메뉴 건너뛰기




Volumn 68, Issue 6, 2008, Pages 1843-1850

Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling

Author keywords

[No Author keywords available]

Indexed keywords

FOCAL ADHESION KINASE; GAMBOGIC ACID; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; VASCULOTROPIN RECEPTOR 2;

EID: 40949101023     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-5944     Document Type: Article
Times cited : (235)

References (42)
  • 1
    • 31844434032 scopus 로고    scopus 로고
    • Inhibition of human telomerase reverse transcriptase gene expression by gambogic acid in human hepatoma SMMC-7721 cells
    • Guo QL, Lin SS, You QD, et al. Inhibition of human telomerase reverse transcriptase gene expression by gambogic acid in human hepatoma SMMC-7721 cells. Life Sci 2006;78:1238-45.
    • (2006) Life Sci , vol.78 , pp. 1238-1245
    • Guo, Q.L.1    Lin, S.S.2    You, Q.D.3
  • 2
    • 23844463880 scopus 로고    scopus 로고
    • Anticancer effect and apoptosis induction of gambogic acid in human gastric cancer line BGC-823
    • Liu W, Guo QL, You QD, Zhao L, Gu HY, Yuan ST. Anticancer effect and apoptosis induction of gambogic acid in human gastric cancer line BGC-823. World J Gastroenterol 2005;11:3655-9.
    • (2005) World J Gastroenterol , vol.11 , pp. 3655-3659
    • Liu, W.1    Guo, Q.L.2    You, Q.D.3    Zhao, L.4    Gu, H.Y.5    Yuan, S.T.6
  • 3
    • 9644266405 scopus 로고    scopus 로고
    • Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells
    • Zhao L, Guo QL, You QD, Wu ZQ, Gu HY. Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells. Biol Pharm Bull 2004;27:998-1003.
    • (2004) Biol Pharm Bull , vol.27 , pp. 998-1003
    • Zhao, L.1    Guo, Q.L.2    You, Q.D.3    Wu, Z.Q.4    Gu, H.Y.5
  • 4
    • 0347320714 scopus 로고    scopus 로고
    • Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay
    • Zhang HZ, Kasibhatla S, Wang Y, et al. Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay. Bioorg Med Chem 2004;12:309-17.
    • (2004) Bioorg Med Chem , vol.12 , pp. 309-317
    • Zhang, H.Z.1    Kasibhatla, S.2    Wang, Y.3
  • 5
    • 2942629656 scopus 로고    scopus 로고
    • General gambogic acids inhibited growth of human hepatoma SMMC-7721 cells in vitro and in nude mice
    • Guo QL, You QD, Wu ZQ, Yuan ST, Zhao L. General gambogic acids inhibited growth of human hepatoma SMMC-7721 cells in vitro and in nude mice. Acta Pharmacol Sin 2004;25:769-74.
    • (2004) Acta Pharmacol Sin , vol.25 , pp. 769-774
    • Guo, Q.L.1    You, Q.D.2    Wu, Z.Q.3    Yuan, S.T.4    Zhao, L.5
  • 6
    • 20344405555 scopus 로고    scopus 로고
    • Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase mRNA expression in the cells
    • Wu ZQ, Guo QL, You QD, Zhao L, Gu HY. Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase mRNA expression in the cells. Biol Pharm Bull 2004;27:1769-74.
    • (2004) Biol Pharm Bull , vol.27 , pp. 1769-1774
    • Wu, Z.Q.1    Guo, Q.L.2    You, Q.D.3    Zhao, L.4    Gu, H.Y.5
  • 7
    • 34047133853 scopus 로고    scopus 로고
    • Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells
    • Yu J, Guo QL, You QD, et al. Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells. Carcinogenesis 2007;28:632-8.
    • (2007) Carcinogenesis , vol.28 , pp. 632-638
    • Yu, J.1    Guo, Q.L.2    You, Q.D.3
  • 8
    • 24744435348 scopus 로고    scopus 로고
    • A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid
    • Kasibhatla S, Jessen KA, Maliartchouk S, et al. A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid. Proc Natl Acad Sci U S A 2005;102:12095-100.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 12095-12100
    • Kasibhatla, S.1    Jessen, K.A.2    Maliartchouk, S.3
  • 9
    • 35349029248 scopus 로고    scopus 로고
    • Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-{κ}B signaling pathway
    • Pandey MK, Sung B, Ahn KS, Kunnumakkara AB, Chaturvedi MM, Aggarwal BB. Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-{κ}B signaling pathway. Blood 2007;110:3517-25.
    • (2007) Blood , vol.110 , pp. 3517-3525
    • Pandey, M.K.1    Sung, B.2    Ahn, K.S.3    Kunnumakkara, A.B.4    Chaturvedi, M.M.5    Aggarwal, B.B.6
  • 10
    • 2942615257 scopus 로고    scopus 로고
    • The anti-angiogenic basis of metronomic chemotherapy
    • Kerbel RS, Kamen BA. The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer 2004;4:423-36.
    • (2004) Nat Rev Cancer , vol.4 , pp. 423-436
    • Kerbel, R.S.1    Kamen, B.A.2
  • 11
    • 0035887463 scopus 로고    scopus 로고
    • Low-dose chemotherapy combined with an antiangiogenic drug reduces human glioma growth in vivo
    • Bello L, Carrabba G, Giussani C, et al. Low-dose chemotherapy combined with an antiangiogenic drug reduces human glioma growth in vivo. Cancer Res 2001;61:7501-6.
    • (2001) Cancer Res , vol.61 , pp. 7501-7506
    • Bello, L.1    Carrabba, G.2    Giussani, C.3
  • 12
    • 0037093209 scopus 로고    scopus 로고
    • Antitumor effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking water
    • Man S, Bocci G, Francia G, et al. Antitumor effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking water. Cancer Res 2002;62:2731-5.
    • (2002) Cancer Res , vol.62 , pp. 2731-2735
    • Man, S.1    Bocci, G.2    Francia, G.3
  • 14
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003;9:669-76.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 16
    • 0037358192 scopus 로고    scopus 로고
    • Integrin avh3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGF
    • Masson-Gadais B, Houle F, Laferriere J, Huot J. Integrin avh3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGF. Cell Stress Chaperones 2003;8:37-52.
    • (2003) Cell Stress Chaperones , vol.8 , pp. 37-52
    • Masson-Gadais, B.1    Houle, F.2    Laferriere, J.3    Huot, J.4
  • 17
    • 0347065353 scopus 로고    scopus 로고
    • Etk/Bmx transactivates vascular endothelial growth factor 2 and recruits phosphatidylinositol 3-kinase to mediate the tumor necrosis factor-induced angiogenic pathway
    • Zhang R, Xu Y, Ekman N, et al. Etk/Bmx transactivates vascular endothelial growth factor 2 and recruits phosphatidylinositol 3-kinase to mediate the tumor necrosis factor-induced angiogenic pathway. J Biol Chem 2003;278:51267-76.
    • (2003) J Biol Chem , vol.278 , pp. 51267-51276
    • Zhang, R.1    Xu, Y.2    Ekman, N.3
  • 18
    • 34548443831 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-2: Structure, function, intracellular signalling and therapeutic inhibition
    • Holmes K, Roberts OL, Thomas AM, Cross MJ. Vascular endothelial growth factor receptor-2: Structure, function, intracellular signalling and therapeutic inhibition. Cell Signal 2007;19:2003-12.
    • (2007) Cell Signal , vol.19 , pp. 2003-2012
    • Holmes, K.1    Roberts, O.L.2    Thomas, A.M.3    Cross, M.J.4
  • 19
    • 18744376552 scopus 로고    scopus 로고
    • Mouse Aortic Ring Assay: A New Approach of the Molecular Genetics of Angiogenesis
    • Masson VV, Devy L, Grignet-Debrus C, et al. Mouse Aortic Ring Assay: A New Approach of the Molecular Genetics of Angiogenesis. Biol Proced Online 2002;4:24-31.
    • (2002) Biol Proced Online , vol.4 , pp. 24-31
    • Masson, V.V.1    Devy, L.2    Grignet-Debrus, C.3
  • 20
    • 34548015409 scopus 로고    scopus 로고
    • Androgen receptor and E2F-1 targeted thymoquinone therapy for hormone-refractory prostate cancer
    • Kaseb AO, Chinnakannu K, Chen D, et al. Androgen receptor and E2F-1 targeted thymoquinone therapy for hormone-refractory prostate cancer. Cancer Res 2007;67:7782-8.
    • (2007) Cancer Res , vol.67 , pp. 7782-7788
    • Kaseb, A.O.1    Chinnakannu, K.2    Chen, D.3
  • 21
    • 0035956985 scopus 로고    scopus 로고
    • Anti-PSCA mAbs inhibit tumor growth and metastasis formation and prolong the survival of mice bearing human prostate cancer xenografts
    • Saffran DC, Raitano AB, Hubert RS, Witte ON, Reiter RE, Jakobovits A. Anti-PSCA mAbs inhibit tumor growth and metastasis formation and prolong the survival of mice bearing human prostate cancer xenografts. Proc Natl Acad Sci U S A 2001;98:2658-63.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 2658-2663
    • Saffran, D.C.1    Raitano, A.B.2    Hubert, R.S.3    Witte, O.N.4    Reiter, R.E.5    Jakobovits, A.6
  • 22
    • 33746858881 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-receptor2: Its biological functions, major signaling pathway, and specific ligand VEGF-E
    • Shibuya M. Vascular endothelial growth factor (VEGF)-receptor2: its biological functions, major signaling pathway, and specific ligand VEGF-E. Endothelium 2006;13:63-9.
    • (2006) Endothelium , vol.13 , pp. 63-69
    • Shibuya, M.1
  • 24
    • 34347407791 scopus 로고    scopus 로고
    • CD13/APN regulates endothelial invasion and filopodia formation
    • Petrovic N, Schacke W, Gahagan JR, et al. CD13/APN regulates endothelial invasion and filopodia formation. Blood 2007;110:142-50.
    • (2007) Blood , vol.110 , pp. 142-150
    • Petrovic, N.1    Schacke, W.2    Gahagan, J.R.3
  • 25
    • 2342430184 scopus 로고    scopus 로고
    • Vasculogenesis and angiogenesis
    • Patan S. Vasculogenesis and angiogenesis. Cancer Treat Res 2004;117:3-32.
    • (2004) Cancer Treat Res , vol.117 , pp. 3-32
    • Patan, S.1
  • 27
    • 33747081043 scopus 로고    scopus 로고
    • Toxicological studies of gambogic acid and its potential targets in experimental animals
    • Guo Q, Qi Q, You Q, Gu H, Zhao L, Wu Z. Toxicological studies of gambogic acid and its potential targets in experimental animals. Basic Clin Pharmacol Toxicol 2006;99:178-84.
    • (2006) Basic Clin Pharmacol Toxicol , vol.99 , pp. 178-184
    • Guo, Q.1    Qi, Q.2    You, Q.3    Gu, H.4    Zhao, L.5    Wu, Z.6
  • 28
    • 28244481510 scopus 로고    scopus 로고
    • Vascular endothelial growth factor contributes to prostate cancer-mediated osteoblastic activity
    • Kitagawa Y, Dai J, Zhang J, et al. Vascular endothelial growth factor contributes to prostate cancer-mediated osteoblastic activity. Cancer Res 2005;65:10921-9.
    • (2005) Cancer Res , vol.65 , pp. 10921-10929
    • Kitagawa, Y.1    Dai, J.2    Zhang, J.3
  • 29
    • 4644301879 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities
    • Le Boeuf F, Houle F, Huot J. Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities. J Biol Chem 2004;279:39175-85.
    • (2004) J Biol Chem , vol.279 , pp. 39175-39185
    • Le Boeuf, F.1    Houle, F.2    Huot, J.3
  • 30
    • 0034615992 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated protein kinase 2 (SAPK2/p38) and geldanamycin-sensitive phosphorylation of focal adhesion kinase
    • Rousseau S, Houle F, Kotanides H, et al. Vascular endothelial growth factor (VEGF)-driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated protein kinase 2 (SAPK2/p38) and geldanamycin-sensitive phosphorylation of focal adhesion kinase. J Biol Chem 2000;275:10661-72.
    • (2000) J Biol Chem , vol.275 , pp. 10661-10672
    • Rousseau, S.1    Houle, F.2    Kotanides, H.3
  • 31
    • 34147171490 scopus 로고    scopus 로고
    • Endothelial cell migration during angiogenesis
    • Lamalice L, Le Boeuf F, Huot J. Endothelial cell migration during angiogenesis. Circ Res 2007;100:782-94.
    • (2007) Circ Res , vol.100 , pp. 782-794
    • Lamalice, L.1    Le Boeuf, F.2    Huot, J.3
  • 32
    • 0036849331 scopus 로고    scopus 로고
    • Brazil DP, Park J, Hemmings BA. PKB binding proteins. Getting in on the Akt. Cell 2002;111:293-303.
    • Brazil DP, Park J, Hemmings BA. PKB binding proteins. Getting in on the Akt. Cell 2002;111:293-303.
  • 33
    • 26044467360 scopus 로고    scopus 로고
    • Xanthone derivatives: New insights in biological activities
    • Pinto MM, Sousa ME, Nascimento MS. Xanthone derivatives: new insights in biological activities. Curr Med Chem 2005;12:2517-38.
    • (2005) Curr Med Chem , vol.12 , pp. 2517-2538
    • Pinto, M.M.1    Sousa, M.E.2    Nascimento, M.S.3
  • 34
    • 2342591455 scopus 로고    scopus 로고
    • The discovery of receptor tyrosine kinases: Targets for cancer therapy
    • Gschwind A, Fischer OM, Ullrich A. The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat Rev Cancer 2004;4:361-70.
    • (2004) Nat Rev Cancer , vol.4 , pp. 361-370
    • Gschwind, A.1    Fischer, O.M.2    Ullrich, A.3
  • 35
    • 34247221517 scopus 로고    scopus 로고
    • The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation
    • Laramee M, Chabot C, Cloutier M, et al. The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation. J Biol Chem 2007;282:7758-69.
    • (2007) J Biol Chem , vol.282 , pp. 7758-7769
    • Laramee, M.1    Chabot, C.2    Cloutier, M.3
  • 36
    • 33749238553 scopus 로고    scopus 로고
    • Discovery and development of sorafenib: A multikinase inhibitor for treating cancer
    • Wilhelm S, Carter C, Lynch M, et al. Discovery and development of sorafenib: a multikinase inhibitor for treating cancer. Nat Rev Drug Discov 2006;5:835-44.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 835-844
    • Wilhelm, S.1    Carter, C.2    Lynch, M.3
  • 37
    • 18444408375 scopus 로고    scopus 로고
    • COX-2: A molecular target for colorectal cancer prevention
    • Brown JR, DuBois RN. COX-2: a molecular target for colorectal cancer prevention. J Clin Oncol 2005;23:2840-55.
    • (2005) J Clin Oncol , vol.23 , pp. 2840-2855
    • Brown, J.R.1    DuBois, R.N.2
  • 39
    • 3242664189 scopus 로고    scopus 로고
    • Mechanisms of inhibition of tumor angiogenesis and vascular tumor growth by epigallocatechin-3-gallate
    • Fassina G, Vene R, Morini M, et al. Mechanisms of inhibition of tumor angiogenesis and vascular tumor growth by epigallocatechin-3-gallate. Clin Cancer Res 2004;10:4865-73.
    • (2004) Clin Cancer Res , vol.10 , pp. 4865-4873
    • Fassina, G.1    Vene, R.2    Morini, M.3
  • 40
    • 28244456279 scopus 로고    scopus 로고
    • Tumor inflammatory angiogenesis and its chemoprevention
    • Albini A, Tosetti F, Benelli R, Noonan DM. Tumor inflammatory angiogenesis and its chemoprevention. Cancer Res 2005;65:10637-41.
    • (2005) Cancer Res , vol.65 , pp. 10637-10641
    • Albini, A.1    Tosetti, F.2    Benelli, R.3    Noonan, D.M.4
  • 41
    • 85047692516 scopus 로고    scopus 로고
    • Signalling pathways of the TNF superfamily: A double-edged sword
    • Aggarwal BB. Signalling pathways of the TNF superfamily: a double-edged sword. Nat Rev Immunol 2003;3:745-56.
    • (2003) Nat Rev Immunol , vol.3 , pp. 745-756
    • Aggarwal, B.B.1
  • 42
    • 33748292990 scopus 로고    scopus 로고
    • Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis
    • He Y, Luo Y, Tang S, et al. Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis. J Clin Invest 2006;116:2344-55.
    • (2006) J Clin Invest , vol.116 , pp. 2344-2355
    • He, Y.1    Luo, Y.2    Tang, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.