The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1α-dependent mechanism

Journal of Biological Chemistry

Volumn 281, Issue 14, 2006, Pages 9030-9037

  Ullah, Mohammed S ^a   Davies, Andrew J ^a   Halestrap, Andrew P ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; COBALT COMPOUNDS; GELS; LUMINESCENCE; MOLECULAR BIOLOGY; ORGANIC ACIDS;

GLYCOLYTIC ENZYMES; HYPOXIA; LACTIC ACID;

BIOLOGICAL MEMBRANES;

COBALT CHLORIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LACTIC ACID; LUCIFERASE; MEMBRANE PROTEIN; MESSENGER RNA; MONOCARBOXYLASE TRANSPORTER 1; MONOCARBOXYLASE TRANSPORTER 2; MONOCARBOXYLASE TRANSPORTER 4; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; HIF1A PROTEIN, HUMAN; MCTS1 PROTEIN, HUMAN; MONOCARBOXYLATE TRANSPORTER; MUSCLE PROTEIN; ONCOPROTEIN; OXYGEN; SLC16A4 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL HYPOXIA; CELL MEMBRANE; CONTROLLED STUDY; DNA PROBE; GENE DELETION; GENE MUTATION; HELA CELL; HUMAN; HUMAN CELL; MEMBRANE TRANSPORT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; UPREGULATION; ADAPTATION; ANIMAL; BIOSYNTHESIS; CELL STRAIN COS1; CERCOPITHECUS; CHO CELL; GENE EXPRESSION PROFILING; HAMSTER; HEART MUSCLE CELL; METABOLISM; PHYSIOLOGY;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; CELL CYCLE PROTEINS; CELL HYPOXIA; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; CHO CELLS; COS CELLS; CRICETINAE; GENE EXPRESSION PROFILING; HELA CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LACTIC ACID; MONOCARBOXYLIC ACID TRANSPORTERS; MUSCLE PROTEINS; MYOCYTES, CARDIAC; ONCOGENE PROTEINS; OXYGEN; PROMOTER REGIONS (GENETICS); RNA, MESSENGER;

EID: 33646917296     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M511397200     Document Type: Article

References (31)

1. Halestrap, A. P., and Price, N. T. (1999) Biochem. J. 343, 281-299
2. Juel, C., and Halestrap, A. P. (1999) J. Physiol. 517, 633-642
3. Halestrap, A. P., and Meredith, D. (2004) Pflugers Arch. Eur. J. Physiol. 447, 619-628
4. Bröer, S., Bröer, A., Schneider, H. P., Stegen, C., Halestrap, A. P., and Deitmer, J. W. (1999) Biochem. J. 341, 529-535
5. Grollman, E. F., Philp, N. J., McPhie, P., Ward, R. D., and Sauer, B. (2000) Biochemistry 39, 9351-9357
6. Dimmer, K. S., Friedrich, B., Lang, F., Deitmer, J. W., and Bröer, S. (2000) Biochem. J. 350, 219-227
7. Manning Fox, J. E., Meredith, D., and Halestrap, A. P. (2000) J. Physiol. 529, 285-293
8. Wilson, M. C., Jackson, V. N., Heddle, C., Price, N. T., Pilegaard, H., Juel, C., Bonen, A., Montgomery, I., Hutter, O. F., and Halestrap, A. P. (1998) J. Biol. Chem. 273, 15920-15926
9. Kirk, P., Wilson, M. C., Heddle, C., Brown, M. H., Barclay, A. N., and Halestrap, A. P. (2000) EMBO J. 19, 3896-3904
10. Muramatsu, T., and Miyauchi, T. (2003) Histol. Histopathol. 18, 981-987
11. Wilson, M. C., Meredith, D., Manning Fox, J. E., Manoharan, C., Davies, A. J., and Halestrap, A. P. (2005) J. Biol. Chem. 280, 27213-27221
12. Wilson, M. C., Meredith, D., and Halestrap, A. P. (2002) J. Biol. Chem. 277, 3666-3672
13. Coles, L., Litt, J., Hatta, H., and Bonen, A. (2004) J. Physiol. 561, 253-261
14. Py, G., Eydoux, N., Lambert, K., Chapot, R., Koulmann, N., Sanchez, H., Bahi, L., Peinnequin, A., Mercier, J., and Bigard, A. X. (2005) Metabolism 54, 634-644
15. van der Meer, D. L., van den Thillart, G. E., Witte, F., de Bakker, M. A., Besser, J., Richardson, M. K., Spaink, H. P., Leito, J. T., and Bagowski, C. P. (2005) Am. J. Physiol. 289, R1512-R1519
16. Ord, J. J., Streeter, E. H., Roberts, I. S., Cranston, D., and Harris, A. L. (2005) Br. J. Cancer 93, 346-354
17. Semenza, G. L. (2001) Trends Mol. Med. 7, 345-350
18. Huang, L. E., and Bunn, H. F. (2003) J. Biol. Chem. 278, 19575-19578
19. Pugh, C. W., and Ratcliffe, P. J. (2003) Nat. Med. 9, 677-684
20. Arsham, A. M., Howell, J. J., and Simon, M. C. (2003) J. Biol. Chem. 278, 29655-29660
21. Cuff, M. A., and Shirazi Beechey, S. P. (2002) Biochem. Biophys. Res. Commun. 292, 1048-1056
22. Yoon, H. Y., and Philp, N. J. (1998) Exp. Eye Res. 67, 417-424
23. Chaudary, N., Shuralyova, I., Liron, T., Sweeney, G., and Coe, I. R. (2002) Biochem. Cell Biol. 80, 655-665
24. Price, N. T., Jackson, V. N., and Halestrap, A. P. (1998) Biochem. J. 329, 321-328
25. Behrooz, A., and Ismail-Beigi, F. (1999) News Physiol. Sci. 14, 105-110
26. Ho, V. T., and Bunn, H. F. (1996) Biochem. Biophys. Res. Commun. 223, 175-180
27. Kimura, H., Weisz, A., Ogura, T., Hitomi, Y., Kurashima, Y., Hashimoto, K., DAcquisto, F., Makuuchi, M., and Esumi, H. (2001) J. Biol. Chem. 276, 2292-2298
28. Maxwell, P. H. (2005) Semin. Cell. Dev. Biol. 16, 523-530
29. Wang, Y. X., Tonouchi, M., Miskovic, D., Hatta, H., and Bonen, A. (2003) Am. J. Physiol. 285, E622-E628
30. Moeller, L. C., Dumitrescu, A. M., and Refetoff, S. (2005) Mol. Endocrinol. 19, 2955-2963
31. Jackson, V. N., Price, N. T., Carpenter, L., and Halestrap, A. P. (1997) Biochem. J. 324, 447-453