UBPY: A growth-regulated human ubiquitin isopeptidase

EMBO Journal

Volumn 17, Issue 12, 1998, Pages 3241-3250

  Naviglio, Silvio ^a   Matteucci, Cristian ^a   Matoskova, Brona ^a   Nagase, Takahiro ^b   Nomura, Nobuo ^b   Di Fiore, Pier Paolo ^a,c   Draetta, Giulio Francesco ^a  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b KAZUSA DNA RESEARCH INSTITUTE   (Japan)

^c UNIVERSITY OF BARI   (Italy)

Author keywords

Cell proliferation; Growth; Ubiquitin isopeptidase; UBPY

Indexed keywords

CELL ENZYME; COMPLEMENTARY DNA; MUTANT PROTEIN; PEPTIDASE; PROTEASOME; RECOMBINANT PROTEIN; UBIQUITIN; UBIQUITIN ISOPEPTIDASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CELL CYCLE S PHASE; CELL GROWTH; CELL INTERACTION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; FIBROBLAST; GENE OVEREXPRESSION; GROWTH DISORDER; GROWTH STIMULATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ANIMALS; CARBON-NITROGEN LYASES; CELL CULTURE TECHNIQUES; CELL DIVISION; ENDOPEPTIDASES; HUMANS; MICE; MUTAGENESIS, SITE-DIRECTED; RECOMBINANT PROTEINS; TRANSFECTION; UBIQUITINS;

MAMMALIA;

EID: 0032526692     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.12.3241     Document Type: Article

References (43)

1. Baker, R.T., Tobias, J.W. and Varshavsky, A. (1992) Ubiquitin-specific proteases of Saccharomyces cerevisiae. Cloning of UBP2 and UBP3, and functional analysis of the UBP gene family. J. Biol. Chem., 267, 23364-23375.
2. Bradford, M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248.
3. Ciechanover, A. (1994) The ubiquitin-proteasome proteolytic pathway. Cell, 79, 13-21.
4. Diehl, J.A., Zindy, F. and Sherr, C.J. (1997) Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. Genes Dev., 11, 957-972.
5. Draetta, G. and Pagano, M. (1996) Cell cycle control and cancer. In Wong, W.W. (ed.). Annual Reports in Medical Chemistry. Vol. 32. Academic Press, pp. 241-248.
6. Ellison, M.J. and Hochstrasser, M. (1991) Epitope-tagged ubiquitin. A new probe for analyzing ubiquitin function. J. Biol. Chem., 266, 21150-21157.
7. Everett, R.D., Meredith, M., Orr, A., Cross, A., Kathoria, M. and Parkinson, J. (1997) A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein. EMBO J., 16, 1519-1530.
8. Falquet, L., Paquet, N., Frutiger, S., Hughes, G.J., Hoang-Van, K. and Jaton, J.C. (1995a) cDNA cloning of a human 100 kDa deubiquitinating enzyme: the 100kDa human de-ubiquitinase belongs to the ubiquitin C-terminal hydrolase family 2 (UCH2). FEBS Lett., 376, 233-237.
9. Falquet, L., Paquet, N., Frutiger, S., Hughes, G.J., Hoang-Van, K. and Jaton, J.C. (1995b) A human de-ubiquitinating enzyme with both isopeptidase and peptidase activities in vitro. FEBS Lett., 359, 73-77.
10. Fischer-Vize, J.A., Rubin, G.M. and Lehmann, R. (1992) The fat facets gene is required for Drosophila eye and embryo development. Development, 116, 985-1000.
11. Goldberg, A.L. (1995) Functions of the proteasome: the lysis at the end of the tunnel. Science, 268, 522-523.
12. Gray, D.A., Inazawa, J., Gupta, K., Wong, A., Ueda, R. and Takahashi, T. (1995) Elevated expression of Unph, a proto-oncogene at 3p21.3, in human lung tumors. Oncogene, 10, 2179-2183.
13. Guadagno, T., Ohtsubo, M., Roberts, J. and Assoian, R. (1993) A link between cyclin A expression and adhesion-dependent cell cycle progression. Science, 262, 1572-1575.
14. Gupta, K., Chevrette, M. and Gray, D.A. (1994) The Unp proto-oncogene encodes a nuclear protein. Oncogene, 9, 1729-1731.
15. Gupta, K., Copeland, N., Gilbert, D., Jenkins, N. and Gray, D. (1993) Unp, a mouse gene related to the tre oncogene. Oncogene, 8, 2307-2310.
16. Hateboer, G., Kerkhoven, R.M., Shvarts, A., Bernards, R. and Beijersbergen, R.L. (1996) Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins. Genes Dev., 10, 2960-2970.
17. Henchoz, S., De Rubertis, F., Pauli, D. and Spierer, P. (1996) The dose of a putative ubiquitin-specific protease affects position-effect variegation in Drosophila melanogaster. Mol. Cell. Biol., 16, 5717-5725.
18. Hochstrasser, M. (1995) Ubiquitin, proteasomes, and the regulation of intracellular protein degradation. Curr. Opin. Cell Biol., 7, 215-223.
19. Huang, Y., Baker, R.T. and Fischer-Vize, J.A. (1995) Control of cell fate by a deubiquitinating enzyme encoded by the fat facets gene. Science, 270, 1828-1831.
20. Huebner, K., Cannizzaro, L.A., Nakamura, T., Hillova, J., Mariage-Samson, R., Hecht, F., Hill, M. and Croce, C.M. (1988) A rearranged transforming gene, tre, is made up of human sequences derived from chromosome regions 5q, 17q and 18q. Oncogene, 3, 449-455.
21. Jaster, R., Zhu, Y., Pless, M., Bhattacharya, S., Mathey-Prevot, B. and D'Andrea, A.D. (1997) JAK2 is required for induction of the murine DUB-1 gene. Mol. Cell. Biol., 17, 3364-3372.
22. Jonnalagadda, S., Butt, T.R., Marsh, J., Sternberg, E.J., Mirabelli, C.K., Ecker, D.J. and Crooke, S.T. (1987) Expression and accurate processing of yeast penta-ubiquitin in Escherichia coli. J. Biol. Chem., 262, 17750-17756.
23. Kalderon, D. (1996) Protein degradation: de-ubiquitinate to decide your fate. Curr. Biol., 6, 662-665.
24. Kumar, S., Kao, W.H. and Howley, P.M. (1997) Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity. J. Biol. Chem., 272, 13548-13554.
25. Moazed, D. and Johnson, D. (1996) A deubiquitinating enzyme interacts with SIR4 and regulates silencing in S.cerevisiae. Cell, 86, 667-677.
26. Mueller, H., Moroni, M.C., Vigo, E., Otzen Petersen, B., Bartek, J. and Helin, K. (1997) Induction of S-phase entry by E2F transcription factors depends on their nuclear localization. Mol. Cell. Biol., 17, 5508-5520.
27. Nakamura, T., Hillova, J., Mariage-Samson, R. and Hill, M. (1988) Molecular cloning of a novel oncogene generated by DNA recombination during transfection. Oncogene Res., 2, 357-370.
28. Nakamura, T., Hillova, J., Mariage-Samson, R., Onno, M., Huebner, K., Cannizzaro, L.A., Boghosian-Sell, L., Croce, C.M. and Hill, M. (1992) A novel transcriptional unit of the tre oncogene widely expressed in human cancer cells. Oncogene, 7, 733-741.
29. Nomura, N. et al. (1994) Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res., 1, 223-229.
30. Pagano, M. (1997) Cell cycle regulation by the ubiquitin pathway. FASEB J., 11, 1067-1075.
31. Pagano, M., Theodoras, A.M., Tam, S.W. and Draetta, G. (1994) Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts. Genes Dev., 8, 1627-1639.
32. Pagano, M., Beer-Romero, P., Glass, S., Tam, S., Theodoras, A., Rolfe, M. and Draetta, G. (1995a) Targeting Ubiquitin-mediated Degradation for Proliferation Inhibitors. In Mihich, E. and Housman, D. (eds), Cancer Genes. Plenum, New York, pp. 241-254.
33. Pagano, M., Tam, S.W., Theodoras, A.M., Romero-Beer, P., Del Sal, G., Chau, V., Yew, R., Draetta, G. and Rolfe, M. (1995b) Role of the ubiquitin-proteasome pathway in regulating aboundance of the cyclin-dependent kinase inhibitor p27. Science, 269, 682-685.
34. Papa, F.R. and Hochstrasser, M. (1993) The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene. Nature, 366, 313-319.
35. Rolfe, M., Chiu, M.I. and Pagano, M. (1997) The ubiquitin-mediated proteolytic pathway as a therapeutic area. J. Mol. Med., 75, 5-17.
36. Sherr, C. and Roberts, J. (1995) Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev., 9, 1149-1163.
37. Swanson, D.A., Freund, C.L., Ploder, L., McInnes, R.R. and Valle, D. (1996) A ubiquitin C-terminal hydrolase gene on the proximal short arm of the X chromosome: implications for X-linked retinal disorders. Hum. Mol. Genet., 5, 533-538.
38. Treier, M., Staszewski, L. and Bohmann, D. (1994) Ubiquitin-dependent c-Jun degradation in vivo is mediated by the ∂ domain. Cell, 78, 787-798.
39. van den Heuvel, S. and Harlow, E. (1993) Distinct roles for cyclin-dependent kinases in cell cycle control. Science, 262, 2050-2054.
40. Wilkinson, K.D. (1997) Regulation of ubiquitin-dependent processes by deubiquitinating enzymes. FASEB J., 11, 1245-1256.
41. Wilkinson, K.D., Tashayev, V.L., O'Connor, L.B., Larsen, C.N., Kasperek, E. and Pickart, C.M. (1995) Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T. Biochemistry, 34, 14535-14546.
42. Zhu, Y., Lambert, K., Corless, C., Copeland, N.G., Gilbert, D.J., Jenkins, N.A. and D'Andrea, A.D. (1997) DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes. J. Biol. Chem., 272, 51-57.
43. Zhu, Y., Pless, M., Inhorn, R., Mathey-Prevot, B. and D'Andrea, A.D. (1996) The murine DUB-1 gene is specifically induced by the beta subunit of interleukin-3 receptor. Mol. Cell. Biol., 16, 4808-4817.