When ubiquitin meets ubiquitin receptors: A signalling connection

Nature Reviews Molecular Cell Biology

Volumn 4, Issue 6, 2003, Pages 491-497

  Di Fiore, Pier Paolo ^a,b,c   Polo, Simona ^a,b   Hofmann, Kay ^d  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d Memorec Biotec GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BRCA2 PROTEIN; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; POLYUBIQUITIN; PROTEIN TYROSINE KINASE; RAB PROTEIN; RECEPTOR PROTEIN; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN PROTEIN LIGASE;

CARBOXY TERMINAL SEQUENCE; DNA DAMAGE; ENDOCYTOSIS; ENDOSOME; FANCONI ANEMIA; HUMAN; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN MODIFICATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; REVIEW; UBIQUITINYLATION;

ANIMALS; CARRIER PROTEINS; ENDOSOMES; FANCONI ANEMIA; HUMANS; MODELS, BIOLOGICAL; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; UBIQUITIN;

EID: 0038362292     PISSN: 14710072     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrm1124     Document Type: Review

References (60)

1. Pickart, C M. Ubiquitin in chains. Trends Biochem. Sci. 25, 544-548 (2000).
2. Deng, L. et al. Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103, 351-361 (2000).
3. Spence, J. et al. Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain. Cell 102, 67-76 (2000).
4. Hicke, L. Protein regulation by monoubiquitin. Nature Rev. Mol. Cell Biol. 2, 195-201 (2001).
5. Hofmann, K. & Bucher, P. The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway. Trends Biochem. Sci. 21, 172-173 (1996).
6. Buchberger, A. From UBA to UBX: new words in the ubiquitin vocabulary. Trends Cell Biol. 12, 216-221 (2002).
7. Wilkinson, C. R. et al. Proteins containing the UBA domain are able to bind to multi-ubiquitin chains. Nature Cell Biol. 3, 939-943 (2001).
8. Ortolan, T. G. et al. The DNA repair protein rad23 is a negative regulator of multi-ubiquitin chain assembly. Nature Cell Biol. 2, 601-608 (2000).
9. Rao, H. & Sastry, A. Recognition of specific ubiquitin conjugates is important for the proteolytic functions of the ubiquitin-associated domain proteins Dsk2 and Rad23. J. Biol. Chem. 277, 11691-11695 (2002).
10. Bertolaet, B. L. et al. UBA domains of DNA damage-inducible proteins interact with ubiquitin. Nature Struct. Biol. 8, 417-422 (2001).
11. Dieckmann, T. et al. Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr. Nature Struct. Biol. 5, 1042-1047 (1998).
12. Mueller, T. D. & Feigon, J. Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions. J. Mol. Biol. 319, 1243-1255 (2002).
13. Hofmann, K. & Falquet, L. A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems. Trends Biochem. Sci. 26, 347-350 (2001).
14. Polo, S. et al. A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins. Nature 416, 451-455 (2002).
15. Ralborg, C. et al. Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes. Nature Cell Biol. 4, 394-398 (2002).
16. Bilodeau, P. S., Urbanowski, J. L., Winistorfer, S. C. & Piper, R. C. The Vps27p Hse1p complex binds ubiquitin and mediates endosomal protein sorting. Nature Cell Biol. 4, 534-539 (2002).
17. Shih, S. C. et al. Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis. Nature Cell Biol. 4, 389-393 (2002).
18. Katz, M. et al. Ligand-independent degradation of epidermal growth factor receptor involves receptor ubiquitylation and Hgs, an adaptor whose ubiquitin-interacting motif targets ubiquitylation by Nedd4. Traffic 3, 740-751 (2002).
19. Oldham, C. E., Mohney, R. P., Miller, S. L., Hanes, R. N. & O'Bryan, J. P. The ubiquitin-interacting motifs target the endocytic adaptor protein epsin for ubiquitination. Curr. Biol. 12, 1112-1116 (2002).
20. Shekhtman, A. & Cowburn, D. A ubiquitin-interacting motif from Hrs binds to and occludes the ubiquitin surface necessary for polyubiquitination in monoubiquitinated proteins. Biochem. Biophys. Res. Commun. 296, 1222-1227 (2002).
21. Ponting, C. P., Cai, Y. D. & Bork, P. The breast cancer gene product TSG101: a regulator of ubiquitination? J. Mol. Med. 75, 467-469 (1997).
22. Bishop, N., Horman, A. & Woodman, P. Mammalian class Evps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates. J. Cell Biol. 157, 91-101 (2002).
23. Pornillos, O., Alam, S. L., Davis, D. R. & Sundquist, W. I. Structure of the Tsg101 UEV domain in complex with the PTAP motif of the HIV-1 p6 protein Nature Struct Biol. 9, 812-817 (2002).
24. Hoege, C., Pfander, B., Moldovan, G. L., Pyrowolakis, G. & Jentsch, S. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 419, 135-141 (2002).
25. Pornillos, O. et al. Structure and functional interactions of the Tsg101 UEV domain. EMBO J. 21, 2397-2406 (2002).
26. Donaldson, K. M., Yin, H., Gekakis, N., Supek, F. & Joazeiro, C. A. Ubiquitin signals protein trafficking via interaction with a novel ubiquitin binding domain in the membrane fusion regulator, Vps9p. Curr. Biol. 13, 258-262 (2003).
27. Shih, C. S. et al. A ubiquitin-binding motif required for intramolecular monoubiquitination, the CUE domain. EMBO J. 17, 1273-1281 (2003).
28. Hunter, T. Signaling - 2000 and beyond. Cell 100, 113-127 (2000).
29. Yaffe, M. B. & Smerdon, S. J. Phosphoserine/threonine binding domains: you can't pSERious? Structure (Camb.) 9, R33-R38 (2001).
30. van Delft, S., Govers, R., Strous, G. J., Verkleij, A. J. & van Bergen en Henegouwen, P. M. Epidermal growth factor induces ubiquitination of Eps 15. J. Biol. Chem. 272, 14013-14016 (1997).
31. Haglund, K., Shimokawa, N., Szymkiewicz, I. & Dikic, I. Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors. Proc. Natl Acad Sci. USA 99, 12191-12196 (2002).
32. Levkowitz, G. et al. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol. Cell 4, 1029-1040 (1999).
33. Soubeyran, P., Kowanetz, K., Szymkiewicz, I., Langdon, W. Y. & Dikic, I. Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors. Nature 416, 183-187 (2002).
34. Morrione, A. et al. mGrb10 interacts with Nedd4. J. Biol. Chem. 274, 24094-24099 (1999).
35. Courbard, J. R. et al. Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH. J. Biol. Chem. 277, 45267-45275 (2002).
36. Garcia-Higuera, I. et al. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol. Cell 7, 249-262 (2001).
37. Taniguchi, T. & D'Andrea, A. D. The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC. Blood 100, 2457-2462 (2002).
38. Wang, Y. et al. BASC, a super complex of BRCA1 associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev. 14, 927-939 (2000).
39. Taniguchi, T. et al. S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood 100, 2414-2420 (2002).
40. Katzmann, D. J., Odorizzi, G. & Emr, S. D. Receptor downregulation and multivesicular-body sorting. Nature Rev. Mol. Cell Biol. 3, 893-905 (2002).
41. Hicke, L. Getting' down with ubiquitin: turning off cell-surface receptors, transporters and channels. Trends Cell Biol. 9, 107-112 (1999).
42. Hicke, L. A new ticket for entry into budding vesicles ubiquitin. Cell 106, 527-530 (2001).
43. Terrell, J., Shih, S., Dunn, R. & Hicke, L. A function for monoubiquitination in the internalization of a G protein-coupled receptor. Mol. Cell 1, 193-202 (1998).
44. Levkowitz, G. et al. c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. Genes Dev. 12, 3663-3674 (1998).
45. Lee, P. S. et al. The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation. EMBO J. 18, 3616-3628 (1999).
46. Strous, G. J., van Kerkhof, P., Govers, R., Ciechanover, A. & Schwartz, A. L. The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor. EMBO J 15, 3806-3812 (1996).
47. Dunn, R. & Hicke, L. Multiple roles for Rsp5p-dependent ubiquitination at the internalization step of endocytosis. J. Biol. Chem. 276, 25974-25981 (2001).
48. Shenoy, S. K., McDonald, P. H., Kohout, T. A. & Lefkowitz, R. J. Regulation of receptor fate by ubiquitination of activated β2-adrenergic receptor and β-arrestin. Science 294, 1307-1313 (2001).
49. Shih, S. C., Sloper-Mould, K. E. & Hicke, L. Monoubiquitin carries a novel internalization signal that is appended to activated receptors. EMBO J. 19, 187-198 (2000).
50. Katzmann, D. J., Babst, M. & Emr, S. D. Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Cell 106, 145-155 (2001).
51. Reggiori, F. & Pelham, H. R. Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting. EMBO J. 20, 5176-5186 (2001).
52. Reggiori, F. & Pelham, H. R. A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodies. Nature Cell Biol. 4, 117-123 (2002).
53. Klapisz, E. et al. A ubiquitin-interacting motif (UIM) is essential for Eps15 and Eps15R ubiquitination. J. Biol. Chem. 277, 30746-30753 (2002).
54. Kanelis, V., Rotin, D. & Forman-Kay, J. D. Solution structure of a Nedd4 WW domain-ENaC peptide complex. Nature Struct. Biol. 8, 407-412 (2001).
55. Hochstrasser, M. Ubiquitin-dependent protein degradation. Annu. Rev. Genet. 30, 405-439 (1996).
56. Timmers, C. et al. Positional cloning of a novel Fanconi anemia gene, FANCD2. Mol. Cell 7, 241-248 (2001).
57. Howlett, N. G. et al. Biallelic inactivation of BRCA2 in Fanconi anemia. Science 297, 606-609 (2002).
58. Hama, H., Tall, G. G. & Horazdovsky, B. F. Vps9p is a guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport. J. Biol. Chem. 274, 15284-15291 (1999).
59. Horiuchi, H. et al. A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. Cell 90, 1149-1159 (1997).
60. Haglund, K. et al. Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation. Nature Cell Biol. 5, 461-466 (2003).