-
1
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O (1956). On the origin of cancer cells. Science 123, 309-314.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
2
-
-
0036176751
-
Positron emission tomography scanning: Current and future applications
-
Czernin J and Phelps ME (2002). Positron emission tomography scanning: current and future applications. Annu Rev Med 53, 89-112.
-
(2002)
Annu Rev Med
, vol.53
, pp. 89-112
-
-
Czernin, J.1
Phelps, M.E.2
-
3
-
-
0035021707
-
Tabulated summary of the FDG PET literature
-
Gambhir SS, Czernin J, Schwimmer J, Silverman DH, Coleman RE, and Phelps MEA (2001). Tabulated summary of the FDG PET literature. J Nucl Med 42, 1S-93S.
-
(2001)
J Nucl Med
, vol.42
-
-
Gambhir, S.S.1
Czernin, J.2
Schwimmer, J.3
Silverman, D.H.4
Coleman, R.E.5
Phelps, M.E.A.6
-
4
-
-
8844224030
-
Microenvironmental and cellular consequences of altered blood flow in tumors
-
Raghunand N, Gatenby RA, and Gillies RJ (2003). Microenvironmental and cellular consequences of altered blood flow in tumors. Br J Radiol 76, S11-S22.
-
(2003)
Br J Radiol
, vol.76
-
-
Raghunand, N.1
Gatenby, R.A.2
Gillies, R.J.3
-
5
-
-
0037335608
-
A mathematical model of tumor oxygen and glucose mass transport and metabolism with complex reaction kinetics
-
Kirkpatrick JP, Brizel DM, and Dewhirst MW (2003). A mathematical model of tumor oxygen and glucose mass transport and metabolism with complex reaction kinetics. Radiat Res 159, 336-344.
-
(2003)
Radiat Res
, vol.159
, pp. 336-344
-
-
Kirkpatrick, J.P.1
Brizel, D.M.2
Dewhirst, M.W.3
-
6
-
-
0030476061
-
Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma
-
Kimura H, Braun RD, Ong ET, Hsu R, Secomb TW, Papahadjopoulos D, Hong K, and Dewhirst MW (1996). Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma. Cancer Res 56, 5522-5528.
-
(1996)
Cancer Res
, vol.56
, pp. 5522-5528
-
-
Kimura, H.1
Braun, R.D.2
Ong, E.T.3
Hsu, R.4
Secomb, T.W.5
Papahadjopoulos, D.6
Hong, K.7
Dewhirst, M.W.8
-
7
-
-
0026083903
-
Tumor angiogenesis and metastasis - Correlation in invasive breast carcinoma
-
Weidner N, Semple JP, Welch WR, and Folkman J (1991). Tumor angiogenesis and metastasis - correlation in invasive breast carcinoma. N Engl J Med 324, 1-8.
-
(1991)
N Engl J Med
, vol.324
, pp. 1-8
-
-
Weidner, N.1
Semple, J.P.2
Welch, W.R.3
Folkman, J.4
-
8
-
-
0030935836
-
Tumour angiogenesis and prognosis
-
Fox SB (1997). Tumour angiogenesis and prognosis. Histopathology 30, 294-301.
-
(1997)
Histopathology
, vol.30
, pp. 294-301
-
-
Fox, S.B.1
-
9
-
-
0033170557
-
Causes and effects of heterogeneous perfusion in tumors
-
Gillies RJ, Schornack PA, Secomb TW, and Raghunand N (1999). Causes and effects of heterogeneous perfusion in tumors. Neoplasia 1, 197-207.
-
(1999)
Neoplasia
, vol.1
, pp. 197-207
-
-
Gillies, R.J.1
Schornack, P.A.2
Secomb, T.W.3
Raghunand, N.4
-
10
-
-
0026468180
-
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
-
Semenza GL and Wang GL (1992). A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12, 5447-5454.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 5447-5454
-
-
Semenza, G.L.1
Wang, G.L.2
-
11
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, and Ratcliffe PJ (1999). The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399, 271-275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
12
-
-
0035917313
-
2 sensing
-
2 sensing. Science 292, 464-468.
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin Jr., W.G.10
-
13
-
-
0035812772
-
HIF-1, O(2), and the 3 PHDs: How animal cells signal hypoxia to the nucleus
-
Semenza GL (2001). HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell 107, 1-3.
-
(2001)
Cell
, vol.107
, pp. 1-3
-
-
Semenza, G.L.1
-
15
-
-
0035917808
-
2-regulated prolyl hydroxylation
-
2-regulated prolyl hydroxylation. Science 292, 468-472.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Kriegsheim, A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
-
16
-
-
0028068606
-
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
-
Semenza GL, Roth PH, Fang HM, and Wang GL (1994). Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem 269, 23757-23763.
-
(1994)
J Biol Chem
, vol.269
, pp. 23757-23763
-
-
Semenza, G.L.1
Roth, P.H.2
Fang, H.M.3
Wang, G.L.4
-
17
-
-
0028805375
-
Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct asacting sequences
-
Ebert BL, Firth JD, and Ratcliffe PJ (1995). Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct asacting sequences. J Biol Chem 270, 29083-29089.
-
(1995)
J Biol Chem
, vol.270
, pp. 29083-29089
-
-
Ebert, B.L.1
Firth, J.D.2
Ratcliffe, P.J.3
-
18
-
-
0030816109
-
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
-
Maxwell PH, Dachs GU, Gleadle JM, Nicholls LG, Harris AL, Stratford IJ, Hankinson O, Pugh CW, and Ratcliffe PJ (1997). Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci USA 94, 8104-8109.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 8104-8109
-
-
Maxwell, P.H.1
Dachs, G.U.2
Gleadle, J.M.3
Nicholls, L.G.4
Harris, A.L.5
Stratford, I.J.6
Hankinson, O.7
Pugh, C.W.8
Ratcliffe, P.J.9
-
19
-
-
0034671307
-
Hypoxia-inducible expression of tumor-associated carbonic anhydrases
-
Wykoff CC, Beasley NJ, Watson PH, Turner KJ, Pastorek J, Sibtain A, Wilson GD, Turley H, Talks KL, Maxwell PH, et al. (2000). Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res 60, 7075-7083.
-
(2000)
Cancer Res
, vol.60
, pp. 7075-7083
-
-
Wykoff, C.C.1
Beasley, N.J.2
Watson, P.H.3
Turner, K.J.4
Pastorek, J.5
Sibtain, A.6
Wilson, G.D.7
Turley, H.8
Talks, K.L.9
Maxwell, P.H.10
-
20
-
-
0029039195
-
Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
-
Levy AP, Levy NS, Wegner S, and Goldberg MA (1995). Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J Biol Chem 270, 13333-13340.
-
(1995)
J Biol Chem
, vol.270
, pp. 13333-13340
-
-
Levy, A.P.1
Levy, N.S.2
Wegner, S.3
Goldberg, M.A.4
-
21
-
-
0028019589
-
Regulation of erythropoietin production. New insights into molecular mechanisms of oxygen homeostasis
-
Semenza GL (1994). Regulation of erythropoietin production. New insights into molecular mechanisms of oxygen homeostasis. Hematol Oncol Clin North Am 8, 863-884.
-
(1994)
Hematol Oncol Clin North Am
, vol.8
, pp. 863-884
-
-
Semenza, G.L.1
-
22
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL, and Simons JW (1999). Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 59, 5830-5835.
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
Lim, M.4
Hilton, D.A.5
Zagzag, D.6
Buechler, P.7
Isaacs, W.B.8
Semenza, G.L.9
Simons, J.W.10
-
23
-
-
0034050902
-
Systematic variation in gene expression patterns in human cancer cell lines
-
Ross DT, Scherf U, Eisen MB, Perou CM, Rees C, Spellman P, Iyer V, Jeffrey SS, Van de Rijn M, Waltham M, et al. (2000). Systematic variation in gene expression patterns in human cancer cell lines. Nat Genet 24, 227-235.
-
(2000)
Nat Genet
, vol.24
, pp. 227-235
-
-
Ross, D.T.1
Scherf, U.2
Eisen, M.B.3
Perou, C.M.4
Rees, C.5
Spellman, P.6
Iyer, V.7
Jeffrey, S.S.8
Van De Rijn, M.9
Waltham, M.10
-
24
-
-
0036798578
-
Further evidence to support the melanocytic origin of MDA-MB-435
-
Ellison G, Klinowska T, Westwood RF, Docter E, French T, and Fox JC (2002). Further evidence to support the melanocytic origin of MDA-MB-435. Mol Pathol 55, 294-299.
-
(2002)
Mol Pathol
, vol.55
, pp. 294-299
-
-
Ellison, G.1
Klinowska, T.2
Westwood, R.F.3
Docter, E.4
French, T.5
Fox, J.C.6
-
25
-
-
2442701892
-
Lineage infidelity of MDA-MB-435 cells: Expression of melanocyte proteins in a breast cancer cell line
-
Sellappan S, Grijalva R, Zhou X, Yang W, Eli MB, Mills GB, and Yu D (2004). Lineage infidelity of MDA-MB-435 cells: expression of melanocyte proteins in a breast cancer cell line. Cancer Res 64, 3479-3485.
-
(2004)
Cancer Res
, vol.64
, pp. 3479-3485
-
-
Sellappan, S.1
Grijalva, R.2
Zhou, X.3
Yang, W.4
Eli, M.B.5
Mills, G.B.6
Yu, D.7
-
27
-
-
0344608877
-
Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism
-
Chen J, Zhao S, Nakada K, Kuge Y, Tamaki N, Okada F, Wang J, Shindo M, Higashino F, Takeda K, et al. (2003). Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. Am J Pathol 162, 1283-1291.
-
(2003)
Am J Pathol
, vol.162
, pp. 1283-1291
-
-
Chen, J.1
Zhao, S.2
Nakada, K.3
Kuge, Y.4
Tamaki, N.5
Okada, F.6
Wang, J.7
Shindo, M.8
Higashino, F.9
Takeda, K.10
-
28
-
-
4444369682
-
Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha
-
Welsh S, Williams R, Kirkpatrick L, Paine-Murrieta G, and Powis G (2004). Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha. Mol Cancer Ther 3, 233-244.
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 233-244
-
-
Welsh, S.1
Williams, R.2
Kirkpatrick, L.3
Paine-Murrieta, G.4
Powis, G.5
-
29
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, and Semenza GL (1996). Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16, 4604-4613.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4604-4613
-
-
Forsythe, J.A.1
Jiang, B.H.2
Iyer, N.V.3
Agani, F.4
Leung, S.W.5
Koos, R.D.6
Semenza, G.L.7
-
31
-
-
0032581277
-
Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
-
Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, et al. (1998). Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394, 485-490.
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.M.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
Neeman, M.7
Bono, F.8
Abramovitch, R.9
Maxwell, P.10
-
32
-
-
0035077154
-
Von Hippel-Lindau tumour suppressor gene is not involved in sporadic human breast cancer
-
Sourvinos G, Miyakis S, Liloglou TL, Field JK, and Spandidos DA (2001). Von Hippel-Lindau tumour suppressor gene is not involved in sporadic human breast cancer. Tumour Biol 22, 131-136.
-
(2001)
Tumour Biol
, vol.22
, pp. 131-136
-
-
Sourvinos, G.1
Miyakis, S.2
Liloglou, T.L.3
Field, J.K.4
Spandidos, D.A.5
-
33
-
-
0037131271
-
Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha
-
Chan DA, Sutphin PD, Denko NC, and Giaccia AJ (2002). Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. J Biol Chem 277, 40112-40117.
-
(2002)
J Biol Chem
, vol.277
, pp. 40112-40117
-
-
Chan, D.A.1
Sutphin, P.D.2
Denko, N.C.3
Giaccia, A.J.4
-
34
-
-
0037044578
-
Activated pp60c-Src leads to elevated hypoxia-inducible factor (HIF)-1alpha expression under normoxia
-
Karni R, Dor Y, Keshet E, Meyuhas O, and Levitzki A (2002). Activated pp60c-Src leads to elevated hypoxia-inducible factor (HIF)-1alpha expression under normoxia. J Biol Chem 277, 42919-42925.
-
(2002)
J Biol Chem
, vol.277
, pp. 42919-42925
-
-
Karni, R.1
Dor, Y.2
Keshet, E.3
Meyuhas, O.4
Levitzki, A.5
-
35
-
-
0032749463
-
Hypoxia-induced activation of HIF-1: Role of HIF-1alpha-Hsp90 interaction
-
Minet E, Mottet D, Michel G, Roland I, Raes M, Remade J, and Michiels C (1999), Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction. FEBS Lett 460, 251-256.
-
(1999)
FEBS Lett
, vol.460
, pp. 251-256
-
-
Minet, E.1
Mottet, D.2
Michel, G.3
Roland, I.4
Raes, M.5
Remade, J.6
Michiels, C.7
-
36
-
-
0037119415
-
Hsp90 regulates a von Hippel Lindau - Independent hypoxia-inducible factor-1 alpha-degradative pathway
-
Isaacs JS, Jung YJ, Mimnaugh EG, Martinez A, Cuttitta F, and Neckers LM (2002). Hsp90 regulates a von Hippel Lindau - independent hypoxia-inducible factor-1 alpha-degradative pathway. J Biol Chem 277, 29936-29944.
-
(2002)
J Biol Chem
, vol.277
, pp. 29936-29944
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mimnaugh, E.G.3
Martinez, A.4
Cuttitta, F.5
Neckers, L.M.6
-
37
-
-
0037189542
-
Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
-
Lu H, Forbes RA, and Verma A (2002). Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J Biol Chem 277, 23111-23115.
-
(2002)
J Biol Chem
, vol.277
, pp. 23111-23115
-
-
Lu, H.1
Forbes, R.A.2
Verma, A.3
-
38
-
-
0037080449
-
Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography
-
Bos R, van Der Hoeven JJ, van Der Wall E, van Der Groep P, van Diest PJ, Comans EF, Joshi U, Semenza GL, Hoekstra OS, Lammertsma AA, et al. (2002). Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography. J Clin Oncol 20, 379-387.
-
(2002)
J Clin Oncol
, vol.20
, pp. 379-387
-
-
Bos, R.1
Van Der Hoeven, J.J.2
Van Der Wall, E.3
Van Der Groep, P.4
Van Diest, P.J.5
Comans, E.F.6
Joshi, U.7
Semenza, G.L.8
Hoekstra, O.S.9
Lammertsma, A.A.10
-
39
-
-
0042242676
-
The glycolytic phenotype in carcinogenesis and tumor invasion: Insights through mathematical models
-
Gatenby RA and Gawlinski ET (2003). The glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical models. Cancer Res 63, 3847-3854.
-
(2003)
Cancer Res
, vol.63
, pp. 3847-3854
-
-
Gatenby, R.A.1
Gawlinski, E.T.2
-
40
-
-
0030499036
-
Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia
-
Berggren M, Gallegos A, Gasdaska JR, Gasdaska PY, Warneke J, and Powis G (1996). Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia. Anticancer Res 16, 3459-3466.
-
(1996)
Anticancer Res
, vol.16
, pp. 3459-3466
-
-
Berggren, M.1
Gallegos, A.2
Gasdaska, J.R.3
Gasdaska, P.Y.4
Warneke, J.5
Powis, G.6
-
41
-
-
17344392308
-
A new mathematical model for relative quantification in real-time RT-PCR
-
Pfaffl MW (2001). A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29, e45.
-
(2001)
Nucleic Acids Res
, vol.29
-
-
Pfaffl, M.W.1
|