CSN facilitates Cullin-RING ubiquitin ligase function by counteracting autocatalytic adapter instability

Nature Cell Biology

Volumn 7, Issue 4, 2005, Pages 387-391

  Wee, Susan ^a   Geyer, Rory K ^a   Toda, Takashi ^b   Wolf, Dieter A ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; BINDING PROTEIN; CULLIN; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; GENE DELETION; GENE MUTATION; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN STABILITY; UBIQUITINATION; YEAST;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CATALYSIS; CULLIN PROTEINS; ENDOPEPTIDASES; MULTIPROTEIN COMPLEXES; PEPTIDE HYDROLASES; PROTEINS; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; UBIQUITIN-PROTEIN LIGASES;

ANIMALIA; SCHIZOSACCHAROMYCES POMBE;

EID: 17344364820     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1241     Document Type: Article

References (27)

1. Cope, G. A. & Deshaies, R. J. COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases. Cell 114, 663-671 (2003).
2. Wolf, D. A., Zhou, C. & Wee, S. The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? Nature Cell Biol. 5, 1029-1033 (2003).
3. Wei, N. & Deng, X. W. The COP9 signalosome. Annu. Rev. Cell Dev. Biol. 19, 261-286 (2003).
4. Groisman, R. et al. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. Cell 113, 357-367 (2003).
5. Zhou, C. et al. Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p. Mol. Cell 11, 927-938 (2003).
6. Deshaies, R. J. SCF and Cullin/Ring H2-based ubiquitin ligases. Annu. Rev. Cell Dev. Biol. 15, 435-467 (1999).
7. Pintard, L. et al. The BTB protein MEL-26 is a substrate-specific adaptor ofthe CUL-3 ubiquitin-ligase. Nature 425, 311-316 (2003).
8. Xu, L. et al. BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature 425, 316-321.
9. Geyer, R., Wee, S., Anderson, S., Yates, J. R. I. & Wolf, D. A. BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases. Mol. Cell 12, 783-790 (2003).
10. Galan, J. M. & Peter, M. Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism. Proc. Natl Acad. Sci. USA 96, 9124-9129 (1999).
11. Wirbelauer, C. et al. The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts. EMBO J. 19, 5362-5375 (2000).
12. Zhou, P. & Howley, P. M. Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases. Mol. Cell 2, 571-580 (1998).
13. Rouillon, A., Barbey, R., Patton, E. E., Tyers, M. & Thomas, D. Feedback-regulated degradation of the transcriptional activator Met4 is triggered by the SCF(Met30) complex. EMBO J. 19, 282-294 (2000).
14. Pan, Z. Q., Kentsis, A., Dias, D. C., Yamoah, K. & Wu, K. Nedd8 on cullin: building an expressway to protein destruction. Oncogene 23, 1985-1997 (2004).
15. Lyapina, S. et al. Promotion of NEDD8-CUL1 conjugate cleavage by COP9 signalosome. Science 292, 1382-1385 (2001).
16. Schwechheimer, C. et al. Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response. Science 292, 1379-1382 (2001).
17. Zhou, C. et al. The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p. BMC Biochemistry 2, 7 (2001).
18. Cope, G. et al. Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of NEDD8 from CUL1. Science 298, 608-611 (2002).
19. Mundt, K. E., Liu, C. & Carr, A. M. Deletion mutants in COP9/signalosome subunits in fission yeast Schizosaccharomyces pombe display distinct phenotypes. Mol. Biol. Cell 13, 493-502 (2002).
20. Pintard, L. et al. Neddylation and deneddylation of CUL-3 is required to target MEI-1/katanin for degradation at the meiosis-to-mitosis transition in C. elegans. Curr. Biol. 13, 911-921 (2003).
21. Mundt, K. E. et al. The COP9/signalosome complex is conserved in fission yeast and has a role in S phase. Curr. Biol. 9, 1427-1430 (1999).
22. Kominami, K., Ochotorena, I. & Toda, T. Two F-box/WD-repeat proteins Pop1 and Pop2 form hetero- and homo- complexes together with cullin-1 in the fission yeast SCF (Skp1-Cullin-1-F-box) ubiquitin ligase. Genes Cells 3, 721-735 (1998).
23. Lehmann, A. et al. Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint. Genes Cells 9, 367-382 (2004).
24. Lu, L., Schulz, H. & Wolf, D. A. The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells. BMC Cell Biol. 3, 22 (2002).
25. Welcker, M. et al. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc. Natl Acad. Sci. USA 101, 9085-9090 (2004).
26. Deffenbaugh, A. E. et al. Release of ubiquitin charged Csc34-A-Ub from the RING domain is essential for ubiquitination of the SCFCdc4-bound substrate Sic1. Cell 114, 611-622 (2003).
27. Bahler, J. et al. Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe. Yeast 14, 943-951 (1998).