Selective vulnerability of synaptic signaling and metabolism to nitrosative stress

Antioxidants and Redox Signaling

Volumn 17, Issue 7, 2012, Pages 992-1012

  Mongin, Alexander A ^a   Dohare, Preeti ^a   Jourd'Heuil, David ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; REACTIVE NITROGEN SPECIES;

ALZHEIMER DISEASE; CELL FUNCTION; DENDRITIC CELL; HUMAN; METABOLISM; MITOCHONDRION; MULTIPLE SCLEROSIS; NERVE FIBER; NITROSATION; NITROSATIVE STRESS; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN MODIFICATION; REVIEW; STROKE; SYNAPSE;

ANIMALS; CENTRAL NERVOUS SYSTEM; HUMANS; NITRIC OXIDE; NITROSATION; REACTIVE NITROGEN SPECIES;

EID: 84864601291     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2012.4559     Document Type: Review

References (284)

1. Abe K, Pan LH, Watanabe M, Kato T, and Itoyama Y. Induction of nitrotyrosine-like immunoreactivity in the lower motor neuron of amyotrophic lateral sclerosis. Neurosci Lett 199: 152-154, 1995.
2. Abriata LA, Cassina A, Tortora V, Marin M, Souza JM, Castro L, Vila AJ, and Radi R. Nitration of solvent-exposed tyrosine 74 on cytochrome c triggers heme iron-methionine 80 bond disruption. Nuclear magnetic resonance and optical spectroscopy studies. J Biol Chem 284: 17-26, 2009.
3. Akulinin VA, Stepanov SS, Semchenko VV, and Belichenko PV. Dendritic changes of the pyramidal neurons in layer V of sensory-motor cortex of the rat brain during the postresuscitation period. Resuscitation 35: 157-164, 1997. (Pubitemid 27387284)
4. Almeida A, Moncada S, and Bolanos JP. Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway. Nat Cell Biol 6: 45-51, 2004. (Pubitemid 38425729)
5. Arriagada PV, Growdon JH, Hedley-Whyte ET, and Hyman BT. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42: 631-639, 1992.
6. Aulak KS, Koeck T, Crabb JW, and Stuehr DJ. Dynamics of protein nitration in cells and mitochondria. Am J Physiol Heart Circ Physiol 286: H30-H38, 2004. (Pubitemid 38049459)
7. Aulak KS, Miyagi M, Yan L, West KA, Massillon D, Crabb JW, and Stuehr DJ. Proteomic method identifies proteins nitrated in vivo during inflammatory challenge. Proc Natl Acad Sci USA 98: 12056-12061, 2001. (Pubitemid 32959825)
8. Bagasra O, Michaels FH, Zheng YM, Bobroski LE, Spitsin SV, Fu ZF, Tawadros R, and Koprowski H. Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis. Proc Natl Acad Sci USA 92: 12041-12045, 1995. (Pubitemid 26014007)
9. Bal-Price A and Brown GC. Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity. J Neurosci 21: 6480-6491, 2001. (Pubitemid 32781092)
10. Balazy M, Kaminski PM, Mao K, Tan J, and Wolin MS. S-Nitroglutathione, a product of the reaction between peroxynitrite and glutathione that generates nitric oxide. J Biol Chem 273: 32009-32015, 1998. (Pubitemid 29177141)
11. Baxter B, Gillingwater TH, and Parson SH. Rapid loss of motor nerve terminals following hypoxia-reperfusion injury occurs via mechanisms distinct from classic Wallerian degeneration. J Anat 212: 827-835, 2008. (Pubitemid 351772662)
12. Beckman JS, Estevez AG, Crow JP, and Barbeito L. Superoxide dismutase and the death of motoneurons in ALS. Trends Neurosci 24: S15-S20, 2001.
13. Behl C, Davis JB, Lesley R, and Schubert D. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 77: 817-827, 1994. (Pubitemid 24187680)
14. Benhar M, Forrester MT, Hess DT, and Stamler JS. Regulated protein denitrosylation by cytosolic and mitochondrial thioredoxins. Science 320: 1050-1054, 2008. (Pubitemid 351929542)
15. Benhar M, Forrester MT, and Stamler JS. Protein denitrosylation: enzymatic mechanisms and cellular functions. Nat Rev Mol Cell Biol 10: 721-732, 2009.
16. Betancur C, Sakurai T, and Buxbaum JD. The emerging role of synaptic cell-adhesion pathways in the pathogenesis of autism spectrum disorders. Trends Neurosci 32: 402-412, 2009.
17. Bhat NR, Zhang P, and Bhat AN. Cytokine induction of inducible nitric oxide synthase in an oligodendrocyte cell line: role of p38 mitogen-activated protein kinase activation. J Neurochem 72: 472-478, 1999. (Pubitemid 29055208)
18. Binder LI, Guillozet-Bongaarts AL, Garcia-Sierra F, and Berry RW. Tau, tangles, and Alzheimer's disease. Biochim Biophys Acta 1739: 216-223, 2005. (Pubitemid 40018540)
19. Bizzozero OA, DeJesus G, Bixler HA, and Pastuszyn A. Evidence of nitrosative damage in the brain white matter of patients with multiple sclerosis. Neurochem Res 30: 139-149, 2005. (Pubitemid 40254214)
20. Bizzozero OA and Zheng J. Identification of major S-nitrosylated proteins in murine experimental autoimmune encephalomyelitis. J Neurosci Res 87: 2881-2889, 2009.
21. Black MM and Lasek RJ. Slow components of axonal transport: two cytoskeletal networks. J Cell Biol 86: 616-623, 1980. (Pubitemid 10016283)
22. Bolanos JP and Almeida A. Roles of nitric oxide in brain hypoxia-ischemia. Biochim Biophys Acta 1411: 415-436, 1999. (Pubitemid 29221965)
23. Bolanos JP, Heales SJ, Land JM, and Clark JB. Effect of peroxynitrite on the mitochondrial respiratory chain: differential susceptibility of neurones and astrocytes in primary culture. J Neurochem 64: 1965-1972, 1995.
24. Bolay H and Dalkara T. Mechanisms of motor dysfunction after transient MCA occlusion: persistent transmission failure in cortical synapses is a major determinant. Stroke 29: 1988-1993, 1998. (Pubitemid 28400007)
25. Bolay H, Gursoy-Ozdemir Y, Sara Y, Onur R, Can A, and Dalkara T. Persistent defect in transmitter release and synapsin phosphorylation in cerebral cortex after transient moderate ischemic injury. Stroke 33: 1369-1375, 2002. (Pubitemid 34517062)
26. Borutaite V, Budriunaite A, and Brown GC. Reversal of nitric oxide-, peroxynitrite-and S-nitrosothiol-induced inhibition of mitochondrial respiration or complex I activity by light and thiols. Biochim Biophys Acta 1459: 405-412, 2000. (Pubitemid 30612414)
27. Bosworth CA, Toledo JC Jr., Zmijewski JW, Li Q, and Lancaster JR Jr. Dinitrosyliron complexes and the mechanism (s) of cellular protein nitrosothiol formation from nitric oxide. Proc Natl Acad Sci USA 106: 4671-4676, 2009.
28. Boullerne AI, Rodriguez JJ, Touil T, Brochet B, Schmidt S, Abrous ND, Le MM, Pua JR, Jensen MA, Mayo W, Arnason BG, and Petry KG. Anti-S-nitrosocysteine antibodies are a predictive marker for demyelination in experimental autoimmune encephalomyelitis: implications for multiple sclerosis. J Neurosci 22: 123-132, 2002. (Pubitemid 34033490)
29. Bredt DS, Glatt CE, Hwang PM, Fotuhi M, Dawson TM, and Snyder SH. Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase. Neuron 7: 615-624, 1991.
30. Bredt DS, Hwang PM, and Snyder SH. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 347: 768-770, 1990.
31. Bredt DS and Snyder SH. Nitric oxide mediates glutamatelinked enhancement of cGMP levels in the cerebellum. Proc Natl Acad Sci USA 86: 9030-9033, 1989. (Pubitemid 20010361)
32. Bredt DS and Snyder SH. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci USA 87: 682-685, 1990.
33. Bredt DS and Snyder SH. Nitric oxide: a physiologic messenger molecule. Annu Rev Biochem 63: 175-195, 1994.
34. Brorson JR, Schumacker PT, and Zhang H. Nitric oxide acutely inhibits neuronal energy production. J Neurosci 19: 147-158, 1999. (Pubitemid 29028957)
35. Brose N, O'Connor V, and Skehel P. Synaptopathy: dysfunction of synaptic function? Biochem Soc Trans 38: 443-444, 2010.
36. Brown CE, Wong C, and Murphy TH. Rapid morphologic plasticity of peri-infarct dendritic spines after focal ischemic stroke. Stroke 39: 1286-1291, 2008. (Pubitemid 351440703)
37. Brown GC. Nitric oxide and mitochondrial respiration. Biochim Biophys Acta 1411: 351-369, 1999. (Pubitemid 29221960)
38. Brown GC and Cooper CE. Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett 356: 295-298, 1994. (Pubitemid 24376992)
39. Buchczyk DP, Briviba K, Hartl FU, and Sies H. Responses to peroxynitrite in yeast: glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a sensitive intracellular target for nitration and enhancement of chaperone expression and ubiquitination. Biol Chem 381: 121-126, 2000. (Pubitemid 30130735)
40. Buchczyk DP, Grune T, Sies H, and Klotz LO. Modifications of glyceraldehyde-3-phosphate dehydrogenase induced by increasing concentrations of peroxynitrite: early recognition by 20S proteasome. Biol Chem 384: 237-241, 2003. (Pubitemid 36348323)
41. Burwell LS, Nadtochiy SM, Tompkins AJ, Young S, and Brookes PS. Direct evidence for S-nitrosation of mitochondrial complex I. Biochem J 394: 627-634, 2006.
42. Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, and Butterfield DA. Nitric oxide in cell survival: a Janus molecule. Antioxid Redox Signal 11: 2717-2739, 2009.
43. Cappelletti G, Maggioni MG, Ronchi C, Maci R, and Tedeschi G. Protein tyrosine nitration is associated with cold-and drug-resistant microtubules in neuronal-like PC12 cells. Neurosci Lett 401: 159-164, 2006.
44. Cappelletti G, Tedeschi G, Maggioni MG, Negri A, Nonnis S, and Maci R. The nitration of tau protein in neurone-like PC12 cells. FEBS Lett 562: 35-39, 2004. (Pubitemid 38388444)
45. Carmichael ST. Cellular and molecular mechanisms of neural repair after stroke: making waves. Ann Neurol 59: 735-742, 2006. (Pubitemid 43673150)
46. Cassina A and Radi R. Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transport. Arch Biochem Biophys 328: 309-316, 1996. (Pubitemid 26160113)
47. Castro L, Rodriguez M, and Radi R. Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide. J Biol Chem 269: 29409-29415, 1994. (Pubitemid 24365085)
48. Centonze D, Muzio L, Rossi S, Cavasinni F, De C, V, Bergami A, Musella A, D'Amelio M, Cavallucci V, Martorana A, Bergamaschi A, Cencioni MT, Diamantini A, Butti E, Comi G, Bernardi G, Cecconi F, Battistini L, Furlan R, and Martino G. Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis. J Neurosci 29: 3442-3452, 2009.
49. Chao CC, Hu S, Molitor TW, Shaskan EG, and Peterson PK. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J Immunol 149: 2736-2741, 1992.
50. Chen CL, Chen J, Rawale S, Varadharaj S, Kaumaya PP, Zweier JL, and Chen YR. Protein tyrosine nitration of the flavin subunit is associated with oxidative modification of mitochondrial complex II in the post-ischemic myocardium. J Biol Chem 283: 27991-28003, 2008.
51. Chen CL, Zhang L, Yeh A, Chen CA, Green-Church KB, Zweier JL, and Chen YR. Site-specific S-glutathiolation of mitochondrial NADH ubiquinone reductase. Biochemistry 46: 5754-5765, 2007. (Pubitemid 46764124)
52. Chen Y, Vartiainen NE, Ying W, Chan PH, Koistinaho J, and Swanson RA. Astrocytes protect neurons from nitric oxide toxicity by a glutathione-dependent mechanism. J Neurochem 77: 1601-1610, 2001. (Pubitemid 32574495)
53. Chen YR, Chen CL, Pfeiffer DR, and Zweier JL. Mitochondrial complex II in the post-ischemic heart: oxidative injury and the role of protein S-glutathionylation. J Biol Chem 282: 32640-32654, 2007. (Pubitemid 350159288)
54. Chevalier-Larsen E and Holzbaur EL. Axonal transport and neurodegenerative disease. Biochim Biophys Acta 1762: 1094-1108, 2006. (Pubitemid 44750577)
55. Chinta SJ and Andersen JK. Reversible inhibition of mitochondrial complex I activity following chronic dopaminergic glutathione depletion in vitro: implications for Parkinson's disease. Free Radic Biol Med 41: 1442-1448, 2006. (Pubitemid 44466728)
56. Cho DH, Nakamura T, Fang J, Cieplak P, Godzik A, Gu Z, and Lipton SA. S-nitrosylation of Drp1 mediates betaamyloid-related mitochondrial fission and neuronal injury. Science 324: 102-105, 2009.
57. Choi DW. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1: 623-634, 1988.
58. Choi DW. Excitotoxic cell death. J Neurobiol 23: 1261-1276, 1992.
59. Chouchani ET, Hurd TR, Nadtochiy SM, Brookes PS, Fearnley IM, Lilley KS, Smith RA, and Murphy MP. Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNODIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation. Biochem J 430: 49-59, 2010.
60. Christopherson KS, Hillier BJ, Lim WA, and Bredt DS. PSD-95 assembles a ternary complex with the N-methyl-Daspartic acid receptor and a bivalent neuronal NO synthase PDZ domain. J Biol Chem 274: 27467-27473, 1999.
61. Chung KK, Dawson TM, and Dawson VL. Nitric oxide, Snitrosylation and neurodegeneration. Cell Mol Biol (Noisy-le-grand) 51: 247-254, 2005.
62. Chung KK, Thomas B, Li X, Pletnikova O, Troncoso JC, Marsh L, Dawson VL, and Dawson TM. S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function. Science 304: 1328-1331, 2004. (Pubitemid 38697430)
63. Cleeter MW, Cooper JM, rley-Usmar VM, Moncada S, and Schapira AH. Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Lett 345: 50-54, 1994.
64. Clementi E, Brown GC, Feelisch M, and Moncada S. Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. Proc Natl Acad Sci USA 95: 7631-7636, 1998. (Pubitemid 28293304)
65. Cosby K, Partovi KS, Crawford JH, Patel RP, Reiter CD, Martyr S, Yang BK, Waclawiw MA, Zalos G, Xu X, Huang KT, Shields H, Kim-Shapiro DB, Schechter AN, Cannon RO III, and Gladwin MT. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med 9: 1498-1505, 2003. (Pubitemid 38004777)
66. Cross AH, Misko TP, Lin RF, Hickey WF, Trotter JL, and Tilton RG. Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice. J Clin Invest 93: 2684-2690, 1994. (Pubitemid 24177187)
67. Danielson SR and Andersen JK. Oxidative and nitrative protein modifications in Parkinson's disease. Free Radic Biol Med 44: 1787-1794, 2008.
68. Danielson SR, Held JM, Oo M, Riley R, Gibson BW, and Andersen JK. Quantitative mapping of reversible mitochondrial Complex I cysteine oxidation in a Parkinson disease mouse model. J Biol Chem 286: 7601-7608, 2011.
69. Davey GP, Peuchen S, and Clark JB. Energy thresholds in brain mitochondria. Potential involvement in neurodegeneration. J Biol Chem 273: 12753-12757, 1998. (Pubitemid 28246828)
70. Davies CA, Mann DM, Sumpter PQ, and Yates PO. A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease. J Neurol Sci 78: 151-164, 1987. (Pubitemid 17031709)
71. Dawson TM and Dawson VL. Molecular pathways of neurodegeneration in Parkinson's disease. Science 302: 819-822, 2003. (Pubitemid 37339614)
72. Dawson VL, Dawson TM, Bartley DA, Uhl GR, and Snyder SH. Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures. J Neurosci 13: 2651-2661, 1993. (Pubitemid 23151779)
73. Dillman JF III, Dabney LP, Karki S, Paschal BM, Holzbaur EL, and Pfister KK. Functional analysis of dynactin and cytoplasmic dynein in slow axonal transport. J Neurosci 16: 6742-6752, 1996. (Pubitemid 26359358)
74. Dillman JF, III, Dabney LP, and Pfister KK. Cytoplasmic dynein is associated with slow axonal transport. Proc Natl Acad Sci USA 93: 141-144, 1996. (Pubitemid 26038116)
75. Dimmeler S, Lottspeich F, and Brune B. Nitric oxide causes ADP-ribosylation and inhibition of glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem 267: 16771-16774, 1992.
76. Dirnagl U, Iadecola C, and Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 22: 391-397, 1999. (Pubitemid 29453643)
77. Doulias PT, Greene JL, Greco TM, Tenopoulou M, Seeholzer SH, Dunbrack RL, and Ischiropoulos H. Structural profiling of endogenous S-nitrosocysteine residues reveals unique features that accommodate diverse mechanisms for protein S-nitrosylation. Proc Natl Acad Sci USA 107: 16958-16963, 2010.
78. Dringen R, Pfeiffer B, and Hamprecht B. Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione. J Neurosci 19: 562-569, 1999. (Pubitemid 29036007)
79. Eiserich JP, Estevez AG, Bamberg TV, Ye YZ, Chumley PH, Beckman JS, and Freeman BA. Microtubule dysfunction by posttranslational nitrotyrosination of alpha-tubulin: a nitric oxide-dependent mechanism of cellular injury. Proc Natl Acad Sci USA 96: 6365-6370, 1999. (Pubitemid 29256671)
80. Eliasson MJ, Huang Z, Ferrante RJ, Sasamata M, Molliver ME, Snyder SH, and Moskowitz MA. Neuronal nitric oxide synthase activation and peroxynitrite formation in ischemic stroke linked to neural damage. J Neurosci 19: 5910-5918, 1999. (Pubitemid 29327926)
81. Erecinska M, Nelson D, and Vanderkooi JM. Effects of NOgenerating compounds on synaptosomal energy metabolism. J Neurochem 65: 2699-2705, 1995.
82. Eu JP, Liu L, Zeng M, and Stamler JS. An apoptotic model for nitrosative stress. Biochemistry 39: 1040-1047, 2000. (Pubitemid 30075332)
83. Feigin VL. Stroke epidemiology in the developing world. Lancet 365: 2160-2161, 2005. (Pubitemid 40853896)
84. Fenyk-Melody JE, Garrison AE, Brunnert SR, Weidner JR, Shen F, Shelton BA, and Mudgett JS. Experimental autoimmune encephalomyelitis is exacerbated in mice lacking the NOS2 gene. J Immunol 160: 2940-2946, 1998. (Pubitemid 28136750)
85. Forster C, Clark HB, Ross ME, and Iadecola C. Inducible nitric oxide synthase expression in human cerebral infarcts. Acta Neuropathol 97: 215-220, 1999. (Pubitemid 29137269)
86. Foster MW, Hess DT, and Stamler JS. Protein S-nitrosylation in health and disease: a current perspective. Trends Mol Med 15: 391-404, 2009.
87. Frautschy SA, Yang F, Irrizarry M, Hyman B, Saido TC, Hsiao K, and Cole GM. Microglial response to amyloid plaques in APPsw transgenic mice. Am J Pathol 152: 307-317, 1998. (Pubitemid 28028071)
88. Fujisawa Y, Kato K, and Giulivi C. Nitration of tyrosine residues 368 and 345 in the beta-subunit elicits FoF1-ATPase activity loss. Biochem J 423: 219-231, 2009.
89. Furchgott RF and Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288: 373-376, 1980. (Pubitemid 11169009)
90. Galea E, Feinstein DL, and Reis DJ. Induction of calciumindependent nitric oxide synthase activity in primary rat glial cultures. Proc Natl Acad Sci USA 89: 10945-10949, 1992.
91. Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F, and. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature 373: 523-527, 1995.
92. Gao C, Guo H, Wei J, Mi Z, Wai PY, and Kuo PC. Identification of S-nitrosylated proteins in endotoxin-stimulated RAW264.7 murine macrophages. Nitric Oxide 12: 121-126, 2005. (Pubitemid 40312454)
93. Gardner PR and Fridovich I. Superoxide sensitivity of the Escherichia coli aconitase. J Biol Chem 266: 19328-19333, 1991. (Pubitemid 21908236)
94. Gardner PR, Martin LA, Hall D, and Gardner AM. Dioxygen-dependent metabolism of nitric oxide in mammalian cells. Free Radic Biol Med 31: 191-204, 2001. (Pubitemid 32607586)
95. Garthwaite J, Charles SL, and Chess-Williams R. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature 336: 385-388, 1988.
96. Gasche Y, Copin JC, Sugawara T, Fujimura M, and Chan PH. Matrix metalloproteinase inhibition prevents oxidative stress-associated blood-brain barrier disruption after transient focal cerebral ischemia. J Cereb Blood Flow Metab 21: 1393-1400, 2001. (Pubitemid 33120943)
97. Gaston B, Reilly J, Drazen JM, Fackler J, Ramdev P, Arnelle D, Mullins ME, Sugarbaker DJ, Chee C, Singel DJ, et al. Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways. Proc Natl Acad Sci USA 90: 10957-10961, 1993. (Pubitemid 23354347)
98. Glantz LA, Gilmore JH, Lieberman JA, and Jarskog LF. Apoptotic mechanisms and the synaptic pathology of schizophrenia. Schizophr Res 81: 47-63, 2006. (Pubitemid 41817206)
99. Go YM, Patel RP, Maland MC, Park H, Beckman JS, Darley-Usmar VM, and Jo H. Evidence for peroxynitrite as a signaling molecule in flow-dependent activation of c-Jun NH(2)-terminal kinase. Am J Physiol 277: H1647-H1653, 1999. (Pubitemid 29522700)
100. Good PF, Hsu A, Werner P, Perl DP, and Olanow CW. Protein nitration in Parkinson's disease. J Neuropathol Exp Neurol 57: 338-342, 1998. (Pubitemid 28182632)
101. Greenamyre JT, Sherer TB, Betarbet R, and Panov AV. Complex I and Parkinson's disease. IUBMB Life 52: 135-141, 2001.
102. Griffiths C and Garthwaite J. The shaping of nitric oxide signals by a cellular sink. J Physiol 536: 855-862, 2001. (Pubitemid 33019420)
103. Grisham MB, Jourd'heuil D, and Wink DA. Nitric oxide. I. Physiological chemistry of nitric oxide and its metabolites: implications in inflammation. Am J Physiol 276: G315-G321, 1999. (Pubitemid 29104144)
104. Gu Z, Kaul M, Yan B, Kridel SJ, Cui J, Strongin A, Smith JW, Liddington RC, and Lipton SA. S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death. Science 297: 1186-1190, 2002. (Pubitemid 36193354)
105. Guix FX, Uribesalgo I, Coma M, and Munoz FJ. The physiology and pathophysiology of nitric oxide in the brain. Prog Neurobiol 76: 126-152, 2005. (Pubitemid 41242885)
106. Hall CN and Garthwaite J. What is the real physiological NO concentration in vivo? Nitric Oxide 21: 92-103, 2009.
107. Halligan KE, Jourd'heuil FL, and Jourd'heuil D. Cytoglobin is expressed in the vasculature and regulates cell respiration and proliferation via nitric oxide dioxygenation. J Biol Chem 284: 8539-8547, 2009.
108. Halliwell B. What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in vivo? FEBS Lett 411: 157-160, 1997. (Pubitemid 27301445)
109. Han D, Canali R, Garcia J, Aguilera R, Gallaher TK, and Cadenas E. Sites and mechanisms of aconitase inactivation by peroxynitrite: modulation by citrate and glutathione. Biochemistry 44: 11986-11996, 2005. (Pubitemid 41285696)
110. Hantraye P, Brouillet E, Ferrante R, Palfi S, Dolan R, Matthews RT, and Beal MF. Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nat Med 2: 1017-1021, 1996. (Pubitemid 26306841)
111. Haqqani AS, Do SK, and Birnboim HC. The role of a formaldehyde dehydrogenase-glutathione pathway in protein S-nitrosation in mammalian cells. Nitric Oxide 9: 172-181, 2003. (Pubitemid 38077278)
112. Hara MR, Agrawal N, Kim SF, Cascio MB, Fujimuro M, Ozeki Y, Takahashi M, Cheah JH, Tankou SK, Hester LD, Ferris CD, Hayward SD, Snyder SH, and Sawa A. S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Nat Cell Biol 7: 665-674, 2005. (Pubitemid 40975747)
113. Hara MR, Cascio MB, and Sawa A. GAPDH as a sensor of NO stress. Biochim Biophys Acta 1762: 502-509, 2006.
114. Hara MR, Thomas B, Cascio MB, Bae BI, Hester LD, Dawson VL, Dawson TM, Sawa A, and Snyder SH. Neuroprotection by pharmacologic blockade of the GAPDH death cascade. Proc Natl Acad Sci USA 103: 3887-3889, 2006. (Pubitemid 43376650)
115. Hardy JA and Higgins GA. Alzheimer's disease: the amyloid cascade hypothesis. Science 256: 184-185, 1992.
116. Hauser SL and Oksenberg Jr. The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. Neuron 52: 61-76, 2006. (Pubitemid 44466355)
117. Haynes V, Traaseth NJ, Elfering S, Fujisawa Y, and Giulivi C. Nitration of specific tyrosines in FoF1 ATP synthase and activity loss in aging. Am J Physiol Endocrinol Metab 298: E978-E987, 2010.
118. He Y, Yu W, and Baas PW. Microtubule reconfiguration during axonal retraction induced by nitric oxide. J Neurosci 22: 5982-5991, 2002. (Pubitemid 35387642)
119. Hirokawa N. Kinesin and dynein superfamily proteins and the mechanism of organelle transport. Science 279: 519-526, 1998. (Pubitemid 28067273)
120. Hirokawa N and Takemura R. Molecular motors and mechanisms of directional transport in neurons. Nat Rev Neurosci 6: 201-214, 2005. (Pubitemid 40342415)
121. Hoffmann J, Haendeler J, Zeiher AM, and Dimmeler S. TNFalpha and oxLDL reduce protein S-nitrosylation in endothelial cells. J Biol Chem 276: 41383-41387, 2001.
122. Huang Z, Huang PL, Ma J, Meng W, Ayata C, Fishman MC, and Moskowitz MA. Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-L-arginine. J Cereb Blood Flow Metab 16: 981-987, 1996. (Pubitemid 26292066)
123. Iadecola C, Zhang F, Casey R, Nagayama M, and Ross ME. Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene. J Neurosci 17: 9157-9164, 1997. (Pubitemid 27498443)
124. Ibi M, Sawada H, Kume T, Katsuki H, Kaneko S, Shimohama S, and Akaike A. Depletion of intracellular glutathione increases susceptibility to nitric oxide in mesencephalic dopaminergic neurons. J Neurochem 73: 1696-1703, 1999. (Pubitemid 29440173)
125. Ignarro LJ, Buga GM, Wood KS, Byrns RE, and Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 84: 9265-9269, 1987.
126. Iyirhiaro GO, Brust TB, Rashidian J, Galehdar Z, Osman A, Phillips M, Slack RS, MacVicar BA, and Park DS. Delayed combinatorial treatment with flavopiridol and minocycline provides longer term protection for neuronal soma but not dendrites following global ischemia. J Neurochem 105: 703-713, 2008. (Pubitemid 351562716)
127. Jaffrey SR, Erdjument-Bromage H, Ferris CD, Tempst P, and Snyder SH. Protein S-nitrosylation: a physiological signal for neuronal nitric oxide. Nat Cell Biol 3: 193-197, 2001. (Pubitemid 32118373)
128. Janssens SP, Shimouchi A, Quertermous T, Bloch DB, and Bloch KD. Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase. J Biol Chem 267: 14519-14522, 1992.
129. Jourd'heuil D, Jourd'heuil FL, and Feelisch M. Oxidation and nitrosation of thiols at low micromolar exposure to nitric oxide. Evidence for a free redical mechanism. J Biol Chem 278: 15720-15726, 2003. (Pubitemid 36799683)
130. Jourd'heuil D, Miranda KM, Kim SM, Espey MG, Vodovotz Y, Laroux S, Mai CT, Miles AM, Grisham MB, and Wink DA. The oxidative and nitrosative chemistry of the nitric oxide/superoxide reaction in the presence of bicarbonate. Arch Biochem Biophys 365: 92-100, 1999. (Pubitemid 29394254)
131. Kahl KG, Schmidt HH, Jung S, Sherman P, Toyka KV, and Zielasek J. Experimental autoimmune encephalomyelitis in mice with a targeted deletion of the inducible nitric oxide synthase gene: increased T-helper 1 response. Neurosci Lett 358: 58-62, 2004. (Pubitemid 38315211)
132. Kahl KG, Zielasek J, Uttenthal LO, Rodrigo J, Toyka KV, and Schmidt HH. Protective role of the cytokine-inducible isoform of nitric oxide synthase induction and nitrosative stress in experimental autoimmune encephalomyelitis of the DA rat. J Neurosci Res 73: 198-205, 2003. (Pubitemid 36835420)
133. Kanaan NM, Morfini GA, LaPointe NE, Pigino GF, Patterson KR, Song Y, Andreadis A, Fu Y, Brady ST, and Binder LI. Pathogenic forms of tau inhibit kinesindependent axonal transport through a mechanism involving activation of axonal phosphotransferases. J Neurosci 31: 9858-9868, 2011.
134. Kanwar M and Kowluru RA. Role of glyceraldehyde 3-phosphate dehydrogenase in the development and progression of diabetic retinopathy. Diabetes 58: 227-234, 2009.
135. Khan M, Sekhon B, Giri S, Jatana M, Gilg AG, Ayasolla K, Elango C, Singh AK, and Singh I. S-Nitrosoglutathione reduces inflammation and protects brain against focal cerebral ischemia in a rat model of experimental stroke. J Cereb Blood Flow Metab 25: 177-192, 2005. (Pubitemid 40171200)
136. Kil IS and Park JW. Regulation of mitochondrial NADP+-dependent isocitrate dehydrogenase activity by glutathionylation. J Biol Chem 280: 10846-10854, 2005.
137. Kim H, Shim J, Han PL, and Choi EJ. Nitric oxide modulates the c-Jun N-terminal kinase/stress-activated protein kinase activity through activating c-Jun N-terminal kinase kinase. Biochemistry 36: 13677-13681, 1997. (Pubitemid 27481615)
138. Kim SF, Huri DA, and Snyder SH. Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science 310: 1966-1970, 2005. (Pubitemid 43005992)
139. Kim YM, Talanian RV, and Billiar TR. Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms. J Biol Chem 272: 31138-31148, 1997. (Pubitemid 27527564)
140. Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Y, and Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392: 605-608, 1998. (Pubitemid 28207717)
141. Kluge I, Gutteck-Amsler U, Zollinger M, and Do KQ. S-nitrosoglutathione in rat cerebellum: identification and quantification by liquid chromatography-mass spectrometry. J Neurochem 69: 2599-2607, 1997. (Pubitemid 27495448)
142. Knott AB and Bossy-Wetzel E. Nitric oxide in health and disease of the nervous system. Antioxid Redox Signal 11: 541-554, 2009.
143. Knowles RG and Moncada S. Nitric oxide synthases in mammals. Biochem J 298: 249-258, 1994. (Pubitemid 24072462)
144. Knowles RG, Palacios M, Palmer RM, and Moncada S. Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase. Proc Natl Acad Sci USA 86: 5159-5162, 1989. (Pubitemid 19182253)
145. Koeck T, Fu X, Hazen SL, Crabb JW, Stuehr DJ, and Aulak KS. Rapid and selective oxygen-regulated protein tyrosine denitration and nitration in mitochondria. J Biol Chem 279: 27257-27262, 2004. (Pubitemid 38812564)
146. Koeck T, Levison B, Hazen SL, Crabb JW, Stuehr DJ, and Aulak KS. Tyrosine nitration impairs mammalian aldolase A activity. Mol Cell Proteomics 3: 548-557, 2004. (Pubitemid 38878514)
147. Koeck T, Willard B, Crabb JW, Kinter M, Stuehr DJ, and Aulak KS. Glucose-mediated tyrosine nitration in adipocytes: targets and consequences. Free Radic Biol Med 46: 884-892, 2009.
148. Kovalenko T, Osadchenko I, Nikonenko A, Lushnikova I, Voronin K, Nikonenko I, Muller D, and Skibo G. Ischemiainduced modifications in hippocampal CA1 stratum radiatum excitatory synapses. Hippocampus 16: 814-825, 2006. (Pubitemid 44650899)
149. Kubler W and Spieckermann PG. Regulation of glycolysis in the ischemic and the anoxic myocardium. J Mol Cell Cardiol 1: 351-377, 1970.
150. Lamas S, Marsden PA, Li GK, Tempst P, and Michel T. Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc Natl Acad Sci USA 89: 6348-6352, 1992.
151. Lancaster JR Jr. Simulation of the diffusion and reaction of endogenously produced nitric oxide. Proc Natl Acad Sci USA 91: 8137-8141, 1994. (Pubitemid 24253901)
152. Lancaster JR Jr. Nitroxidative, nitrosative, and nitrative stress: kinetic predictions of reactive nitrogen species chemistry under biological conditions. Chem Res Toxicol 19: 1160-1174, 2006. (Pubitemid 44454032)
153. Lang AE and Lozano AM. Parkinson's disease. First of two parts. N Engl J Med 339: 1044-1053, 1998. (Pubitemid 28457867)
154. Lang AE and Lozano AM. Parkinson's disease. Second of two parts. N Engl J Med 339: 1130-1143, 1998. (Pubitemid 28465762)
155. Langston JW, Ballard P, Tetrud JW, and Irwin I. Chronic Parkinsonism in humans due to a product of meperidineanalog synthesis. Science 219: 979-980, 1983. (Pubitemid 13189531)
156. LaPointe NE, Morfini G, Pigino G, Gaisina IN, Kozikowski AP, Binder LI, and Brady ST. The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity. J Neurosci Res 87: 440-451, 2009.
157. Lee JY, Kim YH, and Koh JY. Protection by pyruvate against transient forebrain ischemia in rats. J Neurosci 21: RC171, 2001.
158. Leist M, Volbracht C, Kuhnle S, Fava E, Ferrando-May E, and Nicotera P. Caspase-mediated apoptosis in neuronal excitotoxicity triggered by nitric oxide. Mol Med 3: 750-764, 1997. (Pubitemid 28047419)
159. Lewis R, Tannenbaum SR, and Deen WM. Kinetics of N-nitrosation in oxygenated nitric oxide solutions at physiological pH: role of nitrous anhydride and efefcts of phosphate and chloride. J Am Chem Soc 117: 3933-3999, 1995.
160. Li J, Billiar TR, Talanian RV, and Kim YM. Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation. Biochem Biophys Res Commun 240: 419-424, 1997. (Pubitemid 27523676)
161. Li JY, Plomann M, and Brundin P. Huntington's disease: a synaptopathy? Trends Mol Med 9: 414-420, 2003. (Pubitemid 37309642)
162. Lipton P. Ischemic cell death in brain neurons. Physiol Rev 79: 1431-1568, 1999. (Pubitemid 29473320)
163. Lipton SA, Choi YB, Pan ZH, Lei SZ, Chen HS, Sucher NJ, Loscalzo J, Singel DJ, and Stamler JS. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 364: 626-632, 1993. (Pubitemid 23274719)
164. Liu B, Tewari AK, Zhang L, Green-Church KB, Zweier JL, Chen YR, and He G. Proteomic analysis of protein tyrosine nitration after ischemia reperfusion injury: mitochondria as the major target. Biochim Biophys Acta 1794: 476-485, 2009.
165. Liu JS, Zhao ML, Brosnan CF, and Lee SC. Expression of inducible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesions. Am J Pathol 158: 2057-2066, 2001. (Pubitemid 32545191)
166. Lizasoain I, Moro MA, Knowles RG, Darley-Usmar V, and Moncada S. Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose. Biochem J 314: 877-880, 1996. (Pubitemid 26097750)
167. Lo EH, Dalkara T, and Moskowitz MA. Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci 4: 399-415, 2003. (Pubitemid 37280178)
168. Lorenzo A and Yankner BA. Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc Natl Acad Sci USA 91: 12243-12247, 1994. (Pubitemid 24368641)
169. Lowenstein CJ, Alley EW, Raval P, Snowman AM, Snyder SH, Russell SW, and Murphy WJ. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide. Proc Natl Acad Sci USA 90: 9730-9734, 1993. (Pubitemid 23315860)
170. Lowenstein CJ, Glatt CS, Bredt DS, and Snyder SH. Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. Proc Natl Acad Sci USA 89: 6711-6715, 1992.
171. Lundberg JO, Weitzberg E, and Gladwin MT. The nitratenitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov 7: 156-167, 2008. (Pubitemid 351194063)
172. Luth HJ, Holzer M, Gartner U, Staufenbiel M, and Arendt T. Expression of endothelial and inducible NOS-isoforms is increased in Alzheimer's disease, in APP23 transgenic mice and after experimental brain lesion in rat: evidence for an induction by amyloid pathology. Brain Res 913: 57-67, 2001. (Pubitemid 32786931)
173. Malhotra V, Orci L, Glick BS, Block MR, and Rothman JE. Role of an N-ethylmaleimide-sensitive transport component in promoting fusion of transport vesicles with cisternae of the Golgi stack. Cell 54: 221-227, 1988.
174. Malinski T, Bailey F, Zhang ZG, and Chopp M. Nitric oxide measured by a porphyrinic microsensor in rat brain after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab 13: 355-358, 1993. (Pubitemid 23129387)
175. Mandolesi G, Grasselli G, Musumeci G, and Centonze D. Cognitive deficits in experimental autoimmune encephalomyelitis: neuroinflammation and synaptic degeneration. Neurol Sci 31: S255-S259, 2010.
176. 2+ influx elicited by glutamate: role in neuronal death. Mol Pharmacol 36: 106-112, 1989. (Pubitemid 19191266)
177. Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, and Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci USA 82: 4245-4249, 1985. (Pubitemid 15053619)
178. Matsushita K, Morrell CN, Cambien B, Yang SX, Yamakuchi M, Bao C, Hara MR, Quick RA, Cao W, O'Rourke B, Lowenstein JM, Pevsner J, Wagner DD, and Lowenstein CJ. Nitric oxide regulates exocytosis by S-nitrosylation of Nethylmaleimide-sensitive factor. Cell 115: 139-150, 2003. (Pubitemid 37329578)
179. Matthews RT, Beal MF, Fallon J, Fedorchak K, Huang PL, Fishman MC, and Hyman BT. MPP+ induced substantia nigra degeneration is attenuated in nNOS knockout mice. Neurobiol Dis 4: 114-121, 1997. (Pubitemid 27426391)
180. McDonald LJ and Moss J. Stimulation by nitric oxide of an NAD linkage to glyceraldehyde-3-phosphate dehydrogenase. Proc Natl Acad Sci USA 90: 6238-6241, 1993. (Pubitemid 23191490)
181. Miller S, Ross-Inta C, and Giulivi C. Kinetic and proteomic analyses of S-nitrosoglutathione-treated hexokinase A: consequences for cancer energy metabolism. Amino Acids 32: 593-602, 2007. (Pubitemid 46790930)
182. Minc-Golomb D, Tsarfaty I, and Schwartz JP. Expression of inducible nitric oxide synthase by neurones following exposure to endotoxin and cytokine. Br J Pharmacol 112: 720-722, 1994. (Pubitemid 24199072)
183. Mohr S, Hallak H, de Boitte A, Lapetina EG, and Brune B. Nitric oxide-induced S-glutathionylation and inactivation of glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem 274: 9427-9430, 1999.
184. Mohr S, Stamler JS, and Brune B. Mechanism of covalent modification of glyceraldehyde-3-phosphate dehydrogenase at its active site thiol by nitric oxide, peroxynitrite and related nitrosating agents. FEBS Lett 348: 223-227, 1994.
185. Mohr S, Stamler JS, and Brune B. Posttranslational modification of glyceraldehyde-3-phosphate dehydrogenase by S-nitrosylation and subsequent NADH attachment. J Biol Chem 271: 4209-4214, 1996. (Pubitemid 26070523)
186. Moncada S and Bolanos JP. Nitric oxide, cell bioenergetics and neurodegeneration. J Neurochem 97: 1676-1689, 2006. (Pubitemid 43873660)
187. Moncada S and Erusalimsky JD. Does nitric oxide modulate mitochondrial energy generation and apoptosis? Nat Rev Mol Cell Biol 3: 214-220, 2002.
188. Mongin AA. Nitric oxide may contribute to the long-term impairment of synaptic transmission after transient ischemia. Stroke 33: 2348-2350, 2002.
189. Mongin AA. Disruption of ionic and cell volume homeostasis in cerebral ischemia: The perfect storm. Pathophysiology 14: 183-193, 2007. (Pubitemid 350166883)
190. Mongin AA, Nedvetsky PI, and Fedorovich SV. Depolarization of isolated brain nerve endings by nitric oxide donors: Membrane mechanisms. Biochemistry (Mosc) 63: 662-670, 1998. (Pubitemid 128588075)
191. Moore DJ, West AB, Dawson VL and Dawson TM. Molecular pathophysiology of Parkinson's disease. Annu Rev Neurosci 28: 57-87, 2005. (Pubitemid 41098899)
192. Morfini GA, Burns M, Binder LI, Kanaan NM, Lapointe N, Bosco DA, Brown RH, Jr., Brown H, Tiwari A, Hayward L, Edgar J, Nave KA, Garberrn J, Atagi Y, Song Y, Pigino G, and Brady ST. Axonal transport defects in neurodegenerative diseases. J Neurosci 29: 12776-12786, 2009.
193. Morfini GA, Stenoien DL, and Brady ST. Axonal transport. In: Basic Neurochemistry: Molecular, Cellular and Medical Aspects, edited by Siegel GJ, Albers RW, Brady ST, and Price DL. London: Elsevier Academic Press, 2006, pp. 485-501.
194. Mudrick LA and Baimbridge KG. Long-term structural changes in the rat hippocampal formation following cerebral ischemia. Brain Res 493: 179-184, 1989. (Pubitemid 19184601)
195. Murphy TH and Corbett D. Plasticity during stroke recovery: from synapse to behaviour. Nat Rev Neurosci 10: 861-872, 2009.
196. Nakamura T and Lipton SA. Emerging roles of S-nitrosylation in protein misfolding and neurodegenerative diseases. Antioxid Redox Signal 10: 87-101, 2008. (Pubitemid 350115990)
197. Nakamura T and Lipton SA. Cell death: protein misfolding and neurodegenerative diseases. Apoptosis 14: 455-468, 2009.
198. Nathan C, Calingasan N, Nezezon J, Ding A, Lucia MS, La PK, Fuortes M, Lin M, Ehrt S, Kwon NS, Chen J, Vodovotz Y, Kipiani K, and Beal MF. Protection from Alzheimer'slike disease in the mouse by genetic ablation of inducible nitric oxide synthase. J Exp Med 202: 1163-1169, 2005. (Pubitemid 41586946)
199. Nave KA. Myelination and support of axonal integrity by glia. Nature 468: 244-252, 2010.
200. 2+-dependent 14CGABA release from brain synaptosomes: The role of SH-groups. Biochemistry (Mosc) 65: 1027-1035, 2000.
201. Neumann-Haefelin T and Witte OW. Periinfarct and remote excitability changes after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab 20: 45-52, 2000. (Pubitemid 30019829)
202. Osuka K, Feustel PJ, Mongin AA, Tranmer BI, and Kimelberg HK. Tamoxifen inhibits nitrotyrosine formation after reversible middle cerebral artery occlusion in the rat. J Neurochem 76: 1842-1850, 2001. (Pubitemid 32221124)
203. Pacher P, Beckman JS, and Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev 87: 315-424, 2007. (Pubitemid 46217686)
204. Padgett CM and Whorton AR. S-nitrosoglutathione reversibly inhibits GAPDH by S-nitrosylation. Am J Physiol 269: C739-C749, 1995.
205. Paige JS, Xu G, Stancevic B, and Jaffrey SR. Nitrosothiol reactivity profiling identifies S-nitrosylated proteins with unexpected stability. Chem Biol 15: 1307-1316, 2008. (Pubitemid 352841468)
206. Palamalai V and Miyagi M. Mechanism of glyceraldehyde-3-phosphate dehydrogenase inactivation by tyrosine nitration. Protein Sci 19: 255-262, 2010.
207. Palmer RMJ, Ashton DS, and Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 333: 664-666, 1988.
208. Pearce LL, Kanai AJ, Epperly MW, and Peterson J. Nitrosative stress results in irreversible inhibition of purified mitochondrial complexes I and III without modification of cofactors. Nitric Oxide 13: 254-263, 2005. (Pubitemid 41572288)
209. Perlson E, Maday S, Fu MM, Moughamian AJ, and Holzbaur EL. Retrograde axonal transport: pathways to cell death? Trends Neurosci 33: 335-344, 2010.
210. Pluta RM, Dejam A, Grimes G, Gladwin MT, and Oldfield EH. Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage. JAMA 293: 1477-1484, 2005. (Pubitemid 40393292)
211. Prasad R, Giri S, Nath N, Singh I, and Singh AK. GSNO attenuates EAE disease by S-nitrosylation-mediated modulation of endothelial-monocyte interactions. Glia 55: 65-77, 2007. (Pubitemid 44845510)
212. Prime TA, Blaikie FH, Evans C, Nadtochiy SM, James AM, Dahm CC, Vitturi DA, Patel RP, Hiley CR, Abakumova I, Requejo R, Chouchani ET, Hurd TR, Garvey JF, Taylor CT, Brookes PS, Smith RA, and Murphy MP. A mitochondriatargeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury. Proc Natl Acad Sci USA 106: 10764-10769, 2009.
213. Qu J, Nakamura T, Cao G, Holland EA, McKercher SR, and Lipton SA. S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by {beta}-amyloid peptide. Proc Natl Acad Sci USA 108: 14330-14335, 2011.
214. Radi R, Rodriguez M, Castro L, and Telleri R. Inhibition of mitochondrial electron transport by peroxynitrite. Arch Biochem Biophys 308: 89-95, 1994. (Pubitemid 24172608)
215. Rees DD, Palmer RM, and Moncada S. Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci USA 86: 3375-3378, 1989. (Pubitemid 19129614)
216. Renteria RC and Constantine-Paton M. Exogenous nitric oxide causes collapse of retinal ganglion cell axonal growth cones in vitro. J Neurobiol 29: 415-428, 1996. (Pubitemid 26095492)
217. Richards EM, Rosenthal RE, Kristian T, and Fiskum G. Postischemic hyperoxia reduces hippocampal pyruvate dehydrogenase activity. Free Radic Biol Med 40: 1960-1970, 2006. (Pubitemid 43728864)
218. Romero JM and Bizzozero OA. Intracellular glutathione mediates the denitrosylation of protein nitrosothiols in the rat spinal cord. J Neurosci Res 87: 701-709, 2009.
219. Rosahl TW, Spillane D, Missler M, Herz J, Selig DK, Wolff JR, Hammer RE, Malenka RC, and Sudhof TC. Essential functions of synapsin-I and synapsin-II in synaptic vesicle regulation. Nature 375: 488-493, 1995.
220. Rothman SM and Olney JW. Glutamate and the pathophysiology of hypoxic-ischemic brain damage. Ann Neurol 19: 105-111, 1986. (Pubitemid 16114163)
221. Roy S, Winton MJ, Black MM, Trojanowski JQ, and Lee VM. Cytoskeletal requirements in axonal transport of slow component-b. J Neurosci 28: 5248-5256, 2008.
222. Rudkouskaya A, Sim V, Shah AA, Feustel PJ, Jourd'heuil D, and Mongin AA. Long-lasting inhibition of presynaptic metabolism and neurotransmitter release by protein S-nitrosylation. Free Radic Biol Med 49: 757-769, 2010.
223. Ruuls SR, Van Der Linden S, Sontrop K, Huitinga I, and Dijkstra CD. Aggravation of experimental allergic encephalomyelitis (EAE) by administration of nitric oxide (NO) synthase inhibitors. Clin Exp Immunol 103: 467-474, 1996. (Pubitemid 26089951)
224. Salmeen A, Andersen JN, Myers MP, Meng TC, Hinks JA, Tonks NK, and Barford D. Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate. Nature 423: 769-773, 2003. (Pubitemid 36735701)
225. Samdani AF, Dawson TM, and Dawson VL. Nitric oxide synthase in models of focal ischemia. Stroke 28: 1283-1288, 1997. (Pubitemid 27248908)
226. Sarchielli P, Galli F, Floridi A, Floridi A, and Gallai V. Relevance of protein nitration in brain injury: a key pathophysiological mechanism in neurodegenerative, autoimmune, or inflammatory CNS diseases and stroke. Amino Acids 25: 427-436, 2003. (Pubitemid 38041277)
227. Sawa A, Khan AA, Hester LD, and Snyder SH. Glyceraldehyde-3-phosphate dehydrogenase: nuclear translocation participates in neuronal and nonneuronal cell death. Proc Natl Acad Sci USA 94: 11669-11674, 1997. (Pubitemid 27451056)
228. Scheff SW and Price DA. Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies. Neurobiol Aging 24: 1029-1046, 2003. (Pubitemid 37487881)
229. Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D, and Younkin S. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 2: 864-870, 1996. (Pubitemid 26296755)
230. Schiavo G, Gmachl MJ, Stenbeck G, Sollner TH, and Rothman JE. A possible docking and fusion particle for synaptic transmission. Nature 378: 733-736, 1995. (Pubitemid 26001947)
231. -). Free Radic Biol Med 34: 1078-1088, 2003. (Pubitemid 36398568)
232. Schulz JB, Matthews RT, Muqit MM, Browne SE, and Beal MF. Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice. J Neurochem 64: 936-939, 1995.
233. Schweizer M and Richter C. Nitric oxide potently and reversibly deenergizes mitochondria at low oxygen tension. Biochem Biophys Res Commun 204: 169-175, 1994. (Pubitemid 24335277)
234. Selkoe DJ. The molecular pathology of Alzheimer's disease. Neuron 6: 487-498, 1991.
235. Selkoe DJ. Amyloid beta-protein and the genetics of Alzheimer's disease. J Biol Chem 271: 18295-18298, 1996. (Pubitemid 26322675)
236. Selkoe DJ. Alzheimer's disease is a synaptic failure. Science 298: 789-791, 2002. (Pubitemid 35231524)
237. Sequeira SM, Ambrosio AF, Malva JO, Carvalho AP, and Carvalho CM. Modulation of glutamate release from rat hippocampal synaptosomes by nitric oxide. Nitric Oxide 1: 315-329, 1997. (Pubitemid 28078119)
238. Shahani N and Sawa A. Nitric oxide signaling and nitrosative stress in neurons: role for s-nitrosylation. Antioxid Redox Signal 14: 1493-1504, 2011.
239. Shi Q, Feng J, Qu H, and Cheng YY. A proteomic study of S-nitrosylation in the rat cardiac proteins in vitro. Biol Pharm Bull 31: 1536-1540, 2008.
240. Shi Q, Xu H, Yu H, Zhang N, Ye Y, Estevez AG, Deng H, and Gibson GE. Inactivation and reactivation of the mitochondrial alpha-ketoglutarate dehydrogenase complex. J Biol Chem 286: 17640-17648, 2011.
241. Shiva S, Crawford JH, Ramachandran A, Ceaser EK, Hillson T, Brookes PS, Patel RP, and Darley-Usmar VM. Mechanisms of the interaction of nitroxyl with mitochondria. Biochem J 379: 359-366, 2004. (Pubitemid 38570109)
242. Shiva S, Sack MN, Greer JJ, Duranski M, Ringwood LA, Burwell L, Wang X, MacArthur PH, Shoja A, Raghavachari N, Calvert JW, Brookes PS, Lefer DJ, and Gladwin MT. Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer. J Exp Med 204: 2089-2102, 2007. (Pubitemid 47360871)
243. Smith KJ and Lassmann H. The role of nitric oxide in multiple sclerosis. Lancet Neurol 1: 232-241, 2002. (Pubitemid 37159185)
244. Smith MA, Richey Harris PL, Sayre LM, Beckman JS, and Perry G. Widespread peroxynitrite-mediated damage in Alzheimer's disease. J Neurosci 17: 2653-2657, 1997. (Pubitemid 27154998)
245. Souza JM and Radi R. Glyceraldehyde-3-phosphate dehydrogenase inactivation by peroxynitrite. Arch Biochem Biophys 360: 187-194, 1998. (Pubitemid 29001747)
246. Stagi M, Dittrich PS, Frank N, Iliev AI, Schwille P, and Neumann H. Breakdown of axonal synaptic vesicle precursor transport by microglial nitric oxide. J Neurosci 25: 352-362, 2005. (Pubitemid 40105605)
247. Stamler JS, Toone EJ, Lipton SA, and Sucher NJ. (S)NO signals: translocation, regulation, and a consensus motif. Neuron 18: 691-696, 1997. (Pubitemid 27232781)
248. Steinman L and Zamvil SS. How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis. Ann Neurol 60: 12-21, 2006.
249. Stuehr DJ, Cho HJ, Kwon NS, Weise MF, and Nathan CF. Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD-and FMNcontaining flavoprotein. Proc Natl Acad Sci USA 88: 7773-7777, 1991. (Pubitemid 21915236)
250. Stuehr DJ, Santolini J, Wang ZQ, Wei CC, and Adak S. Update on mechanism and catalytic regulation in the NO synthases. J Biol Chem 279: 36167-36170, 2004. (Pubitemid 39128949)
251. Sultana R, Poon HF, Cai J, Pierce WM, Merchant M, Klein JB, Markesbery WR, and Butterfield DA. Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach. Neurobiol Dis 22: 76-87, 2006.
252. Tabatabaie T, Potts JD, and Floyd RA. Reactive oxygen species-mediated inactivation of pyruvate dehydrogenase. Arch Biochem Biophys 336: 290-296, 1996. (Pubitemid 26428244)
253. Taylor ER, Hurrell F, Shannon RJ, Lin TK, Hirst J, and Murphy MP. Reversible glutathionylation of complex I increases mitochondrial superoxide formation. J Biol Chem 278: 19603-19610, 2003. (Pubitemid 36799143)
254. Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, and Katzman R. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30: 572-580, 1991.
255. Thomas DD, Ridnour LA, Espey MG, Donzelli S, Ambs S, Hussain SP, Harris CC, DeGraff W, Roberts DD, Mitchell JB, and Wink DA. Superoxide fluxes limit nitric oxide-induced signaling. J Biol Chem 281: 25984-25993, 2006. (Pubitemid 44401804)
256. Thorns V, Hansen L, and Masliah E. nNOS expressing neurons in the entorhinal cortex and hippocampus are affected in patients with Alzheimer's disease. Exp Neurol 150: 14-20, 1998. (Pubitemid 28146418)
257. Tian J, Kim SF, Hester L, and Snyder SH. S-nitrosylation/activation of COX-2 mediates NMDA neurotoxicity. Proc Natl Acad Sci USA 105: 10537-10540, 2008.
258. Tompkins AJ, Burwell LS, Digerness SB, Zaragoza C, Holman WL, and Brookes PS. Mitochondrial dysfunction in cardiac ischemia-reperfusion injury: ROS from complex I, without inhibition. Biochim Biophys Acta 1762: 223-231, 2006. (Pubitemid 43006028)
259. Tortora V, Quijano C, Freeman B, Radi R, and Castro L. Mitochondrial aconitase reaction with nitric oxide, Snitrosoglutathione, and peroxynitrite: mechanisms and relative contributions to aconitase inactivation. Free Radic Biol Med 42: 1075-1088, 2007. (Pubitemid 46356898)
260. Towfighi A and Saver JL. Stroke declines from third to fourth leading cause of death in the United States: historical perspective and challenges ahead. Stroke 42: 2351-2355, 2011.
261. Tran MH, Yamada K, Nakajima A, Mizuno M, He J, Kamei H, and Nabeshima T. Tyrosine nitration of a synaptic protein synaptophysin contributes to amyloid beta-peptide-induced cholinergic dysfunction. Mol Psychiatry 8: 407-412, 2003. (Pubitemid 36609665)
262. Uehara T, Kikuchi Y, and Nomura Y. Caspase activation accompanying cytochrome c release from mitochondria is possibly involved in nitric oxide-induced neuronal apoptosis in SH-SY5Y cells. J Neurochem 72: 196-205, 1999. (Pubitemid 29013893)
263. Uehara T, Nakamura T, Yao D, Shi ZQ, Gu Z, Ma Y, Masliah E, Nomura Y, and Lipton SA. S-nitrosylated proteindisulphide isomerase links protein misfolding to neurodegeneration. Nature 441: 513-517, 2006. (Pubitemid 44050153)
264. Van Montfort RL, Congreve M, Tisi D, Carr R, and Jhoti H. Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B. Nature 423: 773-777, 2003. (Pubitemid 36735702)
265. Varadarajan S, Yatin S, Aksenova M, and Butterfield DA. Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity. J Struct Biol 130: 184-208, 2000.
266. Vedia L, McDonald B, Reep B, Brune B, Di Silvio M, Billiar TR, and Lapetina EG. Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation. J Biol Chem 267: 24929-24932, 1992.
267. Wahl F, Obrenovitch TP, Hardy AM, Plotkine M, Boulu R, and Symon L. Extracellular glutamate during focal cerebral ischaemia in rats: time course and calcium dependency. J Neurochem 63: 1003-1011, 1994. (Pubitemid 24266614)
268. Wallace MN, Geddes JG, Farquhar DA, and Masson MR. Nitric oxide synthase in reactive astrocytes adjacent to betaamyloid plaques. Exp Neurol 144: 266-272, 1997. (Pubitemid 27224555)
269. Wang X, Su B, Lee HG, Li X, Perry G, Smith MA, and Zhu X. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J Neurosci 29: 9090-9103, 2009.
270. Wilson DW, Wilcox CA, Flynn GC, Chen E, Kuang WJ, Henzel WJ, Block MR, Ullrich A, and Rothman JE. A fusion protein required for vesicle-mediated transport in both mammalian cells and yeast. Nature 339: 355-359, 1989. (Pubitemid 19144224)
271. 2 reaction. Chem Res Toxicol 6: 23-27, 1993. (Pubitemid 23040367)
272. Wong ML, Rettori V, al-Shekhlee A, Bongiorno PB, Canteros G, McCann SM, Gold PW, and Licinio J. Inducible nitric oxide synthase gene expression in the brain during systemic inflammation. Nat Med 2: 581-584, 1996. (Pubitemid 26150687)
273. Wood KC, Batchelor AM, Bartus K, Harris KL, Garthwaite G, Vernon J, and Garthwaite J. Picomolar nitric oxide signals from central neurons recorded using ultrasensitive detector cells. J Biol Chem 286: 43172-43181, 2011.
274. Xie QW, Cho HJ, Calaycay J, Mumford RA, Swiderek KM, Lee TD, Ding A, Troso T, and Nathan C. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 256: 225-228, 1992.
275. Yao D, Gu Z, Nakamura T, Shi ZQ, Ma Y, Gaston B, Palmer LA, Rockenstein EM, Zhang Z, Masliah E, Uehara T, and Lipton SA. Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity. ProcNatl Acad SciUSA101: 10810-10814, 2004. (Pubitemid 38955824)
276. Yi JS, Kim TY, Kyu KD, and Koh JY. Systemic pyruvate administration markedly reduces infarcts and motor deficits in rat models of transient and permanent focal cerebral ischemia. Neurobiol Dis 26: 94-104, 2007.
277. Yu YM, Kim JB, Lee KW, Kim SY, Han PL, and Lee JK. Inhibition of the cerebral ischemic injury by ethyl pyruvate with a wide therapeutic window. Stroke 36: 2238-2243, 2005. (Pubitemid 41429253)
278. Yui Y, Hattori R, Kosuga K, Eizawa H, Hiki K, and Kawai C. Purification of nitric oxide synthase from rat macrophages. J Biol Chem 266: 12544-12547, 1991. (Pubitemid 21907128)
279. Zhang J, Dawson VL, Dawson TM, and Snyder SH. Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Science 263: 687-689, 1994. (Pubitemid 24076297)
280. Zhang J, Jin B, Li L, Block ER, and Patel JM. Nitric oxideinduced persistent inhibition and nitrosylation of active site cysteine residues of mitochondrial cytochrome-c oxidase in lung endothelial cells. Am J Physiol Cell Physiol 288: C840-C849, 2005. (Pubitemid 40395062)
281. Zhang L, Chen CL, Kang PT, Garg V, Hu K, Green-Church KB, and Chen YR. Peroxynitrite-mediated oxidative modifications of complex II: relevance in myocardial infarction. Biochemistry 49: 2529-2539, 2010.
282. Zhang Y and Hogg N. Formation and stability of S-nitrosothiols in RAW 264.7 cells. Am J Physiol Lung Cell Mol Physiol 287: L467-L474, 2004. (Pubitemid 39095899)
283. Zhang Y and Hogg N. The mechanism of transmembrane S-nitrosothiol transport. Proc Natl Acad Sci USA 101: 7891-7896, 2004. (Pubitemid 38698024)
284. Zhao W, Tilton RG, Corbett JA, McDaniel ML, Misko TP, Williamson JR, Cross AH, and Hickey WF. Experimental allergic encephalomyelitis in the rat is inhibited by aminoguanidine, an inhibitor of nitric oxide synthase. J Neuroimmunol 64: 123-133, 1996. (Pubitemid 26096429)