The structure of the mammalian 20S proteasome at 2.75 Å resolution

Structure

Volumn 10, Issue 5, 2002, Pages 609-618

  Unno, Masaki ^a   Mizushima, Tsunehiro ^a   Morimoto, Yukio ^b   Tomisugi, Yoshikazu ^c   Tanaka, Keiji ^d   Yasuoka, Noritake ^b   Tsukihara, Tomitake ^a  

^a OSAKA UNIVERSITY   (Japan)

^b UNIVERSITY OF HYOGO   (Japan)

^c KUMAMOTO UNIVERSITY   (Japan)

^d TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

20S proteasome; Crystal structure analysis; Immunoproteasome; Mammalian proteasome; Ntn hydrolase; Structure organization

Indexed keywords

HYDROLASE; PROTEASOME; CYSTEINE PROTEINASE; MULTIENZYME COMPLEX; PROTEIN SUBUNIT;

AMINO TERMINAL SEQUENCE; ARTICLE; CATTLE; CONSENSUS SEQUENCE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME STRUCTURE; ENZYME SUBUNIT; GENETIC CONSERVATION; MAMMAL; MOLECULAR INTERACTION; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN MOTIF; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS; YEAST; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; HUMAN; LIVER; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ANIMAL; BINDING SITES; CATTLE; CRYSTALLOGRAPHY, X-RAY; CYSTEINE ENDOPEPTIDASES; HUMAN; LIVER; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; SUBSTRATE SPECIFICITY; SUPPORT, NON-U.S. GOV'T; ANIMALS; HUMANS; PROTEASOME ENDOPEPTIDASE COMPLEX;

BOS TAURUS; BOVINAE; MAMMALIA;

EID: 0036103598     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(02)00748-7     Document Type: Article

References (44)

1. Structure and functions of the 20S and 26S proteasomes
2. The ubiquitin system
3. Mechanisms underlying ubiquitination
4. The proteasome: Paradigm of a self-compartmentalizing protease
5. The proteasome, a novel protease regulated by multiple mechanisms
6. The 26S proteasome, a molecular machine designed for controlled proteolysis
7. Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 Å resolution
8. Structure of 20S proteasome from yeast at 2.4 Å resolution
9. A protein catalytic framework with an N-terminal nucleophile is capable of self-activation
10. Autocatalytic processing of the 20S proteasome
11. The proteasome
12. Molecular biology of the proteasome
13. The genetics of proteasomes and antigen processing
14. The MHC class I ligand-generating system: Roles of immunoproteasomes and the interferon-γ-inducible proteasome activator PA28
15. Antigen processing by MHC class I and its regulation by interferon γ
16. Mechanisms of MHC class I-restricted antigen processing
17. Degradation of cell proteins and the generation of MHC class I-presented peptides
18. The specificity of proteasomes: Impact on MHC class I processing and presentation of antigens
19. Antigen processing by the proteasome
20. Comparative genomics of the MHC: Glimpses into the evolution of the adaptive immune system
21. The proteasome activator 11S REG (PA28) and class I antigen presentation
22. PA28 activator protein forms regulatory caps on proteasome stacked rings
23. Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominant MHC ligands
24. Hybrid proteasomes: Induction by interferon-γ and contribution to the ATP-dependent proteolysis
25. Reconstitution of hybrid proteasomes from purified PA700-20S complexes and PA28alphabeta activator: Ultrastructure and peptidase activities
26. Simultaneous binding of PA28 and PA700 activators to 20S proteasomes
27. Structure determination of the constitutive 20S proteasome from bovine liver at 2.75 Å resolution
28. Crystallography and NMR system: A new software suite for macromolecular structure determination
29. Structural comparison of Ntn-hydrolase
30. Evidence for the presence of five distinct proteolytic components cleaving in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids
31. KEKE motifs: Proposed roles in protein-proteon association and presentation of peptides by MHC class I receptors
32. SKP1-SnRK protein kinase interactions mediate proteasomal binding of plant SCF ubiquitin ligase
33. Proteasome complex as a potential cellular target of hepatitis B virus X protein
34. Nuclear location signal-mediated protein transport
35. Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-α
36. Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin α
37. Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin α
38. Structure of importin-β bound to the IBB domain of importin-α
39. A gated channel into the proteasome core particle
40. Structural basis for the activation of 20S proteasome by 11S regulators
41. A graphics model building and refinement system for macromolecules
42. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons
43. Clustal w: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice