USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110

Nature

Volumn 495, Issue 7440, 2013, Pages 255-259

  Li, Ji ^a   D'Angiolella, Vincenzo ^a,c   Seeley, E Scott ^b   Kim, Sehyun ^a   Kobayashi, Tetsuo ^a   Fu, Wenxiang ^a   Campos, Eric I ^a   Pagano, Michele ^a   Dynlacht, Brian David ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; PROTEIN CP110; PROTEIN USP33; UNCLASSIFIED DRUG;

CELL ORGANELLE; ENZYME ACTIVITY; GENOME; HOMEOSTASIS; KNOWLEDGE; PROTEIN; SUBSTRATE; TUMOR;

ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CENTRIOLE; CENTROSOME; PRIORITY JOURNAL; PROTEIN INTERACTION; UBIQUITINATION;

ANIMALS; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE; CENTRIOLES; CENTROSOME; CYCLINS; HOMEOSTASIS; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASMS; PHOSPHOPROTEINS; PROTEIN STABILITY; SKP CULLIN F-BOX PROTEIN LIGASES; UBIQUITIN THIOLESTERASE; UBIQUITINATION;

EID: 84874990849     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11941     Document Type: Article

References (23)

1. Chen, Z., Indjeian, V. B., McManus, M., Wang, L. & Dynlacht, B. D. CP110, acell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. Dev. Cell 3, 339-350 (2002).
2. Spektor, A., Tsang, W. Y., Khoo, D. & Dynlacht, B. D. Cep97 and CP110 suppress a cilia assembly program. Cell 130, 678-690 (2007).
3. Cyclin F controls centrosome homeostasis and mitotic fidelity through CP110 degradation. Nature 466, 138-142 (2010).
4. Li, J. et al. Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres. EMBO Rep. 13, 547-553 (2012).
5. Sowa, M. E., Bennett, E. J., Gygi, S. P. & Harper, J. W. Defining the human deubiquitinating enzyme interaction landscape. Cell 138, 389-403 (2009).
6. Li, Z. et al. Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. J. Biol. Chem. 277, 4656-4662 (2002).
7. Li, Z. et al. Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor. Biochem. Biophys. Res. Commun. 294, 700-709 (2002).
8. Curcio-Morelli, C. et al. Deubiquitination oftype2 iodothyronine deiodinase byvon Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation. J. Clin. Invest. 112, 189-196 (2003).
9. Thorne, C., Eccles, R. L., Coulson, J. M., Urbe, S. & Clague, M. J. Isoform-specific localization of the deubiquitinase USP33 to the Golgi apparatus. Traffic 12, 1563-1574 (2011).
10. D'Angiolella, V. et al. Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair. Cell 149, 1023-1034 (2012).
11. 2 adrenergic receptor recycling and resensitization. EMBO J. 28, 1684-1696 (2009).
12. Chan, J. Y. A clinical overview of centrosome amplification in human cancers. Int. J. Biol. Sci. 7, 1122-1144 (2011).
13. Ganem, N. J., Godinho, S. A. & Pellman, D. Amechanism linking extra centrosomes to chromosomal instability. Nature 460, 278-282 (2009).
14. Buchholz, M. et al. Transcriptome analysis of microdissected pancreatic intraepithelial neoplastic lesions. Oncogene 24, 6626-6636 (2005).
15. Badea, L., Herlea, V., Dima, S. O., Dumitrascu, T. & Popescu, I. Combined gene expression analysis of whole-tissue and microdissected pancreatic ductal adenocarcinoma identifies genes specifically overexpressed in tumor epithelia. Hepatogastroenterology 55, 2016-2027 (2008).
16. Sato, N. et al. Centrosome abnormalities in pancreatic ductal carcinoma. Clin. Cancer Res. 5, 963-970 (1999).
17. Sato, N. et al. Correlation between centrosome abnormalities and chromosomal instability in human pancreatic cancer cells. Cancer Genet. Cytogenet. 126, 13-19 (2001).
18. Shono, M. et al. Stepwise progression of centrosome defects associated with local tumor growth and metastatic process of human pancreatic carcinoma cells transplanted orthotopically into nude mice. Lab. Invest. 81, 945-952 (2001).
19. Cohen, P. & Tcherpakov, M. Willthe ubiquitin system furnishasmany drug targets as protein kinases? Cell 143, 686-693 (2010).
20. Sippl, W., Collura, V. & Colland, F. Ubiquitin-specific proteases as cancer drug targets. Future Oncol. 7, 619-632 (2011).
21. Tansey, W. P. Detection ofubiquitylated proteins in mammalian cells. Cold Spring Harb. Protoc. http://dx.doi.org/10.1101/pdb.prot4616 (2006).
22. Sabbaghian, M. S. et al. Levels ofelevated circulating endothelial cell decline after tumor resection in patients with pancreatic ductal adenocarcinoma. Anticancer Res. 30, 2911-2917 (2010).
23. Seeley, E. S., Carriere, C., Goetze, T., Longnecker, D. S. & Korc, M. Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia. Cancer Res. 69, 422-430 (2009).