5034-7.
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 5034-5037
-
-
Staal, S.P.1
-
16
-
-
0029127042
-
Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas
-
Bellacosa A, de Feo D, Godwin AK, et al. Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas. Int J Cancer 1995;64:280-5.
-
(1995)
Int J Cancer
, vol.64
, pp. 280-285
-
-
Bellacosa, A.1
De Feo, D.2
Godwin, A.K.3
-
17
-
-
0001457668
-
Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
-
Cheng JQ, Ruggeri B, Klein WM, et al. Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc Natl Acad Sci USA 1996;93:3636-41.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 3636-3641
-
-
Cheng, J.Q.1
Ruggeri, B.2
Klein, W.M.3
-
18
-
-
0036632368
-
The phosphatidylinositol 3-kinase AKT pathway in human cancer
-
Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2002:2:489-501.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
19
-
-
0000459773
-
Uber den stoffwechsel der tumoren
-
Warburg O, Posener K, Negelein E. Uber den stoffwechsel der tumoren [in German]. Biochem Z 1924;152:319-44.
-
(1924)
Biochem Z
, vol.152
, pp. 319-344
-
-
Warburg, O.1
Posener, K.2
Negelein, E.3
-
20
-
-
0027282044
-
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
-
Boise LH, Gonzalez-Garcia M, Postema CE, et al. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 1993;74:597-608.
-
(1993)
Cell
, vol.74
, pp. 597-608
-
-
Boise, L.H.1
Gonzalez-Garcia, M.2
Postema, C.E.3
-
21
-
-
0019367611
-
Characterization of an established human malignant glioma cell line: LN-18
-
Diserens AC, de Tribolet N, Martin-Achard A, Gaide AC, Schnegg JF, Carrel S. Characterization of an established human malignant glioma cell line: LN-18. Acta Neuropathol (Berl.) 1981;53:21-8.
-
(1981)
Acta Neuropathol (Berl.)
, vol.53
, pp. 21-28
-
-
Diserens, A.C.1
De Tribolet, N.2
Martin-Achard, A.3
Gaide, A.C.4
Schnegg, J.F.5
Carrel, S.6
-
22
-
-
0029028545
-
Methods for biochemical study of poly(ADP-ribose) metabolism in vitro and in vivo
-
Shah GM, Poirier D, Duchaine C, et al. Methods for biochemical study of poly(ADP-ribose) metabolism in vitro and in vivo. Anal Biochem 1995;227:1-13.
-
(1995)
Anal Biochem
, vol.227
, pp. 1-13
-
-
Shah, G.M.1
Poirier, D.2
Duchaine, C.3
-
23
-
-
0027379174
-
Oxygen conformance of cellular respiration in hepatocytes
-
Schumacker PT, Chandel N, Agusti AG. Oxygen conformance of cellular respiration in hepatocytes. Am J Physiol 1993;265:L395-402,
-
(1993)
Am J Physiol
, vol.265
-
-
Schumacker, P.T.1
Chandel, N.2
Agusti, A.G.3
-
24
-
-
0032977124
-
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines
-
Ishii N, Maier D, Merlo A, et al. Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines. Brain Pathol 1999;9:469-9.
-
(1999)
Brain Pathol
, vol.9
, pp. 469-469
-
-
Ishii, N.1
Maier, D.2
Merlo, A.3
-
25
-
-
0026806805
-
Interleukin-8 is produced in neoplastic and infectious diseases of the human central nervous system
-
Van Meir E, Ceska M, Effenberger F, et al. Interleukin-8 is produced in neoplastic and infectious diseases of the human central nervous system. Cancer Res 1992;52:4297-305.
-
(1992)
Cancer Res
, vol.52
, pp. 4297-4305
-
-
Van Meir, E.1
Ceska, M.2
Effenberger, F.3
-
26
-
-
0030665174
-
Aberrant glycolytic metabolism of cancer cells: A remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase
-
Mathupala SP, Rempel A, Pedersen PL. Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase. J Bioenerg Biomembr 1997;29:339-43.
-
(1997)
J Bioenerg Biomembr
, vol.29
, pp. 339-343
-
-
Mathupala, S.P.1
Rempel, A.2
Pedersen, P.L.3
-
27
-
-
0035990924
-
Inhibition of protein kinase B/Akt. Implications for cancer therapy
-
Hill MM, Hemmings BA. Inhibition of protein kinase B/Akt. implications for cancer therapy. Pharmacol Ther 2002;93:243-51.
-
(2002)
Pharmacol Ther
, vol.93
, pp. 243-251
-
-
Hill, M.M.1
Hemmings, B.A.2
-
28
-
-
0026667730
-
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas
-
Cheng IQ, Godwin AK, Bellacosa A, et al. AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. Proc Natl Acad Sci USA 1992;89:9267-71.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 9267-9271
-
-
Cheng, I.Q.1
Godwin, A.K.2
Bellacosa, A.3
-
29
-
-
0038681075
-
Utility of FDG-PET scanning in lymphoma by WHO classification
-
Elstrom R, Guan L, Nakhoda K, et al. Utility of FDG-PET scanning in lymphoma by WHO classification. Blood 2003;101:3875-6.
-
(2003)
Blood
, vol.101
, pp. 3875-3876
-
-
Elstrom, R.1
Guan, L.2
Nakhoda, K.3
-
30
-
-
0030921103
-
c-Myc transactivation of LDH-A: Implications for tumor metabolism and growth
-
Shim H, Dolde C, Lewis BC, et al. c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc Natl Acad Sci USA 1997;94:6658-63.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 6658-6663
-
-
Shim, H.1
Dolde, C.2
Lewis, B.C.3
-
31
-
-
0034698178
-
Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc
-
Osthus RC, Shim H, Kim S, et al. Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J Biol Chem 2000;275:21797-800.
-
(2000)
J Biol Chem
, vol.275
, pp. 21797-21800
-
-
Osthus, R.C.1
Shim, H.2
Kim, S.3
-
33
-
-
0034050050
-
Loss of PTEN facilitates HIF-1-mediated gene expression
-
Zundel W, Schindler C, Haas-Kogan D, et al. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev 2000;14:391-6.
-
(2000)
Genes Dev
, vol.14
, pp. 391-396
-
-
Zundel, W.1
Schindler, C.2
Haas-Kogan, D.3
-
34
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
Zhong H, Chiles K, Feldser D, et al. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 2000;60:1541-5.
-
(2000)
Cancer Res
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
-
35
-
-
0035477438
-
Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3κ-kinase/Akt signaling pathway
-
Blancher C, Moore JW, Robertson N, Harris AL. Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3κ-kinase/Akt signaling pathway. Cancer Res 2001;61:7349-55.
-
(2001)
Cancer Res
, vol.61
, pp. 7349-7355
-
-
Blancher, C.1
Moore, J.W.2
Robertson, N.3
Harris, A.L.4
-
36
-
-
0034896089
-
Relation of vascular endothelial growth factor production to expression and regulation of hypoxia-inducible factor-1 alpha and hypoxia-inducible factor-2 alpha in human bladder tumors and cell lines
-
Jones A, Fujiyama C, Blanche C, et al. Relation of vascular endothelial growth factor production to expression and regulation of hypoxia-inducible factor-1 alpha and hypoxia-inducible factor-2 alpha in human bladder tumors and cell lines. Clin Cancer Res 2001;7:1263-72.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1263-1272
-
-
Jones, A.1
Fujiyama, C.2
Blanche, C.3
-
37
-
-
0037177867
-
Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription
-
Arsham AM, Plas DR, Thompson CB, Simon MC. Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription. J Biol Chem 2002;277:15162-70.
-
(2002)
J Biol Chem
, vol.277
, pp. 15162-15170
-
-
Arsham, A.M.1
Plas, D.R.2
Thompson, C.B.3
Simon, M.C.4
-
38
-
-
0037090046
-
Heat shock inactivates cellular antioxidant defenses against hydrogen peroxide: Protection by glucose
-
Lord-Fontaine S, Averill-Bates DA. Heat shock inactivates cellular antioxidant defenses against hydrogen peroxide: protection by glucose. Free Radic Biol Med 2002;32:752-65.
-
(2002)
Free Radic Biol Med
, vol.32
, pp. 752-765
-
-
Lord-Fontaine, S.1
Averill-Bates, D.A.2
-
39
-
-
0036320205
-
Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake
-
Edinger AL, Thompson CB. Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. Mol Biol Cell 2002;13:2276-88.
-
(2002)
Mol Biol Cell
, vol.13
, pp. 2276-2288
-
-
Edinger, A.L.1
Thompson, C.B.2
|