Reactive Oxygen Species Generation and Mitochondrial Dysfunction in the Apoptotic Response to Bortezomib, a Novel Proteasome Inhibitor, in Human H460 Non-small Cell Lung Cancer Cells

Journal of Biological Chemistry

Volumn 278, Issue 36, 2003, Pages 33714-33723

  Ling, Yi He ^a   Liebes, Leonard ^b   Zou, Yiyu ^a   Perez Soler, Roman ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DRUG PRODUCTS; ELECTRONS; OXYGEN; PATIENT TREATMENT; TUMORS;

CELL LINES;

BIOCHEMISTRY;

ANTIMYCIN A1; ANTIOXIDANT; BORTEZOMIB; CASPASE; CYCLOSPORIN A; CYTOCHROME C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEASOME INHIBITOR; REACTIVE OXYGEN METABOLITE; ROTENONE; TIRON; ANTINEOPLASTIC AGENT; BORONIC ACID DERIVATIVE; CYSTEINE PROTEINASE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; ENZYME INHIBITOR; MULTIENZYME COMPLEX; PROTEASOME; PROTEIN P53; PROTEINASE INHIBITOR; PYRAZINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; DRUG EFFECT; GENE DISRUPTION; HUMAN; HUMAN CELL; LIVER CYTOSOL; LUNG NON SMALL CELL CANCER; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; PROTEIN FAMILY; CELL CULTURE; CELL MEMBRANE POTENTIAL; CELL SURVIVAL; CHEMICAL MODEL; DOSE RESPONSE; DRUG ANTAGONISM; GENETIC TRANSFECTION; IMMUNOBLOTTING; LUNG TUMOR; METABOLISM; MITOCHONDRION; PATHOLOGY; TIME;

TIRON;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; BORONIC ACIDS; CARCINOMA, NON-SMALL-CELL LUNG; CASPASES; CELL SURVIVAL; CYSTEINE ENDOPEPTIDASES; CYTOCHROME C GROUP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; IMMUNOBLOTTING; INDICATORS AND REAGENTS; LUNG NEOPLASMS; MEMBRANE POTENTIALS; MITOCHONDRIA; MODELS, CHEMICAL; MULTIENZYME COMPLEXES; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; PYRAZINES; REACTIVE OXYGEN SPECIES; TIME FACTORS; TIRON; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0141706672     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302559200     Document Type: Article

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