Thioredoxin reductase is irreversibly modified by curcumin: A novel molecular mechanism for its anticancer activity

Journal of Biological Chemistry

Volumn 280, Issue 26, 2005, Pages 25284-25290

  Fang, Jianguo ^a   Lu, Jun ^a   Holmgren, Arne ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CELLS; CYTOLOGY; ENZYME INHIBITION; MASS SPECTROMETRY; OXIDATION; REDOX REACTIONS; SUBSTRATES; TUMORS;

CYTOSOL; FLAVOENZYMES; ISOENZYMES; POLYPHENOLS;

ENZYMES;

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; ANTIOXIDANT; CURCUMIN; CYSTEINE; DISULFIDE; FLAVOPROTEIN; GLYCINE; ISOENZYME; OXIDIZING AGENT; POLYPHENOL DERIVATIVE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SELENOCYSTEINE; THIOREDOXIN; THIOREDOXIN REDUCTASE; THIOREDOXIN REDUCTASE 1; UNCLASSIFIED DRUG;

ALKYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOTTING; CANCER INHIBITION; CELL NUCLEUS; CONTROLLED STUDY; CURCUMA LONGA; CYTOSOL; DRUG MECHANISM; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; GENE OVEREXPRESSION; HELA CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MAMMAL; MASS SPECTROMETRY; MITOCHONDRION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PHYTOCHEMISTRY; PRIORITY JOURNAL; ROOM TEMPERATURE;

ANIMALS; ANIONS; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL NUCLEUS; CURCUMA; CURCUMIN; CYSTEINE; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MASS SPECTROMETRY; MITOCHONDRIA; MODELS, BIOLOGICAL; MODELS, CHEMICAL; NADP; NADPH OXIDASE; OXIDANTS; OXIDATION-REDUCTION; PEPTIDES; PLANT EXTRACTS; PROTEIN BINDING; RATS; SELENOCYSTEINE; SUPEROXIDES; TEMPERATURE; THIOREDOXIN REDUCTASE (NADPH); TIME FACTORS;

CURCUMA LONGA; MAMMALIA;

EID: 21644477778     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M414645200     Document Type: Article

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