Fatty-acid synthase and human cancer: New perspectives on its role in tumor biology

Nutrition

Volumn 16, Issue 3, 2000, Pages 202-208

  Kuhajda, Francis P ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer; Cerulenin; Fatty acid synthase; Fatty acid synthesis

Indexed keywords

ANTINEOPLASTIC AGENT; CERULENIN; FATTY ACID SYNTHASE;

CANCER; CANCER CELL; CELL CYCLE; FATTY ACID SYNTHESIS; GLYCOLYSIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW;

CELL CYCLE; ENZYME INHIBITORS; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS; GLYCOLYSIS; HUMANS; NEOPLASMS;

EID: 0034002793     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0899-9007(99)00266-X     Document Type: Review

References (74)

1. Boyd N.F., Cousins M., Lockwood G., et al. Dietary fat and breast cancer risk the feasibility of a clinical trial of breast cancer prevention . Lipids. 27:1992;821.
2. Risch H.A., Jain M., Marrett L.D., et al. Dietary fat intake and risk of epithelial ovarian cancer. J Natl Cancer Inst. 86:1994;1409.
3. Risch H.A., Marrett L.D., Jain M., et al. Differences in risk factors for epithelial ovarian cancer by histologic type results of a case-control study . Am J Epidemiol. 144:1996;363.
4. Carroll K.K. Dietary fat and breast cancer. Lipids. 27:1992;793.
5. Reddy B.S. Dietary fat and colon cancer animal model studies . Lipids. 27:1992;807.
6. Kuhajda F.P., Jenner K., Wood F.D., et al. Fatty acid synthesis a potential selective target for antineoplastic therapy . Proc Natl Acad Sci USA. 91:1994;6379.
7. Greenstein J.P. Biochemistry of cancer. 1954;Academic Press, New York.
8. Medes G., Thomas A., Weinhouse S. Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro. Cancer Res. 13:1953;27.
9. Warburg O., Posener K.E.N. Uber den stoffwechsel der carcinomzelle. Biochem Z. 152:1924;309.
10. Nakashima R.A., Paggi M.G., Pedersen P.L. Contributions of glycolysis and oxidative phosphorylation to adenosine 5′-triphosphate production in AS-30D hepatoma cells. Cancer Res. 44:1984;5702.
11. Bustamante E., Morris H.P., Pedersen P.L. Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding. J Biol Chem. 256:1981;8699.
12. Pedersen P.L. Tumor mitochondria and the bioenergetics of cancer cells. Prog Exp Tumor Res. 22:1978;190.
13. Nakashima R.A., Scott L.J., Pedersen P.L. The role of mitochondrial hexodinase binding in the abnormal energy metabolism of tumor cells lines. (review) Ann NY Acad Sci. 488:1986;438.
14. Nakashima R.A., Paggi M.G., Scott L.J., et al. Purification and characterization of a bindable form of mitochondrial bound hexokinase from the highly glycolytic AS-30D rat hepatoma cell line. Cancer Res. 48:1988;913.
15. Arora K., Parry D., Pedersen P. Hexokinase receptors preferential enzyme binding in normal cells to nonmitochondrial sites and in transformed cells to mitochondrial sites . J Bioenerget Biomembr. 24:1992;47.
16. Medes G., Thomas A., Weinhouse S. Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro. Cancer Res. 13:1953;27.
17. Ookhtens M., Kanna R., Lyon I., et al. Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor. Am J Physiol. 247:1984;R146.
18. Goodridge A.G. Fatty acid synthesis in eucaryotes. 1991;Elsevier Science, Amsterdam.
19. Weiss L., Hoffman G., Schreiber R., et al. Fatty-acid biosynthesis in man, a pathway of minor importance. Biol Chem. 367:1986;905.
20. Wakil S. Fatty acid synthase, a proficient multifunctional enzyme. Biochemistry. 28:1989;4523.
21. Smith S. The animal fatty acid synthase one gene, one polypeptide, seven enzymes . FASEB J. 8:1994;1248.
22. Magnuson K., Jackowski S., Rock C.O., et al. Regulation of fatty acid biosynthesis in Escherichia coli. Microbiol Rev. 57:1993;522.
23. Hopwood D.A., Sherman D.H. Molecular genetics of polyketides and its comparison to fatty acid biosynthesis. Annu Rev Genet. 24:1990;37.
24. Dehesh K., Edwards P., Fillatti J., et al. Kas IV a 3-ketoacyl-ACP synthase from Cuphea sp. is a medium chain specific condensing enzyme . Plant J. 15:1998;383.
25. Rastogi N., Goh K.S., Horgen L., et al. Synergistic activities of antituberculous drugs with cerulenin and trans-cinnamic acid against Mycobacterium tuberculosis. FEMS Immunol Med Microbiol. 21:1998;149.
26. Mdluli K., Slayden R.A., Zhu Y., et al. Inhibition of Mycobacterium tuberculosis β-ketoacyl ACP synthase by isoniazid. Science. 283:1998;1607.
27. Cook H.W. Fatty acid desaturation and chain elongation in eucaryotes. 1991;Elsevier, Amsterdam.
28. Christie W.W., Hunter M.L., Clegg R.A. The effects of cerulenin on lipid metabolism in vitro in cellular preparations from the rat. Biochim Biophys Acta. 666:1981;284.
29. Saddik M., Gamble J., Witters L., et al. Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart. J Biol Chem. 268:1993;25836.
30. Alo P.L., Visca P., Marci A., et al. Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients. Cancer. 77:1996;474.
31. Bobrow L.G., Happerfield L.C., Pasternack G.R., et al. The expression of fatty acid synthase in primary breast cancer is it related to prognosis? J Pathol. 172:1994;125a.
32. Jensen V., Ladekarl M., Holm-Nielsen P., et al. The prognostic value of oncogenic antigen 519 (OA-519) expression and proliferative activity detected by antibody MIB-1 in node-negative breast cancer. J Pathol. 176:1995;343.
33. Alo P.L., Visca P., Trombetta G., et al. Fatty acid synthase (FAS) predictive strength in poorly differentiated early breast carcinomas. Tumori. 85:1999;35.
34. Epstein J.I., Carmichael M., Partin A.W. OA-519 (fatty acid synthase) as an independent predictor of pathologic stage in adenocarcinoma of the prostate. Urology. 45:1995;81.
35. Shurbaji M.S., Kalbfleisch J.H., Thurmond T.S. Immunohistochemical detection of a fatty acid synthase (OA-519) as a predictor of progression of prostate cancer. Hum Pathol. 27:1996;917.
36. Rashid A., Pizer E.S., Moga M., et al. Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia. Am J Pathol. 150:1997;201.
37. Pizer E., Lax S., Kuhajda F., et al. Fatty acid synthase expression in endometrial carcinoma correlation with cell proliferation and hormone receptors . Cancer. 83:1998;528.
38. Gansler T.S., Hardman W. III, Hunt D.A., et al. Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival. Hum Pathol. 28:1997;686.
39. Vlad L.D., Axiotis C.A., Merino M.J., et al. Fatty acid synthase is highly expressed in aggressive thyroid tumors. Mod Pathol. 12:1999;70A.
40. Kuhajda FP, Pasternack GR, et al. Cancer related antigen. U.S. Patent No. 5,864,001, 1999.
41. Milgraum L.Z., Witters L.A., Pasternack G.R., et al. Enzymes of the fatty acid synthesis pathway are highly expressed in situ breast carcinoma. Clin Cancer Res. 3:1997;2115.
42. Krontiras H., Roye G.D., Myers R.B., et al. Fatty acid synthase overexpression correlated with malignant phenotype in carcinomas of the oral tongue. Proc Annu Meet Am Assoc Cancer Res. 38:1997;A3629.
43. Omura S. The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis. Bact Rev. 40:1976;681.
44. Funabashi H., Kawaguchi A., Tomoda H., et al. Binding site of cerulenin in fatty acid synthetase. J Biochem. 105:1989;751.
45. Moche M., Schneider G., Edwards P., et al. Structure of the complex between the antibiotic cerulenin and its target, β-ketoacyl-acyl carrier protein synthase. J Biol Chem. 274:1999;6031.
46. Pizer E.S., Wood F.D., Heine H.S., et al. Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer. Cancer Res. 56:1996;1189.
47. Pizer E.S., Chrest F.J., DiGiuseppe J.A., et al. Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines. Cancer Res. 58:1998;4611.
48. Pizer E.S., Wood F.D., Pasternack G.R., et al. Fatty acid synthase (FAS) a target for cytotoxic antimetabolities in HL60 promyelocytic leukemia cells . Cancer Res. 1996:1996;745.
49. Furuya Y., Akimoto S., Yasada K., et al. Apoptosis of androgen-independent prostate cell line induced by inhibition of fatty acid synthesis. Anticancer Res. 17:1997;4589.
50. Pizer E.S., Jackisch C., Wood F.D., et al. Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells. Cancer Res. 56:1996;2745.
51. Paulauskis J.D., Sul H.S. Cloning and expression of mouse fatty acid synthase and other specific mRNAs. Developmental and hormonal regulation in 3T3-L1 cells. J Biol Chem. 263:1988;7049.
52. Moustaid N., Sul H.S. Regulation of expression of the fatty acid synthase gene in 3T3-L1 cells by differentiation and triiodothyronine. J Biol Chem. 266:1991;18550.
53. Paulauskis J.D., Sul H.S. Hormonal regulation of mouse fatty acid synthase gene transcription in liver. J Biol Chem. 264:1989;574.
54. Kinlaw W.B., Church J.L., Harmon J., et al. Direct evidence for a role of the "spot 14" protein in the regulation of lipid synthesis. J Biol Chem. 270:1995;16615.
55. Volpe J.J., Marasa J.C. Hormonal regulation and fatty acid synthetase, acetyl-CoA carboxylase and fatty acid synthesis in mammalian adipose tissue and liver. Biochim Biophys Acta. 380:1975;454.
56. Clarke S.D., Jump D.B. Regulation of gene transcription by polyunsaturated fatty acids. Prog Lipid Res. 32:1993;139.
57. Blake W.L., Clarke S.D. Suppression of rat hepatic fatty acid synthase and S14 gene transcription by dietary polyunsaturated fat. J Nutr. 120:1990;1727.
58. Jump B.J., Clarke S.D., Thelen A., et al. Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids. J Lipid Res. 1994:1994;1076.
59. Cohen W.M., Werrmann J.G., Tota M.R. 13C NMR study of the effects of leptin treatment on kinetics of hepatic intermediary metabolism. Proc Natl Acad Sci USA. 95:1998;7385.
60. Jones B.H., Kim J.H., Zemel M.B., et al. Upregulation of adipocyte metabolism by agouti protein possible paracrine actions in yellow mouse obesity . Am J Physiol. 270:1996;E192.
61. Kalkhoven E., Kwakkenbos-Isbrucker L., de Laat S.W., et al. Synthetic progestins induce proliferation of breast tumor cell lines via the progesterone or estrogen receptor. Mol Cell Endocrinol. 102:1994;45.
62. Chalbos D., Joyeux C., Galtier F., et al. Regulation of fatty acid synthetase by progesterone in normal and tumoral human mammary glands. Rev Esp Fisiol. 46:1990;43.
63. Escot C., Joyeux C., Mathieu M., et al. Regulation of fatty acid synthetase ribonucleic acid in the human endometrium during the menstrual cycle. J Clin Endocrinol Metab. 70:1990;1319.
64. 1 induces differentiation-specific gene expression in fetal rat brown adipocytes. FEBS Lett. 364:1995;193.
65. Bennett M.K., Lopez J.M., Sanchez H.B., et al. Sterol regulation of fatty acid synthase promotor. J Biol Chem. 270:1995;25578.
66. Moustaid N., Beyer R.S., Sul H.S. Identification of an insulin response element in the fatty acid synthase promotor. J Biol Chem. 269:1994;5629.
67. Wang D., Sul H.S. Insulin stimulation of the fatty acid synthase promotor is mediated by the phosphatidylinositol 3-kinase pathway. J Biol Chem. 273:1998;25420.
68. Rangan V.S., Oskouian B., Smith S. Identification of an inverted CCAAT box motif in the fatty-acid synthase gene as a essential element for mediation of transcriptional regulation by cAMP. J Biol Chem. 271:1996;2307.
69. Hsu M.H., Chirala S.S., Wakil S.J. Human fatty-acid synthase gene. J Biol Chem. 271:1996;13584.
70. Swinnen J., Van Veldhoven P., Edquenet M., et al. Androgens markedly stimulate the accumulation of neutral lipids in the human prostatic adenocarcinoma cell line LNCaP. Endocrinology. 137:1996;4468.
71. Swinnen J., Esquenet M., Goossens K., et al. Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP. Cancer Res. 57:1997;1086.
72. Swinnen J.V., Ulrix W., Heyns W., et al. Coordinate regulation of lipogenic gene expression by androgens evidence for a cascade mechanism involving sterol regulatory element binding proteins . Proc Natl Acad Sci USA. 94:1997;12975.
73. 2+-ATPase mRNA expression in NIH 3T3 cells. Biochem Biophys Res Commun. 197:1993;1483.
74. Pizer E.S., Kurman R.J., Pasternack G.R., et al. Expression of fatty acid synthase is closely linked to proliferation and stromal decidualization in cycling endometrium. Int J Gynecol Pathol. 16:1996;45.