Significance of inducible nitric oxide synthase expression in benign and malignant breast epithelium: An immunohistochemical study of 151 cases

Virchows Archiv

Volumn 447, Issue 1, 2005, Pages 24-30

  Bulut, Asiye Safak ^a   Erden, Esra ^a   Sak, Serpil Dizbay ^a   Doruk, Hatice ^a   Kursun, Nazmiye ^a   Dincol, Dilek ^a  

^a ANKARA UNIVERSITY   (Turkey)

Author keywords

Benign breast disease; Breast carcinoma; Immunohistochemistry; Nitric oxide synthase

Indexed keywords

ESTROGEN RECEPTOR; INDUCIBLE NITRIC OXIDE SYNTHASE;

ADULT; AGED; ARTICLE; AXILLARY LYMPH NODE; BREAST; BREAST CARCINOGENESIS; BREAST CARCINOMA; BREAST EPITHELIUM; BREAST FIBROADENOMA; BREAST HYPERPLASIA; CANCER GRADING; CANCER SURVIVAL; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; SURVIVAL RATE;

BREAST; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CELL COUNT; DISEASE-FREE SURVIVAL; FEMALE; FIBROADENOMA; FOLLOW-UP STUDIES; HUMANS; HYPERPLASIA; IMMUNOENZYME TECHNIQUES; LYMPH NODES; LYMPHATIC METASTASIS; MASTECTOMY; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; SURVIVAL RATE;

EID: 23744465234     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-005-1250-2     Document Type: Article

References (40)

1. Aaltomaa SH, Lipponen PK, Viitanen J, Kankkunen JP, Ala-Opas MY, Kosma VM (2000) The prognostic value of inducible nitric oxide synthase in local prostate cancer. BJU Int 86:234-239
2. Brennan PA, Sharma S, Bowden JR, Umar T (2003) Expression of inducible nitric oxide synthase in bone metastasis. Eur J Surg Oncol 27:619-623
3. Chinje EJ, Stratford IJ (1997) Role of nitric oxide in growth of solid tumors: a balancing act. Essays Biochem 32:61-72
4. Choe W, Kim S, Hwang TS, Lee SS (2003) Expression of inducible nitric oxide synthase in thyroid neoplasms: immunohistochemical and molecular analysis. Pathol Int 53:434-439
5. Duenas-Gonzales A, Isales CM, Abad-Hernandez MD, Gonzalez-Sarmiento R, Sangueza O, Rodriguez-Commes J (1997) Expression of inducible nitric oxide synthase in breast cancer correlates with metastatic disease. Mod Path 10:645-649
6. Ekmekçioǧlu S, Ellerhorst J, Smid CM, Prieto VG, Munsell M, Buzaid AC, Grimm EA (2000) Inducible nitric oxide synthase and nitrotyrosine in human metastatic melanoma tumors correlate with poor survival. Clin Cancer Res 6:4768-4775
7. Forstermann U, Closs EI, Pollock JS, Nakane M, Schwarz P, Gath I, Kleinert H (1994) Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions. Hypertension 23(part 2):1121-1131
8. Hong SK, Gul YA, Ithnin H, Talib A, Seow HF (2004) Expression of beta-catenin, COX-2 and iNOS in colorectal cancer: relevance of COX-2 and iNOS inhibitors for treatment in Malaysia. Asian J Surg 27:10-17
9. Huang Z, Zeng ZY, Peng HW, Xia LP, Hou JH (2003) Inducible nitric oxide synthase and basic fibroblast growth factor expression as prognostic factors in supraglottic squamous cell carcinoma. Aizheng 22:978-981
10. Jadeski LC, Hum KO, Chakraborty C, Lala PK (2000) Nitric oxide promotes murine mammary tumor growth and metastasis by stimulating tumor cell migration, invasiveness and angiogenesis. Int J Cancer 86:30-39
11. Kato S, Esumi H, Hirano A, Kato M, Asayama K, Ohama E (2003) Immunohistochemical expression of inducible nitric oxide synthase (iNOS) in human brain tumors: relationship of iNOS to superoxide dismutase (SOD) proteins (SOD1 and SOD2), Ki-67 antigen (MIB-1) and p53 protein. Acta Neuropathol 105: 333-340
12. Kitano H, Kitanishi T, Nakanishi Y, Suzuki M, Takeuchi E, Yazawa Y, Kitajima K, Kimura H, Tooyama I (1999) Expression of inducible nitric oxide synthase in human thyroid papillary carcinomas. Thyroid 9:113-117
13. Klotz T, Bloch W, Volberg C, Engelmann U, Addicks K (1998) Selective expression of inducible nitric oxide synthase in human prostate carcinoma. Cancer 82:1897-1903
14. Kojima M, Morisaki T, Tsukahara Y, Uchiyama A, Matsunari Y, Mibu R, Tanaka M (1999) Nitric oxide synthase expression and nitric oxide production in human colon carcinoma tissue. J Surg Oncol 70:222-229
15. Kong G, Kim EK, Kim WS, Lee KT, Lee YW, Lee JK, Paik SW, Rhee JC (2002) Role of cyclooxygenase-2 and inducible nitric oxide synthase in pancreatic cancer. J Gastroenterol Hepatol 17:914-921
16. Lagares-Garcia JA, Moore RA, Collier B, Heggere M, Diaz F, Qian F (2001) Nitric oxide synthase as a marker in colorectal carcinoma. Am Surgeon 67:709-713
17. Leake R, Barnes D, Pinder S, Ellis I, Anderson L, Anderson T, Adamson R, Rhodes T, Miller K, Walker R (2000) Immunohistochemical detection of steroid receptors in breast cancer: a working protocol. J Clin Pathol 53:634-635
18. Liu CY, Wang CH, Chen TC, Lin HC, Yu CT, Kuo HP (1998) Increased level of exhaled nitric oxide and up-regulation of inducible nitric oxide synthase in patients with primary lung cancer. Br J Cancer 78:534-541
19. Loibl S, Von Minckwitz G, Weber S, Sinn HP, Schini-Kerth VB, Lobysheva I, Nepveu F, Wolf G, Strebhardt K, Kaufmann M (2002) Expression of endothelial and inducible nitric oxide synthase in benign and malignant lesions of the breast and measurement of nitric oxide using electron paramagnetic resonance spectroscopy. Cancer 95:1191-1198
20. Loibl S, Buck A, Strank C, von Minckwitz G, Roller M, Sinn HP, Schini-Kerth V, Solbach C, Strebhardt K, Kaufmann M (2005) The role of early expression of inducible nitric oxide synthase in human breast cancer. Eur J Cancer 41:265-271
21. Niu X-J, Wang Z-R, Wu S-L, Geng Z-M, Zhang Y-F, Qing L (2004) Relationship between inducible nitric oxide synthase expression and angiogenesis in primary gallbladder carcinoma tissue. World J Gastroenterol 10:725-728
22. Nozoe T, Yasuda M, Honda M, Inutsuka S, Korenaga D (2002) Immunohistochemical expression of cytokine induced nitric oxide synthase in colorectal carcinoma. Oncol Rep 9:521-524
23. Oka K, Suzuki Y, Iida H, Nakano T (2003) PD-ECGF positivity correlates with better survival, while iNOS has no predictive value for cervical carcinomas treated with radiotherapy. Int J Radiat Oncol Biol Phys 57:217-221
24. Peng JP, Zheng S, Xiao ZX, Zhang SZ (2003) Inducible nitric oxide synthase expression is related to angiogenesis, bcl-2 and cell proliferation in hepatocellular carcinoma. J Zhejiang Univ Sci 4:221-227
25. Puhakka A, Kinnula V, Napankangas U, Saily M, Koistinen M, Paakko P, Soini Y (2003) High expression of nitric oxide synthases is a favorable prognostic sign in non-small cell lung carcinoma. Acta Pathol Microbiol Immunol Scand 111:1137-1146
26. Pukkila MJ, Kellokoski JK, Virtaniemi JA, Kumpulainen EJ, Johansson RT, Halonen PM, Kosunen AS, Nuutinen J, Kosma VM (2002) Inducible nitric oxide synthase expression in pharyngeal squamous cell carcinoma: relation to p53 expression, clinicopathological data, and survival. Laryngoscope 112:1084-1088
27. Raspollini MR, Amunni G, Villanucci A, Boddi V, Baroni G, Taddei A, Taddei GL (2003) Expression of inducible nitric oxide synthase and cyclooxygenase in ovarian cancer: correlation with clinical outcome. Gynecol Oncol 92:806-812
28. Reveneau S, Arnould R, Jolimoy G, Hilpert S, Lejeune P, Saint-Giorgio V, Belichard C, Jeannin JF (1999) Nitric oxide synthase in human breast cancer is associated with tumor grade, proliferation rate, and expression of progesterone receptors. Lab Invest 79:1215-1225
29. Ropponen KM, Kellokoski JK, Lipponen PK, Eskelinen MJ, Alanne L, Alhava EM, Kosma VM (2000) Expression of inducible nitric oxide synthase in colorectal cancer and its association with prognosis. Scand J Gastroenterol 35:1204-1211
30. Soini Y, Kahlos K, Puhakka A, Lakari E, Saily M, Paakko P, Kinnula V (2000) Expression of inducible nitric oxide synthase in healthy pleura and malignant mesothelioma. Br J Cancer 83:880-886
31. Tanaka H, Kijima H, Tokunaga T, Tajima T, Himeno S, Kenmochi T, Oshiba G, Kise Y, Nishi T, Chino O, Shimada H, Machimura T, Tanaka M, Makuuchi M (1999) Frequent expression of inducible nitric oxide synthase in esophageal squamous cell carcinoma. Int J Oncol 14:1069-1071
32. Tavassoli FA (1999) Ductal intraepithelial neoplasia. In: Tavassoli FA (ed) Pathology of the breast, 2nd edn. Appleton & Lange, Stamford, Connecticut, p 212
33. Tschugguel W, Schneeberger C, Unfried G, Czerwenka K, Weninger W, Mildner M, Gruber DM, Sator MO, Waldhör T, Huber JC (1999) Expression of inducible nitric oxide synthase in human breast cancer depends on tumor grade. Breast Cancer Res Treat 56:145-151
34. Umar T, Bowden J, Cameron S, Willy PJ, Anand R, Baker Ilankoran V, Brennan PA (2003) Expression of inducible nitric oxide synthase in cutaneous adnexal tumors of the head and neck. Int J Oral Maxillofac Surg 32:534-538
35. Vakkala M, Kahlos K, Lakari E, Paakko P, Kinnula V, Soini Y (2000) Inducible nitric oxide synthase expression, apoptosis, and angiogenesis in in-situ and invasive breast carcinomas. Clin Cancer Res 6:2408-2416
36. Vickers SM, MacMillan-Crow LA, Green M, Ellis C, Thomsen JA (1999) Association of increased immunostaining for inducible nitric oxide synthase and nitrotyrosine with fibroblast growth factor transformation in pancreatic cancer. Arch Surg 134:245-251
37. Wang J, Torbenson M, Wang Q, Ro JY, Becich M (2003) Expression of inducible nitric oxide synthase in paired neoplastic and non-neoplastic primary prostate cell cultures and prostatectomy specimen. Urol Oncol 21:117-122
38. Wolf H, Haeckel C, Roessner A (2000) Inducible nitric oxide synthase expression in human urinary bladder cancer. Virchows Arch 437:662-666
39. Yagihashi N, Kasajima H, Sugai S, Matsumoto K, Ebina Y, Morita T, Murakami T, Yagihashi S (2000) Increased in situ expression of nitric oxide synthase in human colorectal cancer. Virchows Arch 436:109-114
40. Zhang M, Pan JW, Ren TR, Zhu YF, Han YJ, Kuhnel W (2003) Correlated expression of inducible nitric oxide synthase and p53, Bax in benign and malignant diseased gallbladder. Ann Anat 185:549-554