An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis

EMBO Journal

Volumn 25, Issue 7, 2006, Pages 1547-1558

  Boeddrich, Annett ^a   Gaumer, Sébastien ^b,h   Haacke, Annette ^c   Tzvetkov, Nikolay ^c   Albrecht, Mario ^d   Evert, Bernd O ^e   Müller, Eva C ^a   Lurz, Rudi ^f   Breuer, Peter ^c   Schugardt, Nancy ^a   Plaßmann, Stephanie ^a   Xu, Kexiang ^b   Warrick, John M ^b   Suopanki, Jaana ^a   Wüllner, Ullrich ^e   Frank, Ronald ^g   Hartl, Ulrich F ^c   Bonini, Nancy M ^b   Wanker, Erich E ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^d MAX PLANCK INSTITUTE FOR INFORMATICS   (Germany)

^e UNIVERSITY OF BONN   (Germany)

^f MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^g HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^h LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

Author keywords

Ataxin 3; Polyglutamine aggregation; VCP

Indexed keywords

ARGININE; ATAXIN 3; CHAPERONE; LYSINE; MUTANT PROTEIN; PROTEIN P97;

AMINO ACID SEQUENCE; ARTICLE; CONCENTRATION (PARAMETERS); DROSOPHILA; IN VIVO STUDY; MOLECULAR RECOGNITION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING;

ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; ARGININE; BRAIN; CELL CYCLE PROTEINS; CERCOPITHECUS AETHIOPS; COS CELLS; DROSOPHILA; INCLUSION BODIES; LYSINE; MOLECULAR SEQUENCE DATA; MUTATION; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR LOCALIZATION SIGNALS; NUCLEAR PROTEINS; PHOTORECEPTORS, INVERTEBRATE; PROTEIN BINDING; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

ATAXIA;

EID: 33645735557     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7601043     Document Type: Article

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