-
1
-
-
50349088876
-
Mdm2 and Mdm4 loss regulates distinct p53 activities
-
Barboza JA, Iwakuma T, Terzian T, El-Naggar AK, Lozano G. (2008). Mdm2 and Mdm4 loss regulates distinct p53 activities. Mol Cancer Res 6: 947-954.
-
(2008)
Mol Cancer Res
, vol.6
, pp. 947-954
-
-
Barboza, J.A.1
Iwakuma, T.2
Terzian, T.3
El-Naggar, A.K.4
Lozano, G.5
-
2
-
-
0033531252
-
Comparative study of the p53-mdm2 and p53-MDMX interfaces
-
Bottger V, Bottger A, Garcia-Echeverria C, Ramos YF, van der Eb AJ, Jochemsen AG et al. (1999). Comparative study of the p53-mdm2 and p53-MDMX interfaces. Oncogene 18: 189-199.
-
(1999)
Oncogene
, vol.18
, pp. 189-199
-
-
Bottger, V.1
Bottger, A.2
Garcia-Echeverria, C.3
Ramos, Y.F.4
Van Der Eb, A.J.5
Jochemsen, A.G.6
-
3
-
-
31544481844
-
Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-kappaB transactivation
-
Campbell KJ, Witty JM, Rocha S, Perkins ND. (2006). Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-kappaB transactivation. Cancer Res 66: 929-935.
-
(2006)
Cancer Res
, vol.66
, pp. 929-935
-
-
Campbell, K.J.1
Witty, J.M.2
Rocha, S.3
Perkins, N.D.4
-
4
-
-
0033545960
-
Inhibition of RNA polymerase II transcription in human cell extracts by cisplatin DNA damage
-
Cullinane C, Mazur SJ, Essigmann JM, Phillips DR, Bohr VA. (1999). Inhibition of RNA polymerase II transcription in human cell extracts by cisplatin DNA damage. Biochemistry 38: 6204-6212.
-
(1999)
Biochemistry
, vol.38
, pp. 6204-6212
-
-
Cullinane, C.1
Mazur, S.J.2
Essigmann, J.M.3
Phillips, D.R.4
Bohr, V.A.5
-
5
-
-
1842431904
-
Tumour suppression: Disruption of HAUSP gene stabilizes p53
-
following 486
-
Cummins JM, Rago C, Kohli M, Kinzler KW, Lengauer C, Vogelstein B. (2004). Tumour suppression: disruption of HAUSP gene stabilizes p53. Nature 428: 1 p following 486.
-
(2004)
Nature
, vol.428
-
-
Cummins, J.M.1
Rago, C.2
Kohli, M.3
Kinzler, K.W.4
Lengauer, C.5
Vogelstein, B.6
-
6
-
-
2942738959
-
Amplification of MDMX (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity
-
Danovi D, Meulmeester E, Pasini D, Migliorini D, Capra M, Frenk R et al. (2004). Amplification of MDMX (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity. Mol Cell Biol 24: 5835-5843.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 5835-5843
-
-
Danovi, D.1
Meulmeester, E.2
Pasini, D.3
Migliorini, D.4
Capra, M.5
Frenk, R.6
-
7
-
-
64149087218
-
Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53
-
Dayal S, Sparks A, Jacob J, Allende-Vega N, Lane DP, Saville MK. (2009). Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53. J Biol Chem 284: 5030-5041.
-
(2009)
J Biol Chem
, vol.284
, pp. 5030-5041
-
-
Dayal, S.1
Sparks, A.2
Jacob, J.3
Allende-Vega, N.4
Lane, D.P.5
Saville, M.K.6
-
8
-
-
0026772765
-
Cisplatin-induced imbalances in the pattern of chimeric marker gene expression in HeLa cells
-
Evans GL, Gralla JD. (1992). Cisplatin-induced imbalances in the pattern of chimeric marker gene expression in HeLa cells. Biochem Biophys Res Comm 184: 1.
-
(1992)
Biochem Biophys Res Comm
, vol.184
, pp. 1
-
-
Evans, G.L.1
Gralla, J.D.2
-
9
-
-
0034708458
-
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
-
Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM. (2000). Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J Biol Chem 275: 8945-8951.
-
(2000)
J Biol Chem
, vol.275
, pp. 8945-8951
-
-
Fang, S.1
Jensen, J.P.2
Ludwig, R.L.3
Vousden, K.H.4
Weissman, A.M.5
-
10
-
-
0036606416
-
MDMX is a negative regulator of p53 activity in vivo
-
Finch RA, Donoviel DB, Potter D, Shi M, Fan A, Freed DD et al. (2002). MDMX is a negative regulator of p53 activity in vivo. Cancer Res 62: 3221-3225.
-
(2002)
Cancer Res
, vol.62
, pp. 3221-3225
-
-
Finch, R.A.1
Donoviel, D.B.2
Potter, D.3
Shi, M.4
Fan, A.5
Freed, D.D.6
-
11
-
-
33644778697
-
Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo
-
Francoz S, Froment P, Bogaerts S, De Clercq S, Maetens M, Doumont G et al. (2006). Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo. Proc Natl Acad Sci USA 103: 3232-3237.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 3232-3237
-
-
Francoz, S.1
Froment, P.2
Bogaerts, S.3
De Clercq, S.4
Maetens, M.5
Doumont, G.6
-
12
-
-
27544493522
-
Identification of an aberrantly spliced form of HDMX in human tumors: A new mechanism for HDM2 stabilization
-
Giglio S, Mancini F, Gentiletti F, Sparaco G, Felicioni L, Barassi F et al. (2005). Identification of an aberrantly spliced form of HDMX in human tumors: a new mechanism for HDM2 stabilization. Cancer Res 65: 9687-9694.
-
(2005)
Cancer Res
, vol.65
, pp. 9687-9694
-
-
Giglio, S.1
Mancini, F.2
Gentiletti, F.3
Sparaco, G.4
Felicioni, L.5
Barassi, F.6
-
13
-
-
33751573462
-
MDMX regulation of p53 response to ribosomal stress
-
Gilkes DM, Chen L, Chen J. (2006). MDMX regulation of p53 response to ribosomal stress. EMBO J 25: 5614-5625.
-
(2006)
EMBO J
, vol.25
, pp. 5614-5625
-
-
Gilkes, D.M.1
Chen, L.2
Chen, J.3
-
14
-
-
0345602153
-
Gene structure, alternate splicing, tissue distribution, cellular localization, and developmental expression pattern of mouse deubiquitinating enzyme isoforms Usp2-45 and Usp2-69
-
Gousseva N, Baker RT. (2003). Gene structure, alternate splicing, tissue distribution, cellular localization, and developmental expression pattern of mouse deubiquitinating enzyme isoforms Usp2-45 and Usp2-69. Gene Expr 11: 163-179.
-
(2003)
Gene Expr
, vol.11
, pp. 163-179
-
-
Gousseva, N.1
Baker, R.T.2
-
15
-
-
12144286902
-
The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer
-
Graner E, Tang D, Rossi S, Baron A, Migita T, Weinstein LJ et al. (2004). The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer. Cancer Cell 5: 253-261.
-
(2004)
Cancer Cell
, vol.5
, pp. 253-261
-
-
Graner, E.1
Tang, D.2
Rossi, S.3
Baron, A.4
Migita, T.5
Weinstein, L.J.6
-
16
-
-
0037205454
-
Mutual dependence of MDM2 and MDMX in their functional inactivation of p53
-
Gu J, Kawai H, Nie L, Kitao H, Wiederschain D, Jochemsen AG et al. (2002). Mutual dependence of MDM2 and MDMX in their functional inactivation of p53. J Biol Chem 277: 19251-19254.
-
(2002)
J Biol Chem
, vol.277
, pp. 19251-19254
-
-
Gu, J.1
Kawai, H.2
Nie, L.3
Kitao, H.4
Wiederschain, D.5
Jochemsen, A.G.6
-
17
-
-
0034624678
-
Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
-
Honda R, Yasuda H. (2000). Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase. Oncogene 19: 1473-1476.
-
(2000)
Oncogene
, vol.19
, pp. 1473-1476
-
-
Honda, R.1
Yasuda, H.2
-
18
-
-
33845256980
-
MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin
-
Hu B, Gilkes DM, Farooqi B, Sebti SM, Chen J. (2006). MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin. J Biol Chem 281: 33030-33035.
-
(2006)
J Biol Chem
, vol.281
, pp. 33030-33035
-
-
Hu, B.1
Gilkes, D.M.2
Farooqi, B.3
Sebti, S.M.4
Chen, J.5
-
19
-
-
35148847384
-
Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation
-
Itahana K, Mao H, Jin A, Itahana Y, Clegg HV, Lindstrom MS et al. (2007). Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell 12: 355-366.
-
(2007)
Cancer Cell
, vol.12
, pp. 355-366
-
-
Itahana, K.1
Mao, H.2
Jin, A.3
Itahana, Y.4
Clegg, H.V.5
Lindstrom, M.S.6
-
20
-
-
0242580250
-
DNA damage-induced MDMX degradation is mediated by MDM2
-
Kawai H, Wiederschain D, Kitao H, Stuart J, Tsai KK, Yuan ZM. (2003). DNA damage-induced MDMX degradation is mediated by MDM2. J Biol Chem 278: 45946-45953.
-
(2003)
J Biol Chem
, vol.278
, pp. 45946-45953
-
-
Kawai, H.1
Wiederschain, D.2
Kitao, H.3
Stuart, J.4
Tsai, K.K.5
Yuan, Z.M.6
-
21
-
-
33847693945
-
A portrait of cisplatin-induced transcriptional changes in mouse embryonic stem cells reveals a dominant p53-like response
-
Kruse JJ, Svensson JP, Huigsloot M, Giphart-Gassler M, Schoonen WG, Polman JE et al. (2007). A portrait of cisplatin-induced transcriptional changes in mouse embryonic stem cells reveals a dominant p53-like response. Mutat Res 617: 58-70.
-
(2007)
Mutat Res
, vol.617
, pp. 58-70
-
-
Kruse, J.J.1
Svensson, J.P.2
Huigsloot, M.3
Giphart-Gassler, M.4
Schoonen, W.G.5
Polman, J.E.6
-
22
-
-
0025173845
-
P53: Oncogene or anti-oncogene?
-
Lane DP, Benchimol S. (1990). p53: oncogene or anti-oncogene? Genes Dev 4: 1-8.
-
(1990)
Genes Dev
, vol.4
, pp. 1-8
-
-
Lane, D.P.1
Benchimol, S.2
-
23
-
-
1842421376
-
A dynamic role of HAUSP in the p53-Mdm2 pathway
-
Li M, Brooks CL, Kon N, Gu W. (2004). A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol Cell 13: 879-886.
-
(2004)
Mol Cell
, vol.13
, pp. 879-886
-
-
Li, M.1
Brooks, C.L.2
Kon, N.3
Gu, W.4
-
24
-
-
0037061508
-
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
-
Li M, Chen D, Shiloh A, Luo J, Nikolaev AY, Qin J et al. (2002). Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature 416: 648-653.
-
(2002)
Nature
, vol.416
, pp. 648-653
-
-
Li, M.1
Chen, D.2
Shiloh, A.3
Luo, J.4
Nikolaev, A.Y.5
Qin, J.6
-
25
-
-
0035827502
-
Divergent N-terminal sequences of a deubiquitinating enzyme modulate substrate specificity
-
Lin H, Yin L, Reid J, Wilkinson KD, Wing SS. (2001). Divergent N-terminal sequences of a deubiquitinating enzyme modulate substrate specificity. J Biol Chem 276: 20357-20363.
-
(2001)
J Biol Chem
, vol.276
, pp. 20357-20363
-
-
Lin, H.1
Yin, L.2
Reid, J.3
Wilkinson, K.D.4
Wing, S.S.5
-
26
-
-
42149105590
-
Structure of the MDM2//MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans
-
Linke K, Mace PD, Smith CA, Vaux DL, Silke J, Day CL. (2008). Structure of the MDM2//MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans. Cell Death Differ 15: 841.
-
(2008)
Cell Death Differ
, vol.15
, pp. 841
-
-
Linke, K.1
MacE, P.D.2
Smith, C.A.3
Vaux, D.L.4
Silke, J.5
Day, C.L.6
-
28
-
-
33646794425
-
Keeping p53 in check: Essential and synergistic functions of Mdm2 and Mdm4
-
DOI 10.1038/sj.cdd.4401912, PII 4401912
-
Marine JC, Francoz S, Maetens M, Wahl G, Toledo F, Lozano G. (2006). Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Cell Death Differ 13: 927-934. (Pubitemid 43753483)
-
(2006)
Cell Death and Differentiation
, vol.13
, Issue.6
, pp. 927-934
-
-
Marine, J.-C.1
Francoz, S.2
Maetens, M.3
Wahl, G.4
Toledo, F.5
Lozano, G.6
-
29
-
-
19444367393
-
Loss of HAUSP-mediated deubiquitina-tion contributes to DNA damage-induced destabilization of Hdmx and Hdm2
-
Meulmeester E, Maurice MM, Boutell C, Teunisse AF, Ovaa H, Abraham TE et al. (2005). Loss of HAUSP-mediated deubiquitina-tion contributes to DNA damage-induced destabilization of Hdmx and Hdm2. Mol Cell 18: 565-576.
-
(2005)
Mol Cell
, vol.18
, pp. 565-576
-
-
Meulmeester, E.1
Maurice, M.M.2
Boutell, C.3
Teunisse, A.F.4
Ovaa, H.5
Abraham, T.E.6
-
30
-
-
0037329056
-
The p53-Mdm2 module and the ubiquitin system
-
Michael D, Oren M. (2003). The p53-Mdm2 module and the ubiquitin system. Semin Cancer Biol 13: 49-58.
-
(2003)
Semin Cancer Biol
, vol.13
, pp. 49-58
-
-
Michael, D.1
Oren, M.2
-
31
-
-
0036311067
-
Mdm4 (MDMX) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development
-
Migliorini D, Lazzerini Denchi E, Danovi D, Jochemsen A, Capillo M, Gobbi A et al. (2002). Mdm4 (MDMX) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol Cell Biol 22: 5527-5538.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 5527-5538
-
-
Migliorini, D.1
Lazzerini Denchi, E.2
Danovi, D.3
Jochemsen, A.4
Capillo, M.5
Gobbi, A.6
-
32
-
-
0028823020
-
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
-
Montes de Oca Luna R, Wagner DS, Lozano G. (1995). Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378: 203-206.
-
(1995)
Nature
, vol.378
, pp. 203-206
-
-
Montes De Oca Luna, R.1
Wagner, D.S.2
Lozano, G.3
-
33
-
-
0034863683
-
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
-
Parant J, Chavez-Reyes A, Little NA, Yan W, Reinke V, Jochemsen AG et al. (2001). Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat Genet 29: 92-95.
-
(2001)
Nat Genet
, vol.29
, pp. 92-95
-
-
Parant, J.1
Chavez-Reyes, A.2
Little, N.A.3
Yan, W.4
Reinke, V.5
Jochemsen, A.G.6
-
34
-
-
0037162494
-
Antagonistic regulation of myogenesis by two deubiquitinating enzymes, UBP45 and UBP69
-
Park KC, Kim JH, Choi EJ, Min SW, Rhee S, Baek SH et al. (2002). Antagonistic regulation of myogenesis by two deubiquitinating enzymes, UBP45 and UBP69. Proc Natl Acad Sci USA 99: 9733-9738.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 9733-9738
-
-
Park, K.C.1
Kim, J.H.2
Choi, E.J.3
Min, S.W.4
Rhee, S.5
Baek, S.H.6
-
35
-
-
33645511223
-
Levels of HdmX expression dictate the sensitivity of normal and transformed cells to Nutlin-3
-
Patton JT, Mayo LD, Singhi AD, Gudkov AV, Stark GR, Jackson MW. (2006). Levels of HdmX expression dictate the sensitivity of normal and transformed cells to Nutlin-3. Cancer Res 66: 3169-3176.
-
(2006)
Cancer Res
, vol.66
, pp. 3169-3176
-
-
Patton, J.T.1
Mayo, L.D.2
Singhi, A.D.3
Gudkov, A.V.4
Stark, G.R.5
Jackson, M.W.6
-
36
-
-
4644365386
-
RNA expression induced by cisplatin in an organ of Corti-derived immortalized cell line
-
Previati M, Lanzoni I, Corbacella E, Magosso S, Giuffre S, Francioso F et al. (2004). RNA expression induced by cisplatin in an organ of Corti-derived immortalized cell line. Hear Res 196: 8-18.
-
(2004)
Hear Res
, vol.196
, pp. 8-18
-
-
Previati, M.1
Lanzoni, I.2
Corbacella, E.3
Magosso, S.4
Giuffre, S.5
Francioso, F.6
-
37
-
-
33746820622
-
The isopeptidase USP2a protects human prostate cancer from apoptosis
-
Priolo C, Tang D, Brahamandan M, Benassi B, Sicinska E, Ogino S et al. (2006). The isopeptidase USP2a protects human prostate cancer from apoptosis. Cancer Res 66: 8625-8632.
-
(2006)
Cancer Res
, vol.66
, pp. 8625-8632
-
-
Priolo, C.1
Tang, D.2
Brahamandan, M.3
Benassi, B.4
Sicinska, E.5
Ogino, S.6
-
38
-
-
33746827805
-
Structural basis of ubiquitin recognition by the deubiquitinating protease USP2
-
Renatus M, Parrado SG, D'Arcy A, Eidhoff U, Gerhartz B, Hassiepen U et al. (2006). Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. Structure 14: 1293-1302.
-
(2006)
Structure
, vol.14
, pp. 1293-1302
-
-
Renatus, M.1
Parrado, S.G.2
D'Arcy, A.3
Eidhoff, U.4
Gerhartz, B.5
Hassiepen, U.6
-
39
-
-
10144259344
-
MDMX: A novel p53-binding protein with some functional properties of MDM2
-
Shvarts A, Steegenga WT, Riteco N, van Laar T, Dekker P, Bazuine M et al. (1996). MDMX: a novel p53-binding protein with some functional properties of MDM2. EMBO J 15: 5349-5357.
-
(1996)
EMBO J
, vol.15
, pp. 5349-5357
-
-
Shvarts, A.1
Steegenga, W.T.2
Riteco, N.3
Van Laar, T.4
Dekker, P.5
Bazuine, M.6
-
40
-
-
0345256652
-
Cisplatin: Mode of cytotoxic action and molecular basis of resistance
-
Siddik ZH. (2003). Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 22: 7265-7279.
-
(2003)
Oncogene
, vol.22
, pp. 7265-7279
-
-
Siddik, Z.H.1
-
41
-
-
34249711818
-
Hetero-oligomerization with MDMX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2
-
Singh RK, Iyappan S, Scheffner M. (2007). Hetero-oligomerization with MDMX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2. J Biol Chem 282: 10901-10907.
-
(2007)
J Biol Chem
, vol.282
, pp. 10901-10907
-
-
Singh, R.K.1
Iyappan, S.2
Scheffner, M.3
-
42
-
-
33847212425
-
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2
-
Stevenson LF, Sparks A, Allende-Vega N, Xirodimas DP, Lane DP, Saville MK. (2007). The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. EMBO J 26: 976-986.
-
(2007)
EMBO J
, vol.26
, pp. 976-986
-
-
Stevenson, L.F.1
Sparks, A.2
Allende-Vega, N.3
Xirodimas, D.P.4
Lane, D.P.5
Saville, M.K.6
-
43
-
-
2342567852
-
Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation
-
Stommel JM, Wahl GM. (2004). Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. EMBO J 23: 1547-1556.
-
(2004)
EMBO J
, vol.23
, pp. 1547-1556
-
-
Stommel, J.M.1
Wahl, G.M.2
-
44
-
-
0033051322
-
MDM2 interacts with MDMX through their RING finger domains
-
Tanimura S, Ohtsuka S, Mitsui K, Shirouzu K, Yoshimura A, Ohtsubo M. (1999). MDM2 interacts with MDMX through their RING finger domains. FEBS Lett 447: 5-9.
-
(1999)
FEBS Lett
, vol.447
, pp. 5-9
-
-
Tanimura, S.1
Ohtsuka, S.2
Mitsui, K.3
Shirouzu, K.4
Yoshimura, A.5
Ohtsubo, M.6
-
45
-
-
33645769536
-
A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network
-
Toledo F, Krummel KA, Lee CJ, Liu CW, Rodewald LW, Tang M et al. (2006). A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network. Cancer Cell 9: 273-285.
-
(2006)
Cancer Cell
, vol.9
, pp. 273-285
-
-
Toledo, F.1
Krummel, K.A.2
Lee, C.J.3
Liu, C.W.4
Rodewald, L.W.5
Tang, M.6
-
46
-
-
34447098700
-
MDM2 and MDM4: P53 regulators as targets in anticancer therapy
-
Toledo F, Wahl GM. (2007). MDM2 and MDM4: p53 regulators as targets in anticancer therapy. Int J Biochem Cell Biol 39: 1476-1482.
-
(2007)
Int J Biochem Cell Biol
, vol.39
, pp. 1476-1482
-
-
Toledo, F.1
Wahl, G.M.2
-
47
-
-
33846193699
-
An essential function of the extreme C terminus of MDM2 can be provided by MDMX
-
Uldrijan S, Pannekoek WJ, Vousden KH. (2007). An essential function of the extreme C terminus of MDM2 can be provided by MDMX. EMBO J 26: 102-112.
-
(2007)
EMBO J
, vol.26
, pp. 102-112
-
-
Uldrijan, S.1
Pannekoek, W.J.2
Vousden, K.H.3
-
48
-
-
33845901313
-
MDM2 inhibitors for cancer therapy
-
Vassilev LT. (2007). MDM2 inhibitors for cancer therapy. Trends Mol Med 13: 23-31.
-
(2007)
Trends Mol Med
, vol.13
, pp. 23-31
-
-
Vassilev, L.T.1
-
49
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z et al. (2004). in vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303: 844-848.
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
Filipovic, Z.6
-
50
-
-
0031463309
-
Cisplatin-and UV-damaged DNA lure the basal transcription factor TFIID/TBP
-
Vichi P, Coin F, Renaud JP, Vermeulen W, Hoeijmakers JH, Moras D, Egly JM. (1997). Cisplatin-and UV-damaged DNA lure the basal transcription factor TFIID/TBP. EMBO J 16: 7444-7456.
-
(1997)
EMBO J
, vol.16
, pp. 7444-7456
-
-
Vichi, P.1
Coin, F.2
Renaud, J.P.3
Vermeulen, W.4
Hoeijmakers, J.H.5
Moras, D.6
Egly, J.M.7
-
51
-
-
0036674617
-
Live or let die: The cell's response to p53
-
Vousden KH, Lu X. (2002). Live or let die: the cell's response to p53. Nat Rev Cancer 2: 594-604.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 594-604
-
-
Vousden, K.H.1
Lu, X.2
-
52
-
-
58749094954
-
Targeting Mdm2 and MDMX in cancer therapy: Better living through medicinal chemistry?
-
Wade M, Wahl GM. (2009). Targeting Mdm2 and MDMX in cancer therapy: better living through medicinal chemistry? Mol Cancer Res 7: 1-11.
-
(2009)
Mol Cancer Res
, vol.7
, pp. 1-11
-
-
Wade, M.1
Wahl, G.M.2
-
53
-
-
33845251005
-
Hdmx modulates the outcome of p53 activation in human tumor cells
-
Wade M, Wong ET, Tang M, Stommel JM, Wahl GM. (2006). Hdmx modulates the outcome of p53 activation in human tumor cells. J Biol Chem 281: 33036-33044.
-
(2006)
J Biol Chem
, vol.281
, pp. 33036-33044
-
-
Wade, M.1
Wong, E.T.2
Tang, M.3
Stommel, J.M.4
Wahl, G.M.5
-
54
-
-
34547615407
-
Quantitative analyses reveal the importance of regulated Hdmx degradation for P53 activation
-
Wang YV, Wade M, Wong E, Li Y-C, Rodewald LW, Wahl GM. (2007). Quantitative analyses reveal the importance of regulated Hdmx degradation for P53 activation. Proc Natl Acad Sci 104: 12365-12370.
-
(2007)
Proc Natl Acad Sci
, vol.104
, pp. 12365-12370
-
-
Wang, Y.V.1
Wade, M.2
Wong, E.3
Li, Y.-C.4
Rodewald, L.W.5
Wahl, G.M.6
-
55
-
-
45849116513
-
Elevated MDM2 boosts the apoptotic activity of p53-MDM2 binding inhibitors by facilitating MDMX degradation
-
Xia M, Knezevic D, Tovar C, Huang B, Heimbrook DC, Vassilev LT. (2008). Elevated MDM2 boosts the apoptotic activity of p53-MDM2 binding inhibitors by facilitating MDMX degradation. Cell Cycle 7: 1604-1612.
-
(2008)
Cell Cycle
, vol.7
, pp. 1604-1612
-
-
Xia, M.1
Knezevic, D.2
Tovar, C.3
Huang, B.4
Heimbrook, D.C.5
Vassilev, L.T.6
-
56
-
-
0035899468
-
Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo
-
Xirodimas D, Saville MK, Edling C, Lane DP, Lain S. (2001). Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo. Oncogene 20: 4972-4983.
-
(2001)
Oncogene
, vol.20
, pp. 4972-4983
-
-
Xirodimas, D.1
Saville, M.K.2
Edling, C.3
Lane, D.P.4
Lain, S.5
|