USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic Development

Molecular Cell

Volumn 46, Issue 4, 2012, Pages 484-494

  Lin, Zhenghong ^a   Yang, Heeyoung ^a   Kong, Qingfei ^a   Li, Jinping ^a   Lee, Sang Myeong ^a,d   Gao, Beixue ^a   Dong, Hongxin ^a   Wei, Jianjun ^a   Song, Jianxun ^b   Zhang, Donna D ^c   Fang, Deyu ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

^d Chonbuk National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PEPTIDASE; PROTEIN P53; SIRTUIN 1; UBIQUITIN SPECIFIC PEPTIDASE 22; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONJUGATION; CONTROLLED STUDY; DEACETYLATION; EMBRYO; EMBRYO DEATH; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; FEMALE; GENE DELETION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PROTEIN DEPLETION; PROTEIN DETERMINATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RNA INTERFERENCE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UBIQUITINATION;

ANIMALS; APOPTOSIS; DNA DAMAGE; EMBRYONIC DEVELOPMENT; ENDOPEPTIDASES; ENZYME STABILITY; FEMALE; HEK293 CELLS; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PREGNANCY; RECOMBINANT PROTEINS; SIRTUIN 1; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINATION;

MUS;

EID: 84861461517     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2012.03.024     Document Type: Article

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