Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 38, 2012, Pages 15115-15120

  Adams, Drew J ^a,b   Dai, Mingji ^a,c   Pellegrino, Giovanni ^a   Wagner, Bridget K ^a   Stern, Andrew M ^a   Shamji, Alykhan F ^a   Schreiber, Stuart L ^a,b,c  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKENE; CYTOTOXIC AGENT; GLUTATHIONE; PIPERLONGUMINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHILICITY; HELA CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ALKENES; ALLELES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; DIOXOLANES; DOSE-RESPONSE RELATIONSHIP, DRUG; HELA CELLS; HUMANS; MODELS, CHEMICAL; OXIDATIVE STRESS; PHENOTYPE; REACTIVE OXYGEN SPECIES; SULFHYDRYL COMPOUNDS;

EID: 84866559458     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1212802109     Document Type: Article

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