Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formation

Biochemical Journal

Volumn 359, Issue 1, 2001, Pages 139-145

  Riobo N A ^a   Clementi, E ^a   Melani, M ^a   Boveris, A ^a   Cadenas, E ^a   Moncada, S ^a   Poderoso, J J ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Complex I; Hydrogen peroxide; Superoxide anion; Ubiquinol

Indexed keywords

BIOLOGICAL ORGANS; BRAIN; HYDROGEN PEROXIDE;

ENZYME ACTIVITY;

ENZYMES;

NITRIC OXIDE; PEROXYNITRITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE; SUPEROXIDE DISMUTASE; 3 NITROTYROSINE; 3-NITROTYROSINE; DRUG DERIVATIVE; HYDROGEN PEROXIDE; MULTIENZYME COMPLEX; NICOTINAMIDE ADENINE DINUCLEOTIDE; OXIDOREDUCTASE; PEROXYNITROUS ACID; SUCCINATE DEHYDROGENASE; SUCCINATE DEHYDROGENASE (UBIQUINONE); SUCCINIC ACID DERIVATIVE; TYROSINE;

ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; ELECTRON TRANSPORT; ENERGY RESOURCE; HEART; LIVER; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT; REACTION ANALYSIS; STEADY STATE; ANIMAL; DRUG EFFECT; ENZYMOLOGY; FEMALE; HEART MITOCHONDRION; IMMUNOBLOTTING; METABOLISM; RAT STRAIN;

ANIMAL; BRAIN; ELECTRON TRANSPORT; FEMALE; HEART; HYDROGEN PEROXIDE; IMMUNOBLOTTING; LIVER; MITOCHONDRIA; MITOCHONDRIA, HEART; MULTIENZYME COMPLEXES; NAD; NADH, NADPH OXIDOREDUCTASES; NITRIC OXIDE; OXIDOREDUCTASES; PEROXYNITROUS ACID; RATS; RATS, SPRAGUE-DAWLEY; SUCCINATE CYTOCHROME C OXIDOREDUCTASE; SUCCINATE DEHYDROGENASE; SUCCINATES; SUPEROXIDE DISMUTASE; SUPEROXIDES; SUPPORT, NON-U.S. GOV'T; TYROSINE;

EID: 0035477926     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3590139     Document Type: Article

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