DUBA: A deubiquitinase that regulates type I interferon production

Science

Volumn 318, Issue 5856, 2007, Pages 1628-1632

  Kayagaki, Nobuhiko ^a   Phung, Qui ^a   Chan, Salina ^a   Chaudhari, Ruchir ^a   Quan, Casey ^a   O'Rourke, Karen M ^a   Eby, Michael ^a   Pietras, Eric ^b   Cheng, Genhong ^b   Bazan, J Fernando ^a   Zhang, Zemin ^a   Arnott, David ^a   Dixit, Vishva M ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; DEUBIQUINATING ENZYME A; INTERFERON; LYSINE; POLYUBIQUITIN; PROTEIN KINASE; SMALL INTERFERING RNA; TANK BINDING KINASE 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

DEFENSE MECHANISM; ENZYME ACTIVITY; GENE EXPRESSION; HOST; IMMUNE RESPONSE; TUMOR;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWNSTREAM PROCESSING; EMBRYO; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOREGULATION; INNATE IMMUNITY; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MOTIF; UBIQUITINATION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; ENDOPEPTIDASES; HUMANS; INTERFERON TYPE I; INTERFERON-ALPHA; MOLECULAR SEQUENCE DATA; NF-KAPPA B; PROTEIN STRUCTURE, TERTIARY; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 3; TOLL-LIKE RECEPTOR 3; UBIQUITIN; UBIQUITINATION;

EID: 36448943427     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1145918     Document Type: Article

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28. We thank members of the Dixit laboratory, I. Wertz, and Y.-M. Loo for discussion, K. Newton for proofreading, R. J. Deshaies for S5a, and M. Vasser, J.-A. Hongo, M. Hazen, P. Chang, A. P. Martinez, D. Davis, and J. Lee for technical assistance.