Glucose transporters: Expression, regulation and cancer

Biological Research

Volumn 35, Issue 1, 2002, Pages 9-26

  Medina, Rodolfo A ^a   Owen, Gareth I ^b  

^a UNIVERSIDAD ANDRÉS BELLO   (Chile)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

Cancer; Cell lines; Estrogen; Expression; Glucose transporters; GLUT; Progesterone

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER; ISOENZYME;

CANCER CELL CULTURE; CELL ISOLATION; CELL PROLIFERATION; CELL SPECIFICITY; CELL TYPE; CLINICAL RESEARCH; CONTROLLED STUDY; DIABETES MELLITUS; ENERGY YIELD; ENZYME SUBSTRATE; GENE OVEREXPRESSION; GLUCOSE TRANSPORT; HORMONAL REGULATION; HUMAN; HUMAN CELL; ISCHEMIA; MAMMAL CELL; MEDICAL LITERATURE; METASTASIS; PROGNOSIS; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; TRANSPORT KINETICS;

MAMMALIA;

EID: 0036077547     PISSN: 07169760     EISSN: None     Source Type: Journal    
DOI: 10.4067/S0716-97602002000100004     Document Type: Review

References (178)

1. Stromal cell oxidation: A mechanism by which tumors obtain vitamin C
2. Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters
3. N-glycosylation of glucose transporter-1 (Glut-1) is associated with increased transporter affinity for glucose in human leukemic cells
4. Glucose transporter glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix
5. Immunohistochemical expression of human erythrocyte glucose transporter and fatty acid synthase in infiltrating breast carcinomas and adjacent typical/atypical hyperplastic or normal breast tissue
6. Glut-1 and hexokinase expression: Relationship with 2-fluoro-2-deoxy-d-glucose uptake in a431 and t47d cells in culture
7. Antitumor activity of creatine analogs produced by alterations in pancreatic hormones and glucose metabolism
8. Glucose metabolism of breast cancer assessed by 18F-FDG PET: Histologic and immunohistochemical tissue analysis
9. Expression of the human erythrocyte glucose transporter GLUT1 in cutaneous neoplasia
10. Beta-cell gene expression and functional characterisation of the human insulinoma cell line CM
11. CD95 (Fas/Apo-1)-induced apoptosis results in loss of glucose transporter function
12. Deregulated simultaneous expression of multiple glucose transporter isoforms in malignant cells and tissues
13. The insulin-sensitive glucose transporter
14. Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene
15. The GLUT5 hexose transporter is also localized to the basolateral membrane of the human jejunum
16. Gene expression of GLUT3 and GLUT1 glucose transporters in human brain tumors
17. Glucose transporter proteins in human insulinoma
18. Persistent myocardial ischemia increases GLUT1 transporter expression in both ischemic and non-ischemic heart regions
19. Differential regulation of the fructose transporters GLUT2 and GLUT5 in the intestinal cell line Caco-2
20. Glucose transporters and FDG uptake in untreated primary human non-small cell lung cancer
21. Overexpression of Glut1 glucose transporter in human breast cancer. An immunohistochemical study
22. Stimulation of glucose uptake by insulin-like growth factor II in human muscle is not mediated by the insulin-like growth factor II/mannose 6-phosphate receptor
23. Inhibition of glucose transporter gene expression by antisense nucleic acids in HL-60 leukemia cells
24. Expression of the human erythrocyte glucose transporter in transitional cell carcinoma of the bladder
25. GLUT-1 expression in ovarian carcinoma: Association with survival and response to chemotherapy
26. Antitumor activity of a novel glyco-nitric oxide conjugate in ovarian carcinoma
27. Estrogen augments glucose transporter and IGF1 expression in primate cerebral cortex
28. Glucose transport in cultured human skeletal muscle cells. Regulation by insulin and glucose in nondiabetic and non-insulin-dependent diabetes mellitus subjects
29. Expression of the facilitated glucose transporters (GLUT1 and GLUT3) by a choriocarcinoma cell line (JAr) and cytotrophoblast cells in culture
30. Fluorodeoxyglucose uptake in human cancer cell lines is increased by hypoxia
31. Regulation of GLUT1-mediated sugar transport by an antiport/uniport switch mechanism
32. Sex hormones induce insulin resistance in 3T3-L1 adipocytes by reducing cellular content of IRS proteins
33. Kinetic analysis of liver-type (GLUT2) and brain-type (GLUT3) glucose transporter in Xenopus oocytes: Substrate specificities and effects of transport inhibitors
34. Human erythrocytes express GLUT5 and transport fructose
35. Signaling mechanisms that regulate glucose transport
36. Oncogenic alterations of metabolism
37. Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar transport facilitators predominantly expressed in brain and leukocytes
38. Glucose transporter 8 (GLUT8): A novel sugar facilitator with glucose transport activity
39. Characterization of the human glucose transporter GLUT11, a novel sugar transport facilitator specifically expressed in heart muscle
40. 18F]2-deoxy-2-fluoroglucose in reperfused rat heart muscle
41. Effects of wortmannin on insulin- and ischemia-induced stimulation of GLUT4 translocation and FDG uptake in perfused rat hearts
42. Contribution of drenergic and drenergic stimulation to ischemia induced glucose transport (GLUT) 4 and GLUT1 translocation in the isolated perfused rat heart
43. Signals mediating stimulation of cardiomyocyte glucose transport by the alpha-adrenergic agonist phenylephrine
44. Hormones and hormone antagonists: Mechanisms of action in carcinogenesis of endometrial and breast cancer
45. Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues
46. Differential centrifugation separates sarcolemmal and endosomal membranes from Langendorff-perfused rat hearts
47. Clinical significance of human erythrocyte glucose transporter 1 expression at the deepest invasive site of advanced colorectal carcinoma
48. The regulation by insulin of glucose transporter gene expression in 3T3 adipocytes
49. Effect of diabetes on myocardial glucose transport system in rats. Implications for diabetic cardiomyopathy
50. Glucose sensing in pancreatic islet beta cells: The key role of glucokinase and the glycolytic intermediates
51. Identification of insulin-like growth factor (IGF) and glucose transporter-1 and -3 mRNA in CNS tumors
52. Expression of human glucose transporter in Xenopus oocytes: Kinetic characterization and substrate specificities of the erythrocyte, liver and brain isoforms
53. Role for glucose transporter 1 protein in human breast cancer
54. Localization of the GLUT1 glucose transporter to brefeldin A-sensitive vesicles of differentiated CIT3 mouse mammary epithelial cells
55. Phorbol esters stimulate muscle glucose transport by a mechanism distinct from the insulin and hypoxia pathways
56. GLUT1 glucose transporter expression in colorectal carcinoma: A marker for poor prognosis
57. GLUT1 glucose transporter expression in benign and malignant thyroid nodules
58. Hyperglycemia regulates the glucose-transport system of clonal choriocarcinoma cells in vitro. A potential molecular mechanism contributing to the adjunct effect of glucose in tumor therapy
59. Polarized distribution of glucose transporter isoforms in Caco-2 cells
60. Modulation of glucose transport in fetal rat lung: A sexual dimorphism
61. Evidence for 5′ AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport
62. Thrombin stimulates glucose transport in human platelets via the translocation of the glucose transporter GLUT-3 from alpha-granules to the cell surface
63. Heterogeneity in glucose sensitivity among pancreatic beta-cells is correlated to differences in glucose phosphorylation rather than glucose transport
64. Correlation of Glut-1 glucose transporter expression
65. Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells
66. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein
67. Metabolic regulation of glucose transport
68. Human rhabdomyosarcoma cells retain insulin-regulated glucose transport activity through glucose transporter 1
69. Expression of facilitative glucose transporter isoforms in lung carcinomas: Its relation to histologic type, differentiation grade, and tumor stage
70. Muscle glucose metabolism in exercising rats: Comparison with insulin stimulation
71. Insulin resistance, diabetes, and the insulin-regulated trafficking of GLUT4
72. Insulin stimulation of GLUT4 translocation: A model for regulated recycling
73. Effects of insulin on steady state kinetics of GLUT4 subcellular distribution in rat adipocytes: Evidence of constitutive GLUT4 recycling
74. The extended GLUT-family of sugar/polyol transport facilitators-nomenclature, sequence characteristics, and potential function of its novel members
75. Proteins that interact with facilitative glucose transporters: Implications for function
76. Effects of insulin and insulin-like growth factor-I on glucose transport and its transporters in soleus muscle of lean and obese mice
77. The trimeric GTP-binding protein (G(q)/G(11)) alpha subunit is required for insulin-stimulated GLUT4 translocation in 3T3L1 adipocytes
78. Control of glucose utilization in working perfused rat heart
79. Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4
80. Expression of glucose transporter-1 in human gastric carcinoma: Association with tumor aggressiveness, metastasis, and patient survival
81. Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues
82. Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle and adipose tissue transporter pseudogene-like sequence (GLUT6)
83. Functional expression of the human HepG2 and rat adipocytes glucose transporters in Xenopus oocytes
84. 17Beta-estradiol attenuates oxidative impairment of synaptic Na+/K+-ATPase activity, glucose transport, and glutamate transport induced by amyloid beta-peptide and iron
85. Bradykinin directly triggers GLUT4 translocation via an insulin-independent pathway
86. A tumor-associated glycosylation change in the glucose transporter GLUT1 controlled by tumor suppressor function in human cell hybrids
87. Requirement of estrogen receptor-{alpha} in insulin-like growth factor-1-induced uterine responses and in vivo evidence for insulin-like growth factor-1/estrogen receptor cross-talk
88. Clonal insulinoma cell line that stably maintains correct glucose responsiveness
89. Hormone-regulated and glucose-sensitive transport of dehydroascorbic acid in immature rat granulosa cells
90. Glucose transporters and in-vivo glucose uptake in skeletal and cardiac muscle: Fasting, insulin stimulation and immunoisolation studies of GLUT1 and GLUT4
91. Characterization of 5′ AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia
92. Differential glycosylation of the GLUT1 glucose transporter in brain capillaries and choroids plexus
93. Differential expression of facilitative glucose transporter (GLUT) genes in primary lung cancers and their liver metastases
94. Immunohistochemical localization of the glucose transporter GLUT1 in choroid plexus papillomas
95. Transmembrane glucose channel: Affinity labeling with a transportable D-glucose diazirine
96. Expression of the Na+/I-symporter gene in human thyroid tumors: A comparison study with other thyroid-specific genes
97. Wortmannin inhibits insulin-stimulated but not contraction-stimulated glucose transport activity in skeletal muscle
98. Membranous expression of glucose transporter-1 protein (GLUT-1) in embryonal neoplasms of the central nervous system
99. Glucose deprivation does not affect GLUT1 targeting in 3T3-L1 adipocytes
100. Molecular cloning of a novel member of the GLUT family of transporters, SLC2A10 (GLUT10), localized on chromosome 20q13.1: A candidate gene for NIDDM susceptibility
101. Rat glucokinase gene: Structure and regulation of insulin
102. Glucose transporter isoforms in brain: Absence of GLUT3 from the blood-brain-barrier
103. Glucose transporter proteins in brain
104. Presence and differential expression of SGLT1, GLUT1, GLUT2, GLUT3, and GLUT5 hexose-transporter mRNAs in Caco-2 cell clones in relation to cell growth and glucose consumption
105. Glucose transport and phosphorylation in single cardiac myocyte: Rate-limiting steps in glucose metabolism
106. Correlation of FDG-PET imaging with Glut-1 and Glut-3 expression in early-stage non-small cell lung cancer
107. Glucose and thyroid hormone co-regulate the expression of the intestinal fructose transporter GLUT5
108. Lactate-induced translocation of GLUT1 and GLUT4 is not mediated by phosphatidylinositol-3-kinase pathway in the rat heart
109. Expression of glucose transporters in head-and-neck tumors
110. Sugar-dependent expression of the fructose transporter GLUT5 in Caco-2 cells
111. Post-ischemic stimulation of 2-deoxyglucose uptake in rat myocardium: Role of translocation of GLUT4
112. Transcriptional activation of the glucose transporter GLUT1 in ventricular cardiac myocytes by hypertrophic agonists
113. Immunohistochemical expression of glucose transporter-1 in human penile proliferative lesions
114. Sequence and structure of human glucose transporter
115. Facilitative glucose transporters
116. Glucose transporter expression in brain. cDNA sequence of mouse GLUT3, the brain facilitative glucose transporter isoform, and identification of sites of expression by in-situ hybridization
117. Gene expression of GLUT3 glucose transporter regulated by glucose in vivo in mouse brain and in vitro in neuronal cell cultures from rat embryos
118. Expression of facilitative glucose transporter isoforms in human brain tumors
119. Developmental expression of GLUT3 glucose transporter in rat brain
120. Temporal analysis of myocardial glucose metabolism by 2-[18F]fluoro-2-deoxy-D-glucose
121. Kinetics of GLUT1 and GLUT4 glucose transporters expressed in Xenopus oocytes
122. Expression of facilitative glucose transporters in gastric tumors
123. Congenital nonprogressive hemangioma: A distinct clinicopathologic entity unlike infantile hemangioma
124. Glucose-transporter-type-I-gene amplification correlates with sialyl-Lewis-X synthesis and proliferation in lung cancer
125. 8-bromo-cyclic AMP stimulates glucose transporter-1 expression in a human choriocarcinoma cell line
126. Structure, function, and regulation of the facilitative glucose transporter gene family
127. Increased glucose transport in ras-transformed fibroblasts: A possible role for N-glycosylation of GLUT1
128. Tissue-specific self-peptides bound by major histocompatibility complex class I molecules of a human pancreatic beta-cell line
129. Brain-type glucose transporter (GLUT-1) is selectively localizes to the blood-brain-barrier. Studies with quantitative Western blotting and in-situ hybridization
130. Tumor mitochondria and the bioenergetics of cancer cells
131. Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9)
132. Insulin-like growth factor-1 regulation of alpha(1)-adrenergic receptor signaling is estradiol dependent in the preoptic area and hypothalamus of female rats
133. Comparative immunohistochemical and molecular analysis of uterine and extrauterine leiomyosarcomas
134. Expression of facilitative glucose transport proteins during development of squamous cell carcinomas of the head and neck
135. Overexpression of glucose transporter 1 and increased FDG uptake in pancreatic carcinoma
136. Mechanisms behind insulin resistance in rat skeletal muscle after oophorectomy and additional testosterone treatment
137. Increased uptake and accumulation of vitamin C in immunodeficiency virus 1-infected hematopoetic cell lines
138. Glucose transporters and transport kinetics in retinoic acid-differentiated T47D human breast cancer cells
139. Identification of novel facilitative transporter like protein-GLUT8
140. Translocation of myocardial GLUT4 and increased glucose uptake through activation of AMPK by AICAR
141. Glut1 expression in T1 and T2 stage colorectal carcinomas: Its relationship to clinicopathological features
142. Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction
143. Abnormal facilitative glucose transporter gene expression in human islet cell tumors
144. Characterization of glucose transport and glucose transporters in the human choriocarcinoma cell line, BeWo
145. Effects of 17beta-estradiol on glucose transporter 1 expression and endothelial cell survival following focal ischemia in the rats
146. Noradrenaline increases glucose transport into brown adipocytes in culture by a mechanism different from that of insulin
147. Translocation of the glucose transporter GLUT4 in cardiac myocytes of the rat
148. Counter-regulation of insulin-stimulated glucose transport by catecholamines in the isolated rat adipose cell
149. The metabolic regulation and vesicular transport of Glut4, the major insulin-responsive glucose transporter
150. Expression of glucose transporter 4 mRNA in adipose tissue and skeletal muscle of ovariectomized rats treated with sex steroid hormones
151. Glucose transporter 4 (GLUT4) mRNA abundance in the adipose tissue and skeletal-muscle tissue of ovariectomized rats treated with 17 beta-estradiol or progesterone
152. Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site
153. Liver glucose transporter: A basolateral protein in hepatocytes and intestine and kidney cells
154. Differences in the expression of glucose transporter protein isoforms in human retinoblastoma cell lines
155. Altered expression of GLUT-1 and GLUT-3 glucose transporters in neurohypophysis of water-deprived or diabetic rats
156. Human HL-60 myeloid leukemia cells transport dehydoascorbic acid via the glucose transporters and accumulate reduced ascorbic acid
157. The importance of glucose transport activity as the rate-limiting step of 2-deoxyglucose uptake in tumorcells in vitro
158. Immunohistochemical staining of GLUT1 in benign, hyperplastic, and malignant endometrial epithelia
159. Developmental expression of GLUT2 in the rat retina
160. Regulation of glucose transporters by estradiol in the immature rat uterus
161. Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise
162. The effects of wortmannin on rat skeletal muscle: Dissociation of signaling pathways for insulin- and contraction-activated hexose transport
163. GLUT1 expression in human breast carcinoma: Correlation with known prognostic markers
164. Overexpression of GLUT1 and GLUT3 in stage I nonsmall cell lung carcinoma is associated with poor survival
165. GLUT 1 expression in transitional cell carcinoma of the urinary bladder is associated with poor patient survival
166. Immunohistochemical detection of GLUT3 in human tumors and normal tissues
167. Relationship between dysplasia, p53 protein accumulation, DNA ploidy, and GLUT1 overexpression in Barrett metaplasia
168. Expression of the neutral amino acids transporter ASCT1 in esophageal carcinomas
169. Overexpression of the human erythrocyte glucose transporter occurs as a late event in human colorectal carcinogenesis and is associated with an increased incidence of lymph node metastases
170. Nitric oxide stimulates glucose transport and metabolism in rat skeletal muscle in vitro
171. Expression of the fructose transporter GLUT5 in human breast cancer
172. Proposed structure of putative glucose channel in GLUT1 facilitative glucose transporter
173. Vascular expression of glucose transporter in and around hematogenous metastases of the human brain. Immunohistochemical observations
174. Reduced GLUT1 expression in Igfl-/- null oocytes and follicles
175. Restoration of Hypoxia-stimulated Glucose Uptake in GLUT4-deficient Muscles by Muscles-specific GLUT4 Transgenic Complementation
176. Glucose transporter Glut-1 is of limited value for detecting breast carcinoma in serous effusions
177. Regulation of glucose transport, and glucose trafficking in the heart: Studies in cardiac myocytes