A mutation in a novel yeast proteasomal gene, RPN11/MPR1, produces a cell cycle arrest, overreplication of nuclear and mitochondrial DNA, and an altered mitochondrial morphology

Molecular Biology of the Cell

Volumn 9, Issue 10, 1998, Pages 2917-2931

  Rinaldi, Teresa ^a   Ricci, Carlo ^a   Porro, Danilo ^b   Bolotin Fukuhara, Monique ^c   Frontali, Laura ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL DNA; GREEN FLUORESCENT PROTEIN; MITOCHONDRIAL DNA; PROTEASOME;

AMINO ACID SEQUENCE; ARTICLE; DNA REPLICATION; ENZYME SUBUNIT; FUNGUS MUTATION; GENE EXPRESSION REGULATION; GENE MUTATION; GROWTH INHIBITION; MITOCHONDRION; NONHUMAN; NUCLEOTIDE SEQUENCE; PLEIOTROPY; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES CEREVISIAE;

EID: 0031709394     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.9.10.2917     Document Type: Article

References (58)

1. Amsterdam, A., Pitzer, F., and Baumeister, W. (1993). Changes in intracellular localization of proteasomes in immortalized ovarian granulosa cells during mitosis associated with a role in cell cycle control. Proc. Natl. Acad. Sci. USA 90, 99-103.
2. Baldari, C., Murray, J.A., Ghiara, P., Cesareni, G., and Galeotti, C.L. (1987). A novel leader peptide which allows efficient secretion of a fragment of human interleukin 1 beta in Saccharomyces cerevisiae. EMBO J. 6, 229-234.
3. Burgess, S.M., Delannoy, M., and Jensen, R.E. (1994). MMM1 encodes a mitochondrial outer membrane protein essential for establishing and maintaining the structure of yeast mitochondria. J. Cell Biol. 126, 1375-1391.
4. Campbell, C.L., Tanaka, N., White, K.H., and Thorsness, P.E. (1994). Mitochondrial morphological and functional defects in yeast caused by yme1 are suppressed by mutation of a 26S protease subunit homologue. Mol. Biol. Cell 5, 899-905.
5. Chalfie, M., Tu, Y., Euskirchen, G., Ward, W.W., and Prasher, D.C. (1994). Green fluorescent protein as a marker for gene expression. Science 263, 802-805.
6. Dawson, S.P., Arnold, J.E., Mayer, N.J., Reynolds, S.E., Billett, M.A., Gordon, C., Colleaux, L., Kloetzel, P.M., Tanaka, K., and Mayer, R.J. (1995). Developmental changes of the 26S proteasome in abdominal intersegmental muscles of Manduca sexta. J. Biol. Chem. 270, 1850-1858.
7. Fisk, H.A., and Yaffe, M.P. (1997). Mutational analysis of Mdm1p function in nuclear and mitochondrial inheritance. J. Cell Biol. 138, 485-494.
8. Gerlinger, U.M., Guckel, R., Hoffmann, M., Wolf, D.H., and Hilt, W. (1997). Yeast cycloheximide-resistant crl mutants defective in protein degradation. Mol. Biol. Cell 8, 2487-2477.
9. Ghislain, M., Udvardy, A., and Mann, C. (1993). S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase. Nature 366, 358-362.
10. Gietz, R.D., and Sugino, A. (1988). New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 74, 527-534.
11. Glickman, M.H., Rubin, D.M., Fried, V.A., and Finley, D. (1998). The regulatory particle of the Saccharomyces cerevisiae proteasome. Mol. Cell. Biol. 18, 3149-3162.
12. Gordon, C., McGurk, G., Dillon, P., Rosen, C., and Hastie, D. (1993). Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit. Nature 366, 355-357.
13. Groll, M., Ditzel, L., Lowe, J., Stock, D., Bochtler, M., and Bartunik, H.D. (1997). Structure of 20S proteasome from yeast at 2,4A resolution. Nature 386, 463-471.
14. Heichman, K.A., and Roberts, J.M. (1996). The yeast CDC16 and CDC27 genes restrict DNA replication to once per cell cycle. Cell 85, 39-48.
15. Hilt, W., and Wolf, D.H. (1996). Proteasomes: destruction as a programme. Trends Biochem. Sci. 21, 96-102.
16. Hochstrasser, M. (1995). Ubiquitin, proteasomes, and the regulation of intracellular protein degradation. Curr. Opin. Cell Biol. 7, 215-223.
17. Hofmann, K., and Bucher, P. (1998). The PCI domain: a common theme in three multiprotein complexes. Trends Biochem. Sci. 23, 204-205.
18. Ito, H., Fukuda, Y., Murata, K., and Kimura, A. (1983). Trasformation of intact yeast cells treated with alkali cations. J. Bacteriol. 153, 163-168.
19. Kim, J., and Struhl, K. (1995). Determinants of half-site spacing preferences that distinguish AP-1 and ATF/CREB bZIP domains. Nucleic Acids Res. 23, 2531-2537.
20. King, R.W., Deshaies, R.J., Peters, J.M., and Kirschner, M.W. (1996). How proteolysis drives the cell cycle. Science 274, 1652-1658.
21. Kominami, K., et al. (1995). Nin1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae. EMBO J. 14, 3105-3115.
22. Kominami, K., et al. (1997). Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multi-copy suppressors of nin1-1. Mol. Biol. Cell 8, 171-187.
23. Kominami, K., and Toh-e, A. (1994). Characterization of the function of the NIN1 gene product of Saccharomyces cerevisiae. Exp. Cell Res. 211, 203-211.
24. Lupas, A. (1996). Coiled coils: new structures and new functions. Trends Biochem. Sci. 21, 375-382.
25. Lupas, A., VanDyke, M., and Stock, J. (1991). Predicting coiled coils from protein sequences. Science 252, 1162-1164.
26. McDonald, H.B., and Byers, B. (1997). A proteasome cap subunit required for spindle pole body duplication in yeast. J. Cell Biol. 137, 539-553.
27. Moreno, S., and Nurse, P. (1994). Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene. Nature 367, 236-242.
28. Murakami, Y., et al. (1995). Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae. Nat. Genet. 10, 261-268.
29. Murray, A. (1995). Cyclin ubiquitination: the destructive end of mitosis. Cell 81, 149-152.
30. Nelson, M.K., Kurihara, T., and Silver, P.A. (1993). Extragenic suppressor of mutations in the cytoplasmic C terminus of SEC63 define five genes in Saccharomyces cerevisiae. Genetics 134, 159-173.
31. Niedenthal, R.K., Riles, L., Johnston, M., and Hegemann, J.H. (1996). Green fluorescent protein as marker for gene expression and subcellular localization in budding yeast. Yeast 12, 773-786.
32. Nunnari, J., Marshall, W.F., Straight, A., Murray, A., Sedat, J.W., and Walter, P. (1997). Mitochondrial transmission during mating in Saccharomyces cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mitochondrial DNA. Mol. Biol. Cell 8, 1233-1242.
33. Nurse, P. (1990). Universal control mechanism regulation onset of M-phase. Nature 344, 503-508.
34. Papa, F.R., and Hochstrasser, M. (1993). The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene. Nature 366, 313-319.
35. Peters, J.M. (1994). Proteasomes: protein degradation machines of the cell. Trends Biochem. Sci. 19, 377-382.
36. Peters, J.M., Franke, W.W., and Kleinschmidt, J.A. (1994). Distinct 19S and 20S subcomplexes of the 26S proteasome and their distribution in the nucleus and the cytoplasm. J. Biol. Chem. 269, 7709-7718.
37. Realini, C., Rogers, S.W., and Rechsteiner, M. (1994). Proposed roles in protein-protein association and presentation of peptides by MHC Class I receptor. FEBS Lett. 348, 109-113.
38. Rechsteiner, M., Hoffman, L., and Dubiel, W. (1993). The multicatalytic and 26S proteases. J. Biol. Chem. 268, 6065-6068.
39. Rep, M., and Grivell, L.A. (1996). The role of protein degradation in mitochondrial function and biogenesis. Curr. Genet. 30, 367-380.
40. Rinaldi, T., Bolotin-Fukuhara, M., and Frontali, L. (1995). A Saccharomyces cerevisiae gene essential for viability has been conserved in evolution. Gene 160, 135-136.
41. Rinaldi, T., Francisci, S., Zennaro, E., Frontali, L., and Bolotin-Fukuhara, M. (1994). Suppression of a mitochondrial point mutation in a tRNA gene can cast light on the mechanisms of 3′ end-processing. Curr. Genet. 25, 451-455.
42. Rivett, A.J. (1993). Proteasomes: multicatalytic proteinase complexes. Biochem. J. 291, 1-10.
43. Rose, M.D., Novick, P., Thomas, J.H., Botstein, D., and Fink, G.R. (1987). A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector. Gene 60, 237-243.
44. Rothstein, R. (1991). Targeting, disruption, replacement and allele rescue: integrative DNA transformation in yeast. Methods Enzymol. 194, 281-301.
45. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1995). Molecular Cloning: A Laboratory Manual, 2nd ed., Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
46. +-dependent transcription and is implicated in the maintenance of chromosome structure. J. Cell Sci. 108, 569-579.
47. Singer, J.D., Manning, B.M., and Formosa, T. (1996). Coordinating DNA replication to produce one copy of the genome requires genes that act in ubiquitin metabolism. Mol. Cell. Biol. 16, 1356-1366.
48. Smith, M.G., Simon, V.R., O'Sullivan, H., and Pon, L.A. (1995). Organelle-cytoskeletal interactions: actin mutations inhibit meiosis-dependent mitochondrial rearrangements in the budding yeast. Mol. Biol. Cell 6, 1381-1396.
49. Sogo, L.F., and Yaffe, M.P. (1994). Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of mitochondrial outer membrane. J. Cell Biol. 126, 1361-1373.
50. Spataro, V., Toda, T., Craig, R., Seeger, M., Dubiel, W., Harris, A.L., and Norbury, C. (1997). Resistance to diverse drugs and ultraviolet light conferred by overexpression of a novel human 26S proteasome subunit. J. Biol. Chem. 272, 30470-30475.
51. Stultz, C.M., White, J.V., and Smith, T.F. (1993). Structural analysis based on state-space modeling. Protein Sci. 2, 305-314.
52. Suzuki, C.K., Rep, M., van Dijl, J.M., Suda, K., Grivell, L.A., and Schatz, G. (1997). ATP-dependent proteases that also chaperone protein biogenesis. Trends Biochem. Sci. 22, 118-123.
53. Thorsness, P.E., White, K.H., and Fox, T.D. (1993). Inactivation of YME1, a member of the ftsH-sec18-PAS1-CDC48 family of putative ATPase-encoding genes, causes increased escape of DNA from mitochondria in Saccharomyces cerevisiae. Mol. Cell. Biol. 13, 5418-5426.
54. Visser, W., van Spronsen, E.A., Nanninga, N., Pronk, J.T., Kuenen, J.G., and van Dijken, J.P. (1995). Effects of growth conditions on mitochondrial morphology in Saccharomyces cerevisiae. Anthonie van Leeuwenhoek 67, 243-253.
55. White, J.V., Stultz, C.M., and Smith, T.F. (1994). Protein classification by stochastic modeling on optimal filtering of amino-acid sequences. Math. Biosci. 119, 35-75.
56. Winston, F., Dollard, C., and Ricupero-Hovasse, S.L. (1995). Construction of a set of convenient Saccharomyces cerevisiae strains that are isogenic to S288C. Yeast 11, 53-55.
57. Yokota, K., et al. (1996). cDNA cloning of p112, the largest regulatory subunit of the human 26S proteasome, and functional analysis of its yeast homologue, Sen3p. Mol. Biol. Cell 7, 853-870.
58. Zennaro, E., Francisci, S., Ragnini, A., Frontali, L., and Bolotin-Fukuhara, M. (1989). A point mutation in a mitochondrial tRNA gene abolishes its 3′ end processing. Nucleic Acids Res. 17, 5751-5764.