Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

Genes and Development

Volumn 15, Issue 11, 2001, Pages 1406-1418

  Gottlob, Kathrin ^a   Majewski, Nathan ^a   Kennedy, Scott ^a,c   Kandel, Eugene ^a   Robey, R Brooks ^a,b   Hay, Nissim ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b Veteran's Administration   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

ATP; Bcl 2; Bcl xL; Cytochrome c; Mitochondrial potential

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOCHROME C; GLUCOSE; HEXOKINASE; MITOCHONDRIAL ENZYME; PROTEIN BCL 2; PROTEIN BCL X; VIRUS VECTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST CULTURE; FLUORESCENCE ACTIVATED CELL SORTER; GLUCOSE METABOLISM; GLYCOLYSIS; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RETROVIRUS;

ANIMALS; APOPTOSIS; BCL-X PROTEIN; CELLS, CULTURED; CYTOCHROME C GROUP; EXORIBONUCLEASES; GLUCOSE; GLYCOLYSIS; HEXOKINASE; ION CHANNELS; MITOCHONDRIA; PORINS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; VOLTAGE-DEPENDENT ANION CHANNELS;

ANIMALIA; UNIDENTIFIED RETROVIRUS;

EID: 0034983918     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.889901     Document Type: Article

References (52)

1. Regulation of hexokinase I: Crystal structure of recombinant human brain hexokinase complexed with glucose and phosphate
2. Regulation of GLUT1 gene transcription by the serine/threonine kinase Aktl
3. Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus: Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels
4. Coordinated regulation of cerebral glycolytic and oxidative metabolism, mediated by mitochondrially bound hexokinase dependent on intramitochondrially generated ATP
5. Interaction of mitochondrially bound rat brain hexokinase with intramitochondrial compartments of ATP generated by oxidative phosphorylation and creatine kinase
6. Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore: Implication for regulation of permeability transition by the kinases
7. Cytosolic pH measurements in single cardiac myocytes using carboxy-seminaphthorhodafluor-1
8. Interaction of mitochondrial porin with cytosolic proteins
9. Cellular energy utilization and supply during hypoxia in embryonic cardiac myocytes
10. Further studies on the coupling of mitochondrially bound hexokinase to intramitochondrially compartmented ATP, generated by oxidative phosphorylation
11. Overexpression of hexokinase II in transgenic mice: Evidence that increased phosphorylation augments muscle glucose uptake
12. Enzymatic assays for 2-deoxyglucose and 2-deoxyglucose 6-phosphate
13. Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
14. Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells
15. The mitochondrial permeability transition pore and its role in cell death
16. Cellular survival: A play in three Akts
17. Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades
18. Mitochondria as the central control point of apoptosis
19. Regulation of neuronal survival by the serine-threonine protein kinase Akt
20. Energy metabolism during apoptosis. Bcl-2 promotes survival in hematopoietic cells induced to apoptose by growth factor withdrawal by stabilizing a form of metabolic arrest
21. The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant
22. Mitochondria and apoptosis
23. BCL-2 family members and the mitochondria in apoptosis
24. Constitutive activation of protein kinase B α by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells
25. Membrane potential-dependent conformational changes in mitochondrially bound hexokinase of brain
26. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB
27. Control of glucose utilization in working perfused rat heart
28. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
29. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal
30. Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria
31. Expression of a constitutively active Akt Ser/Thr kinase in 3T3 -L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
32. Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis
33. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins
34. The mitochondrion in cell death control: Certainties and incognita
35. Changes in intramitochondrial and cytosolic pH: Early events that modulate caspase activation during apoptosis
36. The structure of mammalian hexokinase-1
37. Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc
38. Self-contained, tetracycline-regulated retroviral vector system for gene delivery to mammalian cells
39. Social controls on cell survival and cell death
40. Programmed cell death and the control of cell survival: Lessons from the nervous system
41. + antiporter in suppression of apoptosis by granulocyte macrophage colony-stimulating factor and interleukin-3
42. In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability
43. Thrombin is a novel regulator of hexokinase activity in mesangial cells
44. A model to measure insulin effects on glucose transport and phosphorylation in muscle: A three-tracer study
45. Complexities of metabolic regulation
46. Potential role of protein kinase B in glucose transporter 4 translocation in adipocytes
47. Bcl-2 proteins: Regulators of apoptosis or of mitochondrial homeostasis?
48. Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange
49. Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival
50. Effects of insulin on subcellular localization of hexokinase II in human skeletal muscle in vivo
51. Hexokinases
52. Rat brain hexokinase: Further studies on the specificity of the hexose and hexose 6-phosphate binding sites