Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria

Oncogene

Volumn 25, Issue 34, 2006, Pages 4777-4786

  Mathupala, S P ^a   Ko, Y H ^b   Pedersen, P L ^b  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell death: 3 bromopyruvate; Glycolysis; Hexokinase II; Mitochondria

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; ADENOSINE TRIPHOSPHATE; ANION CHANNEL; BIFONAZOLE; BROMINE DERIVATIVE; BROMOPYRUVIC ACID; CLOTRIMAZOLE; GLUCOSE; GLUCOSE 6 PHOSPHATE; GLUCOSE TRANSPORTER; HEXOKINASE; HEXOKINASE ISOENZYME; LACTIC ACID; LONIDAMINE; MITOCHONDRIAL ENZYME; PORIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; PYRUVIC ACID DERIVATIVE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT ANION CHANNEL;

CANCER CELL; CANCER CONTROL; CANCER STAGING; CANCER THERAPY; CARBOHYDRATE TRANSPORT; CELL DEATH; DRUG MECHANISM; ENZYME ACTIVE SITE; ENZYME ANALYSIS; GENE OVEREXPRESSION; GLUCOSE METABOLISM; GLYCOLYSIS; HUMAN; LIVER CELL CARCINOMA; METABOLIC RATE; METABOLITE; METASTASIS; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NONHUMAN; PHENOTYPE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; PROTEIN TARGETING; REVIEW; TUMOR PROMOTION;

ADENINE NUCLEOTIDES; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; HEXOKINASE; HUMANS; ION CHANNELS; MITOCHONDRIA; NEOPLASMS; RNA PROCESSING, POST-TRANSCRIPTIONAL; TRANSCRIPTION, GENETIC;

ANIMALIA; PYRONIA TITHONUS;

EID: 33746924468     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209603     Document Type: Review

References (91)

1. Ardehali H, Yano Y, Printz RL, Koch S, Whitesell RR, May JM et al. (1996). J Biol Chem 271: 1849-1852.
2. Arora KK, Parry DM, Pedersen PL. (1992). J Bioenerg Biomembr 24: 47-53.
3. Arora KK, Pedersen PL. (1988). J Biol Chem 263: 17422-17428.
4. Azoulay-Zohar H, Israelson A, Abu-Hamad S, Shoshan-Barmatz V. (2004). Biochem J 377: 347-355.
5. Bay DC, Court DA. (2002). Biochem Cell Biol 80: 551-562.
6. Blachly-Dyson E, Zambronicz EB, Yu WH, Adams V, McCabe ER, Adelman J et al. (1993). J Biol Chem 268: 1835-1841.
7. Bustamante E, Morris HP, Pedersen PL. (1981). J Biol Chem 256: 8699-8704.
8. Bustamante E, Pedersen PL. (1977). Proc Natl Acad Sci USA 74: 3735-3739.
9. Bustamante E, Pediaditakis P, He L, Lemasters JJ. (2005). Biochem Biophys Res Commun 334: 907-910.
10. Campanella ME, Chu H, Low PS. (2005). Proc Natl Acad Sci USA 102: 2402-2407.
11. Capano M, Crompton M. (2002). Biochem J 367: 169-178.
12. Cesar MC, Wilson JE. (1998). Arch Biochem Biophys 350: 109-117.
13. Cesar MC, Wilson JE. (2004). Arch Biochem Biophys 422: 191-196.
14. Chen C, Ko Y, Delannoy M, Ludtke SJ, Chiu W, Pedersen PL. (2004). J Biol Chem 279: 31761-31768.
15. Cheng EH, Sheiko TV, Fisher JK, Craigen WJ, Korsmeyer SJ. (2003). Science 301: 513-517.
16. Chevrollier A, Loiseau D, Chabi B, Renier G, Douay O, Malthiery Y et al. (2005). J Bioenerg Biomembr 37: 307-317.
17. Colombini M. (2004). Mol Cell Biochem 256-257: 107-115.
18. Crompton M. (1999). Biochem J 341(Part 2): 233-249.
19. Danial NN, Gramm CF, Scorrano L, Zhang CY, Krauss S, Ranger AM et al. (2003). Nature 424: 952-956.
20. Don AS, Hogg PJ. (2004). Trends Mol Med 10: 372-378.
21. Elstrom RL, Bauer DE, Buzzai M, Karnauskas R, Harris MH, Plas DR et al. (2004). Cancer Res 64: 3892-3899.
22. Fanciulli M, Valentini A, Bruno T, Citro G, Zupi G, Floridi A. (1996). Oncol Res 8: 111-120.
23. Felgner PL, Messer JL, Wilson JE. (1979). J Biol Chem 254: 4946-4949.
24. Floridi A, Bruno T, Miccadei S, Fanciulli M, Federico A, Paggi MG. (1998). Biochem Pharmacol 56: 841-849.
25. Gauthier T, Denis-Pouxviel C, Murat JC. (1990). Int J Biochem 22: 419-423.
26. Geschwind JF, Georgiades CS, Ko YH, Pedersen PL. (2004). Expert Rev Anticancer Ther 4: 449-457.
27. Geschwind JF, Ko YH, Torbenson MS, Magee C, Pedersen PL. (2002). Cancer Res 62: 3909-3913.
28. Goel A, Mathupala SP, Pedersen PL. (2003). J Biol Chem 278: 15333-15340.
29. Gottlob K, Majewski N, Kennedy S, Kandel E, Robey RB, Hay N. (2001). Genes Dev 15: 1406-1418.
30. Graham JF, Cummins CJ, Smith BH, Kornblith PL. (1985). Neurosurgery 17: 537-542.
31. Granville DJ, Gottlieb RA. (2003). Curr Med Chem 10: 1527-1533.
32. Johansson T, Berrez JM, Nelson BD. (1985). Biochem Biophys Res Commun 133: 608-613.
33. Ko YH, Delannoy M, Hullihen J, Chiu W, Pedersen PL. (2003). J Biol Chem 278: 12305-12309.
34. Ko YH, Pedersen PL, Geschwind JF. (2001). Cancer Lett 173: 83-91.
35. Ko YH, Smith BL, Wang Y, Pomper MG, Rini DA, Torbenson MS et al. (2004). Biochem Biophys Res Commun 324: 269-275.
36. Kokoszka JE, Waymire KG, Levy SE, Sligh JE, Cai J, Jones DP et al. (2004). Nature 427: 461-465.
37. Kropp ES, Wilson JE. (1970). Biochem Biophys Res Commun 38: 74-79.
38. Lee MG, Pedersen PL. (2003). J Biol Chem 278: 41047-41058.
39. Lemasters JJ, Holmuhamedov E. (2006). Biochim Biophys Acta 1762: 181-190.
40. Macheda ML, Rogers S, Best JD. (2005). J Cell Physiol 202: 654-662.
41. Majewski N, Nogueira V, Bhaskar P, Coy PE, Skeen JE, Gottlob K et al. (2004a). Mol Cell 16: 819-830.
42. Majewski N, Nogueira V, Robey RB, Hay N. (2004b). Mol Cell Biol 24: 730-740.
43. Mathupala SP, Heese C, Pedersen PL. (1997a). J Biol Chem 272: 22776-22780.
44. Mathupala SP, Rempel A, Pedersen PL. (1997b). J Bioenerg Biomembr 29: 339-343.
45. Mathupala SP, Rempel A, Pedersen PL. (1995). J Biol Chem 270: 16918-16925.
46. Mathupala SP, Rempel A, Pedersen PL. (2001). J Biol Chem 276: 43407-43412.
47. Mayer D, Klimek F, Rempel A, Bannasch P. (1997). Biochem Soc Trans 25: 122-127.
48. Miccoli L, Oudard S, Sureau F, Poirson F, Dutrillaux B, Poupon MF. (1996). Biochem J 313(Part 3): 957-962.
49. Nakashima RA, Mangan PS, Colombini M, Pedersen PL. (1986). Biochemistry 25: 1015-1021.
50. Pastorino JG, Hoek JB. (2003). Curr Med Chem 10: 1535-1551.
51. Pastorino JG, Shulga N, Hoek JB. (2002). J Biol Chem 277: 7610-7618.
52. Pauwels EK, Ribeiro MJ, Stoot JH, McCready VR, Bourguignon M, Maziere B. (1998). Nucl Med Biol 25: 317-322.
53. Pedersen PL. (1978). Prog Exp Tumor Res 22: 190-274.
54. Pedersen PL, Mathupala S, Rempel A, Geschwind JF, Ko YH. (2002). Biochim Biophys Acta 1555: 14-20.
55. Penso J, Beitner R. (1998). Eur J Pharmacol 342: 113-117.
56. Plas DR, Thompson CB. (2005). Oncogene 24: 7435-7442.
57. Printz RL, Osawa H, Ardehali H, Koch S, Granner DK. (1997). Biochem Soc Trans 25: 107-112.
58. Rempel A, Bannasch P, Mayer D. (1994a). Biochem J 303 (Part 1): 269-274.
59. Rempel A, Bannasch P, Mayer D. (1994b). Biochim Biophys Acta 1219: 660-668.
60. Rempel A, Mathupala SP, Griffin CA, Hawkins AL, Pedersen PL. (1996a). Cancer Res 56: 2468-2471.
61. Rempel A, Mathupala SP, Pedersen PL. (1996b). FEBS Lett 385: 233-237.
62. Rose IA, Warms JV. (1967). J Biol Chem 242: 1635-1645.
63. Rose IA, Warms JV. (1982). Arch Biochem Biophys 213: 625-634.
64. Shimizu S, Konishi A, Kodama T, Tsujimoto Y. (2000a). Proc Natl Acad Sci USA 97: 3100-3105.
65. Shimizu S, Narita M, Tsujimoto Y. (1999). Nature 399: 483-487.
66. Shimizu S, Shinohara Y, Tsujimoto Y. (2000b). Oncogene 19: 4309-4318.
67. Shinohara Y, Ishida T, Hino M, Yamazaki N, Baba Y, Terada H. (2000). Eur J Biochem 267: 6067-6073.
68. Shinohara Y, Sagawa I, Ichihara J, Yamamoto K, Terao K, Terada H. (1997). Biochim Biophys Acta 1319: 319-330.
69. Smith TA. (1999). Br J Biomed Sci 56: 285-292.
70. Smith TA. (2000). Br J Biomed Sci 57: 170-178.
71. Sui D, Wilson JE. (1997). Arch Biochem Biophys 345: 111-125.
72. Sui D, Wilson JE. (2004). Biochem Biophys Res Commun 319: 768-773.
73. Tedeschi H, Kinnally KW, Mannella CA. (1989). J Bioenerg Biomembr 21: 451-459.
74. Tsai HJ, Wilson JE. (1995). Arch Biochem Biophys 316: 206-214.
75. Tsai HJ, Wilson JE. (1996). Arch Biochem Biophys 329: 17-23.
76. Tsai HJ, Wilson JE. (1997). Arch Biochem Biophys 338: 183-192.
77. Vander Heiden MG, Chandel NS, Schumacker PT, Thompson CB. (1999). Mol Cell 3: 159-167.
78. Vander Heiden MG, Li XX, Gottleib E, Hill RB, Thompson CB, Colombini M. (2001). J Biol Chem 276: 19414-19419.
79. Vischer U, Blondel B, Wollheim CB, Hoppner W, Seitz HJ, Iynedjian PB. (1987). Biochem J 241: 249-255.
80. Vyssokikh M, Brdiczka D. (2004). Mol Cell Biochem 256-257: 117-126.
81. Vyssokikh MY, Brdiczka D. (2003). Acta Biochim Pol 50: 389-404.
82. Vyssokikh MY, Zorova L, Zorov D, Heimlich G, Jurgensmeier JJ, Brdiczka D. (2002). Mol Biol Rep 29: 93-96.
83. Warburg O, Dickens F, Kaiser Wilhelm-Institut für Biologie B. (1930). The Metabolism of Tumours: Investigations from the Kaiser-Wilhelm Institute for Biology, Berlin-Dahlem. Constable: London.
84. Wei MC, Lindsten T, Mootha VK, Weiler S, Gross A, Ashiya M et al. (2000). Genes Dev 14: 2060-2071.
85. Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ et al. (2001). Science 292: 727-730.
86. Wilson JE. (1995). Rev Physiol Biochem Pharmacol 126: 65-198.
87. Wilson JE. (1997). Biochem Soc Trans 25: 103-107.
88. Wilson JE. (2003). J Exp Biol 206: 2049-2057.
89. Wilson JE, Messer JL, Felgner PL. (1983). Methods Enzymol 97: 469-475.
90. Zaid H, Abu-Hamad S, Israelson A, Nathan I, Shoshan-Barmatz V. (2005). Cell Death Differ 12: 751-760.
91. Zhou H, Hou Q, Chai Y, Hsu YT. (2005). Exp Cell Res 309: 316-328.